DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and T13C2.6

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_872023.2	Gene:	T13C2.6 / 174116	WormBaseID:	WBGene00020481	Length:	911	Species:	Caenorhabditis elegans

Alignment Length:	958	Identity:	261/958 - (27%)
Similarity:	386/958 - (40%)	Gaps:	298/958 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RTHLIINGRHVAISLLLLVGLCGGTAAGTPGSADTR-CDA-GQFQCRDGGCILQAKMCDGRGDCK 116
            ||.|.:.|       .||:.:...:....|..|.|| ||| ..|||:||.||..:..|||..||:
Worm     2 RTCLTLTG-------FLLISMATISVGLQPMGAPTRKCDATNSFQCQDGRCIPMSWRCDGDIDCQ 59

  Fly   117 DSSDELDCDYRLCRPPHWFPCAQPHGA--------CLAAELMCNGIDNCPGGEDELNCPVRPGFR 173
            :..||.:|............|.:...|        |:..:.:|:|..:|....||..|
Worm    60 NEEDEKNCPISEVCGAEEHKCGEVKSARSSLERFKCIPNKWVCDGEFDCEDKSDEFQC------- 117

  Fly   174 FGDTAHRMRSCSKYEFMCQQ---DRT-CIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLC 234
                  :..||.:.:|.|::   |.: |||..::|||:.|||:..|| ..|......||.....|
Worm   118 ------KNVSCQEKQFQCEELSGDYSLCIPETWVCDGQRDCTNGKDE-QNCTSKTSKCPDNNFQC 175

  Fly   235 ANGRCLRRKQWVCDGVDDCGDGSDE-----RGC---LNLCEP----------------------- 268
            :||.|: .|.|||||.:||.|||||     ..|   :|.|.|
Worm   176 SNGNCI-FKNWVCDGEEDCSDGSDELLTAPSNCNRTVNQCPPGEMWKCGSGECIPSRWRCDAEVD 239

  Fly   269 ------QKG------------KFLCRNRETCLTLSEVCDGHSDCSDGSDETDL------------ 303
                  :|.            :|.|:....|:..:.||||..||||||||.|.
Worm   240 CKDHSDEKNCTAIQHTCKLAEEFACKASHNCINKAFVCDGELDCSDGSDEDDCADVRTECKSGER 304

  Fly   304 ------------------------CHSKPDC----DAKKCALGA----------KCHMMPASGAE 330
                                    |:.:.||    |.|:|.:.|          :|...|....|
Worm   305 TCPASYGAYGAESGHVVCIPASSWCNGEEDCPDGGDEKECNMTAPVTCQKGTEYECPSTPLQCIE 369

  Fly   331 ------------------------------------------------CFCPKGFRLAKFEDKCE 347
                                                            |.|..|::|.  ..:|.
Worm   370 MSKLCASAQFDCGDGNMSVCSQKKIIEMCKPSSEGCVCRPSFVRGNNVCHCKDGYKLE--NGQCI 432

  Fly   348 DVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLD---------KDNRTCRAVVYGSKEQQPLLLY 403
            |::|| |...:|.|.|.|..|.|||.|.|||.:.         :....|||:  |.   .||:|.
Worm   433 DINEC-EIAGVCDQICLNIPGSYRCACHAGYQISFGDTKIGSGRIANKCRAM--GG---DPLVLL 491

  Fly   404 TTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVAY---DGSHIYWTNIQNEAESIVKAN-GDGSN 464
            |.:.||.    :.|.|....:.|:.:....:.:.:   :|: :.|:::.  ::.|:|.: |:.||
Worm   492 TNRHTIR----QFDLVNKMHFPVSSSPGSAVAMDFHILNGT-LIWSDVL--SKQILKCSIGNVSN 549

  Fly   465 A-----------EILLTSG-LDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVH 517
            |           ||:||.. :..|:.|||||:...::::|..:..|.|.........||.:.|:.
Worm   550 AFLGTDMCDKKHEIVLTGDKIHTPDGLAVDWVHDLLFWTDGGLDQINVLDMKNGKQRVLYSSDLE 614

  Fly   518 QPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIV-SDNIEWPNGIALDMHQQRIYWVDAK 581
            :||::||.|:.||:||||||:|..|.|:.|||.....|| .|.:.||||:|||...:|:||.|||
Worm   615 EPRAIAVDPEVGLIFWTDWGKKARIERSGMDGQHRTVIVEGDRVVWPNGLALDYVDKRVYWADAK 679

  Fly   582 LGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHR-ILAKD 643
            :.|:.:....|...:|||..  .|:||:.:|:|||:|:::||....|...:||:|.|.| ::.:.
Worm   680 IKSIFSCDYWGKNIKTVLHSHQYLRHPFSMAVFEDRLFYTDWEHDGVITVNKFTGADIRTVMDQV 744

  Fly   644 RTIYAVHIYHPAKQPNSPHGCENATCSHLCLLAEP-----------EIGGH----SCACPDGMRL 693
            ::...|.|||...||...:.|||:.|.||||   |           |...|    |||| :| ..
Worm   745 KSPMTVRIYHKQAQPLMQNKCENSECDHLCL---PRAVYREKERVHEKTWHDRPFSCAC-EG-TT 804

  Fly   694 APDHRRCML-MEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADN 757
            |.|...|.. :|.:.    |:....:               :.|.|:          |.::.|
Worm   805 ASDVLECFADLETKS----GISMFTI---------------FLLLCV----------GGVVAA-- 838

  Fly   758 DQRLILEFQPESHESNVLVRSNLG--NVSALAFDHLSRNLYWADTERA 803
                          ..|:||..:|  ..:||.||:   .:|...||.|
Worm   839 --------------GFVIVRRKMGPRTFTALNFDN---PIYRRTTEEA 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	17/34 (50%)
		LDLa	131..166	CDD:238060	8/42 (19%)
		LDLa	184..216	CDD:238060	13/35 (37%)
		LDLa	227..262	CDD:238060	19/39 (49%)
		LDLa	271..302	CDD:238060	15/42 (36%)
		FXa_inhibition	352..387	CDD:291342	14/43 (33%)
		Ldl_recept_b	442..482	CDD:278487	14/52 (27%)
		LY	466..508	CDD:214531	13/42 (31%)
		Ldl_recept_b	529..569	CDD:278487	22/40 (55%)
		LY	553..595	CDD:214531	18/42 (43%)
		LY	596..637	CDD:214531	17/42 (40%)
		FXa_inhibition	669..700	CDD:291342	15/45 (33%)
		LY	774..815	CDD:214531	12/32 (38%)
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
T13C2.6	NP_872023.2	LDLa	36..67	CDD:238060	14/30 (47%)
		LDLa	73..117	CDD:238060	8/43 (19%)
		LDLa	122..161	CDD:238060	15/39 (38%)
		LDLa	167..199	CDD:197566	17/32 (53%)
		LDLa	214..249	CDD:238060	3/34 (9%)
		LDLa	261..292	CDD:238060	15/30 (50%)
		LDLa	<322..344	CDD:238060	5/21 (24%)
		EGF_CA	433..463	CDD:214542	15/30 (50%)
		LY	564..606	CDD:214531	11/41 (27%)
		LY	606..649	CDD:214531	22/42 (52%)
		LY	649..692	CDD:214531	18/42 (43%)
		LY	696..736	CDD:214531	16/39 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166216
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840