DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and Fbln1

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_001121019.1 Gene:Fbln1 / 315191 RGDID:1308667 Length:705 Species:Rattus norvegicus


Alignment Length:555 Identity:128/555 - (23%)
Similarity:170/555 - (30%) Gaps:234/555 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly  1040 CLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHS 1104
            |...|...|..|||     .::...|.:.     |...|      |||            ||:..
  Rat    37 CTEGNQMANQHRDC-----SLSYTSESKE-----CRMVQ------EQC------------CHNQL 73

  Fly  1105 DEQHC----------------EKFDKS------KKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNS 1147
            :|.||                ..::.|      |:|   .|.|..|:...:              
  Rat    74 EELHCATGINLA
SEPDGCASLHNYNSSLETIFIKRC---CHCCMLGRAAQA-------------- 121

  Fly  1148 DELLCEATSRCEPGM---FQCG---SGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQ--- 1203
                  ....|||.:   :|||   ...|:.|....|  ....||:|..|..   ..|.:.:   
  Rat   122 ------RGQTCEPNLMISYQCGLVFRACCVKGQENSD--FVRGDGTDLQ
DPA---KIPEEEEQED 175

  Fly  1204 -----RCL-LGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTV 1262
                 ||. .|.|         ...|.|..||:.|         ||... ||..|:       .|
  Rat   176 PYLNDRCRGGGPC---------KQQCRDTGDEVIC---------SCFVG-YQLQSD-------GV 214

  Fly  1263 RCNGTTECPRGEDEADCGDVCSIYEFKCRSGRECIRR--EFRCDGQKDCGDG---SDELSC---- 1318
            .|....||..|             ...||.|..||..  .|||.....||.|   :::.:|    
  Rat   215 SCEDINECITG-------------SHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDID 266

  Fly  1319 ELEKGHHN-------QSQIQPWSTSSRSCRPHLFDCQDG-------------ECVDLSRVC---- 1359
            |.|.|.||       |:.:     .|..|||.| .|:.|             ||:.:|..|    
  Rat   267 ECETGIHNCPPDFICQNTL-----GSFRCRPKL-QCKSGFIQDALGNCIDINECLSISAPCPVGQ 325

  Fly  1360 ------------NNFPDCTNGH---DEGPKCA--------------------------------- 1376
                        .|.|:|..|:   :||.:|.                                 
  Rat   326 TCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGY 390

  Fly  1377 ------------TACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCA 1429
                        ..|:...|| :|.|||..||....|||..|:||..|.:||.|::||. ..||:
  Rat   391 YFDGISRTCVDINECQRYPGR-LCGHKCENTPGSYHCSCSAGFRLSVDGRSCEDVNECL-NSPCS 453

  Fly  1430 QLCENTLGGYQCQCHADFMLRQ-DRVSCKSLQSGA 1463
            |.|.|..|.|||.|...:.|.. |.|:|:.:...|
  Rat   454 QECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECA 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060
LDLa 271..302 CDD:238060
FXa_inhibition 352..387 CDD:291342
Ldl_recept_b 442..482 CDD:278487
LY 466..508 CDD:214531
Ldl_recept_b 529..569 CDD:278487
LY 553..595 CDD:214531
LY 596..637 CDD:214531
FXa_inhibition 669..700 CDD:291342
LY 774..815 CDD:214531
LDLa 1032..1062 CDD:238060 6/21 (29%)
LDLa 1074..1109 CDD:238060 8/34 (24%)
LDLa 1118..1152 CDD:238060 4/33 (12%)
LDLa 1157..1189 CDD:197566 11/37 (30%)
LDLa 1198..1232 CDD:238060 9/42 (21%)
LDLa 1243..1279 CDD:238060 9/35 (26%)
LDLa 1283..1318 CDD:238060 11/39 (28%)
LDLa 1340..1371 CDD:197566 14/62 (23%)
FXa_inhibition 1388..1416 CDD:291342 13/27 (48%)
EGF_CA 1418..1452 CDD:214542 14/34 (41%)
Fbln1NP_001121019.1 ANATO 30..85 CDD:237984 17/75 (23%)
ANATO 107..162 CDD:237984 17/79 (22%)
cEGF 201..221 CDD:289433 8/36 (22%)
EGF_CA 218..261 CDD:284955 14/55 (25%)
EGF_CA 264..>300 CDD:284955 12/41 (29%)
EGF_CA 310..356 CDD:284955 10/45 (22%)
EGF_CA 358..391 CDD:214542 0/32 (0%)
cEGF 381..404 CDD:289433 0/22 (0%)
cEGF 423..446 CDD:289433 10/22 (45%)
cEGF 462..486 CDD:289433 8/23 (35%)
vWFA <481..524 CDD:294047 2/8 (25%)
cEGF 506..530 CDD:289433
EGF_CA 527..567 CDD:284955
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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