Protein Alignment yl and yl

DIOPT Version :10

• Sequence 1: NP_996433.1
• Gene: yl / 32367
• FlyBaseID: FBgn0004649
• Length: 1984
• Species: Drosophila melanogaster
• Sequence 2: XP_310672.6
• Gene: yl / 1271818
• VectorBaseID: AGAMI1_010770
• Length: 1906
• Species: Anopheles gambiae
• Alignment Length: 1974
• Identity: 768/1974 - (38%)
• Similarity: 1072/1974 - (54%)
• Gaps: 188/1974 - (9%)

  Fly    43 GSTSSRYGNCQRTHLIINGRHVAISLLLLVGLCGGTAAGTPGS------ADTRCDAGQFQCRDGG 101
            ||.:.:.|..:......|.|.|.: :..:|.|....:||...|      |...|.|.:|||.:|.
Mosquito    33 GSNTRQEGEKRNPFAATNMRLVVL-VATVVLLAANVSAGKVESEKKSTAASKSCGAHEFQCENGA 96

  Fly   102 CILQAKMCDGRGDCKDSSDELDCDYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNC 166
            ||..|..|:...||.|.|||..|||.|||.|.|:.| :....|::....|:|..:|.||:||.||
Mosquito    97 CIPAAGHCNDIQDCADGSDESGCDYFLCRAPFWYRC-RHESTCISGSSRCDGQRDCLGGDDEENC 160

  Fly   167 PVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEG 231
            ...      :..||...|||.||.| .||.|||.|.:|||...|.|.|||..||......|  :|
Mosquito   161 DNY------EVPHRAPLCSKAEFTC-TDRACIPADLVCDGVQHCLDGSDETIGCIDIAGKC--KG 216

  Fly   232 HLCANGRCLRRKQWVCDGVDDCGDGSDERGCLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSD 296
            .||.|..||:...|||||:|||||||||..||:.|..:.||:.|.|..||:.:::||:|..||.|
Mosquito   217 FLCRNKHCLQSHHWVCDGLDDCGDGSDEEHCLSECTLEHGKYECANNHTCVDVTQVCNGADDCGD 281

  Fly   297 GSDETDLCHSKPD-CDAKKCALGAKCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCS 360
            ||||...|....| |.|..|| ...|.::|.....|.|..|||......:|.||:||... .|||
Mosquito   282 GSDEGPGCKVPADGCKALHCA-PQTCKVLPDGKPVCLCGVGFRFEPSAGRCVDVNECARY-GLCS 344

  Fly   361 QGCENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQ 425
            |||.||.|.:||.|...:.|.:|.|||..    |...:.|:|||||..:..|:|    ...|.|.
Mosquito   345 QGCINTPGSFRCTCIDQFHLMRDGRTCEL----SSGTEALMLYTTQKAVGAMYL----TSLHQYY 401

  Fly   426 VAGNLSKVIGVAYDGSHIYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYF 490
            ||..||:||||||||||:|||:|.::.|||.::..|||:...|||:||.:|||:|:||||.||||
Mosquito   402 VAKELSQVIGVAYDGSHVYWTDISHKTESIERSLEDGSDRVQLLTAGLISPEDIALDWLTGNIYF 466

  Fly   491 SDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPI 555
            ||:...||||||:||.:|..:|..::|:||.:|:.||.|.:|::|||...|||||.|||:..:.:
Mosquito   467 SDSGQMHIAVCSSDGYHCRAIVQDELHKPRGIALLPQNGTLFYSDWGNNAMIGRARMDGTEQQVV 531

  Fly   556 VSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSD 620
            |||.|.||||:.||...||:||:||||..::::..|||.|..|||.:||||:.:|:|.|:|||||
Mosquito   532 VSDGIHWPNGLTLDWPNQRLYWIDAKLKRIESMHFDGTDRVVVLDDVLKHPFSIAVFNDRLYWSD 596

  Fly   621 WATKSVHACHKFSGKDHRILAKDRTIYAVHIYHPAKQPNSPHGCENATCSHLCLLAEPEIGGHSC 685
            |.|||:.:|.||:||..:.|..||.|:.||:||.:.||...|.|.|.||:|||||...  ..::|
Mosquito   597 WDTKSIQSCDKFTGKMRQTLVHDRMIFDVHVYHSSIQPKVSHACANHTCTHLCLLTSN--ATYAC 659

  Fly   686 ACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLP-CLINEMVYNRIN 749
            |||.||.|:.|...|..:.|||.:.:|:|..|:.::|..||||...:...|| ..|:.:.:|.:.
Mosquito   660 ACPQGMELSRDKHSCASVAKRQDILLGIGHYLVTLKHHPFGRHATGRGEPLPVATISRLAFNSLT 724

  Fly   750 GSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRH 814
            |.|.:|||.:|.|...:..|..:..||||.:|.::|||||:||..|||:|.||:.||:.||||||
Mosquito   725 GELFVADNSRRAIYTVELGSLRTQRLVRSGIGRITALAFDYLSNTLYWSDAERSTIEIYSLQTRH 789

  Fly   815 RALIRFFPGQEVPIGLTVMPAEGYLYVVLKA-KRHSHIDKIPLSGKGEQVHVFEDDLGDD-DIKL 877
            |::|:.:.|.:.|:.|.::|..|.::|.|:: ..|:|||:..::|:|...||.|:.||.: .|..
Mosquito   790 RSIIQHYLGDDAPVALALIPETGKMFVALRSPSGHTHIDRQDMTGRGPHTHVIEERLGSNGTISF 854

  Fly   878 VTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKS 942
            ..|.:.:::|||||...||..:::......:||..||.|.|||::..:|||...|:.|:||:.|.
Mosquito   855 AVDQDLRSVFWSDSGTNRIEITSFEGDTRHLFREYLREPVSLAIIGSELFWTCRGSQRLYWSDKH 919

  Fly   943 NMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQE-SHPCQQQNGGCSHICVGEGPYH 1006
            |:|..|.|.:....|         :|.|:.:|:|||.|..:. .|||.:.|||||||||..|.|.
Mosquito   920 NVGATKRISVQLPPD---------LAVPDEMPIAASQPTTRRPDHPCTRSNGGCSHICVAGGLYT 975

  Fly  1007 SICLCPAGFVYRDAGNRTCVEALDCEFRCHSGECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKP- 1070
            |.|:||.|.|:.....|.|::|..|.|||.|||||....|||||.||:|.|||..|:.   :.|
Mosquito   976 SACVCPTGMVFNTTLARVCIDAAACAFRCASGECLARGLRCNGRVDCMDQSDEQGCES---KTPA 1037

  Fly  1071 ---KVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKCHVHQHGCDNGKCVD 1132
               ...|..|:|.|..|.:|:....|||:|.||.|.|||.:||.:::...|..:|..|.:|.|||
Mosquito  1038 GAGTTGCRWNEFRCADGSRCIAATSRCDSRPDCADRSDEANCEGYNRRTNCTRYQFSCADGFCVD 1102

  Fly  1133 SSLVCDGTNDCGDNSDELLCE--------ATSRCEPGMFQCGSGSCIAGSWECDGRIDCSDGSDE 1189
            ::..||...||.|.|||..|.        |.:.|..|||:|.||.|:.|||||||..||.|.|||
Mosquito  1103 ATARCDQVPDCPDGSDEQECAGVGGKGGVAATTCAAGMFRCNSGQCVPGSWECDGSPDCHDASDE 1167

  Fly  1190 HDKC-------------VHRSCPPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNI 1241
            |:.|             ....|.....||.:|.|:..:|||||::||||.:||.:|.........
Mosquito  1168 HESCQPAEKKQEEGKGKEQERCGEGRFRCGVGFCISSALVCDGNDDCGDGTDEEHCVGRIGATAA 1232

  Fly  1242 SCAED------QYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKCRSGRECIRRE 1300
            .|:|.      .|:|..: ..|||:..|||||||||.||||..|.: |.:.||:|..| :|||:|
Mosquito  1233 QCSEQAIANGTAYRCARS-GACLPAAARCNGTTECPHGEDETGCSN-CGLREFQCADG-QCIRQE 1294

  Fly  1301 FRCDGQKDCGDGSDELSC----ELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNN 1361
            :|||..:||.|||||.:|    :....|          |.:..|....|:|..|||:.::::|:.
Mosquito  1295 WRCDHDQDCDDGSDERNCTAGADGSTAH----------THAIDCGRDTFECGPGECIPVAKLCDG 1349

  Fly  1362 FPDCTNGHDEGPKCATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQ 1426
            ..||||||||...||:||....|  .|...|:.:|||::|:|.:||.|..|:|:|.|::||...|
Mosquito  1350 RRDCTNGHDEEGACASACTGGLG--PCAQICQKSPAGSICACLEGYELAGDRKTCTDVNECARGQ 1412

  Fly  1427 PCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEVRNLS-EQPVMLNVAWSAN 1490
            ||||.|.|..|.|:|.||..||||.|:.||||:.....||:::.::||.|: :||..::.....|
Mosquito  1413 PCAQQCANVHGSYRCACHDGFMLRPDKASCKSVGPAPHLLYTALDQVRQLTLQQPPRIDTVLRTN 1477

  Fly  1491 DSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQTKVIVRALGLPAPTKLSVDWVTGNVYVLSGAQ- 1554
            .||||..||.:.::..|::||:...:|:.||:|........:..|.:|:||||.||||.....:
Mosquito  1478 GSRITALDLDVRQRRLYYAAENGAALYEHDLRTNETRVLANVGRPDRLAVDWVAGNVYFADATEP 1542

  Fly  1555 EIQACSFVGRMCGRIVHVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDM 1619
            .::.|.|....|.|:.......:||.:|||..:..:||.::.:..:....:.::.||||||.:::
Mosquito  1543 SLKVCHFGRGACARVASFSQRNYVKAVAVDPVNRYLFYALLFSWIFQVPHTIVYRARLDGSLQEI 1607

  Fly  1620 LLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKSNALMH-PSGLSV 1683
            :.::: ..::||..||..||||:.:....||.|:.|   .|..:|  ::.:....|:| |..|||
Mosquito  1608 VTKQA-GIVSALAVDPQAQLLYYTELAGNTLRRVDY---LGQGQR--VLAEDQPGLLHQPVQLSV 1666

  Fly  1684 YENNAFIVNL---GSVEAVQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPCAHAHCHG 1745
            |||.|.:||.   ||:.  ||.|||...|....:||.....::|...||||. ..:.|..|:|..
Mosquito  1667 YENQALVVNRAPPGSIG--QCQLYGQYRCEPYRVNVPPTGLLLVVQESRQPM-VPNVCDRANCTH 1728

  Fly  1746 LCLQADYGYECMCGNRL-VAEGERCPHGSGNEVA--------VLGAVNSLELEHEHEQNGHFHWL 1801
            ||:.......|:|.|.| :|||:||........|        ::||....:...:...:....||
Mosquito  1729 LCVAVGPVARCICENGLEIAEGDRCAEPKDGARAMKPYRGTVLVGAAAPAQPTTDGADDEGAGWL 1793

  Fly  1802 MALF-VLAAGSLI-AGLGYMYYQYRQRGHTDLNINMHFQNPLATLGGTKAFLEHERAEAGVGFTT 1864
            ..|. ||...:|: |.:|..:|.||||.....::.:||.|
Mosquito  1794 AGLLHVLLYVTLVGATVGAGWYVYRQRFQHKFDVGIHFNN------------------------- 1833

  Fly  1865 ETGTVSSRGSNDTFTTTSATSSFAAQQFSVPNALQRLLRPRQSASGDPMAQELLLESPSRESKLH 1929
                           |..:||.:|..:.........|               .|::.|:....|.
Mosquito  1834 ---------------TELSTSEYAQVELCKVEGRNVL---------------TLVQHPAEADALS 1868

  Fly  1930 ALDGGGAGGDGDGGRGVGRQVPDI 1953
            |:.|   ..||:|        |||
Mosquito  1869 AISG---ATDGNG--------PDI 1881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	16/33 (48%)
		LDLa	131..166	CDD:238060	11/34 (32%)
		LDLa	184..216	CDD:238060	18/31 (58%)
		LDLa	227..262	CDD:238060	21/34 (62%)
		LDLa	271..302	CDD:238060	16/30 (53%)
		FXa_inhibition	352..387	CDD:464251	16/34 (47%)
		Ldl_recept_b	442..483	CDD:459654	20/40 (50%)
		LY	466..508	CDD:214531	27/41 (66%)
		Ldl_recept_b	529..569	CDD:459654	21/39 (54%)
		LY	553..595	CDD:214531	21/41 (51%)
		LY	596..637	CDD:214531	24/40 (60%)
		FXa_inhibition	669..700	CDD:464251	14/30 (47%)
		LY	774..815	CDD:214531	25/40 (63%)
		LDLa	1032..1062	CDD:238060	19/29 (66%)
		LDLa	1074..1109	CDD:238060	16/34 (47%)
		LDLa	1118..1152	CDD:238060	15/33 (45%)
		LDLa	1157..1189	CDD:197566	19/31 (61%)
		LDLa	1198..1232	CDD:238060	16/33 (48%)
		LDLa	1243..1279	CDD:238060	20/41 (49%)
		LDLa	1283..1318	CDD:238060	19/34 (56%)
		LDLa	1340..1371	CDD:197566	13/30 (43%)
		FXa_inhibition	1388..1416	CDD:464251	12/27 (44%)
		EGF_CA	1418..1452	CDD:214542	19/33 (58%)
yl	XP_310672.6	None