DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and Lrp1

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_036011543.1	Gene:	Lrp1 / 16971	MGIID:	96828	Length:	4562	Species:	Mus musculus

Alignment Length:	2011	Identity:	531/2011 - (26%)
Similarity:	778/2011 - (38%)	Gaps:	635/2011 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FNLTSQTRAHPSSGGSTSSRYGN---CQRTHLIINGRHVAISLLLLVGL--CGGTAAGTPGSADT 88
            |:||....:|..........|.|   |::|....|......::|...|:  ||..:...|.: .|
Mouse  2558 FSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDDCGDGSDEIPCN-KT 2621

  Fly    89 RCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCD-------YR---------------LCRP 131
            .|..|:|:||||.||..:..|:...||:|:|||::|.       :|               ||..
Mouse  2622 ACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMNCSTTDCSSYFRLGVKGVLFQPCERTSLCYA 2686

  Fly   132 PHW-----------------------------FPCAQPHGACLAAELMCNGIDNCPGGEDELNCP 167
            |.|                             |.|  |.|.|:.....|:..|:|..||||.:|
Mouse  2687 PSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFAC--PSGRCIPMSWTCDKEDDCENGEDETHC- 2748

  Fly   168 VRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCK-----QAEITC 227
                         .:.||:.:|.||..| ||...::|||..||.|.|||.|.|:     .:..:|
Mouse  2749 -------------NKFCSEAQFECQNHR-CISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSC 2799

  Fly   228 PGEGHLCANGRCLRRKQWVCDGVDDCGDGSDE---RGCL--NLCEPQKGKFLCRNRETCLTLSEV 287
            ||. |:|...|      |:|||..||.||:||   .|||  :.|:.:  :|:|:|| .|:....|
Mouse  2800 PGT-HVCVPER------WLCDGDKDCTDGADESVTAGCLYNSTCDDR--EFMCQNR-LCIPKHFV 2854

  Fly   288 CDGHSDCSDGSDET-------------------------------DLCHSKPD------------ 309
            ||...||:|||||:                               :.||...|
Mouse  2855 CDHDRDCADGSDESPECEYPTCGPNEFRCANGRCLSSRQWECDGENDCHDHSDEAPKNPHCTSPE 2919

  Fly   310 ----------CDAKKCALGA----------------KCHMMPA----------------SGAECF 332
                      |.:.:|...|                .||:...                .|.:|.
Mouse  2920 HKCNASSQFLCSSGRCVAEALLCNGQDDCGDGSDERGCHVNECLSRKLSGCSQDCEDLKIGFKCR 2984

  Fly   333 CPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYL-LDKDNRTCRAVVYGSKE 396
            |..||||......|.|:|||..... |||.|.||.|.|:|:|..||. ...|..:|:||.    :
Mouse  2985 CRPGFRLKDDGRTCADLDECSTTFP-CSQLCINTHGSYKCLCVEGYAPRGGDPHSCKAVT----D 3044

  Fly   397 QQPLLLYTTQMTIMGMHLREDNVRNHVYQ-VAGNLSKVIGVAYD--GSHIYWTNIQNEAESIVKA 458
            ::|.|::..:     .:||:.|:....|. :...|:..:.:.:|  ...||||::..:...|.:.
Mouse  3045 EEPFLIFANR-----YYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRM 3104

  Fly   459 NGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLA 523
            :.:|||.::|..:||..|:.|||||:..|:|:.|.....|.|...:|....|||:..:.:||:|.
Mouse  3105 HLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALV 3169

  Fly   524 VWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTV 588
            |..|.|.::|||||:..:|||..||||....||...|.||||:.:|...:||||.||:...::..
Mouse  3170 VDVQNGYLYWTDWGDHSLIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYIEFA 3234

  Fly   589 RPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHRILAKDRTIYA---VH 650
            ..||:.|..||...:.|.:.|.:|||.:||:||.|||::..||.:|.:..:|..  |::.   :|
Mouse  3235 SLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGANKTLLIS--TLHRPMDLH 3297

  Fly   651 IYHPAKQPNSP-HGCE--NATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLFIG 712
            ::|..:||:.| |.|:  |..||:||||:..  |||.||||....|..|.|.|:
Mouse  3298 VFHALRQPDVPNHPCKVNNGGCSNLCLLSPG--GGHKCACPTNFYLGGDGRTCV----------- 3349

  Fly   713 LGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVR 777
                                             :....|..:..||:
Mouse  3350 ---------------------------------SNCTASQFVCKNDK------------------ 3363

  Fly   778 SNLGNVSALAFDHLSRNLYW-ADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYV 841
                   .:.|       :| .||
Mouse  3364 -------CIPF-------WWKCDT----------------------------------------- 3373

  Fly   842 VLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHS 906
                                     |||.||                                ||
Mouse  3374 -------------------------EDDCGD--------------------------------HS 3381

  Fly   907 QIFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPN 971
                                                             |:|    |..|
Mouse  3382 -------------------------------------------------DEP----PDCP----- 3388

  Fly   972 GIPLAASSPVGQESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE--------- 1027
                         ...|:.....||         ..||..|| |:.  .|:..|.:
Mouse  3389 -------------EFKCRPGQFQCS---------TGICTNPA-FIC--DGDNDCQDNSDEANCDI 3428

  Fly  1028 --ALDCEFRC-HSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQC-- 1087
              .|..:|:| ::..|:....||||:.:|.|..||.:|       |:|.|:||||.|...::|
Mouse  3429 HVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC-------PEVTCAPNQFQCSITKRCIP 3486

  Fly  1088 ---------------------------VDKER------------RCDNRKDCHDHSDE--QHCEK 1111
                                       ||:.|            :||...||.|.|||  :.|::
Mouse  3487 RVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDE 3551

  Fly  1112 FDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSR-CEPGMFQCGSGSCIAGSW 1175
                :.|..:|..|.|.:||.....||..|||||||||..|  |.| |....|.|.:|.||||.|
Mouse  3552 ----RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC--TPRPCSESEFSCANGRCIAGRW 3610

  Fly  1176 ECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMN 1240
            :|||..||:|||||.| |..| |..|..:|..|.|:.....||...||.|.|||..|||...|
Mouse  3611 KCDGDHDCADGSDEKD-CTPR-CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRT-- 3671

  Fly  1241 ISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDE--ADCGD-VCSIYE-FKCRSGRECIRREF 1301
              |..|::||.:.|  |.|...:|:|..:|....||  .:|.. :|.... |:|::.|.|:....
Mouse  3672 --CPLDEFQCNNTL--CKPLAWKCDGEDDCGDNSDENPEECARFICPPNRPFRCKNDRVCLWIGR 3732

  Fly  1302 RCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHL-FDCQDGECVDLSRVCNNFPDC 1365
            :|||..:||||:||..||            |.:..:..|:... |.|::..|:..|..||.|.||
Mouse  3733 QCDGVDNCGDGTDEEDCE------------PPTAQNPHCKDKKEFLCRNQRCLSSSLRCNMFDDC 3785

  Fly  1366 TNGHDE-----GPKCATACRSASGRQVC--QHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQ 1423
            .:|.||     .|| .|:|  |:...:|  :.:|..|...|.|:|..|:.....|..|.||:||.
Mouse  3786 GDGSDEEDCSIDPK-LTSC--ATNASMCGDEARCVRTEKAAYCACRSGFHTVPGQPGCQDINECL 3847

  Fly  1424 EQQPCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLF-SSFNEVRNL--------SEQ 1479
            ....|:|||.||.||:.|.|..:||...:  :||:..|...:|: :..||:|:|        .||
Mouse  3848 RFGTCSQLCNNTKGGHLCSCARNFMKTHN--TCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQ 3910

  Fly  1480 PVMLNVAWSANDS-RITGFDLAMHRQMGYFSAEDEGIV------------------YQIDLQTKV 1525
                  .:..::| ||...|:.:.....|::....|.:                  .||| :...
Mouse  3911 ------TFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQID-RGVT 3968

  Fly  1526 IVRALGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVGRMCGRIVH--VKSPRHVKHLAVDGYH 1587
            .:...||..|..:::|||.|||| ..||...|:.....|.....::.  :..|..:   .||...
Mouse  3969 HLNISGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAI---VVDPLR 4030

  Fly  1588 ARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLER 1652
            ..:::     ..:| ...:|..|.:||:.|:.|:|.:..:.|.|..|.|.:.||:.|..:..:.
Mouse  4031 GTMYW-----SDWG-NHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIG- 4088

  Fly  1653 ISYRLK-TGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINV 1716
             |.||. |.|:    :.......|.||..:.|:|:..:.|...:....:...:|    |...||:
Mouse  4089 -SIRLNGTDPI----VAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFG----HSPLINL 4144

  Fly  1717 L----NAQDIVVAGRSRQPQKASHPCAHAHCHGLCLQADYGYECMCGNRLVAEGERCPHGS 1773
            .    :|.|:|:..:.:||: .::||....|..|||.:..|..|.|.|     |:|..:|:
Mouse  4145 TGGLSHASDVVLYHQHKQPE-VTNPCDRKKCEWLCLLSPSGPVCTCPN-----GKRLDNGT 4199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	16/33 (48%)
		LDLa	131..166	CDD:238060	14/63 (22%)
		LDLa	184..216	CDD:238060	15/31 (48%)
		LDLa	227..262	CDD:238060	16/37 (43%)
		LDLa	271..302	CDD:238060	15/61 (25%)
		FXa_inhibition	352..387	CDD:291342	14/35 (40%)
		Ldl_recept_b	442..482	CDD:278487	14/39 (36%)
		LY	466..508	CDD:214531	15/41 (37%)
		Ldl_recept_b	529..569	CDD:278487	20/39 (51%)
		LY	553..595	CDD:214531	16/41 (39%)
		LY	596..637	CDD:214531	17/40 (43%)
		FXa_inhibition	669..700	CDD:291342	16/30 (53%)
		LY	774..815	CDD:214531	4/41 (10%)
		LDLa	1032..1062	CDD:238060	11/30 (37%)
		LDLa	1074..1109	CDD:238060	18/77 (23%)
		LDLa	1118..1152	CDD:238060	17/33 (52%)
		LDLa	1157..1189	CDD:197566	18/32 (56%)
		LDLa	1198..1232	CDD:238060	13/33 (39%)
		LDLa	1243..1279	CDD:238060	12/37 (32%)
		LDLa	1283..1318	CDD:238060	14/35 (40%)
		LDLa	1340..1371	CDD:197566	11/31 (35%)
		FXa_inhibition	1388..1416	CDD:291342	8/29 (28%)
		EGF_CA	1418..1452	CDD:214542	16/33 (48%)
Lrp1	XP_036011543.1	LDLa	27..60	CDD:197566
		LDLa	72..105	CDD:197566
		FXa_inhibition	120..149	CDD:405372
		FXa_inhibition	159..189	CDD:405372
		LY	276..315	CDD:214531
		LY	317..359	CDD:214531
		LY	362..402	CDD:214531
		FXa_inhibition	487..520	CDD:405372
		LY	552..594	CDD:214531
		LY	595..634	CDD:214531
		LY	641..690	CDD:214531
		LY	<701..734	CDD:214531
		FXa_inhibition	808..843	CDD:405372
		LDLa	854..886	CDD:197566
		LDLa	896..929	CDD:238060
		LDLa	936..968	CDD:197566
		LDLa	979..1012	CDD:238060
		LDLa	1033..1066	CDD:238060
		LDLa	1080..1115	CDD:238060
		LDLa	1122..1158	CDD:238060
		LDLa	1163..1196	CDD:238060
		FXa_inhibition	1203..1239	CDD:405372
		LY	1354..1394	CDD:214531
		LY	1398..1441	CDD:214531
		LY	1442..1486	CDD:214531
		LY	1631..1667	CDD:214531
		LY	1668..1711	CDD:214531
		LY	1715..1752	CDD:214531
		LY	1752..1793	CDD:214531
		FXa_inhibition	1868..1904	CDD:405372
		LY	1934..1974	CDD:214531
		LY	1977..2017	CDD:214531
		LY	2018..2061	CDD:214531
		LY	2063..2105	CDD:214531
		FXa_inhibition	2177..2212	CDD:405372
		YvrE	2271..2481	CDD:225921
		Ldl_recept_b	2362..2403	CDD:395012
		LY	2388..2429	CDD:214531
		FXa_inhibition	2500..2532	CDD:405372
		LDLa	2545..2575	CDD:238060	4/16 (25%)
		LDLa	2584..2618	CDD:238060	7/33 (21%)
		LDLa	2623..2657	CDD:238060	16/33 (48%)
		LDLa	<2684..2706	CDD:238060	3/21 (14%)
		LDLa	2714..2748	CDD:238060	12/35 (34%)
		LDLa	2752..2783	CDD:197566	15/31 (48%)
		LDLa	2791..2824	CDD:197566	14/39 (36%)
		LDLa	2835..2867	CDD:197566	14/34 (41%)
		LDLa	2875..2908	CDD:197566	2/32 (6%)
		LDLa	2925..2957	CDD:238060	3/31 (10%)
		cEGF	2980..3003	CDD:403760	9/22 (41%)
		EGF_CA	3000..>3029	CDD:214542	14/29 (48%)
		LY	3067..3111	CDD:214531	10/43 (23%)
		LY	3112..3154	CDD:214531	15/41 (37%)
		LY	3156..3198	CDD:214531	21/41 (51%)
		LY	3200..3241	CDD:214531	16/40 (40%)
		LY	3242..3282	CDD:214531	17/39 (44%)
		FXa_inhibition	3312..3348	CDD:405372	18/37 (49%)
		LDLa	3352..3383	CDD:238060	14/209 (7%)
		LDLa	3392..3426	CDD:238060	10/45 (22%)
		LDLa	3431..3466	CDD:238060	12/34 (35%)
		LDLa	3470..3503	CDD:197566	7/32 (22%)
		LDLa	3511..3544	CDD:197566	9/32 (28%)
		LDLa	3554..3588	CDD:238060	17/33 (52%)
		LDLa	3593..3627	CDD:238060	20/34 (59%)
LDLa	3631..3665	CDD:238060	13/33 (39%)
LDLa	3671..3703	CDD:197566	11/37 (30%)
LDLa	3713..3749	CDD:238060	14/35 (40%)
LDLa	3764..3794	CDD:238060	12/29 (41%)
LY	3973..4010	CDD:214531	14/36 (39%)
Ldl_recept_b	4031..4071	CDD:395012	10/45 (22%)
LY	4055..4096	CDD:214531	12/42 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710