DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and lrp-1

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_001379135.1 Gene:lrp-1 / 172520 WormBaseID:WBGene00003071 Length:4753 Species:Caenorhabditis elegans


Alignment Length:2145 Identity:584/2145 - (27%)
Similarity:895/2145 - (41%) Gaps:433/2145 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 SADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPPHWFPCAQP--HG-ACLA 146
            :|.:.|:...|:|.||.||.....|||.|||.|..||.||.:..|:...| .|...  |. :|:|
 Worm    48 TASSVCNENDFRCNDGKCIRTEWKCDGSGDCSDGEDEKDCPHPGCKSDQW-QCDTYTWHSVSCIA 111

  Fly   147 AELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCT 211
            ....|:.|.:|..|.||.:||          |..:...|:..|||...|.|..:...|||:.||.
 Worm   112 EYQRCDNITDCADGSDEKDCP----------ASTVDCSSQNVFMCADGRQCFDVSKKCDGKYDCR 166

  Fly   212 DKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERG-------------CL 263
            |.|||...|.:....|......||:.....:|.|||||..||.|||||..             |.
 Worm   167 DLSDEKDSCSRNHTACFQYQFRCADKTQCIQKSWVCDGSKDCADGSDEPDTCEFKKCTANEFQCK 231

  Fly   264 N-LCEPQK-------------------------GKFLCRNRETCLTLSEVCDGHSDCSDGSDETD 302
            | .|:|:|                         ||:.|.....|:...::|||..||:||:||..
 Worm   232 NKRCQPRKFRCDYYDDCGDNSDEDECGEYRCPPGKWNCPGTGHCIDQLKLCDGSKDCADGADEQQ 296

  Fly   303 LCHSKPDCDAKKCALGAKCHMMPASGAECFCPKGFRL-AKFEDKCEDVDECKEQDDLCSQGCENT 366
             | |:..|.:..|..|  ||..| .|.||.||.|::| .:|...|.|::||.| ...|.|.|.|.
 Worm   297 -C-SQNLCPSLGCQAG--CHPSP-HGGECTCPSGYKLDDRFHRTCSDINECAE-FGYCDQLCANH 355

  Fly   367 SGGYRCVC--DAGYLL-----DKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMH-LREDNVRNHV 423
            ..|:.|.|  |...|.     .|||.|.|.... |.....:.|:..:..  |:: |...|....|
 Worm   356 RPGFTCSCLGDCFTLQMEHGPGKDNLTMRGYCV-SNNADKMKLFVARRE--GLYRLNPKNPDEEV 417

  Fly   424 YQVA-GNLSKVIGVAYDGSHIYWTN-IQNEAESI-VKANGDGSNAEILLTSGLDAPEDLAVDWLT 485
            .::| |.....|...|....|:||: :.:.|.|. |...|:.|..:.|....|..|..|||||:|
 Worm   418 KKLASGEFIYGIDFDYGDRKIFWTDRLAHSAFSADVDDEGEISQIKKLSLKSLVYPRCLAVDWIT 482

  Fly   486 QNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGS 550
            ..:|..::..|.|.|.|.||....||:...:..|..:|:.|.:|.||:|:   :..:..|:|||:
 Worm   483 NTLYIIESGSRRIDVSSYDGERRTVLLADGLTLPLDIALDPLRGEMFFTN---QLKLEAAAMDGT 544

  Fly   551 RSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGM--LKHPYGLAIFE 613
            ..|.:|:.:....:||.:|:..:|:||||.|:..::::...|..||.|..||  :.||:|||:|:
 Worm   545 NRRTLVNTHTHQVSGIVVDITAKRVYWVDPKVDRLESIDYQGNDRRIVAQGMNVVPHPFGLALFD 609

  Fly   614 DQLYWSDWATKSVHACHKFSGKDHRIL--AKDRTIYAVHI--YHPAKQPNS----------PHGC 664
            ..|||:||....|....|| |.|.::|  ..:..::.:.|  |||..||..          .:.|
 Worm   610 QYLYWTDWTRLGVIQVEKF-GSDTKLLWSNTENNVFPMGISAYHPMAQPGPGQSECLAMKIENPC 673

  Fly   665 ENATCSHLCLLAEPEIG---GHSCACPDGMRLAPDHRRCM-----LMEKRQRLFIG--------- 712
            .||.|..:|:|::...|   |:.||||.|.:|. :.:||:     |:....::..|         
 Worm   674 TNADCEGMCILSKDNGGFGVGYKCACPIGQKLV-NGKRCIDSIDYLLFSSNKIVRGIFPEINEKA 737

  Fly   713 LGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESH-ESNVLV 776
            |.:.:|.|  :...:.::...:.:.|.::       ..|...||.....|...:|:.. .:.|||
 Worm   738 LAEAVLPI--SPISQRRIGMYFEVECDVH-------GNSFFYADIMDNTIYRIRPDGEGAAPVLV 793

  Fly   777 RSNLGNVSALAFDHLSRNLYWADTERAVIEVLSL---------QTRHRALIRFFPGQEV--PIGL 830
            ..|.| :.:::||.:|:.||:.|..|..:||:.:         :...|.||     .|:  |:.:
 Worm   794 THNDG-LFSMSFDWISKQLYYVDNIRNSLEVVKIGETGLVHPDELVRRQLI-----TELRDPVSV 852

  Fly   831 TVMPAEGYLYVVLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGR 895
            .|.|.:|.|:.. :|.|.:.|.:..:.|:..|| :....||... ::..|:....:.|.|:.|..
 Worm   853 VVHPWKGLLFYA-EAMRPAAIYRCHIDGQNCQV-IRNTTLGRPS-EMAIDFAENRLCWGDTLLKT 914

  Fly   896 ISYSNYRVPHSQIFRGK-------------------------LRRPYSLAMVHHDLFWNELGTPR 935
            ||..:        |.||                         .:||||:..|             
 Worm   915 ISCMD--------FDGKNVVKLDIDNPIPVAITIMNEYIYYVHQRPYSIRRV------------- 958

  Fly   936 IYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASS----PVGQES--HPCQQQNGG 994
                ||.|.|..|::.....|:.:.            ..|.|.|    |:..:|  |||:...  
 Worm   959 ----HKKNGGGSKIVREFGADERSI------------FSLKACSHQNQPIPDDSREHPCRASQ-- 1005

  Fly   995 CSHICVG------EGPYHSICLCPAGFVYRDAGNRTC-------VEAL----DCEFRCHSGECLT 1042
            |:.:|..      .....:.|.|..||:.....|.:|       :|.|    ..:|:|.:|.|:.
 Worm  1006 CTQLCFATPSESHPNELEAKCACRQGFMINKENNHSCQKDPAEKIEQLCSSNSTQFQCKNGRCIP 1070

  Fly  1043 MNHRCNGRRDCVDNSDEMNCDEE-----HRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHD 1102
            ...:|:|..||:|.|||:  ||:     |..:    |:.|...|.:.::|:..:..||...||.|
 Worm  1071 KEWKCDGENDCLDESDEI--DEKGDKCFHETE----CAENTIKCRNTKKCIPAQYGCDGDNDCGD 1129

  Fly  1103 HSDE--QHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELL--CEATSRCEPGMF 1163
            :|||  ::| |..:...|...:..|||.:|:.....||..|||||.|||.|  | ..:.|....|
 Worm  1130 YSDEDVKYC-KDGQKPVCAAKKFQCDNHRCIPEQWKCDSDNDCGDGSDEKLEMC-GNATCAANQF 1192

  Fly  1164 QCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPP----DMQ-RCLLG-QCLDRSLVCDGHND 1222
            .|.:|.||...|.|||..||.||:|| ||   ..|||    .:| ||..| ||:.....|||.:|
 Worm  1193 SCANGRCIPIYWLCDGDNDCYDGTDE-DK---ERCPPVQCSALQFRCANGRQCVPLRNHCDGQSD 1253

  Fly  1223 CGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDE----ADCGDVC 1283
            |.|.|||.:|...:.    ||..||::|.|: .:|:|::.:|:|..:|..|.||    ...|..|
 Worm  1254 CEDGSDEDSCAVTAE----SCTPDQFKCVSS-GLCIPASWKCDGQQDCDDGSDEPKFGCTSGRQC 1313

  Fly  1284 SIYEFKCRSGRECIRREFRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQ 1348
            |..:|||.:|| ||...:.|||:.||||||||.|   |:|...       |.::|.|......|:
 Worm  1314 SSDQFKCGNGR-CILNNWLCDGENDCGDGSDESS---ERGCKT-------SMNARKCPFEHVACE 1367

  Fly  1349 DGE--CVDLSRVCNNFPDCTNGHDEGPKCATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDA 1411
            :.:  |:.|.::|:....|..|.|||.:||....||. |..|..||..:|.|.:|||..|.:| .
 Worm  1368 NDQETCIPLHQLCDGKTHCPGGTDEGGRCARDLCSAD-RAGCSFKCHNSPNGPICSCPFGEQL-V 1430

  Fly  1412 DQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQ---------SGATLLF 1467
            ::..|...:||.:...|:|.|::...|:.|.|...:.|..|:.:||...         |....::
 Worm  1431 NKTKCEPENECLDSSSCSQRCKDEKHGFTCSCDEGYELDVDKRTCKVADNVKDTRIYVSNRNRIY 1495

  Fly  1468 SSFNEVRN------LSEQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQTKVI 1526
            .|.:::.|      :.|..:.|  ||.:...||...|:   |:....||...|       ....:
 Worm  1496 YSDHKLDNWHTFGAIVENAIAL--AWDSLTDRIYWSDI---REKKILSANRNG-------TNATV 1548

  Fly  1527 VRALGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVG-RMCGRIVH--VKSPRHVKHLAVDGYH 1587
            ..|.||.....:::|||..|:| |.|....|:..:... :....:||  |..||.:   |||...
 Worm  1549 FIADGLDITEGIALDWVGRNLYWVDSSLNTIEVANLEDPKQRTLLVHQNVSQPRGI---AVDPRK 1610

  Fly  1588 ARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLER 1652
            ..:|:     ..:||... |..|.:||:.|.::::....:...:..|.....:||.|..:..::.
 Worm  1611 GVMFW-----TDWGQNPC-IERASMDGTDRQIIVKTKIYWPNTIALDYTTDRVYFADSKLDFIDF 1669

  Fly  1653 ISYRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISI--- 1714
            ::|   .|..|..  :|..|..:.||..|:::|:..:              |..|...|:.:   
 Worm  1670 VNY---DGSGRTQ--VLASSKFVQHPHALAIFEDMMY--------------YSDRRLQKLQVYPK 1715

  Fly  1715 ------------NVLNAQDIVVAGRSRQPQKASHPCAHAHCHGLCLQADYG-YECMC--GNRLVA 1764
                        ....|..:|......||...::||:...|..|||..:.. :.|.|  |.:|.|
 Worm  1716 YPNGTTSEYPSHTFSKALGVVAVHPVLQPVIKNNPCSTNPCSHLCLLNNKNTFTCKCPMGEKLDA 1780

  Fly  1765 EGERCPHGSGNEVAVLGAVN--SLELEHEHEQNGHFHWLMALFVLAAGSLIAGLGYMYYQYRQRG 1827
            .|::|...:...:.::...|  .:|:....|:...        |||....::|||..        
 Worm  1781 SGKKCIDDAKPFLVIIQKTNVFGIEMNSASEKETP--------VLAGMVPLSGLGNA-------- 1829

  Fly  1828 HTDLNINMHFQNPLATLGGTKAFLEH-ERAEAGVGFTTETGTVSS--RGSNDTFTTTSATSSFA- 1888
                     |......|......||| ..|:.....||::....|  .|.|.|...:||....| 
 Worm  1830 ---------FDAAYDALSEEMFILEHTNHAKTLAQITTDSAIYRSTVNGGNKTKMFSSAVPDDAY 1885

  Fly  1889 -------AQQFSVPNALQR---------------LLRPRQSASG--DPMAQELLLESPSRESKLH 1929
                   .:...|.|.:.:               :|...||.:.  .|:|    :...:.:..:.
 Worm  1886 CLGFDWNGRNLVVGNKITQTIEIIRTQGKQYRSVILSNDQSPTAVVTPVA----IAVDADKGYVF 1946

  Fly  1930 ALDGGGAGGDGDGGR-GVGRQVPDIL----VADMDDDAAKS-----------AGQFGG-NYAGND 1977
            .||.||...|....| |:....|.::    :|::|..|..:           ||:... .|.|.|
 Worm  1947 WLDRGGGAADAKVARAGLDGSNPLVIASNDLAELDHIAIDTTNTRVYFSEAKAGRISSVTYDGQD 2011

  Fly  1978  1977
             Worm  2012  2011

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 16/33 (48%)
LDLa 131..166 CDD:238060 11/37 (30%)
LDLa 184..216 CDD:238060 13/31 (42%)
LDLa 227..262 CDD:238060 16/47 (34%)
LDLa 271..302 CDD:238060 13/30 (43%)
FXa_inhibition 352..387 CDD:291342 14/41 (34%)
Ldl_recept_b 442..482 CDD:278487 13/41 (32%)
LY 466..508 CDD:214531 16/41 (39%)
Ldl_recept_b 529..569 CDD:278487 12/39 (31%)
LY 553..595 CDD:214531 12/41 (29%)
LY 596..637 CDD:214531 19/42 (45%)
FXa_inhibition 669..700 CDD:291342 11/33 (33%)
LY 774..815 CDD:214531 14/49 (29%)
LDLa 1032..1062 CDD:238060 12/29 (41%)
LDLa 1074..1109 CDD:238060 12/36 (33%)
LDLa 1118..1152 CDD:238060 16/35 (46%)
LDLa 1157..1189 CDD:197566 14/31 (45%)
LDLa 1198..1232 CDD:238060 18/39 (46%)
LDLa 1243..1279 CDD:238060 13/39 (33%)
LDLa 1283..1318 CDD:238060 20/34 (59%)
LDLa 1340..1371 CDD:197566 7/32 (22%)
FXa_inhibition 1388..1416 CDD:291342 10/27 (37%)
EGF_CA 1418..1452 CDD:214542 9/33 (27%)
lrp-1NP_001379135.1 LDLa 53..87 CDD:238060 16/33 (48%)
LDLa 92..131 CDD:238060 12/39 (31%)
LDLa 140..173 CDD:238060 15/32 (47%)
LDLa 182..216 CDD:238060 16/33 (48%)
LDLa 223..257 CDD:238060 5/33 (15%)
LDLa 262..297 CDD:238060 13/35 (37%)
LY 463..505 CDD:214531 16/41 (39%)
LY 507..546 CDD:214531 13/41 (32%)
LY 547..589 CDD:214531 12/41 (29%)
LY 883..925 CDD:214531 13/51 (25%)
exchanger_TraA <1054..1451 CDD:411343 153/426 (36%)
LDLa 1057..1087 CDD:197566 10/29 (34%)
LDLa 1146..1177 CDD:197566 13/30 (43%)
LDLa 1187..1219 CDD:238060 16/32 (50%)
LDLa 1228..1263 CDD:238060 15/34 (44%)
LDLa 1270..1302 CDD:238060 11/32 (34%)
LDLa 1313..1344 CDD:238060 18/31 (58%)
FXa_inhibition 1447..1475 CDD:405372 8/27 (30%)
LY 1511..1545 CDD:214531 11/45 (24%)
LY 1548..1585 CDD:214531 11/36 (31%)
LY 1590..1634 CDD:214531 15/52 (29%)
LY 1635..1677 CDD:214531 6/44 (14%)
Ldl_recept_b 1943..1986 CDD:423042 11/42 (26%)
LY 1971..2012 CDD:214531 8/41 (20%)
LY 2015..2052 CDD:214531
LY 2193..2239 CDD:214531
LY 2240..2283 CDD:214531
LY 2284..2325 CDD:214531
LY 2570..2612 CDD:214531
LY 2613..2655 CDD:214531
LDLa 2794..2824 CDD:197566
LDLa 2834..2868 CDD:238060
LDLa 2874..2907 CDD:197566
LDLa 2961..2994 CDD:238060
LDLa 3012..3038 CDD:238060
LDLa 3048..3088 CDD:197566
LDLa 3099..3131 CDD:197566
LDLa 3140..3174 CDD:238060
LDLa 3186..3218 CDD:197566
FXa_inhibition 3276..3305 CDD:405372
LY 3382..3424 CDD:214531
Ldl_recept_b 3445..3490 CDD:395012
LY 3476..3516 CDD:214531
FXa_inhibition 3586..3623 CDD:405372
LDLa 3627..3660 CDD:197566
LDLa 3671..3705 CDD:238060
LDLa 3792..3825 CDD:197566
LDLa 3837..3868 CDD:238060
LDLa 3878..3912 CDD:238060
LDLa 3917..3951 CDD:238060
LDLa 3958..3990 CDD:197566
LDLa 4049..4083 CDD:238060
FXa_inhibition 4097..>4121 CDD:405372
EGF_CA 4132..4163 CDD:214542
NHL 4219..>4431 CDD:302697
NHL repeat 4219..4257 CDD:271320
NHL repeat 4267..4330 CDD:271320
NHL repeat 4333..4371 CDD:271320
NHL repeat 4373..4410 CDD:271320
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
54.670

Return to query results.
Submit another query.