DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and Lrp2

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	NP_001074557.1	Gene:	Lrp2 / 14725	MGIID:	95794	Length:	4660	Species:	Mus musculus

Alignment Length:	2043	Identity:	554/2043 - (27%)
Similarity:	864/2043 - (42%)	Gaps:	372/2043 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYR----- 127
            |||.:..|....:|      ..|.:|.|:|.:|.||..:..|||..||.|.:||:.|..|
Mouse    12 LLLAIAACLAPVSG------QECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCGSG 70

  Fly   128 --------LCRPPHWFPCAQ--------------------------PHGACLAAELMCNGIDNCP 158
                    .|.|..|. |.|                          .:|.|:..|..|:.:.:||
Mouse    71 FFLCPAEGTCIPSSWV-CDQDKDCSDGADEQQNCPGTTCSSQQLTCSNGQCVPIEYRCDHVSDCP 134

  Fly   159 GGEDELNC--------------------------PVRPGFRFGDTAHRMRSCSKYEFMCQQDRTC 197
            .|.||.||                          ..|..   .|.|:....||:.||.|.... |
Mouse   135 DGSDERNCYYPTCDQLTCANGACYNTSQKCDHKVDCRDS---SDEANCTTLCSQKEFQCGSGE-C 195

  Fly   198 IPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGC 262
            |...::||...||.|.||| ..|...  ||.|....|:||:|: .:.|||||.|||.|..||.||
Mouse   196 ILRAYVCDHDNDCEDNSDE-HNCNYD--TCGGHQFTCSNGQCI-NQNWVCDGDDDCQDSGDEDGC 256

  Fly   263 -----LNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCAL---GA 319
                 .:.|.|:  ::.|.....|:::.:||||..||.:|.||.:....: .|....|::   ..
Mouse   257 ESNQRHHTCYPR--EWACPGSGRCISMDKVCDGVPDCPEGEDENNATSGR-YCGTGLCSILNCEY 318

  Fly   320 KCHMMPASGAECFCPKGFRLAKFEDK-CEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDK- 382
            :||..| .|.|||||.|..:...:.: |.|.|:|:.. .:|.|.||:..|.::|:|:.||:|::
Mouse   319 QCHQTP-YGGECFCPPGHIINSNDSRTCIDFDDCQIW-GICDQKCESRQGRHQCLCEEGYILERG 381

  Fly   383 ------DNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGV--AYD 439
                  |:.:..::::.:..         .:.:..:|.|  |.|  :...:.|...|:||  .|.
Mouse   382 QHCKSNDSFSAASIIFSNGR---------DLLVGDLHGR--NFR--ILAESKNRGIVMGVDFHYQ 433

  Fly   440 GSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSND 504
            ...::||:...  ..:...:.:|.|.:.:|...:||||:|||||:...:|..:..:..|.|.:.:
Mouse   434 KHRVFWTDPMQ--AKVFSTDINGLNTQEILNVSIDAPENLAVDWINNKLYLVETRVNRIDVVNLE 496

  Fly   505 GLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGE---KPMIGRASMDGSRSRPIVSDNIEWPNGI 566
            |.....|:|:::..||.:|:.|..|.:|::|||.   :|.:.||.||||..:.:|:..:.||.||
Mouse   497 GNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKLGWPAGI 561

  Fly   567 ALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHAC 629
            .||:..:|:||||::...::||..||..|:||..|  ::.||:|:::||:.::::||...:|...
Mouse   562 TLDLVSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKA 626

  Fly   630 HKFSGKDHRILAKDR-TIYAVHIYHPAKQPN--SPHGCENATCSHLCLLA-EPEIG--GHSCACP 688
            :||:..:.::..:.. |.:.|.:||..:|||  :|.|..|..|:.:|:|: ..:.|  |:.|.|.
Mouse   627 NKFTDTNPQVYHQSSLTPFGVTVYHALRQPNATNPCGNNNGGCAQICVLSHRTDNGGLGYRCKCE 691

  Fly   689 DGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYT-LPCLINEMVYNRINGSL 752
            .|..|..|...|:.:  :..|.......:..|..|...:..|....| .|.....:.::..:.::
Mouse   692 FGFELDADEHHCVAV--KNFLLFSSQTAVRGIPFTLSTQEDVMVPVTGSPSFFVGIDFDAQHSTI 754

  Fly   753 IIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRAL 817
            ..:|..:.:|.:.:.:.....|:..:.|.||..|:||.:||||||.|.....:.|:.|..:.|..
Mouse   755 FYSDLSKNIIYQQKIDGTGKEVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSRRQ 819

  Fly   818 IRFFPGQEVPIGLTVMPAEGYLYV--------VLKA-KRHSHIDKIPLSGKGEQVHVFEDDLGDD 873
            |  ......|..:.|.||.||:::        :::| ...||:           :.:....||..
Mouse   820 I--ISNLNNPRSIVVHPAAGYMFLSDWFRPAKIMRAWSDGSHL-----------MPIVNTSLGWP 871

  Fly   874 DIKLVTDYETQTIFWSDSDLGRISYSNY------RVPHSQIFRGKLRRPYSLAMVHHDLFWNELG 932
            : .|..|:.|..::|.|:...:|.:||.      |:.|..    ::..|:.|.:...::|..:..
Mouse   872 N-GLAIDWSTSRLYWVDAFFDKIEHSNLDGLDRKRLGHVD----QMTHPFGLTVFKDNVFLTDWR 931

  Fly   933 TPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQQNGGCSH 997
            ...|....||:.|...|:       ...|...:.|...:......::...|.:||    ||.|||
Mouse   932 LGAIIRVRKSDGGDMTVV-------RRGISSIMHVKAYDADLQTGTNYCSQTTHP----NGDCSH 985

  Fly   998 ICVGEGPYHSICLCPAGF-VYRDAGNRTC----------VEALDCEFRCHSGECLTMNHRCNGRR 1051
            .|.....:..:|.||.|. :.||  ..||          .:.....|.|::|:|:....||:|..
Mouse   986 FCFPVPNFQRVCGCPYGMKLQRD--QMTCEGDPAREPPTQQCGSSSFPCNNGKCVPSIFRCDGVD 1048

  Fly  1052 DCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSK 1116
            ||.|||||..|...:.     .||.:.|.|..|.||:..:.|||.:.||.|.||||:|.....|.
Mouse  1049 DCHDNSDEHQCGALNN-----TCSSSAFTCVHGGQCIPGQWRCDKQNDCLDGSDEQNCPTRSPSS 1108

  Fly  1117 KCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSWECDGRI 1181
            .|......|||..|:....|||..|||.|.|||..|:|:..|.|..|:|....||:..:.|||..
Mouse  1109 TCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNCQASGTCHPTQFRCPDHRCISPLYVCDGDK 1173

  Fly  1182 DCSDGSDEHDKCVHRSCPPDMQRCLLG-QCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAE 1245
            ||.|||||.. || .:|.....:|..| .|::....|||..||.|.|||..|.|....|   |..
Mouse  1174 DCVDGSDEAG-CV-LNCTSSQFKCADGSSCINSRYRCDGVYDCKDNSDEAGCPTRPPGM---CHP 1233

  Fly  1246 DQYQCTSNLKICLPSTVRCNGTTECPRGEDEAD-C-GDVCSIYEFKCRSGRECIRREFRCDGQKD 1308
            |::||..: ..|:|:|..|:|..:|.:|.||.: | ...||...|.|.:| .||...:.|||..|
Mouse  1234 DEFQCQGD-GTCIPNTWECDGHPDCIQGSDEHNGCVPKTCSPSHFLCDNG-NCIYNSWVCDGDND 1296

  Fly  1309 CGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEGP 1373
            |.|.|||..|..:..|...||   |.....|.           ||:||.:|:...||.||.||.|
Mouse  1297 CRDMSDEKDCPTQPFHCPSSQ---WQCPGYSI-----------CVNLSALCDGVFDCPNGTDESP 1347

  Fly  1374 KC-ATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLG 1437
            .| ..:|...:|.  |.|:|...|.||.|.|..||:|..|.|:|.|::||.....|:|.|.|..|
Mouse  1348 LCNQDSCLHFNGG--CTHRCIQGPFGATCVCPIGYQLANDTKTCEDVNECDIPGFCSQHCVNMRG 1410

  Fly  1438 GYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEVRNLSEQPVMLNVAWSANDSRITGFDLAMH 1502
            .::|.|..::.|..|..:||...|...||.                    .|:..:|...::..|
Mouse  1411 SFRCACDPEYTLESDGRTCKVTASENLLLV--------------------VASRDKIIMDNITAH 1455

  Fly  1503 RQMGYFSAEDEGIVYQIDLQT------------------------KVIVRALGLPAPTKLSVDWV 1543
            ....|...:|...|..:|..:                        |.:|...||.....::|||:
Mouse  1456 THNIYSLVQDVSFVVALDFDSVTGRVFWSDLLEGKTWSAFQNGTDKRVVHDSGLSLTEMIAVDWI 1520

  Fly  1544 TGNVYVLSGAQEIQACSFVGRMCGRIVHVKSPRHVKHLAVD-------------GYHARIFYIVI 1595
            ..|:|......|....|.:......::..|:....:.||:|             |:|.|
Mouse  1521 GRNIYWTDYTLETIEVSKIDGSHRTVLISKNVTKPRGLALDPRMGDNVMFWSDWGHHPR------ 1579

  Fly  1596 RTEGYGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKTG 1660
                       |..|.:||:.|.:::|....:...|:.|...:|:||:|.::..:|...|   .|
Mouse  1580 -----------IERASMDGTMRTVIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDY---DG 1630

  Fly  1661 PMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINVLNAQDIVVA 1725
            ..||.  ::.....|.||..|:::|::.|..:.|:.:.:|...:..|....:..:|.....|:..
Mouse  1631 QNRRQ--VIASDLVLHHPHALTLFEDSVFWTDRGTHQVMQANKWHGRNQSVVMYSVPQPLGIIAI 1693

  Fly  1726 GRSRQPQKASHPCAHAHCHGLCL---QADYGYECMC--GNRLVAEGERC---------------- 1769
            ..|||| .:.:|||.|.|..|||   |....|.|.|  |..|..:...|
Mouse  1694 HPSRQP-SSPNPCASATCSHLCLLSAQEPRHYSCACPSGWNLSDDSVNCVRGDQPFLISVRENVI 1757

  Fly  1770 ------PHGSGNE--VAVLGAVNSLELEHEH--------EQNGHFHWL---------MALFVLAA 1809
                  |....|:  |.:.|..:..::|.:.        |..|..|.:         .|...|..
Mouse  1758 FGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKTDGSNRTAFAPLSLLG 1822

  Fly  1810 GSLIAGLGYMYYQYRQRGHTDLNINMHFQNP------LATLGGT----KAFLEHERAEAGVGFTT 1864
            .||...|.:            ::.|:::..|      :.||.|.    |..:.::....||||..
Mouse  1823 SSLGLALDW------------VSRNIYYTTPASRSIEVLTLRGDTRYGKTLITNDGTPLGVGFPV 1875

  Fly  1865 ETGTVSSRGS---NDTFTTTSATSSFAA 1889
            ......:||.   :|..|.:...:..|:
Mouse  1876 GIAVDPARGKLYWSDHGTDSGVPAKIAS 1903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	15/33 (45%)
		LDLa	131..166	CDD:238060	13/60 (22%)
		LDLa	184..216	CDD:238060	13/31 (42%)
		LDLa	227..262	CDD:238060	17/34 (50%)
		LDLa	271..302	CDD:238060	11/30 (37%)
		FXa_inhibition	352..387	CDD:291342	12/41 (29%)
		Ldl_recept_b	442..482	CDD:278487	11/39 (28%)
		LY	466..508	CDD:214531	14/41 (34%)
		Ldl_recept_b	529..569	CDD:278487	17/42 (40%)
		LY	553..595	CDD:214531	16/41 (39%)
		LY	596..637	CDD:214531	13/42 (31%)
		FXa_inhibition	669..700	CDD:291342	10/33 (30%)
		LY	774..815	CDD:214531	16/40 (40%)
		LDLa	1032..1062	CDD:238060	14/29 (48%)
		LDLa	1074..1109	CDD:238060	17/34 (50%)
		LDLa	1118..1152	CDD:238060	15/33 (45%)
		LDLa	1157..1189	CDD:197566	14/31 (45%)
		LDLa	1198..1232	CDD:238060	13/34 (38%)
		LDLa	1243..1279	CDD:238060	13/36 (36%)
		LDLa	1283..1318	CDD:238060	16/34 (47%)
		LDLa	1340..1371	CDD:197566	9/30 (30%)
		FXa_inhibition	1388..1416	CDD:291342	13/27 (48%)
		EGF_CA	1418..1452	CDD:214542	11/33 (33%)
Lrp2	NP_001074557.1	LDLa	28..62	CDD:238060	15/33 (45%)
		LDLa	67..99	CDD:197566	5/32 (16%)
		LDLa	108..142	CDD:238060	9/33 (27%)
		LDLa	148..179	CDD:238060	3/33 (9%)
		LDLa	183..217	CDD:238060	15/35 (43%)
		LDLa	222..256	CDD:238060	17/34 (50%)
		LDLa	265..299	CDD:238060	13/35 (37%)
		LDL-receptor class B 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	435..477		14/43 (33%)
		LY	460..500	CDD:214531	14/39 (36%)
		LDL-receptor class B 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	478..520		10/41 (24%)
		LY	502..547	CDD:214531	18/44 (41%)
		LDL-receptor class B 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	521..567		19/45 (42%)
		LY	550..590	CDD:214531	16/39 (41%)
		LDL-receptor class B 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	568..612		18/43 (42%)
		FXa_inhibition	662..703	CDD:291342	12/40 (30%)
		LDL-receptor class B 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	752..794		9/41 (22%)
		LY	775..817	CDD:214531	16/41 (39%)
		LDL-receptor class B 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	795..836		13/42 (31%)
		LDL-receptor class B 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	837..880		9/54 (17%)
		Ldl_recept_b	837..877	CDD:278487	8/51 (16%)
		LY	863..903	CDD:214531	10/40 (25%)
		LDL-receptor class B 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	881..924		9/46 (20%)
		FXa_inhibition	980..1012	CDD:291342	12/33 (36%)
		LDLa	1025..1059	CDD:238060	14/33 (42%)
		Ldl_recept_a	1065..1101	CDD:278486	17/35 (49%)
		LDLa	1110..1144	CDD:238060	15/33 (45%)
		LDLa	1150..1184	CDD:238060	16/34 (47%)
		LDLa	1188..1223	CDD:238060	13/34 (38%)
		LDLa	1231..1263	CDD:197566	11/32 (34%)
		LDLa	1272..1306	CDD:238060	16/34 (47%)
		LDLa	1313..1345	CDD:197566	13/45 (29%)
		FXa_inhibition	1354..1389	CDD:291342	15/36 (42%)
		EGF_CA	1391..1430	CDD:214542	12/38 (32%)
		LDL-receptor class B 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1479..1521		7/41 (17%)
		LY	1502..1544	CDD:214531	10/41 (24%)
		LDL-receptor class B 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1522..1564		8/41 (20%)
		LY	1546..1590	CDD:214531	11/60 (18%)
		LDL-receptor class B 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1567..1610		11/59 (19%)
		LY	1592..1633	CDD:214531	10/43 (23%)
		LDL-receptor class B 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1611..1655		14/48 (29%)
		LDL-receptor class B 13. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1656..1696		6/39 (15%)
		LDL-receptor class B 14. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1791..1833		8/53 (15%)
		LDL-receptor class B 15. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1834..1883		10/48 (21%)
		LDL-receptor class B 16. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1884..1931		4/20 (20%)
		Ldl_recept_b	1884..1928	CDD:278487	4/20 (20%)
		LY	1912..1954	CDD:214531
		LDL-receptor class B 17. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1932..1973
		LDL-receptor class B 18. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1974..2014
		FXa_inhibition	2023..2059	CDD:291342
		LDL-receptor class B 19. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2108..2157
		LDL-receptor class B 20. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2158..2202
		LY	2183..2226	CDD:214531
		LDL-receptor class B 21. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2203..2246
		LY	2228..2268	CDD:214531
		LDL-receptor class B 22. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2247..2290
		LDL-receptor class B 23. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2291..2333
		FXa_inhibition	2347..2383	CDD:291342
		LDL-receptor class B 24. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2432..2478
		LY	2460..2501	CDD:214531
		LDL-receptor class B 25. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2479..2519
		LY	2503..2543	CDD:214531
		LDL-receptor class B 26. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2520..2563
		LDL-receptor class B 27. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2564..2605
		LDL-receptor class B 28. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2606..2647
FXa_inhibition	2656..2693	CDD:291342
LDLa	2700..2732	CDD:197566
LDLa	2742..2776	CDD:238060
LDLa	2783..2818	CDD:238060
LDLa	2822..2855	CDD:197566
LDLa	2865..2899	CDD:238060
LDLa	2908..2939	CDD:197566
LDLa	2950..2986	CDD:197566
LDLa	2995..3029	CDD:238060
LDLa	3034..3066	CDD:238060
LDLa	3077..3111	CDD:238060
cEGF	3134..3157	CDD:289433
vWFA	<3149..3192	CDD:294047
LY	3221..3262	CDD:214531
LDL-receptor class B 29. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3241..3283
LY	3264..3306	CDD:214531
Ldl_recept_b	3284..3331	CDD:278487
LDL-receptor class B 30. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3284..3326
LDL-receptor class B 31. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3335..3378
Ldl_recept_b	3335..3375	CDD:278487
LY	3360..3401	CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3379..3421
LY	3406..3443	CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3422..3462
FXa_inhibition	3471..>3500	CDD:291342
LDLa	3514..3548	CDD:238060
LDLa	3555..3586	CDD:197566
LDLa	3595..3627	CDD:197566
LDLa	3636..3668	CDD:197566
LDLa	3684..3716	CDD:238060
LDLa	3723..3756	CDD:238060
LDLa	3761..3795	CDD:238060
LDLa	3800..3834	CDD:238060
LDLa	3844..3876	CDD:238060
LDLa	3887..3917	CDD:197566
LDLa	3930..3964	CDD:238060
EGF_CA	4009..4049	CDD:214542
LY	4143..4178	CDD:214531
LDL-receptor class B 34. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4156..4198
LDL-receptor class B 35. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4199..4242
Ldl_recept_b	4199..4239	CDD:278487
LY	4224..4266	CDD:214531
LDL-receptor class B 36. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4244..4285
SH3-binding. /evidence=ECO:0000255	4454..4463
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4457..4462
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4460..4465
Endocytosis signal. /evidence=ECO:0000255	4522..4527
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4558..4660
Interaction with DAB2. /evidence=ECO:0000250\|UniProtKB:P98164	4597..4610
NPXY motif	4603..4606
SH2-binding. /evidence=ECO:0000255	4606..4609
SH3-binding. /evidence=ECO:0000255	4619..4630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.670