DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and Egf

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_011238312.1	Gene:	Egf / 13645	MGIID:	95290	Length:	1221	Species:	Mus musculus

Alignment Length:	1187	Identity:	261/1187 - (21%)
Similarity:	373/1187 - (31%)	Gaps:	473/1187 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 IDNCPGGEDELNCPVRPGF---------------RFGDTAHRMRSCSKYEFMCQQDRTCIPIDF- 202
            |.|...|:|.:...:.|.|               |..|.|.........|.:.|:.|.|   .|
Mouse   277 IANKHTGKDTVRINLHPSFVTPGKLMVVHPRAQPRTEDAAKDPGESLDPELLKQRGRPC---RFG 338

  Fly   203 MCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCLNLCE 267
            :|:..|    ||...|               ||.|..|.|.:..|:.|::|  .:...||...||
Mouse   339 LCERDP----KSHSSA---------------CAEGYTLSRDRKYCEDVNEC--ATQNHGCTLGCE 382

  Fly   268 PQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDC--DAKKCALGAKCHMMPASGAE 330
            ...|.:.|    ||.|      |.....||..    ||....|  :..||:.|.   ::.:.|..
Mouse   383 NTPGSYHC----TCPT------GFVLLPDGKQ----CHELVSCPGNVSKCSHGC---VLTSDGPR 430

  Fly   331 CFCPKGFRLAKFEDKCEDVDECKEQDD-LCSQGC-ENTSGGYRCVCDAGYLLDKDNRTCRAVVYG 393
            |.||.|..|.:....|..   |...|: .|||.| ....|.:.|.|..||.|..|.::|.|
Mouse   431 CICPAGSVLGRDGKTCTG---CSSPDNGGCSQICLPLRPGSWECDCFPGYDLQSDRKSCAA---- 488

  Fly   394 SKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKVIGVA----YD--GSHIYWTNIQNEA 452
             ...|||||:.....|..||....:     |:|.  ||:.:|:.    ||  .|.||:.  |...
Mouse   489 -SGPQPLLLFANSQDIRHMHFDGTD-----YKVL--LSRQMGMVFALDYDPVESKIYFA--QTAL 543

  Fly   453 ESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVTQDVH 517
            :.|.:||.|||..|.|:|.|:|..|.||:||:.:.||::|:....:......|.:..:::.:.:.
Mouse   544 KWIERANMDGSQRERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHHRIIIQERIS 608

  Fly   518 QPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKL 582
            :||.:||.|:...:||||.|..|.|..||:.||....|.|.|:..|:||.:|.....:||.|.|.
Mouse   609 RPRGIAVHPRARRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITIDYLTDTLYWCDTKR 673

  Fly   583 GSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDH-RILAKDRTI 646
            ..::....||:.||.::...:.||:.||:|||.|:.||||..||...:|.:|::. |:.......
Mouse   674 SVIEMANLDGSKRRRLIQNDVGHPFSLAVFEDHLWVSDWAIPSVIRVNKRTGQNRVRLQGSMLKP 738

  Fly   647 YAVHIYHPAKQPNS-PHGCENATCSHLCLLAEPEIGGHSCACPDGMRLAPDHRRCMLMEKRQRLF 710
            .::.:.||..:|.: |....|..|.|:|   :..:|...|.|.:|...|.|.:.|:
Mouse   739 SSLVVVHPLAKPGADPCLYRNGGCEHIC---QESLGTARCLCREGFVKAWDGKMCL--------- 791

  Fly   711 IGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVL 775
                                                                    |:.:.  :|
Mouse   792 --------------------------------------------------------PQDYP--IL 798

  Fly   776 VRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLY 840
            ...|                  ||..:   ||.||....:|        |||
Mouse   799 SGEN------------------ADLSK---EVTSLSNSTQA--------EVP------------- 821

  Fly   841 VVLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPH 905
                                       ||.|.:...||.:.             .:|..||
Mouse   822 ---------------------------DDDGTESSTLVAEI-------------MVSGMNY---- 842

  Fly   906 SQIFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVPVATP 970
                                               :.:.||
Mouse   843 -----------------------------------EDDCGP------------------------ 848

  Fly   971 NGIPLAASSPVGQESHPCQQQNGGC-SHI-CVGEGPYHSICLCPAGFVYRDAGNRTCVEALDCEF 1033
                                  ||| ||. ||.:|. .:.|.|..||. || || .|.:..:|..
Mouse   849 ----------------------GGCGSHARCVSDGE-TAECQCLKGFA-RD-GN-LCSDIDECVL 887

  Fly  1034 RCHSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRK 1098
                           .|.||...|.                                  ||.|.:
Mouse   888 ---------------ARSDCPSTSS----------------------------------RCINTE 903

  Fly  1099 D---CHDHSDEQHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEP 1160
            .   |                :|.....| |...|.|......|.::||:|:   .|..|.
Mouse   904 GGYVC----------------RCSEGYEG-DGISCFDIDECQRGAHNCGENA---ACTNTE---- 944

  Fly  1161 GMFQCGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGD 1225
            |.:.|          .|.|| ..|.|         .|||......|||:        |||:  .|
Mouse   945 GGYNC----------TCAGR-PSSPG---------LSCPDSTAPSLLGE--------DGHH--LD 979

  Fly  1226 KSDELNCGTDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKC 1290
            ::....|.:         :.|.|        ||      ||..          |..:.|:..:.|
Mouse   980 RNSYPGCPS---------SYDGY--------CL------NGGV----------CMHIESLDSYTC 1011

  Fly  1291 R-----SGRECIRREFR 1302
            .     ||..|..|:.|
Mouse  1012 NCVIGYSGDRCQTRDLR 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060
		LDLa	131..166	CDD:238060	4/11 (36%)
		LDLa	184..216	CDD:238060	9/32 (28%)
		LDLa	227..262	CDD:238060	8/34 (24%)
		LDLa	271..302	CDD:238060	8/30 (27%)
		FXa_inhibition	352..387	CDD:291342	13/36 (36%)
		Ldl_recept_b	442..482	CDD:278487	17/39 (44%)
		LY	466..508	CDD:214531	14/41 (34%)
		Ldl_recept_b	529..569	CDD:278487	17/39 (44%)
		LY	553..595	CDD:214531	13/41 (32%)
		LY	596..637	CDD:214531	17/40 (43%)
		FXa_inhibition	669..700	CDD:291342	9/30 (30%)
		LY	774..815	CDD:214531	8/40 (20%)
		LDLa	1032..1062	CDD:238060	4/29 (14%)
		LDLa	1074..1109	CDD:238060	4/37 (11%)
		LDLa	1118..1152	CDD:238060	9/33 (27%)
		LDLa	1157..1189	CDD:197566	7/31 (23%)
		LDLa	1198..1232	CDD:238060	9/33 (27%)
		LDLa	1243..1279	CDD:238060	6/35 (17%)
		LDLa	1283..1318	CDD:238060	7/25 (28%)
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
Egf	XP_011238312.1	LY	<86..114	CDD:214531
		LY	<125..156	CDD:214531
		LY	158..199	CDD:214531
		FXa_inhibition	370..405	CDD:373209	13/50 (26%)
		FXa_inhibition	418..446	CDD:373209	8/30 (27%)
		FXa_inhibition	453..486	CDD:373209	12/32 (38%)
		LY	514..556	CDD:214531	16/45 (36%)
		LY	557..599	CDD:214531	14/41 (34%)
		LY	600..643	CDD:214531	16/42 (38%)
		LY	643..686	CDD:214531	13/42 (31%)
		LY	687..728	CDD:214531	17/40 (43%)
		FXa_inhibition	755..790	CDD:373209	10/37 (27%)
		EGF_CA	881..921	CDD:311536	12/105 (11%)
		EGF_CA	923..>951	CDD:311536	9/44 (20%)
		PHA02887	<986..1023	CDD:165214	12/69 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900