DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and Lrp6

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_017448147.1 Gene:Lrp6 / 312781 RGDID:1304749 Length:1613 Species:Rattus norvegicus


Alignment Length:1111 Identity:313/1111 - (28%)
Similarity:467/1111 - (42%) Gaps:195/1111 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   352 CKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLRE 416
            |.|::..||..|.....|.||.|..|:.|..|.:||  :|     .:..||::.:..|..:.|..
  Rat   592 CAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC--IV-----PEAFLLFSRRADIRRISLET 649

  Fly   417 DNVRNHVYQVAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDL 479
            :|  |:|......:.:...:.:|  .:.||||:|  ..::|.:|..:||..|.::..|||.||.:
  Rat   650 NN--NNVAIPLTGVKEASALDFDVTDNRIYWTDI--SLKTISRAFMNGSALEHVVEFGLDYPEGM 710

  Fly   480 AVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGR 544
            |||||.:|:|::|.....|.|...||.:..|||.:|:..||:||:.|.:|.|:||:||.||.|.|
  Rat   711 AVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDR 775

  Fly   545 ASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGL 609
            |:||||....:| .|:...||:.:|..::|:||.|.....:::....|..|..:.|. |.||:||
  Rat   776 AAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADD-LPHPFGL 838

  Fly   610 AIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYAVH--------IYHPAKQPN-SPHGCE 665
            ..::|.:||:||:.:|:...:|.||       ::|||...|        ::|.::|.. :.....
  Rat   839 TQYQDYIYWTDWSRRSIERANKTSG-------QNRTIIQGHLDYVMDILVFHSSRQAGWNECASS 896

  Fly   666 NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGR--- 727
            |..||||| ||.| :||..|.||....|..|:|.|....          ..||..:.:|..|   
  Rat   897 NGHCSHLC-LAVP-VGGFVCGCPAHYSLNADNRTCSAPT----------TFLLFSQKSAINRMVI 949

  Fly   728 -HQVSKSYTLPC----LINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSA-- 785
             .|.|....||.    .:..:.|:.::..|...|:.|.:|.:.|.:..:...:|.|::.|.:.  
  Rat   950 DEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEI 1014

  Fly   786 ----LAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPG-QEVPIGLTVMPAEGYLYVVLKA 845
                |:.|..||.:||......||:|..|..|...::  ..| |:.|..:.|.|.:||:|.....
  Rat  1015 QPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVV--LKGEQDRPRAIVVNPEKGYMYFTNLQ 1077

  Fly   846 KRHSHIDKIPLSGKGEQVHVFEDDLG-DDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIF 909
            :|...|::..|.|...:|..|.   | ...:.|..|.:...:||:||||.||..|:....:..:.
  Rat  1078 ERSPKIERAALDGTEREVLFFS---GLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVL 1139

  Fly   910 R-GKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGI 973
            . ..:.:|..|.:..:   |       :||..|......| ||:..::....:.  ..:|..:.|
  Rat  1140 EDSNILQPVGLTVFEN---W-------LYWIDKQQQMIEK-IDMTGREGRTKVQ--ARIAQLSDI 1191

  Fly   974 PLAASSPVGQ-ESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVEALDC---EFR 1034
            .......:.: ..|||.|.||||||||:.:|...:.|.||...|... ...:|.|...|   :|.
  Rat  1192 HAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQ-DELSCGEPPTCSPQQFT 1255

  Fly  1035 CHSG--ECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNR 1097
            |.:|  :|:.:..||:|..:|.|:|||:||.         :||.:||.|.|| ||:|...||:..
  Rat  1256 CFTGDIDCIPVAWRCDGFTECEDHSDELNCP---------VCSESQFQCASG-QCIDGALRCNGD 1310

  Fly  1098 KDCHDHSDEQHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEP-- 1160
            .:|.|.|||::||..     |.:.|..|.||:||.....||...||.|.||||.|..|....|  
  Rat  1311 ANCQDKSDEKNCEVL-----CLIDQFRCANGQCVGKHKKCDHNVDCSDRSDELDCYPTEEPAPQA 1370

  Fly  1161 --------GM-----------FQC---------GSGSCIAGSWECDGRIDCSDGSDEHDKCVHRS 1197
                    |:           |.|         |.|..:...:...|......|...|...:..|
  Rat  1371 TNTVGSVIGVIVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGS 1435

  Fly  1198 CPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQY-------------- 1248
            . |.|.|   |:.:..||...| ...|...|..:. |.:|:.:.|..:..|              
  Rat  1436 L-PGMSR---GKSMISSLSIMG-GSSGPPYDRAHV-TGASSSSSSSTKGTYFPAILNPPPSPATE 1494

  Fly  1249 --------QCTSNLKICLPSTVRCNG------------TTECPRGEDEADCGDVC-SIYEFKCRS 1292
                    ..:||    .|||.|...            ||.|..        ||| |.|....|.
  Rat  1495 RSHYTMEFGYSSN----SPSTHRSYSYRPYSYRHFAPPTTPCST--------DVCDSDYAPSRRM 1547

  Fly  1293 GRECIRREFRCDGQKDC-------GDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDG 1350
            ......:.:..|...|.       ...|..||.|     .|.....|...:.||...||:.....
  Rat  1548 TSVATAKGYTSDLNYDSEPVPPPPTPRSQYLSAE-----ENYESCPPSPYTERSYSHHLYPPPPS 1607

  Fly  1351 ECVDLS 1356
            .|.|.|
  Rat  1608 PCTDSS 1613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060
LDLa 184..216 CDD:238060
LDLa 227..262 CDD:238060
LDLa 271..302 CDD:238060
FXa_inhibition 352..387 CDD:291342 12/34 (35%)
Ldl_recept_b 442..482 CDD:278487 16/39 (41%)
LY 466..508 CDD:214531 18/41 (44%)
Ldl_recept_b 529..569 CDD:278487 19/39 (49%)
LY 553..595 CDD:214531 10/41 (24%)
LY 596..637 CDD:214531 15/40 (38%)
FXa_inhibition 669..700 CDD:291342 16/30 (53%)
LY 774..815 CDD:214531 14/46 (30%)
LDLa 1032..1062 CDD:238060 12/31 (39%)
LDLa 1074..1109 CDD:238060 17/34 (50%)
LDLa 1118..1152 CDD:238060 16/33 (48%)
LDLa 1157..1189 CDD:197566 8/61 (13%)
LDLa 1198..1232 CDD:238060 9/33 (27%)
LDLa 1243..1279 CDD:238060 10/69 (14%)
LDLa 1283..1318 CDD:238060 8/42 (19%)
LDLa 1340..1371 CDD:197566 5/17 (29%)
FXa_inhibition 1388..1416 CDD:291342
EGF_CA 1418..1452 CDD:214542
Lrp6XP_017448147.1 NHL 55..272 CDD:302697
NHL repeat 55..93 CDD:271320
LY 89..127 CDD:214531
NHL repeat 97..132 CDD:271320
NHL repeat 140..176 CDD:271320
Ldl_recept_b 150..190 CDD:278487
LY 175..216 CDD:214531
NHL repeat 181..217 CDD:271320
NHL repeat 226..253 CDD:271320
FXa_inhibition 286..323 CDD:291342
LY 353..393 CDD:214531
LY 397..437 CDD:214531
LY 438..481 CDD:214531
LY 483..524 CDD:214531
LY 525..558 CDD:214531
FXa_inhibition 592..627 CDD:291342 12/34 (35%)
LY 656..694 CDD:214531 8/39 (21%)
LY 697..739 CDD:214531 18/41 (44%)
LY 740..783 CDD:214531 24/42 (57%)
LY 783..825 CDD:214531 10/42 (24%)
LY 827..866 CDD:214531 15/46 (33%)
FXa_inhibition 893..929 CDD:291342 17/37 (46%)
LY 958..998 CDD:214531 8/39 (21%)
LY 1001..1048 CDD:214531 14/46 (30%)
Ldl_recept_b 1069..1110 CDD:278487 11/43 (26%)
LY 1094..1136 CDD:214531 14/44 (32%)
FXa_inhibition 1207..1243 CDD:291342 15/36 (42%)
LDLa 1249..1285 CDD:238060 13/35 (37%)
LDLa 1288..1322 CDD:238060 17/34 (50%)
LDLa 1326..1360 CDD:238060 16/33 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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