| Sequence 1: | NP_996433.1 | Gene: | yl / 32367 | FlyBaseID: | FBgn0004649 | Length: | 1984 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_035566.2 | Gene: | Sorl1 / 20660 | MGIID: | 1202296 | Length: | 2215 | Species: | Mus musculus |
| Alignment Length: | 1215 | Identity: | 314/1215 - (25%) |
|---|---|---|---|
| Similarity: | 461/1215 - (37%) | Gaps: | 404/1215 - (33%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 257 SDERG--CLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSD-ETDLCHSKPDCDAK--KCA 316
Fly 317 LGAK---------CHMMPASGAECF-----CP--------KGFRLAKFEDKCEDVDECKEQDDLC 359
Fly 360 SQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVY 424
Fly 425 QVAGNLSKVIGVA-----------YDGSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPED 478
Fly 479 LAVDWLTQNIYFSDNIMRHIAVCSNDG------LNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWG 537
Fly 538 E-KPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDG 601
Fly 602 MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRT-IYAVHIYHPAKQPNSPHGCE 665
Fly 666 NATCSHLCLLAEPEI-GGHSCACPDGMR---LAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFG 726
Fly 727 RHQVSKSYTLPCLINEMVYNRINGSLIIA------DNDQRLILEFQPESHESNVLVRSNLGNVSA 785
Fly 786 LAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSH 850
Fly 851 IDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRR 915
Fly 916 PYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSP 980
Fly 981 VGQESHPCQQQNGGCSH-ICVGEGPYHSICLCPAGFVYRDAGNRTCVEAL--DCE---FRCHSGE 1039
Fly 1040 CLTMNHRCNGRRDCVDNSDE--MNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHD 1102
Fly 1103 HSDEQHCEKFDKSKKC-HVHQHGCDN-GKCVDSSLVCDGTNDCGDNSDELLC--------EATSR 1157
Fly 1158 CEPGMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQR-----CLLGQCLDRSLVC 1217
Fly 1218 DGHNDCGDKSDELNCGTDSSTM------NISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDE 1276
Fly 1277 ADCGDV--------------CSIYEFKCRSGRECIRREFRCDGQKDCGDGSDELSCELEKGHHNQ 1327
Fly 1328 SQIQPWSTSSRSCRPHLFDCQDGE-CVDLSRVCNNFPDCTNGHDE 1371 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| yl | NP_996433.1 | LDLa | 90..124 | CDD:238060 | |
| LDLa | 131..166 | CDD:238060 | |||
| LDLa | 184..216 | CDD:238060 | |||
| LDLa | 227..262 | CDD:238060 | 5/6 (83%) | ||
| LDLa | 271..302 | CDD:238060 | 7/31 (23%) | ||
| FXa_inhibition | 352..387 | CDD:291342 | 7/34 (21%) | ||
| Ldl_recept_b | 442..482 | CDD:278487 | 11/39 (28%) | ||
| LY | 466..508 | CDD:214531 | 15/47 (32%) | ||
| Ldl_recept_b | 529..569 | CDD:278487 | 23/40 (58%) | ||
| LY | 553..595 | CDD:214531 | 16/41 (39%) | ||
| LY | 596..637 | CDD:214531 | 15/40 (38%) | ||
| FXa_inhibition | 669..700 | CDD:291342 | 12/34 (35%) | ||
| LY | 774..815 | CDD:214531 | 5/40 (13%) | ||
| LDLa | 1032..1062 | CDD:238060 | 14/34 (41%) | ||
| LDLa | 1074..1109 | CDD:238060 | 15/34 (44%) | ||
| LDLa | 1118..1152 | CDD:238060 | 14/35 (40%) | ||
| LDLa | 1157..1189 | CDD:197566 | 15/31 (48%) | ||
| LDLa | 1198..1232 | CDD:238060 | 15/38 (39%) | ||
| LDLa | 1243..1279 | CDD:238060 | 11/35 (31%) | ||
| LDLa | 1283..1318 | CDD:238060 | 16/34 (47%) | ||
| LDLa | 1340..1371 | CDD:197566 | 13/31 (42%) | ||
| FXa_inhibition | 1388..1416 | CDD:291342 | |||
| EGF_CA | 1418..1452 | CDD:214542 | |||
| Sorl1 | NP_035566.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 59..84 | ||
| VPS10 | 124..753 | CDD:214740 | 32/157 (20%) | ||
| BNR 1 | 136..147 | ||||
| BNR 2 | 232..243 | ||||
| BNR 3 | 441..452 | ||||
| BNR 4 | 521..532 | ||||
| BNR 5 | 562..573 | ||||
| Sortilin_C | 588..753 | CDD:292523 | 32/157 (20%) | ||
| LY | 780..821 | CDD:214531 | 5/41 (12%) | ||
| LDL-receptor class B 1 | 800..843 | 11/43 (26%) | |||
| LY | 824..866 | CDD:214531 | 15/41 (37%) | ||
| LDL-receptor class B 2 | 844..887 | 14/47 (30%) | |||
| LY | 868..910 | CDD:214531 | 22/46 (48%) | ||
| LDL-receptor class B 3 | 888..932 | 24/45 (53%) | |||
| Ldl_recept_b | 890..929 | CDD:278487 | 22/38 (58%) | ||
| LY | 913..953 | CDD:214531 | 16/41 (39%) | ||
| LDL-receptor class B 4 | 933..972 | 16/39 (41%) | |||
| LDL-receptor class B 5 | 973..1013 | 11/39 (28%) | |||
| LDLa | 1078..1112 | CDD:238060 | 13/70 (19%) | ||
| LDLa | 1117..1153 | CDD:238060 | 17/97 (18%) | ||
| Ldl_recept_a | 1157..1192 | CDD:278486 | 8/39 (21%) | ||
| Ldl_recept_a | 1198..1230 | CDD:278486 | 13/31 (42%) | ||
| LDLa | 1240..1271 | CDD:238060 | 14/31 (45%) | ||
| LDLa | 1281..1308 | CDD:197566 | 11/26 (42%) | ||
| LDLa | 1325..1359 | CDD:238060 | 17/34 (50%) | ||
| LDLa | 1373..1403 | CDD:238060 | 13/29 (45%) | ||
| LDLa | 1419..1453 | CDD:238060 | 11/35 (31%) | ||
| LDLa | 1471..1506 | CDD:238060 | 16/34 (47%) | ||
| LDLa | 1514..1549 | CDD:238060 | 15/33 (45%) | ||
| FN3 | 1557..1630 | CDD:238020 | |||
| FN3 | 1651..1742 | CDD:238020 | |||
| FN3 | 1752..1831 | CDD:238020 | |||
| FN3 | 1935..2022 | CDD:238020 | |||
| FN3 | 2026..2113 | CDD:238020 | |||
| Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250|UniProtKB:Q92673 | 2162..2165 | ||||
| Endocytosis signal. /evidence=ECO:0000255 | 2173..2178 | ||||
| Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250|UniProtKB:Q92673 | 2191..2215 | ||||
| Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250|UniProtKB:Q92673 | 2202..2215 | ||||
| DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250|UniProtKB:Q92673 | 2209..2213 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.810 | |||||