| Sequence 1: | NP_996433.1 | Gene: | yl / 32367 | FlyBaseID: | FBgn0004649 | Length: | 1984 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_786938.2 | Gene: | Ldlr / 300438 | RGDID: | 2998 | Length: | 879 | Species: | Rattus norvegicus |
| Alignment Length: | 659 | Identity: | 236/659 - (35%) |
|---|---|---|---|
| Similarity: | 347/659 - (52%) | Gaps: | 67/659 - (10%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 75 CGGTAAGTPGS-----ADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPPHW 134
Fly 135 FPCAQPHGACLAAELMCNGIDNCPGGEDE--LNCPVRPGFRFGDTAHRMRS--CSKYEFMCQQDR 195
Fly 196 TCIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDER 260
Fly 261 GCLNL--CEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKP--DCDAKKCA--LGA 319
Fly 320 KCHMMP--ASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDK 382
Fly 383 DNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAYD--GSHIYW 445
Fly 446 TNI-QNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCA 509
Fly 510 VLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQR 574
Fly 575 IYWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDH 637
Fly 638 RILAKD-RTIYAVHIYHPAKQPNSPHGCE-----NATCSHLCLLAEPEIGGHS----CACPDGMR 692
Fly 693 LAPDHRRCM 701 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| yl | NP_996433.1 | LDLa | 90..124 | CDD:238060 | 15/33 (45%) |
| LDLa | 131..166 | CDD:238060 | 11/36 (31%) | ||
| LDLa | 184..216 | CDD:238060 | 15/31 (48%) | ||
| LDLa | 227..262 | CDD:238060 | 13/34 (38%) | ||
| LDLa | 271..302 | CDD:238060 | 14/30 (47%) | ||
| FXa_inhibition | 352..387 | CDD:291342 | 15/34 (44%) | ||
| Ldl_recept_b | 442..482 | CDD:278487 | 12/40 (30%) | ||
| LY | 466..508 | CDD:214531 | 14/41 (34%) | ||
| Ldl_recept_b | 529..569 | CDD:278487 | 16/39 (41%) | ||
| LY | 553..595 | CDD:214531 | 18/41 (44%) | ||
| LY | 596..637 | CDD:214531 | 14/42 (33%) | ||
| FXa_inhibition | 669..700 | CDD:291342 | 19/34 (56%) | ||
| LY | 774..815 | CDD:214531 | |||
| LDLa | 1032..1062 | CDD:238060 | |||
| LDLa | 1074..1109 | CDD:238060 | |||
| LDLa | 1118..1152 | CDD:238060 | |||
| LDLa | 1157..1189 | CDD:197566 | |||
| LDLa | 1198..1232 | CDD:238060 | |||
| LDLa | 1243..1279 | CDD:238060 | |||
| LDLa | 1283..1318 | CDD:238060 | |||
| LDLa | 1340..1371 | CDD:197566 | |||
| FXa_inhibition | 1388..1416 | CDD:291342 | |||
| EGF_CA | 1418..1452 | CDD:214542 | |||
| Ldlr | NP_786938.2 | Ldl_recept_a | 25..58 | CDD:395011 | |
| Ldl_recept_a | 66..104 | CDD:395011 | 4/14 (29%) | ||
| Ldl_recept_a | 107..143 | CDD:395011 | 15/35 (43%) | ||
| Ldl_recept_a | 196..232 | CDD:395011 | 17/37 (46%) | ||
| Ldl_recept_a | 235..271 | CDD:395011 | 14/36 (39%) | ||
| Ldl_recept_a | 279..309 | CDD:395011 | 12/30 (40%) | ||
| FXa_inhibition | 319..353 | CDD:405372 | 12/34 (35%) | ||
| EGF_CA | 355..389 | CDD:214542 | 17/34 (50%) | ||
| LDL-receptor class B 1 | 398..439 | 10/47 (21%) | |||
| NHL | <435..628 | CDD:302697 | 68/192 (35%) | ||
| NHL repeat | 435..469 | CDD:271320 | 7/33 (21%) | ||
| LDL-receptor class B 2 | 440..485 | 15/44 (34%) | |||
| NHL repeat | 476..514 | CDD:271320 | 13/37 (35%) | ||
| LDL-receptor class B 3 | 486..528 | 11/41 (27%) | |||
| LDL-receptor class B 4 | 529..572 | 18/42 (43%) | |||
| Ldl_recept_b | 529..569 | CDD:395012 | 16/39 (41%) | ||
| NHL repeat | 555..600 | CDD:271320 | 21/44 (48%) | ||
| LDL-receptor class B 5 | 573..615 | 19/41 (46%) | |||
| NHL repeat | 606..628 | CDD:271320 | 10/21 (48%) | ||
| LDL-receptor class B 6 | 616..658 | 9/41 (22%) | |||
| Ldl_recept_b | 616..655 | CDD:395012 | 8/38 (21%) | ||
| FXa_inhibition | 674..711 | CDD:405372 | 20/37 (54%) | ||
| Clustered O-linked oligosaccharides | 717..788 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 718..797 | ||||
| Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130 | 830..879 | ||||
| NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130 | 842..847 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 1 | 1.000 | - | - | FOG0002088 | |
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.900 | |||||