DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and Lrp12

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_001128355.1 Gene:Lrp12 / 314941 RGDID:1304943 Length:858 Species:Rattus norvegicus


Alignment Length:478 Identity:113/478 - (23%)
Similarity:159/478 - (33%) Gaps:187/478 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   994 GCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVEALDCEF--RCHSGECLTMNHR---CNGRRDC 1053
            |.|..| ||.|..  ...|.|.:............::|.:  |.:.||.:|::.:   ..|.|.|
  Rat    42 GVSTAC-GETPEQ--IRGPTGIITSPGWPSDYPAKINCSWLIRANPGEIITISFQDFDIQGSRRC 103

  Fly  1054 VDNSDEMNCD-----EEHRR-----KPKVLCSPNQ--FACHSGEQCVDKERRCDNRKDCH----- 1101
              ..|.:..:     |.:|.     .|..:.|.:.  ...||.:..        :||...     
  Rat   104 --TLDWLTIETYKNIESYRACGSTIPPPYISSQDHVWIRFHSDDSV--------SRKGFRLAYFS 158

  Fly  1102 DHSDEQHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLC---------EATSR 1157
            ..|:|.||       .|  .|..|.||||:..:..|:..::|||:|||.:|         .|...
  Rat   159 GKSEEPHC-------AC--DQFRCGNGKCIPEAWKCNSMDECGDSSDEEVCVQDAHPPTTTAFQP 214

  Fly  1158 CEPGMFQCGSG-----SCIAGSWECDGRIDCSDGSDEHDKCVHRSC------------------- 1198
            |....|||.|.     :|:..|.:|||.|||.|..||.| |...:|                   
  Rat   215 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID-CDMPTCGQWLKYFYGTFSSPNYPDF 278

  Fly  1199 -PP-----------DMQRCLL-------------------------------------------- 1207
             ||           |.::.:|                                            
  Rat   279 YPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPRKLLRVLTAFDSHAPLTV 343

  Fly  1208 ----GQ--------------------------------------CLDRSLVCDGHNDCGDKSDEL 1230
                ||                                      |......|||:..|.:..||:
  Rat   344 VSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDEI 408

  Fly  1231 NCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKCRSGRE 1295
            ||     ||   |.::::.|:.| .:|.|.:.|||....||.|.||.:| ..|....|.|::.| 
  Rat   409 NC-----TM---CQKEEFPCSRN-GVCYPRSDRCNYQNHCPNGSDEKNC-FFCQPGNFHCKNNR- 462

  Fly  1296 CIRREFRCDGQKDCGDGSDELSC 1318
            |:...:.||.|.||||||||.||
  Rat   463 CVFESWVCDSQDDCGDGSDEESC 485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060
LDLa 271..302 CDD:238060
FXa_inhibition 352..387 CDD:291342
Ldl_recept_b 442..482 CDD:278487
LY 466..508 CDD:214531
Ldl_recept_b 529..569 CDD:278487
LY 553..595 CDD:214531
LY 596..637 CDD:214531
FXa_inhibition 669..700 CDD:291342
LY 774..815 CDD:214531
LDLa 1032..1062 CDD:238060 8/34 (24%)
LDLa 1074..1109 CDD:238060 7/41 (17%)
LDLa 1118..1152 CDD:238060 14/33 (42%)
LDLa 1157..1189 CDD:197566 14/36 (39%)
LDLa 1198..1232 CDD:238060 14/150 (9%)
LDLa 1243..1279 CDD:238060 13/35 (37%)
LDLa 1283..1318 CDD:238060 16/34 (47%)
LDLa 1340..1371 CDD:197566
FXa_inhibition 1388..1416 CDD:291342
EGF_CA 1418..1452 CDD:214542
Lrp12NP_001128355.1 CUB 47..158 CDD:238001 23/123 (19%)
LDLa 166..200 CDD:238060 15/42 (36%)
LDLa 215..254 CDD:238060 17/39 (44%)
CUB 267..371 CDD:238001 6/103 (6%)
LDLa 375..410 CDD:238060 7/34 (21%)
LDLa 413..448 CDD:238060 13/35 (37%)
LDLa 451..485 CDD:238060 16/34 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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