DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and lrp-2

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:NP_491270.2 Gene:lrp-2 / 171981 WormBaseID:WBGene00003072 Length:4858 Species:Caenorhabditis elegans


Alignment Length:2611 Identity:542/2611 - (20%)
Similarity:838/2611 - (32%) Gaps:1045/2611 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 CQRTHLIINGRHVAISLLLLVGLCGGTAAGTPGSADTR-------CDAGQFQCRDGGCILQAKMC 109
            |.:|..||..:.           |.|......| ||..       ||..:|:|..|.||.|:::|
 Worm  1020 CSKTKCIIKSKR-----------CNGVQECDNG-ADEEDCPRSKLCDPDEFRCGTGLCIKQSQVC 1072

  Fly   110 DGRGDCKDSSDELDC-DYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFR 173
            ||:..|.|..||..| :...|.....|.||.....||.....|:|:.:|....||.:     .|.
 Worm  1073 DGKMQCLDGLDEEHCNEEEKCLQGRQFRCANGKSTCLDLIFRCDGVADCEDSSDESD-----EFC 1132

  Fly   174 FGDTAHRMRSCSKY-EFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHL-CAN 236
            .|:::   .:|.|. :||| .|..|:....:|||.|||....||.. |..:  .|....|| |.|
 Worm  1133 KGNSS---STCGKMNQFMC-ADGKCLRSFQLCDGFPDCLTGEDETE-CPPS--MCDSTTHLSCLN 1190

  Fly   237 GRCLRRKQWVCDGVDDCGDGSDERGCLNL--------CEPQKGKFLCRNRE-TCLTLSEVCDGHS 292
            |:....||..|||||||||.|||:.|..:        |  |...:.|.... .|::...:|||.:
 Worm  1191 GQKCISKQLECDGVDDCGDNSDEKHCTEIRLDEAALRC--QSPMYQCDGPNFKCISDKHLCDGTN 1253

  Fly   293 DCSDGSDETDLCHSKPDC-DAKKCALGAKCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQD 356
            ||.:|.||...|..  :| ||........|...|. |..|.||....|.|....|...|.|:...
 Worm  1254 DCEEGDDEGLWCTF--NCTDADDLGCSHTCRPTPV-GPICSCPDDHYLDKNGVTCSKKDPCRFGQ 1315

  Fly   357 DLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLRE----- 416
              |||.|......:.|.|:..:.|..|..:|    .....::|.|:|:.:..|..:..:.     
 Worm  1316 --CSQYCSPHGSSHFCYCEDSFKLGADRSSC----ISDDPRKPFLIYSNRHEIRMIQSKYPGSLP 1374

  Fly   417 --DNVRNHV-----YQVAGNLSKVIGVAYDGSHIYWTNIQNEAESIVKANGDGSN---AEILLTS 471
              .|:.|.:     |...|::|           ||||::  .|:.|.....|...   ...:::.
 Worm  1375 MITNLVNAIALDFKYHQNGSVS-----------IYWTDL--SADKIYTGLVDQRTILYQRTIVSY 1426

  Fly   472 GLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDW 536
            |:...|.:||||::.|||:.|:.:..|.|.|.||...|.::.|::...||||:..::|.||||||
 Worm  1427 GVFNAEGIAVDWISGNIYWIDSFLDTIQVVSEDGTKRATVINQNMGNARSLAIDVEEGFMFWTDW 1491

  Fly   537 GE-KPMIGRASMDGSRSRPIV--SDNIE---WPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGR 595
            .| .|.|.|||:.|: :|.|:  ..||.   ||||||||...:|:||.|||..|:.|:..||...
 Worm  1492 EESNPRIERASLAGN-NRAIIWKISNIAQAGWPNGIALDTIAKRVYWADAKSDSIHTITYDGRDH 1555

  Fly   596 RTVL--DGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRT-IYAVHIYHPAKQ 657
            ..|.  ...|.|.:|:.::|..:|:|||.|.::....|:.|.:..|:.:..| .:::.|.|.:||
 Worm  1556 VIVFRDPERLGHCFGIDVYEGHVYFSDWRTNTISKVDKWFGSNVSIIERVATQPFSLKIVHRSKQ 1620

  Fly   658 P-NSPHGCENATCSHLCL----------------------------------------------- 674
            . ...:.|:...|:.:||                                               
 Worm  1621 KMQIKNSCDGFKCNGICLNNGKNKATCQCTNLQSTTDDGCVDIQQVLLVATKNGVRGFSTDPPHP 1685

  Fly   675 ----------------------------------------------------------------- 674
                                                                             
 Worm  1686 HAFPLVSGKQYENIRAVGSFNNRLQVLDDYTTHIATVNLTGTADDGVLATGSDLYGVSGMAVDPV 1750

  Fly   675 ----------------------------LAE-----------------------------PEI-- 680
                                        |||                             |.|  
 Worm  1751 VGSTYITLSIDGVGSVEVISADGKSRRVLAESSSSNPMKLPRDILFMNTKLFWFEDSTSPPSIFS 1815

  Fly   681 ---------------------------------------------------------GG------ 682
                                                                     ||      
 Worm  1816 MSAAGDDLKKLKVNSTLLNKFYNPTVDRFYSKIYWISQGKVIQFDPKSEVVQEIQIPGGDGNVSS 1880

  Fly   683 ---------------------------------------------HS------------------ 684
                                                         ||                  
 Worm  1881 IAVDMTNGDILIGEFIRIANQTTIRRLGMKGTKAIQRGSVMLVPLHSSIKFFLSTVDITAKNVPD 1945

  Fly   685 ------------------CACPDGMRL------APDHRRCMLMEKRQRLFIG------LGQVLLE 719
                              |.|..|..|      :||.|.....:......:|      .|.::.:
 Worm  1946 ECKKCPSLCLRSSDKKFQCVCSQGFELVNGKCRSPDKRVFFATDDGSLHSVGWYKNSKTGDLIQK 2010

  Fly   720 IE----HTAFGRHQVSKSYTLPCLI----NEMVY-----NRI-----NGS---LIIADNDQRL-- 761
            ..    |:..|:.::.|      |:    |::||     |.:     |||   ::.:.|..|:  
 Worm  2011 YRAHSLHSDIGKKRILK------LVADAKNDLVYVVTRQNEVWKCATNGSFAHIVYSTNSHRIAA 2069

  Fly   762 -----------------------ILEFQPESH-------------------------------ES 772
                                   |:...|:.|                               .|
 Worm  2070 ITLDRVTGYLLVSARESISPKGFIVLIDPDRHSEAIHQVIVEDEDKIPYEIAVDPPKGKLFWASS 2134

  Fly   773 NVLVRSNL-----------GNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHR----------- 815
            :.:..||.           .::||:|.|.....|.:.|:|:|.::.:.....:.           
 Worm  2135 SCIKSSNYYGTEAKCIVSKSSISAIAIDENRSRLCFVDSEKAAVDCVDYNGNNEQRNVAMFKAQP 2199

  Fly   816 -----------------------------------------ALIRFFPGQEV------------- 826
                                                     :|::..|.|::             
 Worm  2200 MGDIVSLVFNGDEMYFFDKFNSSGSIVRGLVQQDGSVVLKDSLVKVHPRQKIRVIDFDVMDVKSS 2264

  Fly   827 ----------------------------------------------------------------- 826
                                                                             
 Worm  2265 VLFTACSNNNGGCEHLCITTPSENSPTVRKECLCVHSTRLDNGSCGSSDSFIAFTRFTSIEFLST 2329

  Fly   827 -PIGLT--------------------------------------------------------VMP 834
             |..||                                                        |:|
 Worm  2330 KPGDLTSPNKQITSNGCVMSKIGAVTADATRGRIYFADYDKFRITAVNFDGTGCVVIAEDVGVVP 2394

  Fly   835 AEGY------LY--------------------------------VVLKAKRH------------- 848
            :..|      ||                                .|....||             
 Worm  2395 SMAYDEVHTELYFVRANPASIWRINVADNNLESYPTEPKIVLTLTVRDRPRHIAIHPCRMLLFFT 2459

  Fly   849 ------SHIDKIPLSG-KGEQVHVFEDDLGDDDIK-LVTDYETQTIFWSDSDLGRISYSNYRVPH 905
                  |.|:::..|| |.:|  :.::||  .|:: |..|.:::.:::|||...:||..::...|
 Worm  2460 NNAITGSVIERVYFSGFKRDQ--IVQEDL--HDLRGLTIDLDSEKLYFSDSKDFKISRCDFDGSH 2520

  Fly   906 SQIFRGKLR----RPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKD-DPAAIMPYV 965
            .::......    .|:.|::...::.:.:       |..:|.:|..|:.....:: :.|..:|..
 Worm  2521 RELVVSNTDIPSIHPFELSIYDDEIIFTD-------WVRRSVVGVNKITGSDNRNINRATDVPVG 2578

  Fly   966 PVATPNGIPLAASSPVGQESHPCQ-----QQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTC 1025
            .|..........|.........|:     ..||..|..|.||...:|             .||||
 Worm  2579 LVVVDTKREYCTSDACADNELKCEDYCRLMANGQASCACNGERRLNS-------------DNRTC 2630

  Fly  1026 VEALD---C---EFRC-HSGECLTMNHRCNGRRDC--VDNSDEMNCDEEHRRKPKVLCSPNQFAC 1081
            ....|   |   ||:| ||..|:.....|:...||  .|:.|...|...       :|.|..|.|
 Worm  2631 TGEFDGKKCAENEFKCLHSDRCIRYEDTCDRYNDCPMFDDEDTKYCSTR-------VCRPGYFNC 2688

  Fly  1082 HSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDN 1146
            .:| .|:.:::.|:...||.:.:||.:|       .|:.::..|.:|.|:.|...|:...||.|.
 Worm  2689 GNG-LCIPEQKVCNRINDCANFADESNC-------TCNENEFRCQSGACIPSKARCNHMQDCNDA 2745

  Fly  1147 SDELLCEATSRCE-------PGMFQCGSGS-CIAGSWECDGRIDCSDGSDEHDKCVH-------- 1195
            |||:.|...: |.       .|:..|.:.| ||..||:|||..||.|||||.|..|.        
 Worm  2746 SDEIGCPFRN-CSALNEFGMTGLINCATTSQCIHPSWKCDGTNDCYDGSDEKDCFVEFDATGGSV 2809

  Fly  1196 ---RSCPPDMQ-RCLLGQ-CLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLK 1255
               |||....| .||..: |:.:...|||..||.|.|||.||...      .|...::.|.|:.|
 Worm  2810 SAPRSCDAKTQFACLATRTCMPKHWQCDGQPDCADGSDEKNCDAK------KCTSFEFSCESSKK 2868

  Fly  1256 ICLPSTVRCNGTTECPRGEDEADCGDVCSI----YEFKCRSGRECIRREFRCDGQKDCGD----- 1311
             |:|...:|:|..:||.||||..|...|..    ..|:|.:.| ||...:||||..||.|     
 Worm  2869 -CIPLEQKCDGRRDCPDGEDEHQCETECDSKGGNATFRCTNHR-CIPMAWRCDGTDDCMDNAKSL 2931

  Fly  1312 GSDELSCELEK-GHHNQSQ-------------------IQPWS---------TSSRSCRPHLFDC 1347
            ||||:.|...: ..|..|:                   ||..|         :..|.|:|:.:.|
 Worm  2932 GSDEVDCAAGRTSFHVPSRCADETCVVACELTAVLCDGIQDCSDGFDEKNCASLDRQCKPNEWMC 2996

  Fly  1348 QDGECVDLSRVCNNFPDCTNGHDE-------------GPKCATACRSASG-------RQVC---- 1388
            ..|:|:|..|:|:...||.:|.||             |.....:|...:|       :|:|    
 Worm  2997 DSGQCIDSGRLCDASVDCVDGSDEWVEICSLSEPPRRGCPSGWSCLLTNGTIGCLQEQQLCDGRR 3061

  Fly  1389 -------------QHKCRAT------------PAG-AVCSCFDGYRLDA-DQKSCLDIDECQEQQ 1426
                         |..|.:|            .|| ..|||.|||.|.. |:|:||....|.:..
 Worm  3062 DCMSGIDEQCDNPQGNCSSTRNSCDQTWNCQRHAGFESCSCDDGYHLSPYDKKTCLRSPSCPKAN 3126

  Fly  1427 PCAQLC-ENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEVRNLSEQPVMLNVAWSAN 1490
             |:..| :....|:||.|...::|.:::..|:                ||.:.:..:|.|    .
 Worm  3127 -CSHFCIDRRDVGHQCFCAPGYILSENQKDCR----------------RNDTIEAEILMV----Y 3170

  Fly  1491 DSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQTKVIV--------RALGLPA------------- 1534
            ..|:..|.:..|.:....|....|:....|:::.::.        ...|:.:             
 Worm  3171 GHRLKLFTIDGHAKATLLSNLTNGVALDYDVKSDLVYWTDVAHDGNKAGITSMSNQPNTYRVINS 3235

  Fly  1535 -PTK----LSVDWVTGNVYVLSGAQE-IQACSFVGRMCGRIVHVKSP-RHVKHLAVDGYHARIFY 1592
             |||    ::|||:..|:|......: |..|...||. .||:...:| ...:.:.:|...|.:|:
 Worm  3236 LPTKGIDGIAVDWLGRNIYYTDRNHDAIAVCDMRGRF-NRILLKGTPLNDPRAIVLDPLQALVFW 3299

  Fly  1593 IVIRTEGYGQTSSEIHMARLDGSRRDMLLQ-RSESFMTALTTDPHQQLLYFVDQHMRTLERISYR 1656
                 ..:| .|:.|....:|||...::|| |:..:..||..|...|.|||.|.|...:...:| 
 Worm  3300 -----TDWG-ASAHIGRMNMDGSNEQVILQDRTIRWPNALAVDAPAQRLYFGDAHRDYIASCNY- 3357

  Fly  1657 LKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNL--GSVEAVQCALYGSRICHKIS-INVLN 1718
              .|..||  ::|:.|  :.|...|:|:|:..:..:.  .::|.|          |||: .|   
 Worm  3358 --DGSKRR--MVLRGS--VRHIFALAVFEDYVYWSDWHNHTIERV----------HKITGTN--- 3403

  Fly  1719 AQDIVVAGRSRQP----------------QKASHPCAH-AHCHGLCLQADY--------GYECMC 1758
             :.:::..:..:|                :.|.|||:. |.|..||:.|:.        .:.|||
 Worm  3404 -RKVLIQDKQYRPMGFKIVHPSLQSMGSLKTARHPCSQPARCDNLCIPANTPDLTTSSDNFTCMC 3467

  Fly  1759 GNRLVAEGERC 1769
            .....:||..|
 Worm  3468 AQGFRSEGRSC 3478

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 15/33 (45%)
LDLa 131..166 CDD:238060 10/34 (29%)
LDLa 184..216 CDD:238060 13/32 (41%)
LDLa 227..262 CDD:238060 20/35 (57%)
LDLa 271..302 CDD:238060 10/31 (32%)
FXa_inhibition 352..387 CDD:291342 9/34 (26%)
Ldl_recept_b 442..482 CDD:278487 10/42 (24%)
LY 466..508 CDD:214531 15/41 (37%)
Ldl_recept_b 529..569 CDD:278487 24/45 (53%)
LY 553..595 CDD:214531 22/46 (48%)
LY 596..637 CDD:214531 12/42 (29%)
FXa_inhibition 669..700 CDD:291342 19/351 (5%)
LY 774..815 CDD:214531 10/51 (20%)
LDLa 1032..1062 CDD:238060 11/32 (34%)
LDLa 1074..1109 CDD:238060 11/34 (32%)
LDLa 1118..1152 CDD:238060 12/33 (36%)
LDLa 1157..1189 CDD:197566 16/39 (41%)
LDLa 1198..1232 CDD:238060 14/35 (40%)
LDLa 1243..1279 CDD:238060 14/35 (40%)
LDLa 1283..1318 CDD:238060 17/43 (40%)
LDLa 1340..1371 CDD:197566 11/30 (37%)
FXa_inhibition 1388..1416 CDD:291342 15/58 (26%)
EGF_CA 1418..1452 CDD:214542 8/34 (24%)
lrp-2NP_491270.2 LDLa 80..119 CDD:197566
LDLa 130..162 CDD:197566
LY 668..702 CDD:214531
LY 707..758 CDD:214531
LY 759..801 CDD:214531
LDLa 968..1000 CDD:197566
LDLa 1013..1047 CDD:238060 9/38 (24%)
LDLa 1053..1087 CDD:238060 15/33 (45%)
LDLa 1098..1129 CDD:238060 10/30 (33%)
LDLa 1144..1175 CDD:238060 13/32 (41%)
LDLa 1182..1216 CDD:238060 19/33 (58%)
FXa_inhibition 1276..1305 CDD:291342 8/29 (28%)
LY 1421..1463 CDD:214531 15/41 (37%)
LY 1465..1508 CDD:214531 19/43 (44%)
LY 1521..1555 CDD:214531 18/33 (55%)
LY 2480..2521 CDD:214531 11/44 (25%)
LDLa 2681..2715 CDD:238060 11/34 (32%)
LDLa 2717..2751 CDD:238060 12/33 (36%)
LDLa <2774..2798 CDD:238060 15/23 (65%)
LDLa 2819..2851 CDD:238060 13/31 (42%)
LDLa 2856..2891 CDD:238060 14/35 (40%)
LDLa 2904..2938 CDD:238060 16/34 (47%)
LDLa 2988..3020 CDD:197566 11/31 (35%)
LY 3231..3270 CDD:214531 10/38 (26%)
Ldl_recept_b 3296..3336 CDD:278487 12/45 (27%)
LY 3319..3362 CDD:214531 14/45 (31%)
LY 3363..3404 CDD:214531 13/58 (22%)
LDLa 3481..3514 CDD:197566
LDLa 3574..3609 CDD:238060
LDLa 3614..3649 CDD:197566
LDLa 3659..3693 CDD:238060
LDLa 3881..3912 CDD:238060
LY 4084..4125 CDD:214531
LY 4139..4181 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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