DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment yl and ldlr

DIOPT Version :9

Sequence 1:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster
Sequence 2:	XP_002942891.1	Gene:	ldlr / 100495826	XenbaseID:	XB-GENE-962372	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	742	Identity:	238/742 - (32%)
Similarity:	354/742 - (47%)	Gaps:	146/742 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 SLLLLVGLCGGTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDE---------- 121
            |.|||:|||..:|.    |...:||..:|||.||.||....:|||..:|||.|||
Frog    10 SFLLLLGLCHVSAI----SEVRKCDRSEFQCGDGKCIPYKWICDGSAECKDGSDESPETCKVVTC 70

  Fly   122 ----LDCDYRL--CRPPHW--------------------------FPCAQPHGACLAAELMCNGI 154
                ..|..||  |.|..|                          |.|..  |.|::.:.:|:..
Frog    71 GADHFSCGGRLNRCIPLLWKCDGQTDCENGSDENDCTRKVCADDQFTCRS--GKCISLDFVCDED 133

  Fly   155 DNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRTCIPIDFMCDGRPDCTDKSDEVAG 219
            .:|..|.||..||.             .:|:...|.|:....|||..:.|||.|||.|.||| ..
Frog   134 LDCDDGSDESYCPA-------------PTCNPAMFQCKDKGICIPKLWACDGDPDCEDGSDE-QH 184

  Fly   220 CK-----QAEITC-PGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGCLN-LCEPQKGKFLCRN 277
            |:     :.:..| |.|.| |.:|.|: ...|.|||..||.|.|||:.|:. .|.|.  :|.| |
Frog   185 CEGREPIKTDKPCSPLEFH-CGSGECI-HMSWKCDGGYDCKDKSDEKDCVKPTCRPD--EFQC-N 244

  Fly   278 RETCLTLSEVCDGHSDCSDGSDE-------------------------TDLCHSKPDC------D 311
            ..||:..|..||...||.|.|||                         ..:|:.|.||      .
Frog   245 DGTCIHGSRQCDREYDCKDLSDEEGCVNVTKCEGPDVFKCRSGECITMDKVCNKKRDCRDWSDEP 309

  Fly   312 AKKCA-------LGAKCHMMP--ASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQGCENTS 367
            .|:|.       .|...|:..  ..|.||.|.:|:||.. :.:|||::|| |..:.|||.|.|..
Frog   310 IKECGENECMRNNGGCAHICNDLKIGYECLCNEGYRLVD-KKRCEDINEC-ENPNTCSQICINLD 372

  Fly   368 GGYRCVCDAGYLLDKDNRTCRA---VVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGN 429
            |||:|.|..||.:|....:|::   |.|        |.:|.:..:..|.|......:.:.::...
Frog   373 GGYKCECREGYQMDPVTASCKSIGTVAY--------LFFTNRHEVRKMTLDRSEYTSFIPRLKNV 429

  Fly   430 LSKVIGVAYDGSHIYWTNIQNE---AESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFS 491
            ::..:.:|  .:.|||:::...   :.|:.||: :.|:.|.:::|.:.||:.:||||:..|||::
Frog   430 VALDMEIA--SNKIYWSDLTQRKIYSASMDKAD-NTSHHETVISSQIQAPDGIAVDWIHGNIYWT 491

  Fly   492 DNIMRHIAVCSNDGLNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSRSRPIV 556
            |:....|:|.:.:|.....|.:.|:.:||.:.|.|.:|.|:|||||....|.:..::|....|:|
Frog   492 DSKFSTISVANTEGSKRKTLFSDDLAKPRDIVVDPSQGFMYWTDWGLPAKIEKGGLNGVDRYPLV 556

  Fly   557 SDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVL--DGMLKHPYGLAIFEDQLYWS 619
            ::||||||||.||:..||:||||:||.|:..:...|..|.||:  :..|.||:||.:|||.::|:
Frog   557 TENIEWPNGITLDLTNQRLYWVDSKLHSLSCIDVTGQNRITVISDETHLAHPFGLTVFEDLVFWT 621

  Fly   620 DWATKSVHACHKFSGKDHRILAKD-RTIYAVHIYHPAKQPNSPHGCE-----NATCSHLCLLAEP 678
            |...:::.:.::.:|.:...:|:| .:...:.:||..:||.:.:.||     |..|.:|||.| |
Frog   622 DIENEAIFSANRLTGSNITKVAEDLLSPEDIVLYHNLRQPKAENWCESHHLGNGGCEYLCLPA-P 685

  Fly   679 EIGGHS----CACPDGMRLAPDHRRCM 701
            .|...|    |||||||.|..|.|.|:
Frog   686 LITSRSPKFTCACPDGMHLGADMRSCV 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
yl	NP_996433.1	LDLa	90..124	CDD:238060	18/47 (38%)
		LDLa	131..166	CDD:238060	11/60 (18%)
		LDLa	184..216	CDD:238060	14/31 (45%)
		LDLa	227..262	CDD:238060	17/35 (49%)
		LDLa	271..302	CDD:238060	14/55 (25%)
		FXa_inhibition	352..387	CDD:291342	15/34 (44%)
		Ldl_recept_b	442..482	CDD:278487	12/42 (29%)
		LY	466..508	CDD:214531	15/41 (37%)
		Ldl_recept_b	529..569	CDD:278487	19/39 (49%)
		LY	553..595	CDD:214531	22/41 (54%)
		LY	596..637	CDD:214531	13/42 (31%)
		FXa_inhibition	669..700	CDD:291342	18/34 (53%)
		LY	774..815	CDD:214531
		LDLa	1032..1062	CDD:238060
		LDLa	1074..1109	CDD:238060
		LDLa	1118..1152	CDD:238060
		LDLa	1157..1189	CDD:197566
		LDLa	1198..1232	CDD:238060
		LDLa	1243..1279	CDD:238060
		LDLa	1283..1318	CDD:238060
		LDLa	1340..1371	CDD:197566
		FXa_inhibition	1388..1416	CDD:291342
		EGF_CA	1418..1452	CDD:214542
ldlr	XP_002942891.1	Ldl_recept_a	27..60	CDD:365841	16/32 (50%)
		Ldl_recept_a	68..106	CDD:365841	6/37 (16%)
		LDLa	111..145	CDD:238060	9/35 (26%)
		Ldl_recept_a	149..185	CDD:365841	16/36 (44%)
		Ldl_recept_a	195..231	CDD:365841	17/37 (46%)
		Ldl_recept_a	235..270	CDD:365841	16/37 (43%)
		LDLa	278..308	CDD:381805	4/29 (14%)
		FXa_inhibition	318..352	CDD:373209	9/34 (26%)
		EGF_CA	354..384	CDD:214542	15/30 (50%)
		LY	419..457	CDD:214531	5/39 (13%)
		Ldl_recept_b	439..482	CDD:278487	12/43 (28%)
		Ldl_recept_b	486..525	CDD:278487	11/38 (29%)
		Ldl_recept_b	529..569	CDD:278487	19/39 (49%)
		LY	555..595	CDD:214531	21/39 (54%)
		Ldl_recept_b	616..655	CDD:278487	6/38 (16%)
		FXa_inhibition	674..711	CDD:373209	19/37 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910