DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment yl and LOC100536757

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_021334054.1	Gene:	LOC100536757 / 100536757	-ID:	-	Length:	600	Species:	Danio rerio

Alignment Length:	749	Identity:	193/749 - (25%)
Similarity:	287/749 - (38%)	Gaps:	205/749 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 HVAISLLLLVGL-CGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDY 126
            |:...|||..|: |.....|.|     :|...||.|.:..|:..:..||...||.|.|||:.|
Zfish    15 HLGAFLLLWTGVSCLPLTEGFP-----KCTVLQFVCANSRCVSLSSRCDAVNDCGDGSDEISC-- 72

  Fly   127 RLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMC 191
                   |                     ||..|                           .|.|
Zfish    73 -------W---------------------NCTNG---------------------------SFHC 82

  Fly   192 QQDRTCIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDG 256
            ....:|:....:|||||||.|.:||                                .:|.|...
Zfish    83 VASESCVSSSSVCDGRPDCADGADE--------------------------------QLDTCTSF 115

  Fly   257 SDERGCLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCAL---- 317
            |..:.|      .:.:|.|.|.: |:..|..||..|||.|||||       .|||..:||:
Zfish   116 SQAQPC------ARSEFTCTNGQ-CVPNSWRCDHSSDCKDGSDE-------EDCDHNECAVNNGG 166

  Fly   318 -GAKCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLD 381
             ...|..:| .|..|.||||.||.: :..||.||:|.:. |:|.|.|.:::|...|.|..||.|.
Zfish   167 CSHTCIDLP-FGFRCDCPKGMRLVQ-DTHCEVVDQCLDA-DVCDQICVHSNGSVVCDCQDGYQLT 228

  Fly   382 KDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQ--VAGNLSKVIGVAYDGSH-- 442
            .....|||.  |....   :..:||..|..|.|.....||...:  ..|.:|.:      .:|
Zfish   229 AGTGQCRAT--GGLAH---VAVSTQEGIKMMDLSGSEERNITDKRLSPGPVSAL------NAHNT 282

  Fly   443 IYWTNIQNEAESIVKANGDGSNAEILLTSGLDAPE--------------DLAVDWLTQNIYFSDN 493
            :||::.:|               :|:....||:.:              .|||||:.:::|:...
Zfish   283 LYWSSPEN---------------DIIYRMSLDSGDHRPAVWLKASKGIVGLAVDWIHESLYWIST 332

  Fly   494 IMR--HIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIV 556
            ..|  |:|...|....   |:...:.:|.::||.|..|.:||.:.||...|.|..:||.....:|
Zfish   333 STRALHMASLKNTKQR---LLISGLSKPTAVAVQPLLGYVFWAEGGESARIERVGLDGESRFALV 394

  Fly   557 SDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLD--GMLKHPYGLAIFEDQLYWS 619
            ...:..|..|:||:.:..:||.|:.|.|:..|..||..|:||::  |.|..|:||||||.::|||
Zfish   395 VSFVRNPVAISLDIPRGLLYWADSGLRSISRVLFDGQYRKTVVESNGYLDQPFGLAIFESRVYWS 459

  Fly   620 DWATKSVHACHKFSGKDHRILAK--DRTIYAVHIYHPAKQPNSPHGCENATCSHLCLLAEPEIGG 682
            |..|.|:.:..|.:|...|:..:  ..:...:.|.||..||...            :|:..||..
Zfish   460 DQLTNSICSADKHNGTMLRVPQRLGSASPAGLVILHPLLQPADK------------VLSPSEIKT 512

  Fly   683 HSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFG------RHQVSKSYTLPCLIN 741
            .|     ...|.|...:..|.:.:..|.:.|..|:|.:  ..||      |.::....::..|
Zfish   513 SS-----NKELLPSETKTALPDSQFTLMLTLIAVILSV--LLFGLVLWWQRSELCAHRSVSLL-- 568

  Fly   742 EMVYNRINGSLIIADNDQRLILEFQPESHESNVL 775
                    |.:.:.::...|:|...|..||...|
Zfish   569 --------GDVTLKESQDPLLLSSLPAVHEHQTL 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	13/33 (39%)
		LDLa	131..166	CDD:238060	4/34 (12%)
		LDLa	184..216	CDD:238060	11/31 (35%)
		LDLa	227..262	CDD:238060	3/34 (9%)
		LDLa	271..302	CDD:238060	15/30 (50%)
		FXa_inhibition	352..387	CDD:291342	11/34 (32%)
		Ldl_recept_b	442..482	CDD:278487	9/55 (16%)
		LY	466..508	CDD:214531	13/57 (23%)
		Ldl_recept_b	529..569	CDD:278487	12/39 (31%)
		LY	553..595	CDD:214531	13/41 (32%)
		LY	596..637	CDD:214531	19/42 (45%)
		FXa_inhibition	669..700	CDD:291342	6/30 (20%)
		LY	774..815	CDD:214531	1/2 (50%)
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
LOC100536757	XP_021334054.1	LDLa	38..72	CDD:238060	13/33 (39%)
		PRKCSH-like	<45..>112	CDD:193472	29/155 (19%)
		LDLa	121..155	CDD:238060	16/47 (34%)
		FXa_inhibition	160..193	CDD:317114	12/34 (35%)
		Ldl_recept_b	367..407	CDD:278487	12/39 (31%)
		LY	393..433	CDD:214531	13/39 (33%)
		LY	434..476	CDD:214531	19/41 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900