DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and LpR1

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster

Alignment Length:	817	Identity:	245/817 - (29%)
Similarity:	352/817 - (43%)	Gaps:	225/817 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 GTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKD----------------SSDELDCD 125
            ||..|...|.:.:||..||||..|.||....:|||..||||                |||:..|.
  Fly   123 GTPLGIGQSLEAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCG 187

  Fly   126 YRLCRPPHW---------------------------FPCAQPHGACLAAELMCNGIDNCPGGEDE 163
            ...|.|..|                           |.| |....|:....:|:|.::|....||
  Fly   188 NGNCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKC-QTVDQCIPRSWLCDGSNDCRDKSDE 251

  Fly   164 LNCPVRPGFRFGDTAHRMRSCSKYEFMCQQ-DRTCIPIDFMCDGRPDCTDKSDE---VAGCKQAE 224
            .:|             |.|:||..|:.|:. :..|:|:.:|||...||:|.|||   ...|:..|
  Fly   252 AHC-------------RARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCNQTCRADE 303

  Fly   225 ITCP-----------------GEG----------------HLCANGRCLRRKQWVCDGVDDCGDG 256
            .||.                 |:|                |.|.||.|: .|:|||||..||.||
  Fly   304 FTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAEHTCTNGACI-AKRWVCDGDPDCSDG 367

  Fly   257 SDERGCLNLCEPQ----KGKFLCRNRETCLTLSEVCDGHSDCSDGSDETD--------------- 302
            ||||.|.|:.:..    ..::.|::|.|||..|.:|||..||.||.||..
  Fly   368 SDERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQC 432

  Fly   303 ----------LCHSKPDC----DAKKCAL--------------------GAKCHMMPAS------ 327
                      .|:...||    |.:.|.|                    |.:|  :|.|
  Fly   433 GDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQC--VPLSKVCDKR 495

  Fly   328 -----------------------------------GAECFCPKGFRLAKFEDKCEDVDECKEQDD 357
                                               |..|.|.:|::|:..:..|:|::|| |...
  Fly   496 KDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINEC-EVPG 559

  Fly   358 LCSQGCENTSGGYRCVCDAGYLLDKDNRT-CRAVVYGSKEQQPLLLYTTQMTIMGM---HLREDN 418
            .|||.|.|..||::|.|:|||:.|..|.| |:|     .|....||...:..|..:   |:...:
  Fly   560 KCSQICVNEIGGFKCECEAGYMRDPKNHTRCKA-----SEGHASLLLARRHDIRKIALDHMEMTS 619

  Fly   419 VRNHVYQVAGNLSKVIGVAYDGSHIYWTNIQNEAESIVKANGD-GSNAEILLTSGLDAPEDLAVD 482
            :.|     :...:..:...:....|:|:::  ..:||.||..| |:...::||......:.||||
  Fly   620 IVN-----STKAATALDFVFRTGMIFWSDV--TTQSIYKAPIDEGNEKTVVLTKSSVTSDGLAVD 677

  Fly   483 WLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASM 547
            |:..::||:|.....|.:.:.:|....|||...:..|||:|:.|.:|.|:|:|||..|.|.||.|
  Fly   678 WIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGM 742

  Fly   548 DGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVL--DGMLKHPYGLA 610
            |||....|:|.:::|||||.||:.::||||||.||..:.:...||:.|..||  ...|:||:.:.
  Fly   743 DGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSIT 807

  Fly   611 IFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTI---YAVHIYHPAKQPNSPHGCE--NATCS 670
            .|||.:||:||..::|...:||:|:|...:.....:   ..||:|||.:||:..:.|:  |..||
  Fly   808 TFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSVNGHCS 872

  Fly   671 HLCLLA------EPEIGGHSCACPDGMRLAPDHRRCM 701
            ||||.|      .|.|   |||||.|::|..|...|:
  Fly   873 HLCLPAPRINERSPRI---SCACPTGLKLMVDGLMCV 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	19/49 (39%)
		LDLa	131..166	CDD:238060	11/61 (18%)
		LDLa	184..216	CDD:238060	13/32 (41%)
		LDLa	227..262	CDD:238060	22/67 (33%)
		LDLa	271..302	CDD:238060	15/30 (50%)
		FXa_inhibition	352..387	CDD:291342	17/35 (49%)
		Ldl_recept_b	442..482	CDD:278487	12/40 (30%)
		LY	466..508	CDD:214531	12/41 (29%)
		Ldl_recept_b	529..569	CDD:278487	21/39 (54%)
		LY	553..595	CDD:214531	19/41 (46%)
		LY	596..637	CDD:214531	16/42 (38%)
		FXa_inhibition	669..700	CDD:291342	17/36 (47%)
		LY	774..815	CDD:214531
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	16/31 (52%)
		LDLa	178..210	CDD:197566	7/31 (23%)
		LDLa	219..254	CDD:238060	9/35 (26%)
		LDLa	259..295	CDD:238060	15/35 (43%)
		LDLa	343..373	CDD:238060	19/30 (63%)
		LDLa	383..415	CDD:197566	13/31 (42%)
		Ldl_recept_a	423..459	CDD:278486	4/35 (11%)
		LDLa	476..504	CDD:197566	4/29 (14%)
		FXa_inhibition	514..549	CDD:291342	5/34 (15%)
		EGF_CA	551..581	CDD:214542	15/30 (50%)
		LY	662..702	CDD:214531	12/39 (31%)
		LY	704..747	CDD:214531	22/42 (52%)
		LY	749..790	CDD:214531	19/40 (48%)
		FXa_inhibition	864..905	CDD:291342	19/43 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840