DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and Lrp4

DIOPT Version :10

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_766256.3 Gene:Lrp4 / 228357 MGIID:2442252 Length:1905 Species:Mus musculus


Alignment Length:2081 Identity:513/2081 - (24%)
Similarity:792/2081 - (38%) Gaps:564/2081 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 CGGTAAGTPGSADTRCDA-----GQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPP-- 132
            ||       .::|.:||.     .:|:|.||.||.:...|||..||||.|||..|...:..||  
Mouse   135 CG-------DNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCN 192

  Fly   133 -HWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRT 196
             ..|.||  :|.|:.....|:|.|:|....||.:|          ::|  :.|...||||... .
Mouse   193 LEEFQCA--YGRCILDIYHCDGDDDCGDWSDESDC----------SSH--QPCRSGEFMCDSG-L 242

  Fly   197 CIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERG 261
            ||...:.|||..||.|:||| ..|..:  .|..|...|.:|||: |..|.|||.|||.|.|||..
Mouse   243 CINSGWRCDGDADCDDQSDE-RNCTTS--MCTAEQFRCRSGRCV-RLSWRCDGEDDCADNSDEEN 303

  Fly   262 CLNLCEPQ--KGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKP-----DCDAKKCALGA 319
            |.|...||  ..:|||.|.. |:...::|:|.:||.|.|||:...:.:|     :|:........
Mouse   304 CENTGSPQCASDQFLCWNGR-CIGQRKLCNGINDCGDSSDESPQQNCRPRTGEENCNVNNGGCAQ 367

  Fly   320 KCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDN 384
            ||.|: ....:|.|..|:||.:....|:||:||.| :..|||||.||.|.::|.|:|||.|..|.
Mouse   368 KCQMV-RGAVQCTCHTGYRLTEDGRTCQDVNECAE-EGYCSQGCTNTEGAFQCWCEAGYELRPDR 430

  Fly   385 RTCRAVVYGSKEQQPLLLYTTQMTIMGM--HLREDNVRNHVYQVAGNLSKVIGVAYDGSH----I 443
            |:|:|:     ..:|:||:..::.|..:  |      |:....:..||...|  |.|..|    :
Mouse   431 RSCKAL-----GPEPVLLFANRIDIRQVLPH------RSEYTLLLNNLENAI--ALDFHHRRELV 482

  Fly   444 YWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNC 508
            :|:::  ..:.|::||.:|||.|.::::||::|..|||||:...:|::|:....|.|.:.||.:.
Mouse   483 FWSDV--TLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545

  Fly   509 AVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQ 573
            .||:.|.:.:||::|:.|.:|.::|||||..|.|..:|||||..|.|...::.||||:.:|...:
Mouse   546 KVLLWQSLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR 610

  Fly   574 RIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHR 638
            |:||||||...::....||:.|:.|:...|.||:.:.:|||.|||:||.|||:::.:||:||:..
Mouse   611 RMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQE 675

  Fly   639 ILAKDRTIYA--VHIYHPAKQPNSPHGC--ENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRR 699
            |: :::..:.  :|..||.:||...:.|  .|..|:||||   |....::||||.|.|....|..
Mouse   676 II-RNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL---PSGQNYTCACPTGFRKINSHAC 736

  Fly   700 CMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQR---- 760
            ...::|    |: |....::|...:|....:|         ::::......|.:..|.|.|    
Mouse   737 AQSLDK----FL-LFARRMDIRRISFDTEDLS---------DDVIPLADVRSAVALDWDSRDDHV 787

  Fly   761 --------LILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRAL 817
                    .|...:.:.....|:|.::|.:.:.||.|.::..|||.|.....|||.:.....|.:
Mouse   788 YWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTV 852

  Fly   818 IRFFPGQEVPIGLTVMPAEGYLYVV---LKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVT 879
            : .:...:.|..:.|.|..||:|..   ...|    |::..:.....||.:..:....:.  |..
Mouse   853 L-IWENLDRPRDIVVEPMGGYMYWTDWGASPK----IERAGMDASSRQVIISSNLTWPNG--LAI 910

  Fly   880 DYETQTIFWSDSDLGRISYSNYRVPHSQIFRG-KLRRPYSLAMVHHDLFWNELGTPRIY------ 937
            ||.:|.::|:|:.:..|.::.......::..| :|..|:.|.:....::|.:..|..|.      
Mouse   911 DYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSADRLT 975

  Fly   938 ----WTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSHI 998
                .|.:.|:.....|.:..:..|       ||.|                 .|..:||||||:
Mouse   976 GLDRETLQENLENLMDIHVFHRQRP-------PVTT-----------------LCAVENGGCSHL 1016

  Fly   999 CV-GEGPYHSICLCPAGF-VYRDAGNRTCVEALDCEFRCHSGECLTMNHRCNGRRDCVD------ 1055
            |: ...|....|.||.|. :.||  .:||...::        ..|....|.:.|...:|      
Mouse  1017 CLRSPNPSGFSCTCPTGINLLRD--GKTCSPGMN--------SFLIFARRIDVRMVSLDIPYFAD 1071

  Fly  1056 ----------NSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCE 1110
                      |:..:..|            |.:...:..:..:.:..|..  .|...|.|     
Mouse  1072 VVVPINMTMKNTIAIGVD------------PLEGKVYWSDSTLHRISRAS--LDGSQHED----- 1117

  Fly  1111 KFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSW 1175
                                    ::..|.    ..:|.|..:|..|   .::...:|:      
Mouse  1118 ------------------------IITTGL----QTTDGLAVDAIGR---KVYWTDTGT------ 1145

  Fly  1176 ECDGRIDCS--DGSDEHDKCVHRSCPPDMQRCLLGQCLD--RSLVCDGH------NDCGDKSDEL 1230
               .||:..  |||              |::.|:.|.||  |::|....      .|.|:.:...
Mouse  1146 ---NRIEVGNLDGS--------------MRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLE 1193

  Fly  1231 NCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKCRSGRE 1295
            ..|.|.|                     ..||..|.....|.|. ..|                 
Mouse  1194 RSGMDGS---------------------DRTVLINNNLGWPNGL-TVD----------------- 1219

  Fly  1296 CIRREFRCDGQKDCGDGSDELSCELE----KGHHNQSQIQP------------------WSTSSR 1338
                  :...|....|...|   .:|    .|.:..:.:.|                  |.|.| 
Mouse  1220 ------KTSSQLLWADAHTE---RIEVADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRS- 1274

  Fly  1339 SCRPHLFDCQDGECVDLSRVCNNFP---DCTNGHDEGPKCATACRSASGRQVCQHKCRATPAGAV 1400
               .|..|...|..|.|.|  :|.|   |........|.....|.|.:|.  |.|.|...|:|..
Mouse  1275 ---IHRADKSTGSNVILVR--SNLPGLMDIQAVDRAQPLGFNKCGSRNGG--CSHLCLPRPSGFS 1332

  Fly  1401 CSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATL 1465
            |:|..|.:|..|:|:|   |...|                                      ..|
Mouse  1333 CACPTGIQLKGDRKTC---DPSPE--------------------------------------TYL 1356

  Fly  1466 LFSSFNEVRNLS-----------EQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGIVYQI 1519
            ||||...:|.:|           ..|.:.||.....||        :|           |.||..
Mouse  1357 LFSSRGSIRRISLDTDDHTDVHVPVPGLNNVISLDYDS--------VH-----------GKVYYT 1402

  Fly  1520 DLQTKVIVRA------------LGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVGRMCGRIV- 1570
            |:...||.||            .||.....|:||||..|:| ..:|...|:|....| .|.::: 
Mouse  1403 DVFLDVIRRADLNGSNMETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDG-SCRKVLI 1466

  Fly  1571 --HVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTT 1633
              .:..||.:......||   :|:     ..:|.. ::|..|.||||.|.:|:.....:...||.
Mouse  1467 NNSLDEPRAIAVFPRKGY---LFW-----TDWGHI-AKIERANLDGSERKVLINTDLGWPNGLTL 1522

  Fly  1634 DPHQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEA 1698
            |...:.:|:||.|   |:||......|.:|:..:     :.:.||..|:..:...:..:..:...
Mouse  1523 DYDTRRIYWVDAH---LDRIESADLNGKLRQVLV-----SHVSHPFALTQQDRWIYWTDWQTKSI 1579

  Fly  1699 VQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPCA--HAHCHGLCLQADYGYECMCGN- 1760
            .:...|..|....:..||....||:|.  |.|.|..::.|.  :..|..||......:.|.|.: 
Mouse  1580 QRVDKYSGRNKETVLANVEGLMDIIVV--SPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDE 1642

  Fly  1761 -----------------RLVAEGERCP---------------------HGSGNEV----AVLG-- 1781
                             |..:..|:.|                     .|:|...    |.||  
Mouse  1643 PDGHPCSLVPGLVPPAPRATSMNEKSPVLPNTLPTTLHSSTTKTRTSLEGAGGRCSERDAQLGLC 1707

  Fly  1782 -----AVNSLELEHEHEQ---NGHFHWLMALFVLAAGSLIAGLGYMYYQYRQRGHTDLNI-NMHF 1837
                 ||.:...|..|..   .|....|:.|.|:||        .|.|::|:...||..: |:.:
Mouse  1708 AHSNEAVPAAPGEGLHVSYAIGGLLSILLILLVIAA--------LMLYRHRKSKFTDPGMGNLTY 1764

  Fly  1838 QNPLATLGGTKAFLEHE-----------RAEAG-------------------VGFTTETGTV--- 1869
            .||.......:..||..           :.|.|                   .|...|.|.:   
Mouse  1765 SNPSYRTSTQEVKLEAAPKPAVYNQLCYKKEGGPDHSYTKEKIKIVEGIRLLAGDDAEWGDLKQL 1829

  Fly  1870 -SSRGS--NDTFTTTSATSSFAAQQFSVPNALQRLLRPRQSASG---DPMAQELLLESPSRESKL 1928
             ||||.  .|.....:.|.|.                  |::||   |...::||.|..|..|.:
Mouse  1830 RSSRGGLLRDHVCMKTDTVSI------------------QASSGSLDDTETEQLLQEEQSECSSV 1876

  Fly  1929 H 1929
            |
Mouse  1877 H 1877

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 18/38 (47%)
LDLa 131..166 CDD:238060 13/37 (35%)
LDLa 184..216 CDD:238060 14/31 (45%)
LDLa 227..262 CDD:238060 18/34 (53%)
LDLa 271..302 CDD:238060 13/30 (43%)
FXa_inhibition 352..387 CDD:464251 18/34 (53%)
Ldl_recept_b 442..483 CDD:459654 15/44 (34%)
LY 466..508 CDD:214531 15/41 (37%)
Ldl_recept_b 529..569 CDD:459654 19/39 (49%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 19/40 (48%)
FXa_inhibition 669..700 CDD:464251 13/30 (43%)
LY 774..815 CDD:214531 13/40 (33%)
LDLa 1032..1062 CDD:238060 5/45 (11%)
LDLa 1074..1109 CDD:238060 5/34 (15%)
LDLa 1118..1152 CDD:238060 3/33 (9%)
LDLa 1157..1189 CDD:197566 7/33 (21%)
LDLa 1198..1232 CDD:238060 9/41 (22%)
LDLa 1243..1279 CDD:238060 5/35 (14%)
LDLa 1283..1318 CDD:238060 3/34 (9%)
LDLa 1340..1371 CDD:197566 9/33 (27%)
FXa_inhibition 1388..1416 CDD:464251 11/27 (41%)
EGF_CA 1418..1452 CDD:214542 2/33 (6%)
Lrp4NP_766256.3 LDLa 27..66 CDD:238060
Ldl_recept_a 70..105 CDD:395011
LDLa 110..142 CDD:238060 3/13 (23%)
LDLa 148..182 CDD:238060 16/33 (48%)
LDLa 231..265 CDD:238060 16/35 (46%)
LDLa 270..304 CDD:238060 18/34 (53%)
LDLa 311..343 CDD:197566 12/32 (38%)
FXa_inhibition 358..393 CDD:464251 9/35 (26%)
EGF_CA 395..434 CDD:214542 21/39 (54%)
LY 460..502 CDD:214531 12/45 (27%)
LDL-receptor class B 1 480..522 16/43 (37%)
LY 505..545 CDD:214531 14/39 (36%)
LDL-receptor class B 2 523..565 13/41 (32%)
LDL-receptor class B 3 566..609 20/42 (48%)
Ldl_recept_b 566..607 CDD:459654 19/40 (48%)
LY 590..632 CDD:214531 16/41 (39%)
LDL-receptor class B 4 610..652 16/41 (39%)
LY 633..673 CDD:214531 18/39 (46%)
LDL-receptor class B 5 653..693 15/40 (38%)
FXa_inhibition 702..>729 CDD:464251 13/29 (45%)
YncE 749..982 CDD:442618 46/248 (19%)
LDL-receptor class B 6 785..827 7/41 (17%)
LY 808..850 CDD:214531 13/41 (32%)
LDL-receptor class B 7 828..870 11/42 (26%)
LDL-receptor class B 8 871..914 10/48 (21%)
Ldl_recept_b 871..912 CDD:459654 8/46 (17%)
LY 895..937 CDD:214531 9/43 (21%)
LDL-receptor class B 9 915..956 8/40 (20%)
LDL-receptor class B 10 957..998 6/40 (15%)
FXa_inhibition 1006..1043 CDD:464251 15/38 (39%)
NHL <1085..1277 CDD:302697 44/316 (14%)
NHL repeat 1085..1123 CDD:271320 6/80 (8%)
LDL-receptor class B 11 1093..1135 8/76 (11%)
NHL repeat 1128..1161 CDD:271320 10/58 (17%)
LDL-receptor class B 12 1136..1178 14/67 (21%)
NHL repeat 1166..1203 CDD:271320 9/57 (16%)
LDL-receptor class B 13 1179..1222 11/87 (13%)
Ldl_recept_b 1179..1219 CDD:459654 10/61 (16%)
NHL repeat 1212..1244 CDD:271320 8/58 (14%)
LDL-receptor class B 14 1223..1263 6/42 (14%)
NHL repeat 1253..1277 CDD:271320 3/27 (11%)
LDL-receptor class B 15 1264..1306 12/47 (26%)
FXa_inhibition 1313..1348 CDD:464251 14/36 (39%)
Vgb 1359..1583 CDD:443399 61/260 (23%)
LDL-receptor class B 16 1397..1439 14/41 (34%)
LDL-receptor class B 17 1440..1482 9/42 (21%)
LDL-receptor class B 18 1483..1526 15/51 (29%)
Ldl_recept_b 1483..1524 CDD:459654 14/49 (29%)
LY 1507..1547 CDD:214531 11/42 (26%)
LDL-receptor class B 19 1527..1568 12/48 (25%)
LDL-receptor class B 20 1569..1610 8/42 (19%)
FXa_inhibition 1617..1648 CDD:464251 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1661..1696 4/34 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905 9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

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