DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and Lrp4

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_766256.3 Gene:Lrp4 / 228357 MGIID:2442252 Length:1905 Species:Mus musculus


Alignment Length:2081 Identity:513/2081 - (24%)
Similarity:792/2081 - (38%) Gaps:564/2081 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 CGGTAAGTPGSADTRCDA-----GQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPP-- 132
            ||       .::|.:||.     .:|:|.||.||.:...|||..||||.|||..|...:..||  
Mouse   135 CG-------DNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCN 192

  Fly   133 -HWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRT 196
             ..|.||  :|.|:.....|:|.|:|....||.:|          ::|  :.|...||||... .
Mouse   193 LEEFQCA--YGRCILDIYHCDGDDDCGDWSDESDC----------SSH--QPCRSGEFMCDSG-L 242

  Fly   197 CIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERG 261
            ||...:.|||..||.|:||| ..|..:  .|..|...|.:|||: |..|.|||.|||.|.|||..
Mouse   243 CINSGWRCDGDADCDDQSDE-RNCTTS--MCTAEQFRCRSGRCV-RLSWRCDGEDDCADNSDEEN 303

  Fly   262 CLNLCEPQ--KGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKP-----DCDAKKCALGA 319
            |.|...||  ..:|||.|.. |:...::|:|.:||.|.|||:...:.:|     :|:........
Mouse   304 CENTGSPQCASDQFLCWNGR-CIGQRKLCNGINDCGDSSDESPQQNCRPRTGEENCNVNNGGCAQ 367

  Fly   320 KCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDN 384
            ||.|: ....:|.|..|:||.:....|:||:||.| :..|||||.||.|.::|.|:|||.|..|.
Mouse   368 KCQMV-RGAVQCTCHTGYRLTEDGRTCQDVNECAE-EGYCSQGCTNTEGAFQCWCEAGYELRPDR 430

  Fly   385 RTCRAVVYGSKEQQPLLLYTTQMTIMGM--HLREDNVRNHVYQVAGNLSKVIGVAYDGSH----I 443
            |:|:|:     ..:|:||:..::.|..:  |      |:....:..||...|  |.|..|    :
Mouse   431 RSCKAL-----GPEPVLLFANRIDIRQVLPH------RSEYTLLLNNLENAI--ALDFHHRRELV 482

  Fly   444 YWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNC 508
            :|:::  ..:.|::||.:|||.|.::::||::|..|||||:...:|::|:....|.|.:.||.:.
Mouse   483 FWSDV--TLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545

  Fly   509 AVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQ 573
            .||:.|.:.:||::|:.|.:|.::|||||..|.|..:|||||..|.|...::.||||:.:|...:
Mouse   546 KVLLWQSLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGR 610

  Fly   574 RIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHR 638
            |:||||||...::....||:.|:.|:...|.||:.:.:|||.|||:||.|||:::.:||:||:..
Mouse   611 RMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQE 675

  Fly   639 ILAKDRTIYA--VHIYHPAKQPNSPHGC--ENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRR 699
            |: :::..:.  :|..||.:||...:.|  .|..|:||||   |....::||||.|.|....|..
Mouse   676 II-RNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCL---PSGQNYTCACPTGFRKINSHAC 736

  Fly   700 CMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQR---- 760
            ...::|    |: |....::|...:|....:|         ::::......|.:..|.|.|    
Mouse   737 AQSLDK----FL-LFARRMDIRRISFDTEDLS---------DDVIPLADVRSAVALDWDSRDDHV 787

  Fly   761 --------LILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRAL 817
                    .|...:.:.....|:|.::|.:.:.||.|.::..|||.|.....|||.:.....|.:
Mouse   788 YWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTV 852

  Fly   818 IRFFPGQEVPIGLTVMPAEGYLYVV---LKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVT 879
            : .:...:.|..:.|.|..||:|..   ...|    |::..:.....||.:..:....:.  |..
Mouse   853 L-IWENLDRPRDIVVEPMGGYMYWTDWGASPK----IERAGMDASSRQVIISSNLTWPNG--LAI 910

  Fly   880 DYETQTIFWSDSDLGRISYSNYRVPHSQIFRG-KLRRPYSLAMVHHDLFWNELGTPRIY------ 937
            ||.:|.::|:|:.:..|.::.......::..| :|..|:.|.:....::|.:..|..|.      
Mouse   911 DYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGQRIYWTDWQTKSIQSADRLT 975

  Fly   938 ----WTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSHI 998
                .|.:.|:.....|.:..:..|       ||.|                 .|..:||||||:
Mouse   976 GLDRETLQENLENLMDIHVFHRQRP-------PVTT-----------------LCAVENGGCSHL 1016

  Fly   999 CV-GEGPYHSICLCPAGF-VYRDAGNRTCVEALDCEFRCHSGECLTMNHRCNGRRDCVD------ 1055
            |: ...|....|.||.|. :.||  .:||...::        ..|....|.:.|...:|      
Mouse  1017 CLRSPNPSGFSCTCPTGINLLRD--GKTCSPGMN--------SFLIFARRIDVRMVSLDIPYFAD 1071

  Fly  1056 ----------NSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCE 1110
                      |:..:..|            |.:...:..:..:.:..|..  .|...|.|     
Mouse  1072 VVVPINMTMKNTIAIGVD------------PLEGKVYWSDSTLHRISRAS--LDGSQHED----- 1117

  Fly  1111 KFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSW 1175
                                    ::..|.    ..:|.|..:|..|   .::...:|:      
Mouse  1118 ------------------------IITTGL----QTTDGLAVDAIGR---KVYWTDTGT------ 1145

  Fly  1176 ECDGRIDCS--DGSDEHDKCVHRSCPPDMQRCLLGQCLD--RSLVCDGH------NDCGDKSDEL 1230
               .||:..  |||              |::.|:.|.||  |::|....      .|.|:.:...
Mouse  1146 ---NRIEVGNLDGS--------------MRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLE 1193

  Fly  1231 NCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKCRSGRE 1295
            ..|.|.|                     ..||..|.....|.|. ..|                 
Mouse  1194 RSGMDGS---------------------DRTVLINNNLGWPNGL-TVD----------------- 1219

  Fly  1296 CIRREFRCDGQKDCGDGSDELSCELE----KGHHNQSQIQP------------------WSTSSR 1338
                  :...|....|...|   .:|    .|.:..:.:.|                  |.|.| 
Mouse  1220 ------KTSSQLLWADAHTE---RIEVADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRS- 1274

  Fly  1339 SCRPHLFDCQDGECVDLSRVCNNFP---DCTNGHDEGPKCATACRSASGRQVCQHKCRATPAGAV 1400
               .|..|...|..|.|.|  :|.|   |........|.....|.|.:|.  |.|.|...|:|..
Mouse  1275 ---IHRADKSTGSNVILVR--SNLPGLMDIQAVDRAQPLGFNKCGSRNGG--CSHLCLPRPSGFS 1332

  Fly  1401 CSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATL 1465
            |:|..|.:|..|:|:|   |...|                                      ..|
Mouse  1333 CACPTGIQLKGDRKTC---DPSPE--------------------------------------TYL 1356

  Fly  1466 LFSSFNEVRNLS-----------EQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGIVYQI 1519
            ||||...:|.:|           ..|.:.||.....||        :|           |.||..
Mouse  1357 LFSSRGSIRRISLDTDDHTDVHVPVPGLNNVISLDYDS--------VH-----------GKVYYT 1402

  Fly  1520 DLQTKVIVRA------------LGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVGRMCGRIV- 1570
            |:...||.||            .||.....|:||||..|:| ..:|...|:|....| .|.::: 
Mouse  1403 DVFLDVIRRADLNGSNMETVIGHGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDG-SCRKVLI 1466

  Fly  1571 --HVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTT 1633
              .:..||.:......||   :|:     ..:|.. ::|..|.||||.|.:|:.....:...||.
Mouse  1467 NNSLDEPRAIAVFPRKGY---LFW-----TDWGHI-AKIERANLDGSERKVLINTDLGWPNGLTL 1522

  Fly  1634 DPHQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEA 1698
            |...:.:|:||.|   |:||......|.:|:..:     :.:.||..|:..:...:..:..:...
Mouse  1523 DYDTRRIYWVDAH---LDRIESADLNGKLRQVLV-----SHVSHPFALTQQDRWIYWTDWQTKSI 1579

  Fly  1699 VQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPCA--HAHCHGLCLQADYGYECMCGN- 1760
            .:...|..|....:..||....||:|.  |.|.|..::.|.  :..|..||......:.|.|.: 
Mouse  1580 QRVDKYSGRNKETVLANVEGLMDIIVV--SPQRQTGTNACGVNNGGCTHLCFARASDFVCACPDE 1642

  Fly  1761 -----------------RLVAEGERCP---------------------HGSGNEV----AVLG-- 1781
                             |..:..|:.|                     .|:|...    |.||  
Mouse  1643 PDGHPCSLVPGLVPPAPRATSMNEKSPVLPNTLPTTLHSSTTKTRTSLEGAGGRCSERDAQLGLC 1707

  Fly  1782 -----AVNSLELEHEHEQ---NGHFHWLMALFVLAAGSLIAGLGYMYYQYRQRGHTDLNI-NMHF 1837
                 ||.:...|..|..   .|....|:.|.|:||        .|.|::|:...||..: |:.:
Mouse  1708 AHSNEAVPAAPGEGLHVSYAIGGLLSILLILLVIAA--------LMLYRHRKSKFTDPGMGNLTY 1764

  Fly  1838 QNPLATLGGTKAFLEHE-----------RAEAG-------------------VGFTTETGTV--- 1869
            .||.......:..||..           :.|.|                   .|...|.|.:   
Mouse  1765 SNPSYRTSTQEVKLEAAPKPAVYNQLCYKKEGGPDHSYTKEKIKIVEGIRLLAGDDAEWGDLKQL 1829

  Fly  1870 -SSRGS--NDTFTTTSATSSFAAQQFSVPNALQRLLRPRQSASG---DPMAQELLLESPSRESKL 1928
             ||||.  .|.....:.|.|.                  |::||   |...::||.|..|..|.:
Mouse  1830 RSSRGGLLRDHVCMKTDTVSI------------------QASSGSLDDTETEQLLQEEQSECSSV 1876

  Fly  1929 H 1929
            |
Mouse  1877 H 1877

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 18/38 (47%)
LDLa 131..166 CDD:238060 13/37 (35%)
LDLa 184..216 CDD:238060 14/31 (45%)
LDLa 227..262 CDD:238060 18/34 (53%)
LDLa 271..302 CDD:238060 13/30 (43%)
FXa_inhibition 352..387 CDD:291342 18/34 (53%)
Ldl_recept_b 442..482 CDD:278487 14/43 (33%)
LY 466..508 CDD:214531 15/41 (37%)
Ldl_recept_b 529..569 CDD:278487 19/39 (49%)
LY 553..595 CDD:214531 16/41 (39%)
LY 596..637 CDD:214531 19/40 (48%)
FXa_inhibition 669..700 CDD:291342 13/30 (43%)
LY 774..815 CDD:214531 13/40 (33%)
LDLa 1032..1062 CDD:238060 5/45 (11%)
LDLa 1074..1109 CDD:238060 5/34 (15%)
LDLa 1118..1152 CDD:238060 3/33 (9%)
LDLa 1157..1189 CDD:197566 7/33 (21%)
LDLa 1198..1232 CDD:238060 9/41 (22%)
LDLa 1243..1279 CDD:238060 5/35 (14%)
LDLa 1283..1318 CDD:238060 3/34 (9%)
LDLa 1340..1371 CDD:197566 9/33 (27%)
FXa_inhibition 1388..1416 CDD:291342 11/27 (41%)
EGF_CA 1418..1452 CDD:214542 2/33 (6%)
Lrp4NP_766256.3 LDLa 27..66 CDD:238060
Ldl_recept_a 70..105 CDD:278486
LDLa 110..142 CDD:238060 3/13 (23%)
LDLa 148..182 CDD:238060 16/33 (48%)
LDLa 231..265 CDD:238060 16/35 (46%)
LDLa 270..304 CDD:238060 18/34 (53%)
LDLa 311..343 CDD:197566 12/32 (38%)
FXa_inhibition 358..393 CDD:291342 9/35 (26%)
EGF_CA 395..434 CDD:214542 21/39 (54%)
NHL <471..622 CDD:302697 60/154 (39%)
NHL repeat 471..507 CDD:271320 12/39 (31%)
LDL-receptor class B 1 480..522 16/43 (37%)
LY 505..545 CDD:214531 14/39 (36%)
NHL repeat 510..550 CDD:271320 15/39 (38%)
LDL-receptor class B 2 523..565 13/41 (32%)
NHL repeat 555..589 CDD:271320 17/33 (52%)
LDL-receptor class B 3 566..609 20/42 (48%)
LY 590..632 CDD:214531 16/41 (39%)
NHL repeat 598..622 CDD:271320 12/23 (52%)
LDL-receptor class B 4 610..652 16/41 (39%)
LY 633..673 CDD:214531 18/39 (46%)
LDL-receptor class B 5 653..693 15/40 (38%)
FXa_inhibition 702..>729 CDD:291342 13/29 (45%)
LY 766..806 CDD:214531 5/39 (13%)
LDL-receptor class B 6 785..827 7/41 (17%)
LY 808..850 CDD:214531 13/41 (32%)
LDL-receptor class B 7 828..870 11/42 (26%)
LDL-receptor class B 8 871..914 10/48 (21%)
Ldl_recept_b 871..911 CDD:278487 8/45 (18%)
LY 895..937 CDD:214531 9/43 (21%)
LDL-receptor class B 9 915..956 8/40 (20%)
LY 938..979 CDD:214531 7/40 (18%)
LDL-receptor class B 10 957..998 6/40 (15%)
FXa_inhibition 1006..1043 CDD:291342 15/38 (39%)
NHL <1085..1277 CDD:302697 44/316 (14%)
NHL repeat 1085..1123 CDD:271320 6/80 (8%)
LDL-receptor class B 11 1093..1135 8/76 (11%)
NHL repeat 1128..1161 CDD:271320 10/58 (17%)
LDL-receptor class B 12 1136..1178 14/67 (21%)
NHL repeat 1166..1203 CDD:271320 9/57 (16%)
LDL-receptor class B 13 1179..1222 11/87 (13%)
NHL repeat 1212..1244 CDD:271320 8/58 (14%)
LDL-receptor class B 14 1223..1263 6/42 (14%)
NHL repeat 1253..1277 CDD:271320 3/27 (11%)
LDL-receptor class B 15 1264..1306 12/47 (26%)
FXa_inhibition 1313..1348 CDD:291342 14/36 (39%)
LY 1379..1418 CDD:214531 14/57 (25%)
LDL-receptor class B 16 1397..1439 14/41 (34%)
LY 1420..1460 CDD:214531 13/40 (33%)
LDL-receptor class B 17 1440..1482 9/42 (21%)
LDL-receptor class B 18 1483..1526 15/51 (29%)
Ldl_recept_b 1483..1523 CDD:278487 14/48 (29%)
LY 1507..1547 CDD:214531 11/42 (26%)
LDL-receptor class B 19 1527..1568 12/48 (25%)
LY 1549..1589 CDD:214531 5/44 (11%)
LDL-receptor class B 20 1569..1610 8/42 (19%)
FXa_inhibition 1617..1648 CDD:291342 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1661..1696 4/34 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905 9/26 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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