DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and SORCS3

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_055793.1	Gene:	SORCS3 / 22986	HGNCID:	16699	Length:	1222	Species:	Homo sapiens

Alignment Length:	815	Identity:	157/815 - (19%)
Similarity:	249/815 - (30%)	Gaps:	289/815 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   384 NRTCRAVVYGSKEQ-----------QPLLLYTTQMTIMGMHLREDNVRNH-VYQVAGNLSKVIGV 436
            :|..|.:..||:|:           :.|.|.:|...:.|     |:..|. :...:|:.|.||.:
Human   154 SRGSRPLAKGSREEVKAPRAGGSAAEDLRLPSTSFALTG-----DSAHNQAMVHWSGHNSSVILI 213

  Fly   437 AYDGSHIYWTNIQNEAESIVKANGD-GSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAV 500
            .   :.:|..|:.:..||.:..:.| |:..|.|       .:.:.:..:...:|.:....|.|.:
Human   214 L---TKLYDFNLGSVTESSLWRSTDYGTTYEKL-------NDKVGLKTVLSYLYVNPTNKRKIML 268

  Fly   501 CSNDGLNCAVLVTQD---VHQPRSLAVWPQKGLMF---WTDWGEKPMIGR---ASMDGSRSRPIV 556
            .|:..:..::|::.|   .:|...|..:.| .|:|   ..||.....:.:   :|||..|...::
Human   269 LSDPEMESSILISSDEGATYQKYRLTFYIQ-SLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLM 332

  Fly   557 SDNIEWPNGIALDMHQQRIYW------VDAKLGSVQTVRPDGTGR----------RTVLDGMLKH 605
            .:.|. ||         |.||      .:|.|..::....||...          .|...|
Human   333 HERIT-PN---------RFYWSVAGLDKEADLVHMEVRTTDGYAHYLTCRIQECAETTRSG---- 383

  Fly   606 PYGLAIFEDQLYWSD-----WATKSVHACH---------------KFS-GKDHRILAKDRT-IYA 648
            |:..:|....|...|     ..|.|..|.:               |:| .||..|::.|.. ::|
Human   384 PFARSIDISSLVVQDEYIFIQVTTSGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFA 448

  Fly   649 V------------------HIYHPAKQPN--SPHGCENATCSHL--------CLLAEPEIGG--- 682
            .                  .||......|  |..|........|        ..||..::..
Human   449 AVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVK 513

  Fly   683 -----------HSCACPD-GMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYT 735
                       .....|| .:|.:|.|  |:|.      |..| .:.|::....:...::|...|
Human   514 TYITYNKGRDWRLLQAPDVDLRGSPVH--CLLP------FCSL-HLHLQLSENPYSSGRISSKET 569

  Fly   736 LPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADT 800
            .|.|:  :....|...|...|               ..|.:.|:.||.....||. ..|:::.|.
Human   570 APGLV--VATGNIGPELSYTD---------------IGVFISSDGGNTWRQIFDE-EYNVWFLDW 616

  Fly   801 ERAVIEV--LSLQTRHRALIRFFPGQE-VPIGLTVMPAEGYLYV---VLKAKRHSHIDKIPLSGK 859
            ..|::.:  ..|..|| ..:.|..|.. ...|.|.:|    |:|   :::|...:||
Human   617 GGALVAMKHTPLPVRH-LWVSFDEGHSWDKYGFTSVP----LFVDGALVEAGMETHI-------- 668

  Fly   860 GEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRRPYSLAMVHH 924
                                    .|:|      |..|               ||..:.|..|.:
Human   669 ------------------------MTVF------GHFS---------------LRSEWQLVKVDY 688

  Fly   925 DLFWNELGTPRIYWT-HKSN------MGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVG 982
            ...::...|...|.| |..|      ||.||   |.:|..|                 .|...:|
Human   689 KSIFSRHCTKEDYQTWHLLNQGEPCVMGERK---IFKKRKP-----------------GAQCALG 733

  Fly   983 QE------SHPCQQQNGGCSHICVGEGPYHSICL-----CPAGFVYRDAGNRTCVEALDCEFRCH 1036
            ::      |.||                   :|.     |..|  |...|...||.|........
Human   734 RDHSGSVVSEPC-------------------VCANWDFECDYG--YERHGESQCVPAFWYNPASP 777

  Fly  1037 SGECLTMNHRCN--GRRDCVDNSDEMNCDEEHRRK 1069
            |.:|.......|  |.|..|.|    ||.:..|.|
Human   778 SKDCSLGQSYLNSTGYRRIVSN----NCTDGLREK 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060
		LDLa	131..166	CDD:238060
		LDLa	184..216	CDD:238060
		LDLa	227..262	CDD:238060
		LDLa	271..302	CDD:238060
		FXa_inhibition	352..387	CDD:291342	1/2 (50%)
		Ldl_recept_b	442..482	CDD:278487	8/40 (20%)
		LY	466..508	CDD:214531	6/41 (15%)
		Ldl_recept_b	529..569	CDD:278487	11/45 (24%)
		LY	553..595	CDD:214531	10/47 (21%)
		LY	596..637	CDD:214531	12/61 (20%)
		FXa_inhibition	669..700	CDD:291342	8/53 (15%)
		LY	774..815	CDD:214531	11/42 (26%)
		LDLa	1032..1062	CDD:238060	7/31 (23%)
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
SORCS3	NP_055793.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..70
		DUF3628	<73..>184	CDD:289100	6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..180		5/25 (20%)
		VPS10	219..817	CDD:214740	141/742 (19%)
		BNR 1	231..242		2/10 (20%)
		BNR 2	279..290		2/10 (20%)
		BNR 3	320..331		4/10 (40%)
		BNR 4	515..526		0/10 (0%)
		BNR 5	592..603		3/10 (30%)
		BNR 6	634..645		2/10 (20%)
		Sortilin_C	665..817	CDD:292523	46/242 (19%)
		PKD	831..904	CDD:279180
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910