DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and Lrp1

DIOPT Version :10

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_008763615.1 Gene:Lrp1 / 299858 RGDID:1307535 Length:4562 Species:Rattus norvegicus


Alignment Length:2061 Identity:542/2061 - (26%)
Similarity:797/2061 - (38%) Gaps:659/2061 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MCQAEHQVHPS----EQRIRVES---PKMTASRR-------------GFNLTSQTRAHPSSGGST 45
            :|...||.|.:    ..||..|.   ..|.:|.|             .|:||....:|.......
  Rat  2510 LCLLTHQGHVNCSCRGGRILQEDFTCRAMNSSCRAQDEFECANGECISFSLTCDGVSHCKDKSDE 2574

  Fly    46 SSRYGN---CQRTHLIINGRHVAISLLLLVGL--CGGTAAGTPGSADTRCDAGQFQCRDGGCILQ 105
            ...|.|   |::|....|......::|...|:  ||..:...|.: .|.|..|:|:||||.||..
  Rat  2575 KPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPCN-KTACGVGEFRCRDGSCIGN 2638

  Fly   106 AKMCDGRGDCKDSSDELDCD-------YR---------------LCRPPHW-------------- 134
            :..|:...||:|:|||::|.       :|               ||..|.|              
  Rat  2639 SSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE 2703

  Fly   135 ---------------FPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSC 184
                           |.|  |.|.|:.....|:..|:|..||||.:|              .:.|
  Rat  2704 RDCPGVKRPRCPLNYFAC--PSGRCIPMSWTCDKEDDCENGEDETHC--------------NKFC 2752

  Fly   185 SKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCK-----QAEITCPGEGHLCANGRCLRRKQ 244
            |:.:|.||..| ||...::|||..||.|.|||.|.|:     .:..:|||. |:|...|      
  Rat  2753 SEAQFECQNHR-CISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGT-HVCVPER------ 2809

  Fly   245 WVCDGVDDCGDGSDE---RGCL--NLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDET--- 301
            |:|||..||.||:||   .|||  :.|:.:  :|:|:|| .|:....|||...||:|||||:   
  Rat  2810 WLCDGDKDCADGADESISAGCLYNSTCDDR--EFMCQNR-LCIPKHFVCDHDRDCADGSDESPEC 2871

  Fly   302 ----------------------------DLCHSKPD----------------------CDAKKCA 316
                                        :.||...|                      |.:.:|.
  Rat  2872 EYPTCGPNEFRCANGRCLSSRQWECDGENDCHDHSDEAPKNPHCTSPEHKCNASSQFLCSSGRCV 2936

  Fly   317 LGA----------------KCHMMPA----------------SGAECFCPKGFRLAKFEDKCEDV 349
            ..|                .||:...                .|.:|.|..||||......|.||
  Rat  2937 AEALLCNGQDDCGDGSDERGCHVNECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADV 3001

  Fly   350 DECKEQDDLCSQGCENTSGGYRCVCDAGYL-LDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMH 413
            |||..... |||.|.||.|.|:|:|..||. ...|..:|:||.    :::|.|::..:     .:
  Rat  3002 DECSTTFP-CSQLCINTHGSYKCLCVEGYAPRGGDPHSCKAVT----DEEPFLIFANR-----YY 3056

  Fly   414 LREDNVRNHVYQ-VAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDA 475
            ||:.|:....|. :...|:..:.:.:|  |..||||::..:...|.:.:.:|||.::|..:||..
  Rat  3057 LRKLNLDGSNYTLLKQGLNNAVALDFDYRGQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSN 3121

  Fly   476 PEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKP 540
            |:.|||||:..|:|:.|.....|.|...:|....|||:..:.:||:|.|..|.|.::|||||:..
  Rat  3122 PDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3186

  Fly   541 MIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKH 605
            :|||..||||....||...|.||||:.:|...:||||.||:...::....||:.|..||...:.|
  Rat  3187 LIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPH 3251

  Fly   606 PYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYA---VHIYHPAKQPNSP-HGCE- 665
            .:.|.:|||.:||:||.|||::..||.:|.:..:|..  |::.   :|::|..:||:.| |.|: 
  Rat  3252 IFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLIS--TLHRPMDLHVFHALRQPDVPNHPCKV 3314

  Fly   666 -NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQ 729
             |..||:||||:..  |||.||||....|..|.|.|:                            
  Rat  3315 NNGGCSNLCLLSPG--GGHKCACPTNFYLGGDGRTCV---------------------------- 3349

  Fly   730 VSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRN 794
                            :....|..:..||:                         .:.|      
  Rat  3350 ----------------SNCTASQFVCKNDK-------------------------CIPF------ 3367

  Fly   795 LYW-ADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSHIDKIPLSG 858
             :| .||                                                          
  Rat  3368 -WWKCDT---------------------------------------------------------- 3373

  Fly   859 KGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRRPYSLAMVH 923
                    |||.||                                ||                 
  Rat  3374 --------EDDCGD--------------------------------HS----------------- 3381

  Fly   924 HDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPC 988
                                            |:|    |..|                  ...|
  Rat  3382 --------------------------------DEP----PDCP------------------EFKC 3392

  Fly   989 QQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE-----------ALDCEFRC-HSGECL 1041
            :.....||         ..||..|| |:.  .|:..|.:           .|..:|:| ::..|:
  Rat  3393 RPGQFQCS---------TGICTNPA-FIC--DGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCI 3445

  Fly  1042 TMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQC------------------- 1087
            ....||||:.:|.|..||.:|       |:|.|:||||.|...::|                   
  Rat  3446 PGIFRCNGQDNCGDGEDERDC-------PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE 3503

  Fly  1088 ----------VDKER------------RCDNRKDCHDHSDE--QHCEKFDKSKKCHVHQHGCDNG 1128
                      ||:.|            :||...||.|.|||  :.|::    :.|..:|..|.|.
  Rat  3504 PANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDE----RTCEPYQFRCKNN 3564

  Fly  1129 KCVDSSLVCDGTNDCGDNSDELLCEATSR-CEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDK 1192
            :||.....||..|||||||||..|  |.| |....|.|.:|.||||.|:|||..||:|||||.| 
  Rat  3565 RCVPGRWQCDYDNDCGDNSDEESC--TPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKD- 3626

  Fly  1193 CVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKIC 1257
            |..| |..|..:|..|.|:.....||...||.|.|||..|||...|    |..|::||.:.|  |
  Rat  3627 CTPR-CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRT----CPLDEFQCNNTL--C 3684

  Fly  1258 LPSTVRCNGTTECPRGEDEADCGDVCSIYE------FKCRSGRECIRREFRCDGQKDCGDGSDEL 1316
            .|...:|:|..:|  |::..:..:.|:.::      |:|::.|.|:....:|||..:||||:||.
  Rat  3685 KPLAWKCDGEDDC--GDNSDENPEECTRFQCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEE 3747

  Fly  1317 SCELEKGHHNQSQIQPWSTSSRSCRPHL-FDCQDGECVDLSRVCNNFPDCTNGHDE-----GPKC 1375
            .||            |.:..:..|:... |.|::..|:..|..||.|.||.:|.||     .|| 
  Rat  3748 DCE------------PPTAQNPHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPK- 3799

  Fly  1376 ATACRSASGRQVC--QHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGG 1438
            .|:|  |:...:|  :.:|..|...|.|:|..|:.....|..|.||:||.....|:|||.||.||
  Rat  3800 LTSC--ATNASMCGDEARCVRTEKAAYCACRPGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGG 3862

  Fly  1439 YQCQCHADFMLRQDRVSCKSLQSGATLLF-SSFNEVRNL--------SEQPVMLNVAWSANDS-R 1493
            :.|.|..:||...:  :||:..|...:|: :..||:|:|        .||      |:..::| |
  Rat  3863 HLCSCARNFMKTHN--TCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQ------AFQGDESVR 3919

  Fly  1494 ITGFDLAMHRQMGYFSAEDEGIV------------------YQIDLQTKVIVRALGLPAPTKLSV 1540
            |...|:.:.....|::....|.:                  .||| :....:...||..|..:::
  Rat  3920 IDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQID-RGVTHLNISGLKMPRGIAI 3983

  Fly  1541 DWVTGNVY-VLSGAQEIQACSFVGRMCGRIVH--VKSPRHVKHLAVDGYHARIFYIVIRTEGYGQ 1602
            |||.|||| ..||...|:.....|.....::.  :..|..:   .||.....:::     ..:| 
  Rat  3984 DWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI---VVDPLRGTMYW-----SDWG- 4039

  Fly  1603 TSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLK-TGPMRRPE 1666
            ...:|..|.:||:.|:.|:|.:..:.|.|..|.|.:.||:.|..:..:.  |.||. |.|:    
  Rat  4040 NHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIG--SIRLNGTDPI---- 4098

  Fly  1667 IMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINVL----NAQDIVVAGR 1727
            :.:.....|.||..:.|:|:..:.|...:....:...:|    |...||:.    :|.|:|:..:
  Rat  4099 VAVDSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFG----HSPLINLTGGLSHASDVVLYHQ 4159

  Fly  1728 SRQPQKASHPCAHAHCHGLCLQADYGYECMCGNRLVAEGERCPHGS 1773
            .:||: .::||....|..|||.:..|..|.|.|     |:|..:|:
  Rat  4160 HKQPE-VTNPCDRKKCEWLCLLSPSGPVCTCPN-----GKRLDNGT 4199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 16/33 (48%)
LDLa 131..166 CDD:238060 14/63 (22%)
LDLa 184..216 CDD:238060 15/31 (48%)
LDLa 227..262 CDD:238060 16/37 (43%)
LDLa 271..302 CDD:238060 15/61 (25%)
FXa_inhibition 352..387 CDD:464251 14/35 (40%)
Ldl_recept_b 442..483 CDD:459654 15/40 (38%)
LY 466..508 CDD:214531 15/41 (37%)
Ldl_recept_b 529..569 CDD:459654 20/39 (51%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 17/40 (43%)
FXa_inhibition 669..700 CDD:464251 16/30 (53%)
LY 774..815 CDD:214531 4/41 (10%)
LDLa 1032..1062 CDD:238060 11/30 (37%)
LDLa 1074..1109 CDD:238060 18/77 (23%)
LDLa 1118..1152 CDD:238060 17/33 (52%)
LDLa 1157..1189 CDD:197566 18/32 (56%)
LDLa 1198..1232 CDD:238060 13/33 (39%)
LDLa 1243..1279 CDD:238060 11/35 (31%)
LDLa 1283..1318 CDD:238060 14/40 (35%)
LDLa 1340..1371 CDD:197566 11/31 (35%)
FXa_inhibition 1388..1416 CDD:464251 8/29 (28%)
EGF_CA 1418..1452 CDD:214542 16/33 (48%)
Lrp1XP_008763615.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:464251
FXa_inhibition 159..189 CDD:464251
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:464251
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:464251
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060
FXa_inhibition 1203..1239 CDD:464251
Vgb 1328..>1521 CDD:443399
LY 1354..1394 CDD:214531
LY 1398..1441 CDD:214531
LY 1631..1667 CDD:214531
LY 1668..1711 CDD:214531
LY 1715..1752 CDD:214531
LY 1752..1793 CDD:214531
FXa_inhibition 1868..1904 CDD:464251
LY 1934..1974 CDD:214531
LY 1977..2017 CDD:214531
LY 2018..2061 CDD:214531
LY 2063..2105 CDD:214531
FXa_inhibition 2177..2212 CDD:464251
LY 2293..2333 CDD:214531
Ldl_recept_b 2362..2404 CDD:459654
LY 2388..2429 CDD:214531
FXa_inhibition 2500..2532 CDD:464251 6/21 (29%)
LDLa 2545..2575 CDD:238060 4/29 (14%)
LDLa 2584..2618 CDD:238060 7/33 (21%)
LDLa 2623..2657 CDD:238060 16/33 (48%)
LDLa <2684..2706 CDD:238060 3/21 (14%)
LDLa 2714..2748 CDD:238060 12/35 (34%)
LDLa 2752..2783 CDD:197566 15/31 (48%)
LDLa 2791..2824 CDD:197566 14/39 (36%)
LDLa 2835..2867 CDD:197566 14/34 (41%)
LDLa 2875..2908 CDD:197566 2/32 (6%)
LDLa 2925..2957 CDD:238060 3/31 (10%)
cEGF 2982..3003 CDD:463661 9/20 (45%)
EGF_CA 3000..>3029 CDD:214542 15/29 (52%)
LY 3067..3111 CDD:214531 11/43 (26%)
LY 3112..3154 CDD:214531 15/41 (37%)
LY 3156..3198 CDD:214531 21/41 (51%)
LY 3200..3241 CDD:214531 16/40 (40%)
LY 3242..3282 CDD:214531 17/39 (44%)
FXa_inhibition 3312..3348 CDD:464251 18/37 (49%)
LDLa 3352..3383 CDD:238060 14/209 (7%)
LDLa 3392..3426 CDD:238060 10/45 (22%)
LDLa 3431..3466 CDD:238060 12/34 (35%)
LDLa 3470..3503 CDD:197566 7/32 (22%)
LDLa 3511..3544 CDD:197566 9/32 (28%)
LDLa 3554..3588 CDD:238060 17/33 (52%)
LDLa 3593..3627 CDD:238060 20/34 (59%)
LDLa 3631..3665 CDD:238060 13/33 (39%)
LDLa 3671..3703 CDD:197566 12/39 (31%)
LDLa 3713..3749 CDD:238060 13/35 (37%)
LDLa 3764..3794 CDD:238060 12/29 (41%)
YncE 3880..4082 CDD:442618 49/217 (23%)
LY 3973..4010 CDD:214531 14/36 (39%)
Ldl_recept_b 4031..4072 CDD:459654 10/46 (22%)
LY 4055..4096 CDD:214531 12/42 (29%)
Blue background indicates that the domain is not in the aligned region.

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