DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and Lrp1

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_008763615.1 Gene:Lrp1 / 299858 RGDID:1307535 Length:4562 Species:Rattus norvegicus


Alignment Length:2061 Identity:542/2061 - (26%)
Similarity:797/2061 - (38%) Gaps:659/2061 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MCQAEHQVHPS----EQRIRVES---PKMTASRR-------------GFNLTSQTRAHPSSGGST 45
            :|...||.|.:    ..||..|.   ..|.:|.|             .|:||....:|.......
  Rat  2510 LCLLTHQGHVNCSCRGGRILQEDFTCRAMNSSCRAQDEFECANGECISFSLTCDGVSHCKDKSDE 2574

  Fly    46 SSRYGN---CQRTHLIINGRHVAISLLLLVGL--CGGTAAGTPGSADTRCDAGQFQCRDGGCILQ 105
            ...|.|   |::|....|......::|...|:  ||..:...|.: .|.|..|:|:||||.||..
  Rat  2575 KPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPCN-KTACGVGEFRCRDGSCIGN 2638

  Fly   106 AKMCDGRGDCKDSSDELDCD-------YR---------------LCRPPHW-------------- 134
            :..|:...||:|:|||::|.       :|               ||..|.|              
  Rat  2639 SSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDE 2703

  Fly   135 ---------------FPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSC 184
                           |.|  |.|.|:.....|:..|:|..||||.:|              .:.|
  Rat  2704 RDCPGVKRPRCPLNYFAC--PSGRCIPMSWTCDKEDDCENGEDETHC--------------NKFC 2752

  Fly   185 SKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCK-----QAEITCPGEGHLCANGRCLRRKQ 244
            |:.:|.||..| ||...::|||..||.|.|||.|.|:     .:..:|||. |:|...|      
  Rat  2753 SEAQFECQNHR-CISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGT-HVCVPER------ 2809

  Fly   245 WVCDGVDDCGDGSDE---RGCL--NLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDET--- 301
            |:|||..||.||:||   .|||  :.|:.:  :|:|:|| .|:....|||...||:|||||:   
  Rat  2810 WLCDGDKDCADGADESISAGCLYNSTCDDR--EFMCQNR-LCIPKHFVCDHDRDCADGSDESPEC 2871

  Fly   302 ----------------------------DLCHSKPD----------------------CDAKKCA 316
                                        :.||...|                      |.:.:|.
  Rat  2872 EYPTCGPNEFRCANGRCLSSRQWECDGENDCHDHSDEAPKNPHCTSPEHKCNASSQFLCSSGRCV 2936

  Fly   317 LGA----------------KCHMMPA----------------SGAECFCPKGFRLAKFEDKCEDV 349
            ..|                .||:...                .|.:|.|..||||......|.||
  Rat  2937 AEALLCNGQDDCGDGSDERGCHVNECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADV 3001

  Fly   350 DECKEQDDLCSQGCENTSGGYRCVCDAGYL-LDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMH 413
            |||..... |||.|.||.|.|:|:|..||. ...|..:|:||.    :::|.|::..:     .:
  Rat  3002 DECSTTFP-CSQLCINTHGSYKCLCVEGYAPRGGDPHSCKAVT----DEEPFLIFANR-----YY 3056

  Fly   414 LREDNVRNHVYQ-VAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDA 475
            ||:.|:....|. :...|:..:.:.:|  |..||||::..:...|.:.:.:|||.::|..:||..
  Rat  3057 LRKLNLDGSNYTLLKQGLNNAVALDFDYRGQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSN 3121

  Fly   476 PEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKP 540
            |:.|||||:..|:|:.|.....|.|...:|....|||:..:.:||:|.|..|.|.::|||||:..
  Rat  3122 PDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHS 3186

  Fly   541 MIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKH 605
            :|||..||||....||...|.||||:.:|...:||||.||:...::....||:.|..||...:.|
  Rat  3187 LIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYIEFASLDGSNRHVVLSQDIPH 3251

  Fly   606 PYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYA---VHIYHPAKQPNSP-HGCE- 665
            .:.|.:|||.:||:||.|||::..||.:|.:..:|..  |::.   :|::|..:||:.| |.|: 
  Rat  3252 IFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLIS--TLHRPMDLHVFHALRQPDVPNHPCKV 3314

  Fly   666 -NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQ 729
             |..||:||||:..  |||.||||....|..|.|.|:                            
  Rat  3315 NNGGCSNLCLLSPG--GGHKCACPTNFYLGGDGRTCV---------------------------- 3349

  Fly   730 VSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRN 794
                            :....|..:..||:                         .:.|      
  Rat  3350 ----------------SNCTASQFVCKNDK-------------------------CIPF------ 3367

  Fly   795 LYW-ADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSHIDKIPLSG 858
             :| .||                                                          
  Rat  3368 -WWKCDT---------------------------------------------------------- 3373

  Fly   859 KGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRRPYSLAMVH 923
                    |||.||                                ||                 
  Rat  3374 --------EDDCGD--------------------------------HS----------------- 3381

  Fly   924 HDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPC 988
                                            |:|    |..|                  ...|
  Rat  3382 --------------------------------DEP----PDCP------------------EFKC 3392

  Fly   989 QQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE-----------ALDCEFRC-HSGECL 1041
            :.....||         ..||..|| |:.  .|:..|.:           .|..:|:| ::..|:
  Rat  3393 RPGQFQCS---------TGICTNPA-FIC--DGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCI 3445

  Fly  1042 TMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQC------------------- 1087
            ....||||:.:|.|..||.:|       |:|.|:||||.|...::|                   
  Rat  3446 PGIFRCNGQDNCGDGEDERDC-------PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE 3503

  Fly  1088 ----------VDKER------------RCDNRKDCHDHSDE--QHCEKFDKSKKCHVHQHGCDNG 1128
                      ||:.|            :||...||.|.|||  :.|::    :.|..:|..|.|.
  Rat  3504 PANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDE----RTCEPYQFRCKNN 3564

  Fly  1129 KCVDSSLVCDGTNDCGDNSDELLCEATSR-CEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDK 1192
            :||.....||..|||||||||..|  |.| |....|.|.:|.||||.|:|||..||:|||||.| 
  Rat  3565 RCVPGRWQCDYDNDCGDNSDEESC--TPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKD- 3626

  Fly  1193 CVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKIC 1257
            |..| |..|..:|..|.|:.....||...||.|.|||..|||...|    |..|::||.:.|  |
  Rat  3627 CTPR-CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRT----CPLDEFQCNNTL--C 3684

  Fly  1258 LPSTVRCNGTTECPRGEDEADCGDVCSIYE------FKCRSGRECIRREFRCDGQKDCGDGSDEL 1316
            .|...:|:|..:|  |::..:..:.|:.::      |:|::.|.|:....:|||..:||||:||.
  Rat  3685 KPLAWKCDGEDDC--GDNSDENPEECTRFQCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEE 3747

  Fly  1317 SCELEKGHHNQSQIQPWSTSSRSCRPHL-FDCQDGECVDLSRVCNNFPDCTNGHDE-----GPKC 1375
            .||            |.:..:..|:... |.|::..|:..|..||.|.||.:|.||     .|| 
  Rat  3748 DCE------------PPTAQNPHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPK- 3799

  Fly  1376 ATACRSASGRQVC--QHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGG 1438
            .|:|  |:...:|  :.:|..|...|.|:|..|:.....|..|.||:||.....|:|||.||.||
  Rat  3800 LTSC--ATNASMCGDEARCVRTEKAAYCACRPGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGG 3862

  Fly  1439 YQCQCHADFMLRQDRVSCKSLQSGATLLF-SSFNEVRNL--------SEQPVMLNVAWSANDS-R 1493
            :.|.|..:||...:  :||:..|...:|: :..||:|:|        .||      |:..::| |
  Rat  3863 HLCSCARNFMKTHN--TCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQ------AFQGDESVR 3919

  Fly  1494 ITGFDLAMHRQMGYFSAEDEGIV------------------YQIDLQTKVIVRALGLPAPTKLSV 1540
            |...|:.:.....|::....|.:                  .||| :....:...||..|..:::
  Rat  3920 IDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQID-RGVTHLNISGLKMPRGIAI 3983

  Fly  1541 DWVTGNVY-VLSGAQEIQACSFVGRMCGRIVH--VKSPRHVKHLAVDGYHARIFYIVIRTEGYGQ 1602
            |||.|||| ..||...|:.....|.....::.  :..|..:   .||.....:::     ..:| 
  Rat  3984 DWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI---VVDPLRGTMYW-----SDWG- 4039

  Fly  1603 TSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLK-TGPMRRPE 1666
            ...:|..|.:||:.|:.|:|.:..:.|.|..|.|.:.||:.|..:..:.  |.||. |.|:    
  Rat  4040 NHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIG--SIRLNGTDPI---- 4098

  Fly  1667 IMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINVL----NAQDIVVAGR 1727
            :.:.....|.||..:.|:|:..:.|...:....:...:|    |...||:.    :|.|:|:..:
  Rat  4099 VAVDSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFG----HSPLINLTGGLSHASDVVLYHQ 4159

  Fly  1728 SRQPQKASHPCAHAHCHGLCLQADYGYECMCGNRLVAEGERCPHGS 1773
            .:||: .::||....|..|||.:..|..|.|.|     |:|..:|:
  Rat  4160 HKQPE-VTNPCDRKKCEWLCLLSPSGPVCTCPN-----GKRLDNGT 4199

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 16/33 (48%)
LDLa 131..166 CDD:238060 14/63 (22%)
LDLa 184..216 CDD:238060 15/31 (48%)
LDLa 227..262 CDD:238060 16/37 (43%)
LDLa 271..302 CDD:238060 15/61 (25%)
FXa_inhibition 352..387 CDD:291342 14/35 (40%)
Ldl_recept_b 442..482 CDD:278487 14/39 (36%)
LY 466..508 CDD:214531 15/41 (37%)
Ldl_recept_b 529..569 CDD:278487 20/39 (51%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 17/40 (43%)
FXa_inhibition 669..700 CDD:291342 16/30 (53%)
LY 774..815 CDD:214531 4/41 (10%)
LDLa 1032..1062 CDD:238060 11/30 (37%)
LDLa 1074..1109 CDD:238060 18/77 (23%)
LDLa 1118..1152 CDD:238060 17/33 (52%)
LDLa 1157..1189 CDD:197566 18/32 (56%)
LDLa 1198..1232 CDD:238060 13/33 (39%)
LDLa 1243..1279 CDD:238060 11/35 (31%)
LDLa 1283..1318 CDD:238060 14/40 (35%)
LDLa 1340..1371 CDD:197566 11/31 (35%)
FXa_inhibition 1388..1416 CDD:291342 8/29 (28%)
EGF_CA 1418..1452 CDD:214542 16/33 (48%)
Lrp1XP_008763615.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:291342
FXa_inhibition 161..189 CDD:291342
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:291342
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:291342
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060
FXa_inhibition 1203..1239 CDD:291342
LY 1354..1394 CDD:214531
LY 1398..1441 CDD:214531
LY 1442..1486 CDD:214531
LY 1631..1667 CDD:214531
LY 1668..1711 CDD:214531
LY 1715..1752 CDD:214531
LY 1752..1793 CDD:214531
FXa_inhibition 1868..1904 CDD:291342
LY 1934..1974 CDD:214531
LY 1977..2017 CDD:214531
LY 2018..2061 CDD:214531
LY 2063..2105 CDD:214531
FXa_inhibition 2177..2212 CDD:291342
YvrE 2271..2481 CDD:225921
Ldl_recept_b 2362..2403 CDD:278487
LY 2388..2429 CDD:214531
FXa_inhibition 2500..2532 CDD:291342 6/21 (29%)
LDLa 2545..2575 CDD:238060 4/29 (14%)
LDLa 2584..2618 CDD:238060 7/33 (21%)
LDLa 2623..2657 CDD:238060 16/33 (48%)
LDLa <2684..2706 CDD:238060 3/21 (14%)
LDLa 2714..2748 CDD:238060 12/35 (34%)
LDLa 2752..2783 CDD:197566 15/31 (48%)
LDLa 2791..2824 CDD:197566 14/39 (36%)
LDLa 2835..2867 CDD:197566 14/34 (41%)
LDLa 2875..2908 CDD:197566 2/32 (6%)
LDLa 2925..2957 CDD:238060 3/31 (10%)
cEGF 2980..3003 CDD:289433 10/22 (45%)
EGF_CA 3000..>3029 CDD:214542 15/29 (52%)
LY 3067..3111 CDD:214531 11/43 (26%)
LY 3112..3154 CDD:214531 15/41 (37%)
LY 3156..3198 CDD:214531 21/41 (51%)
LY 3200..3241 CDD:214531 16/40 (40%)
LY 3242..3282 CDD:214531 17/39 (44%)
FXa_inhibition 3312..3348 CDD:291342 18/37 (49%)
LDLa 3352..3383 CDD:238060 14/209 (7%)
LDLa 3392..3426 CDD:238060 10/45 (22%)
LDLa 3431..3466 CDD:238060 12/34 (35%)
LDLa 3470..3503 CDD:197566 7/32 (22%)
LDLa 3511..3544 CDD:197566 9/32 (28%)
LDLa 3554..3588 CDD:238060 17/33 (52%)
LDLa 3593..3627 CDD:238060 20/34 (59%)
LDLa 3631..3665 CDD:238060 13/33 (39%)
LDLa 3671..3703 CDD:197566 12/39 (31%)
LDLa 3713..3749 CDD:238060 13/35 (37%)
LDLa 3764..3794 CDD:238060 12/29 (41%)
LY 3973..4010 CDD:214531 14/36 (39%)
Ldl_recept_b 4031..4071 CDD:278487 10/45 (22%)
LY 4055..4096 CDD:214531 12/42 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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