DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and lrp2b

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_021335953.1 Gene:lrp2b / 101886177 ZFINID:ZDB-GENE-111115-1 Length:4577 Species:Danio rerio


Alignment Length:2039 Identity:583/2039 - (28%)
Similarity:890/2039 - (43%) Gaps:330/2039 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 LCGGTAAGTPGSADTR------CDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPP 132
            :|.|.|....||.:.|      |...||.||:|.||.:...||...||.|:|||.:|:|..|...
Zfish    58 VCDGEADCADGSDEQRTCSGQTCSPDQFTCREGQCIPKQYNCDHVPDCVDNSDENNCNYPACTEK 122

  Fly   133 HWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTC 197
               .||  :|||......||||.:|..|.||.||              .|.|..::|.| .:..|
Zfish   123 ---TCA--NGACYNNAQHCNGILDCRDGSDESNC--------------TRHCQSHQFEC-ANGFC 167

  Fly   198 IPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGC 262
            ||:.|:||...||.|.||| ..|:..  ||.|....|:||||: .:||||||::||||.|||.||
Zfish   168 IPMPFVCDHWDDCGDNSDE-QNCEYR--TCSGSEFACSNGRCM-PQQWVCDGINDCGDFSDENGC 228

  Fly   263 ---LNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKC-ALGA--KC 321
               :..|.|  |::.|.....|:.:::|||.|.||..|:||:: ..:...||..:| ||..  :|
Zfish   229 DPGIRDCYP--GEWPCPGSSLCVPVNKVCDEHPDCPGGTDESN-ATAHLTCDLHQCSALSCEYRC 290

  Fly   322 HMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRT 386
            |..|..|| |:||.||.:|.....|.|.|:||.. .:|...||:..|.:.|.|..||.|:: ...
Zfish   291 HPTPQGGA-CYCPDGFTVANDSRTCVDYDDCKIW-GICDHFCEDRPGTHHCSCADGYFLEQ-GHV 352

  Fly   387 CRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQV---AGNLSKVIGVAYD--GSHIYWT 446
            |:|.:.|.   .|.|::|.     |..::..::.....::   :......:||.|:  ...::||
Zfish   353 CKANISGG---LPQLIFTD-----GRDIKMADIHGRFIRLLVQSDGKGYAVGVGYNWHTQRVFWT 409

  Fly   447 NIQNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVL 511
            :  ..::.:...|.|||:...:|:..:...:::||||:...:|..:..:..|..|..||.|...|
Zfish   410 D--TSSQKVFSINFDGSDKMEVLSEAVHNAQNVAVDWINFKLYLVEERVERIEACDYDGGNRVTL 472

  Fly   512 VTQDVHQPRSLAVWPQKGLMFWTDWGEKP---MIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQ 573
            :.:::..|..||:.|..|.||:||.|:..   .:.||.||||....:|...:..|.||.||:..:
Zfish   473 IAENLVTPHGLALDPTVGYMFFTDSGDNTDDVKLERAFMDGSNRFDLVRTRLGSPTGITLDLVTK 537

  Fly   574 RIYWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKD 636
            |:||.|:....|:||...|..|:|||:|  .:.||:|:::||:..:::||....|...::|:|.|
Zfish   538 RVYWTDSHFNLVETVTYSGLDRKTVLNGGHQVPHPFGISVFENHAFFTDWVKMGVIRTNRFNGSD 602

  Fly   637 HRILAKDRTIYA-VHIYHPAKQP--NSPHGCENATCSHLCLLA---EPEIGGHSCACPDGMRLAP 695
            ...|.:...... :.:.|||.||  .:|.|..|..|..:|||:   :.:..|:.|.|..|..|..
Zfish   603 PTFLYRSTNRPGQIVVSHPALQPFVINPCGRHNGGCQQICLLSHRTDNDGLGYRCMCRLGYDLQD 667

  Fly   696 DHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRHQVSKSYTLP----------------CLINEMV 744
            |...|..:  :..|.:...|.:..|......:..|    |||                ..:..:.
Zfish   668 DRHSCFKI--KDYLLVAYAQAVRGIPLNVSSQEDV----TLPLSGLADTFSGSGVEYDASVESVF 726

  Fly   745 YNRINGSLIIADNDQRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYW-ADTERAVIEVL 808
            ||         |..::||.:.........||....:|.|.::|:|..|:.|:| :.|.|:|....
Zfish   727 YN---------DRMRQLIYKSNINGTSHKVLTGYRVGAVESMAYDWTSKILFWTSSTYRSVCAFK 782

  Fly   809 SLQTRHRALIRFFPGQEVPIGLTVMPAEGYLY--------VVLKAKRHSHIDKIPLSGKGEQVHV 865
            ......:.:::   ....|.|:.|.|:.|||:        |:.:|..... :.:||         
Zfish   783 VTDGSRQDIVK---NLIYPRGIAVHPSAGYLFWSDWYRPAVITRAYTDGS-NAVPL--------- 834

  Fly   866 FEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFR--GKLRRPYSLAMVHHD-LF 927
            ....||..: .|..||....::|.|:.|.||.:.:......|.|.  |::..|:||. :|.| ||
Zfish   835 INTTLGWPN-GLAVDYMMDRLYWVDAQLDRIEHVSIDGFDRQAFSSIGQITHPFSLT-IHTDHLF 897

  Fly   928 WNELGTPRIYWTHKSNMGP----RKVID-IMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHP 987
            .::..|..::...|.:.|.    ||.|. ||.....:|.:..:..:..|.||             
Zfish   898 VSDWRTNSVFRMRKRDGGDNIMLRKGISGIMNIKAYSADLQDLFKSRCNMIP------------- 949

  Fly   988 CQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE----------ALDCEFRCHSGECLT 1042
                ||.|||.|........:|.||.|...:: ..|.||:          ..|..|.|..|.|:.
Zfish   950 ----NGRCSHFCFPTPASSRVCGCPFGMKLQE-NQRDCVKDDSEPPPDDNCGDYAFPCDGGRCVP 1009

  Fly  1043 MNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQ 1107
            ..:||:|..||||.:||:||     ..|...|||..|.| ..:.|:....|||...||.|.|||.
Zfish  1010 NTYRCDGVNDCVDKTDEVNC-----TLPGATCSPYAFTC-GNKHCIPARWRCDGHDDCGDGSDET 1068

  Fly  1108 HCEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEAT-SRCEPGMFQCGSGSCI 1171
            :|.....: .|...|..|.||.|:..:.|||..|||||.|||..|.:: :.|:||.|.|....||
Zfish  1069 NCPTRGPT-TCSSSQFACTNGNCIPKTWVCDAFNDCGDGSDERHCNSSITTCQPGFFLCPDHRCI 1132

  Fly  1172 AGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLG-QCLDRSLVCDGHNDCGDKSDELNCGTD 1235
            ..|:.|||..||.|||||.| ||: :|......|..| ||:.:|..|||..||.|.|||..|.|.
Zfish  1133 YNSYVCDGDQDCLDGSDEKD-CVY-TCGTYEFACASGDQCVSQSYRCDGVYDCKDHSDESGCPTR 1195

  Fly  1236 SSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEAD-CGD-VCSIYEFKCRSGRECIR 1298
            ...:   |.::::||..: ..|:|....|:|..:|..|.||.: |.. .||..:|:|.:| .|:.
Zfish  1196 RPGL---CHDNEFQCQVD-GFCIPKEWECDGHPDCVDGSDEHNGCPPRTCSSVQFQCANG-NCVS 1255

  Fly  1299 REFRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDC-QDGECVDLSRVCNNF 1362
            :.:.|||:.||.|.|||.:|               .|...||....:.| .|..|:..::||:..
Zfish  1256 KNWVCDGENDCRDMSDETNC---------------PTPPFSCPSGQWLCPTDQVCIMNAQVCDGQ 1305

  Fly  1363 PDCTNGHDEGPKC-ATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQ 1426
            .||.||.||.|.| ...|:..:|.  |.|.|...|.||.|:|..|::|..|.|:|.||:||....
Zfish  1306 RDCPNGADESPICNEDDCKVNNGG--CSHGCIQGPFGAQCTCDPGFQLLNDSKTCDDINECLIPG 1368

  Fly  1427 PCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSG-ATLLFSSFNEV--RNLSEQPVMLNVAWS 1488
            .|:|.|.|..|.::|.|...:.|..|..:|::...| |.||.:..:::  ..::..|.:::...|
Zfish  1369 FCSQTCFNERGSFRCYCEDGYQLEPDGRTCRATSPGNALLLVARRSQIIGNRINFWPPIISPIVS 1433

  Fly  1489 ANDSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQT---KVIVRALGLPAPTKLSVDWVTGNVY-V 1549
            ........||....|.  |:....:.::|. ..|.   |..|.:.||..|..::||||..|:| .
Zfish  1434 GMSIVAVDFDNVNKRV--YWGDSSDKMIYS-SFQNGTDKKQVFSSGLMVPESIAVDWVGRNIYWT 1495

  Fly  1550 LSGAQEIQACSFVGRMCGRIV--HVKSPRHVKHLAVD-GYHARIFYIVIRTEGYGQTSSEIHMAR 1611
            .|..|.|:..:..|.....::  :|.|||   .|.:| ..|..:.:    ...:|| :..|..|.
Zfish  1496 DSVMQNIEVATLDGHFRKILITKNVTSPR---GLVLDPRNHTNLMF----WSDWGQ-NPRIEQAS 1552

  Fly  1612 LDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERISYRLKTGPMRR----PEIMLQKS 1672
            :||..|..::.....:...||.|...:.:||||.:::.::...|   .|..|.    .:|:||: 
Zfish  1553 MDGLGRRAIVTSKVYWPNGLTLDYTTRRVYFVDAYLKYIDYCDY---DGKNRHQVFASDIVLQQ- 1613

  Fly  1673 NALMHPSGLSVYENNAFIVNLGSVEAVQC-ALYGSRICHKISINVLNAQDIVVAGRSRQPQKASH 1736
                 |.|::::|:|.|..:..:.:.::. ..:|..|...:: .|.....||:....:|| .|.:
Zfish  1614 -----PHGITIFEDNIFWSDSYTSQIMRTNKFHGGNITTLLT-GVYQCMGIVMDHPIKQP-IAFN 1671

  Fly  1737 PCAHAHCHGLCLQAD-----YGYECMCGNRLVAEGERC----------------------PHGSG 1774
            ||.:..|..|||.:.     |..:|..|..|.::|..|                      |:.:.
Zfish  1672 PCENNPCSQLCLLSTLRPRYYRCDCQSGWILASDGRTCTKDETPFLMVVRDTVIMGIPLNPNDTS 1736

  Fly  1775 NE--VAVLGAVNSLELEHEHEQNGHFHWLMALFVLAAGSLIAGLGYMYYQYRQRGHTDLNINMHF 1837
            |.  ..:.|.....:::.: ::....:|            :.|.|.:|     |..||......|
Zfish  1737 NNAMAPISGITQGRDIDFD-DREQFVYW------------VQGTGAIY-----RSKTDGANRTQF 1783

  Fly  1838 QNPLATLGGTKAFLEHERAEAGVGFTTETGTVSSRGSNDTFTTTSATSSFAAQQFS---VPNALQ 1899
            . |.|.:|          :.:|:.|...|..:..  :|.|...........:|.:.   :.|.  
Zfish  1784 A-PAAIIG----------SPSGLAFDWITRIMYY--TNPTIKAIEVIRVDGSQHYRKTIITNT-- 1833

  Fly  1900 RLLRPRQSASGDPMAQELLLESPSRESKLHALDGGGAGGDGDGGRGVGRQVPDILVADMDDDAAK 1964
                .:...:|.|:...|   .|:| .||...|.|...|          ..|.|..||||     
Zfish  1834 ----GKPEGAGQPIGIAL---DPAR-GKLFWTDRGSDSG----------VPPKISSADMD----- 1875

  Fly  1965 SAGQFGGN----YAGNDANARFVS 1984
                 |||    |.||.....|::
Zfish  1876 -----GGNVKNLYTGNLVKVEFIA 1894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 16/33 (48%)
LDLa 131..166 CDD:238060 13/34 (38%)
LDLa 184..216 CDD:238060 13/31 (42%)
LDLa 227..262 CDD:238060 20/34 (59%)
LDLa 271..302 CDD:238060 12/30 (40%)
FXa_inhibition 352..387 CDD:291342 11/34 (32%)
Ldl_recept_b 442..482 CDD:278487 8/39 (21%)
LY 466..508 CDD:214531 10/41 (24%)
Ldl_recept_b 529..569 CDD:278487 16/42 (38%)
LY 553..595 CDD:214531 14/41 (34%)
LY 596..637 CDD:214531 14/42 (33%)
FXa_inhibition 669..700 CDD:291342 10/33 (30%)
LY 774..815 CDD:214531 12/41 (29%)
LDLa 1032..1062 CDD:238060 13/29 (45%)
LDLa 1074..1109 CDD:238060 15/34 (44%)
LDLa 1118..1152 CDD:238060 17/33 (52%)
LDLa 1157..1189 CDD:197566 16/31 (52%)
LDLa 1198..1232 CDD:238060 15/34 (44%)
LDLa 1243..1279 CDD:238060 11/36 (31%)
LDLa 1283..1318 CDD:238060 15/34 (44%)
LDLa 1340..1371 CDD:197566 10/31 (32%)
FXa_inhibition 1388..1416 CDD:291342 12/27 (44%)
EGF_CA 1418..1452 CDD:214542 12/33 (36%)
lrp2bXP_021335953.1 LDLa 2..34 CDD:238060
LDLa 38..71 CDD:197566 5/12 (42%)
LDLa 80..114 CDD:238060 16/33 (48%)
LDLa 123..151 CDD:238060 13/29 (45%)
LDLa 155..189 CDD:238060 15/35 (43%)
LDLa 194..228 CDD:238060 20/34 (59%)
LDLa 235..269 CDD:238060 14/35 (40%)
FXa_inhibition 324..>347 CDD:317114 8/22 (36%)
LY 429..469 CDD:214531 10/39 (26%)
LY 471..516 CDD:214531 17/44 (39%)
LY 519..559 CDD:214531 14/39 (36%)
FXa_inhibition 631..672 CDD:317114 12/40 (30%)
Ldl_recept_b 808..848 CDD:278487 10/50 (20%)
LY 834..874 CDD:214531 11/49 (22%)
FXa_inhibition 950..982 CDD:317114 11/32 (34%)
LDLa 995..1029 CDD:238060 14/33 (42%)
LDLa 1036..1070 CDD:238060 15/34 (44%)
LDLa 1078..1112 CDD:238060 17/33 (52%)
LDLa 1119..1153 CDD:238060 19/34 (56%)
LDLa 1157..1192 CDD:238060 15/34 (44%)
LDLa 1200..1234 CDD:238060 11/34 (32%)
LDLa 1241..1275 CDD:238060 15/34 (44%)
LDLa 1282..1314 CDD:197566 10/31 (32%)
FXa_inhibition 1323..1358 CDD:317114 14/36 (39%)
EGF_CA 1360..1398 CDD:214542 13/37 (35%)
YncE 1388..>1660 CDD:331368 66/292 (23%)
LY 1470..1512 CDD:214531 14/41 (34%)
Ldl_recept_b 1535..1575 CDD:278487 9/44 (20%)
LY 1559..1601 CDD:214531 9/44 (20%)
LY 1789..1824 CDD:214531 6/46 (13%)
LY 1837..1879 CDD:214531 18/65 (28%)
LY 1922..1958 CDD:214531
FXa_inhibition 1991..2027 CDD:317114
Ldl_recept_b 2170..2210 CDD:278487
LY 2195..2236 CDD:214531
LY 2427..2468 CDD:214531
LY 2468..2510 CDD:214531
LY 2513..2553 CDD:214531
FXa_inhibition 2623..2660 CDD:317114
LDLa 2667..2699 CDD:197566
LDLa 2709..2743 CDD:238060
LDLa 2750..2785 CDD:238060
LDLa 2789..2822 CDD:197566
LDLa 2831..2863 CDD:197566
LDLa 2873..2905 CDD:197566
LDLa 2915..2952 CDD:197566
LDLa 2961..2995 CDD:238060
LDLa 2999..3031 CDD:197566
Ldl_recept_a 3042..3077 CDD:278486
cEGF 3100..3123 CDD:315355
vWFA <3115..3158 CDD:320736
LY 3189..3229 CDD:214531
LY 3230..3272 CDD:214531
Ldl_recept_b 3303..3341 CDD:278487
LY 3327..3367 CDD:214531
LY 3374..3409 CDD:214531
LDLa 3480..3512 CDD:197566
LDLa 3521..3552 CDD:197566
LDLa 3561..3593 CDD:197566
LDLa 3602..3634 CDD:197566
LDLa 3646..3682 CDD:238060
LDLa 3689..3722 CDD:238060
LDLa 3727..3761 CDD:238060
LDLa 3766..3800 CDD:238060
LDLa 3810..3841 CDD:197566
LDLa 3854..3883 CDD:197566
LDLa 3896..3930 CDD:238060
EGF_CA 3975..4014 CDD:214542
LY 4107..4142 CDD:214531
LY 4143..4186 CDD:214531
LY 4187..4230 CDD:214531
FXa_inhibition 4306..>4324 CDD:317114
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.710

Return to query results.
Submit another query.