DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and lrp4

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_017212642.2 Gene:lrp4 / 110351181 ZFINID:ZDB-GENE-130129-1 Length:1913 Species:Danio rerio


Alignment Length:2002 Identity:502/2002 - (25%)
Similarity:781/2002 - (39%) Gaps:523/2002 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 CDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPPHWFPCAQPHGACLAAELMCNGI 154
            |:..:|.|::|.||.....|||..||.|:||| .||.|.|.... |.|..  |:|:|....|:|.
Zfish   112 CEEDEFHCQNGYCIRSLWYCDGDNDCGDNSDE-QCDKRKCSDKE-FRCTD--GSCIAEHWYCDGD 172

  Fly   155 DNCPGGEDELNCPVRPGFRFGD--TAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEV 217
            .:|..|.||.|||       .|  ||    :||..||.|...| ||...:.|||..||.|.|||.
Zfish   173 SDCKDGTDEENCP-------SDVMTA----TCSVEEFQCAYGR-CILDIYHCDGDDDCGDWSDES 225

  Fly   218 -----AGCKQAEITCPG----------EGHL----------------------CANGRCLRRKQW 245
                 ..|:.||..|..          :|..                      |.:|||: |..|
Zfish   226 DCSSHQPCRSAEFMCSSGMCINAGWRCDGEFDCDDQSDEKNCSTSMCMADQFRCMSGRCV-RLSW 289

  Fly   246 VCDGVDDCGDGSDERGCLNL----CEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDE---TDL 303
            .|||.|||.|||||.||...    |.|.  :|||.|.. |:...:||:...||.||:||   .| 
Zfish   290 RCDGEDDCSDGSDEEGCEKTETPPCAPD--QFLCGNGR-CIGQRKVCNDVKDCEDGTDEHPHQD- 350

  Fly   304 CHSK---PDCDAKKCALGAKCHMMPASG-AECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCE 364
            |.||   .:|:........||.|  :.| .:|.|..|:.|......|.|||||.: |..|||||.
Zfish   351 CRSKSSDENCNVNNGGCSQKCQM--SRGLVQCTCHTGYTLTADGKTCRDVDECAD-DGYCSQGCT 412

  Fly   365 NTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGM--HLREDNVRNHVYQVA 427
            |..||::|.|..||.|..|.|:|:|:     ..:|:||:..::.|..:  |      |:....:.
Zfish   413 NIEGGFQCWCVQGYELRPDKRSCKAL-----GPEPVLLFANRIDIRQVLPH------RSEYTLLL 466

  Fly   428 GNLSKVIGVAYDGSH--IYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYF 490
            .||...|.:.:..|.  ::|:::  ..:.|::|:.:|||.|.::::||::|..||:||:...:|:
Zfish   467 SNLENAIALDFHHSQELVFWSDV--TLDRIMRASLNGSNVEEVVSTGLESPGGLAIDWIHNKLYW 529

  Fly   491 SDNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPI 555
            :|:....|.|.:.||.:..||:.|.:.:||::|:.|.:|.::|||||..|.|..|:||||..:.|
Zfish   530 TDSGTSRIEVSNLDGTHRKVLLWQRMEKPRAIALHPIEGKIYWTDWGNMPRIEYANMDGSNRKII 594

  Fly   556 VSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSD 620
            ...::.||||:.:|....|:||||||...::....||..|:.|:...|.||:.:.:|||.|||:|
Zfish   595 ADTHLFWPNGLTIDYASHRMYWVDAKHHVIERADLDGKNRKAVISQGLPHPFAITVFEDSLYWTD 659

  Fly   621 WATKSVHACHKFSGKDHRILAKDRTIYA--VHIYHPAKQPN---SPHGCENATCSHLCLLAEPEI 680
            |.|||:::.:||:||:..:: :::..:.  :|..||.:||.   :..|..|..||||||   |..
Zfish   660 WHTKSINSANKFTGKNQEVI-RNKLHFPMDIHTLHPQRQPAGGINRCGSNNGGCSHLCL---PSN 720

  Fly   681 GGHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVY 745
            ..::|.||.|.|....|.....::|          .||....|...|.....:..|..:|.    
Zfish   721 KTYTCVCPTGFRKLDQHNCAQSLDK----------FLLFARRTDIRRISFDTTEQLDAVIP---- 771

  Fly   746 NRINGSLIIADNDQRLILEFQPESHES----------------------NVLVRSNLGNVSALAF 788
                    :||....:.|::.....||                      .|:|.::|.:.:.||.
Zfish   772 --------LADVRNAVALDWDSLDSESFIYWTDVTTDSINRALWDGSKQEVVVDTSLESPAGLAI 828

  Fly   789 DHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAEGYLYVVLKAKRHSHIDK 853
            |.|:..|||.|.....|||.:.....|.:: .:...:.|..:.|.|..|::|.. ....:..|::
Zfish   829 DWLTHKLYWTDAGTDRIEVSNTDGSMRTVL-IWENLDRPRDIVVDPIGGFMYWT-DWGANPKIER 891

  Fly   854 IPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRG-KLRRPY 917
            ..:......|.:..:....:.  |..||.|:.::|:|:.:..|.|.|:.....|:..| :|..|:
Zfish   892 AGMDAWNRTVIISSNLTWPNG--LAIDYSTERLYWADASVKTIEYGNFDGSGRQVLIGSQLPHPF 954

  Fly   918 SLAMVHHDLFWNELGTPRIYWT---HKSNMGPRKVIDIMEKDDPAAIMPYVPVATPNGIPLAASS 979
            .|.: |.|         |||||   .||.....|:..:..|                  .||.:.
Zfish   955 GLTL-HED---------RIYWTDWQSKSIQSADKLTGLDRK------------------TLAENL 991

  Fly   980 PVGQESH-----------PCQQQNGGCSHIC-VGEGPYHSICLCPAGFVYRDAGNRTCVEALDCE 1032
            ....:.|           .|...||||||:| :...|....|.||.| :...|..:||..|::  
Zfish   992 ENLMDIHMFHNHRTKVQTGCLVNNGGCSHLCLLAPAPKSWSCACPTG-INLQADGKTCAHAMN-- 1053

  Fly  1033 FRCHSGECLTMNHRCNGRRDCVD----------------NSDEMNCDEEHRRKPKVLCSPNQFAC 1081
                  ..|....|.:.|...:|                |:..:..|            |.:...
Zfish  1054 ------SFLVFARRTDIRMISLDIPYFADVVLAVNTSMKNTIAIGVD------------PIEGKV 1100

  Fly  1082 HSGEQCVDKERRCDNRKDCHDHSDEQHCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGT------ 1140
            :..:..:.|..|          |:....|          |:.....|......|..|..      
Zfish  1101 YWSDSTLKKISR----------SNINGTE----------HEDIISTGLMTTDGLAVDSVGRKIYW 1145

  Fly  1141 NDCGDNSDELLCEATSRCEPGMFQ-CGSGSCIAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQR 1204
            .|.|.|..|:.....|..:..::| ..|...||...|. |.:..:|.. ||.| :.||......|
Zfish  1146 TDTGTNRIEVANLNGSMRKVLVWQNLDSPRAIALYHEM-GYMYWTDWG-EHAK-LERSSMDGSDR 1207

  Fly  1205 CLL---------GQCLDRS----LVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKI 1256
            .:|         |..:|::    |..|.|.:..:.|| || |::..|: :|..:..|..|.    
Zfish  1208 VVLINNNLGWPNGLAVDKAGSQLLWADAHTERIEASD-LN-GSNRRTL-VSPVQHPYGLTV---- 1265

  Fly  1257 CLPSTVRCNGTTECPRGEDEADCGDVCSIYEFKCRSGRECIRREFRCDGQKDCGDGSDELSCELE 1321
                                  .|......:::.||    |.|     ..|:.|:.:..:     
Zfish  1266 ----------------------LGSHMYWTDWQSRS----IHR-----ADKNTGENAIII----- 1294

  Fly  1322 KGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDCTNGHDEGPKCATACRSASGRQ 1386
                            ||..|.|.|.|   .||                   :.|:|..:..||:
Zfish  1295 ----------------RSSLPGLMDIQ---AVD-------------------RTASAGLNKCGRR 1321

  Fly  1387 --VCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQPCAQLCENTLGGYQCQCHADFML 1449
              .|.|.|.....|..|:|..|..|.||.:||.|:.|                        .::|
Zfish  1322 NGGCSHLCLPRLNGTSCACPTGVLLKADGRSCEDLPE------------------------TYLL 1362

  Fly  1450 RQDRVSCKSLQSGA---TLLFSSFNEVRNLSEQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAE 1511
            ..:|||.:.:....   |.:|....|::|:.                          .:.|.|.|
Zfish  1363 FSNRVSVRRISLDTHDHTDVFVPVAELQNVI--------------------------SLDYDSVE 1401

  Fly  1512 DEGIVYQIDLQTKVIVR------------ALGLPAPTKLSVDWVTGNVY-VLSGAQEIQACSFVG 1563
            .:  :|..|:...||.|            :.||.....|:||||..|:| ..:|...|:.....|
Zfish  1402 RK--LYYTDVSLDVIRRVNLDGSDMETVISSGLKTTDGLAVDWVARNMYWTDTGRNTIEVAHLDG 1464

  Fly  1564 RMCGRIVH--VKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLDGSRRDMLLQRSES 1626
            .....:|:  :..||.:......|:   :|:     ..:|.. ::|..|.|||:.|.:|:.....
Zfish  1465 TSRKVLVNNSLDEPRAIAVFPSKGF---LFW-----TDWGHI-AKIERAFLDGTDRKVLINTDLG 1520

  Fly  1627 FMTALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRRPEIMLQKSNALMHPSGLS----VY--- 1684
            :...||.|...:.:::||.|   |:||......|.:|  :|::   :.:.||..|:    ||   
Zfish  1521 WPNGLTLDYDTRRIFWVDAH---LDRIESSDLNGKLR--QILI---SPVSHPFALTQLKPVYSPL 1577

  Fly  1685 -------ENNAFIV----NLGSVEAVQCALYGSRICHKISINVLNAQDIVVAGRSRQPQKASHPC 1738
                   :...:|.    ...|::.|.  .:..|....:..||....||:|.  |.|.|..::.|
Zfish  1578 TPFSRISQQERWIYWTDWQTKSIQRVD--KHTGRSKETVLANVEGLMDIIVV--SPQRQSGTNHC 1638

  Fly  1739 A--HAHCHGLCLQADYGYECMCGNRLVAEGERCPHGSGNEVAV---------------------- 1779
            |  :..|..|||.....:.|.|.:.  |:...|...:|:..|.                      
Zfish  1639 AANNGGCTHLCLARSNSFICACPDE--ADSRPCSTIAGHVPASPEKDTTGTQTPRKQATEKPHQG 1701

  Fly  1780 LGAVN------SLE-------LEHEHEQNGHFHWLM--ALFVLAAGSLIAGLGYMYYQYRQRGHT 1829
            |..||      |||       :....:::.|..:::  ||.:||...|||  .::.|::::....
Zfish  1702 LSLVNCTEMNLSLEDCFQNSVISAPRDESPHISYVIGGALSILAILILIA--AFIIYRHKKFKFA 1764

  Fly  1830 DLNI-NMHFQNP------------LATLGGTKAFLEHERAEAGV---GFTTE 1865
            |..: |:.:.||            .|......:.|.:::...||   |:|.|
Zfish  1765 DPGVSNLTYSNPSYRTSTQEVKIETAQKPAINSQLRYKKEVQGVVDGGYTKE 1816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 15/33 (45%)
LDLa 131..166 CDD:238060 11/34 (32%)
LDLa 184..216 CDD:238060 15/31 (48%)
LDLa 227..262 CDD:238060 19/66 (29%)
LDLa 271..302 CDD:238060 13/33 (39%)
FXa_inhibition 352..387 CDD:291342 17/34 (50%)
Ldl_recept_b 442..482 CDD:278487 12/41 (29%)
LY 466..508 CDD:214531 14/41 (34%)
Ldl_recept_b 529..569 CDD:278487 18/39 (46%)
LY 553..595 CDD:214531 15/41 (37%)
LY 596..637 CDD:214531 19/40 (48%)
FXa_inhibition 669..700 CDD:291342 13/30 (43%)
LY 774..815 CDD:214531 14/40 (35%)
LDLa 1032..1062 CDD:238060 5/45 (11%)
LDLa 1074..1109 CDD:238060 4/34 (12%)
LDLa 1118..1152 CDD:238060 8/39 (21%)
LDLa 1157..1189 CDD:197566 7/32 (22%)
LDLa 1198..1232 CDD:238060 10/46 (22%)
LDLa 1243..1279 CDD:238060 2/35 (6%)
LDLa 1283..1318 CDD:238060 6/34 (18%)
LDLa 1340..1371 CDD:197566 6/30 (20%)
FXa_inhibition 1388..1416 CDD:291342 10/27 (37%)
EGF_CA 1418..1452 CDD:214542 3/33 (9%)
lrp4XP_017212642.2 LDLa 29..68 CDD:238060
Ldl_recept_a 72..107 CDD:278486
LDLa 111..143 CDD:197566 13/30 (43%)
LDLa 150..184 CDD:238060 12/36 (33%)
LDLa 233..267 CDD:238060 5/33 (15%)
LDLa 272..306 CDD:238060 17/34 (50%)
LDLa 314..345 CDD:238060 13/33 (39%)
FXa_inhibition 360..395 CDD:317114 9/36 (25%)
EGF_CA 397..436 CDD:214542 21/39 (54%)
NHL 473..690 CDD:302697 77/219 (35%)
NHL repeat 473..511 CDD:271320 9/39 (23%)
LY 507..547 CDD:214531 13/39 (33%)
NHL repeat 515..551 CDD:271320 12/35 (34%)
NHL repeat 558..594 CDD:271320 17/35 (49%)
Ldl_recept_b 568..608 CDD:278487 18/39 (46%)
LY 592..634 CDD:214531 15/41 (37%)
NHL repeat 599..640 CDD:271320 16/40 (40%)
NHL repeat 644..681 CDD:271320 17/37 (46%)
FXa_inhibition 705..739 CDD:317114 15/36 (42%)
LY <777..810 CDD:214531 3/32 (9%)
LY 813..855 CDD:214531 14/41 (34%)
Ldl_recept_b 876..916 CDD:278487 5/42 (12%)
LY 901..942 CDD:214531 10/42 (24%)
LY 943..984 CDD:214531 15/50 (30%)
FXa_inhibition 1011..1048 CDD:317114 14/37 (38%)
NHL <1090..1282 CDD:302697 47/259 (18%)
NHL repeat 1090..1128 CDD:271320 7/69 (10%)
LY 1123..1163 CDD:214531 8/39 (21%)
NHL repeat 1133..1166 CDD:271320 7/32 (22%)
Ldl_recept_b 1184..1224 CDD:278487 10/41 (24%)
NHL repeat 1217..1249 CDD:271320 10/33 (30%)
NHL repeat 1258..1282 CDD:271320 6/53 (11%)
FXa_inhibition 1318..1353 CDD:317114 12/34 (35%)
LY 1389..1423 CDD:214531 9/61 (15%)
LY 1425..1467 CDD:214531 12/41 (29%)
Ldl_recept_b 1488..1528 CDD:278487 12/48 (25%)
LY 1512..1552 CDD:214531 10/42 (24%)
FXa_inhibition 1638..>1662 CDD:317114 8/23 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.