DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and fbn2

DIOPT Version :10

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_002931771.2 Gene:fbn2 / 100494368 XenbaseID:XB-GENE-494557 Length:2891 Species:Xenopus tropicalis


Alignment Length:2236 Identity:436/2236 - (19%)
Similarity:637/2236 - (28%) Gaps:908/2236 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 LCG-GTAAGTPGSADTRCDAGQFQCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPPHWFPC 137
            ||| ||...||||.:..|    |:..:.|.::..       :|.| .||.:.:..|||       
 Frog  1097 LCGSGTCINTPGSFECEC----FEGFESGFMMMK-------NCMD-IDECERNPLLCR------- 1142

  Fly   138 AQPHGACLAAE--LMCNGIDNCPGGED---------ELN----------------------CPVR 169
               .|.|:..|  .:|    |||.|.:         ::|                      |...
 Frog  1143 ---GGECINTEGSFLC----NCPNGHELTPSGDACVDINECALSDNLCRNGKCVNIVGTYQCSCN 1200

  Fly   170 PGF-----RFGDT-------------AHRMRSCSKYEFMCQQ-------DRTCIPIDFMCDGRPD 209
            ||:     |.|.|             .|...|...||..|.:       .|||..|| .|:..||
 Frog  1201 PGYQATLDRLGCTDIDECTIMNGGCDTHCTNSEGSYECSCLEGYALMPDKRTCTDID-ECEDNPD 1264

  Fly   210 CTDKSDEVAGCKQAEITCPGEGH-LCANGRCLRRKQWVCDGVDDCGDGSDERGCL-NLCEPQKGK 272
            ..|...    |    ...|||.. ||.:|.........|..|::|...|:.  |: ..||..||.
 Frog  1265 ICDGGQ----C----TNIPGEYRCLCFDGFMASMDMKTCIDVNECDINSNI--CMFGECENTKGS 1319

  Fly   273 FLCRNRETCLTLSEVCDGHSDCSDGSD---ETDLCHSKPDC------------------------ 310
            |:|.    |.....|..|.:.|:|..:   :|..||....|                        
 Frog  1320 FVCH----CQVGYAVKKGTTGCTDVDECEIDTHNCHLHATCLNVPGSFKCTCKEGWIGNGIKCND 1380

  Fly   311 ------DAKKCALGAKCHMMPASGAECFCPKGFRLAKFEDKCEDVDECKEQDDLCSQG-CENTSG 368
                  ...:|::.|.|...|.| ..|.|.:|:....|  .|.|||||.|..:||..| |.|..|
 Frog  1381 LDECLNGTHRCSVSAHCLNTPGS-YHCSCAEGYTGDGF--TCSDVDECTENINLCENGQCLNIPG 1442

  Fly   369 GYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQMTIMGMHLREDNVRNHVYQVAGNLSKV 433
            .|||.||.|:....|:|:|:.:  .....|.:.::.|...:.||.....|....:.:..||.   
 Frog  1443 SYRCECDMGFTPASDSRSCQDI--DECAFQNICVFGTCSNLPGMFRCICNEGYELDRTGGNC--- 1502

  Fly   434 IGVAYDGSHIYWTNIQNEAESIVKANGDGSNAEILLTSG---LDAPEDL--------AVDWLTQN 487
                        |::...|:.|...||...|     |.|   .:.|.|.        .||....|
 Frog  1503 ------------TDVDECADPINCVNGFCVN-----TPGRYECNCPPDFQLNPTGVGCVDTRVGN 1550

  Fly   488 IYFSDNIMRHIAVCSNDG-LNCAVLVTQDVHQPRSLAVWPQKGLMFWTDWGEKPMIGRASMDGSR 551
            .|     :.|.|  ..|| ::|:..:...|                                 ||
 Frog  1551 CY-----LNHGA--RGDGTISCSTEIGVGV---------------------------------SR 1575

  Fly   552 SRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGSVQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQL 616
            |....|....|.|...:        ..........|:.|.|.|.|       .:|..: |.||  
 Frog  1576 SSCCCSLGKAWGNPCEI--------CPPVNSSEYNTLCPGGEGFR-------PNPITI-ILED-- 1622

  Fly   617 YWSDWATKSVHACHKFSGKDHRILAKDRTIYAVHIYHPAKQPNSPHGCENATCSHLCLLAEPEIG 681
                     :..|.:..|.                            |:...|.:       ..|
 Frog  1623 ---------IDECQELPGL----------------------------CQGGNCIN-------TFG 1643

  Fly   682 GHSCACPDGMRLAPDHRRCMLMEKRQRLFIGLGQVLLEIEHTAFGRH---------QVSKSYTLP 737
            ...|.||.|..|:.:.|.|   |.....|...|.......:...|.:         ||:..:...
 Frog  1644 SFQCECPQGYYLSEETRIC---EDIDECFTHPGVCGPGTCYNTLGNYTCICPSEYMQVNGGHNCM 1705

  Fly   738 CLINEMVYNRINGSLIIADNDQRLILEFQPESHESNVLVRS-----NLGNV-----------SAL 786
            .:.....|...||:  ..||:    |.|       ||..:.     |:|..           ...
 Frog  1706 DMRKSFCYRTYNGT--TCDNE----LPF-------NVTKKMCCCTYNIGKAWSKPCEPCPTPGTA 1757

  Fly   787 AFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPG--QEVPIGLTVMPAEGYLYVVLKAKRHS 849
            .|.||..::                          ||  .::..|              ||....
 Frog  1758 NFKHLCGSI--------------------------PGFTFDIHTG--------------KAVDID 1782

  Fly   850 HIDKIP-LSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKL 913
            ...:|| :...|    |..:.:|....:..|.:....:.....|:...|..:|            
 Frog  1783 ECKEIPGICTNG----VCINQIGSFRCECPTGFSYNDLLLVCEDIDECSSGDY------------ 1831

  Fly   914 RRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPR-KVIDIME-KDDPAAIMPYVPVATP------ 970
                 ....:.|.. |..||.|...:....:.|. ..||..| .:.|........|.|.      
 Frog  1832 -----FCQRNADCI-NSPGTYRCECSTGFKLLPNGACIDRNECLEIPNVCSHGTCVDTEGSYHCV 1890

  Fly   971 --NGIPLAASSPVGQESHPCQQQ---NGGCSHICVGEGPYHSIC--------------------- 1009
              ||..::....:..:...|::|   ||.|.:..   |.|:.:|                     
 Frog  1891 CNNGFKVSPDQTMCMDIDECERQPCGNGTCKNTV---GSYNCLCYPGFEITHNNDCLDIDECSSL 1952

  Fly  1010 ---LCPAGFVYRDAGN---------------RTCVEALDC---EFRCHSGEC--LTMNHRC---- 1047
               :|..|..:.:.|:               :.|::..:|   ...|..|.|  |..:.||    
 Frog  1953 YGQVCRNGHCFNEIGSFICLCNEGYELTPDGKNCIDINECVAFPGSCSPGTCQNLEGSFRCICPP 2017

  Fly  1048 ---NGRRDCVDNSDEMNCDEEHRRKPKV----LCS--PNQFAC---------HSGEQCVDKER-- 1092
               ..|.:|:| .||  |.||    |.:    .||  |..|.|         .:|.:|.|..:  
 Frog  2018 GYEVERENCID-IDE--CIEE----PNICLFGACSNTPGSFQCICPPGFVLSENGRRCFDTRQSF 2075

  Fly  1093 --------RCDNRKDCHDHSDEQHCEKF------DKSKKCH-----------VHQHG-------- 1124
                    :|...|..:....:..|.|.      |..:.|.           .:.||        
 Frog  2076 CFTRFENGKCSVPKAYNSTKAKCCCSKMPGEGWGDPCELCPKEGEVAFQDLCPYGHGTIPGIGDT 2140

  Fly  1125 -------------CDNGKCVDSSLVCDGTNDC----GDNSD--ELLCEATSRCEPGMFQCGSGSC 1170
                         |.||.|:::    ||:..|    |.|.|  .:.|..|..|..|. .||:|:|
 Frog  2141 REDVNECLENPGICANGHCINT----DGSFRCECPMGYNLDYTGVNCVDTDECSIGN-PCGNGTC 2200

  Fly  1171 --IAGSWECDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLGQ--CLDRSLVCDGHNDCGD------ 1225
              ..|::||    .|.:|.:.....|   | .|:..|:|..  |..|.:...|..:|..      
 Frog  2201 TNAIGTFEC----LCDEGFEPGPMMV---C-EDINECILNPLLCAFRCINTYGAYECTCPAGYIL 2257

  Fly  1226 KSDELNCGTDSSTMNISCAEDQYQCTSNLKIC--LPSTVRC---NGTTECPRGE---DEADCGDV 1282
            :.|:..| .|..    .|.|..:.|.|...:|  |..|..|   .|....|.||   ||.:|...
 Frog  2258 REDQKMC-KDLD----ECIEGFHDCESRGMVCKNLIGTFMCICPPGMVRRPDGEGCMDENECRTK 2317

  Fly  1283 CSIYEFKCRSGRECIRR--EFRCDGQKDCGDG--------------------------------- 1312
            ..|    |.:|| |:..  .:||    ||.:|                                 
 Frog  2318 PGI----CENGR-CVNTIGSYRC----DCNEGFQSTPSGTECLDTRQGFCFSEVLQTMCQMSSSS 2373

  Fly  1313 -----SDELSCELEKGHHNQSQIQP----------------WSTSSR---SCR--PHLFDCQDGE 1351
                 ..|..|...:|..||.:|.|                ::|..:   .|:  |:|  |::|:
 Frog  2374 RNHVTKSECCCNGGRGWGNQCEICPLPGTAQYKKMCPHGPGYTTDGKDIDECKVMPNL--CRNGQ 2436

  Fly  1352 CVDLSRVCNNFPD----CTNGHDE---GPKCATACRSASGRQVCQHKCRATPAGAVCSCFDGYRL 1409
            |:      ||...    |..|:..   |..|......:...:.|...|:.|.....|||..||.|
 Frog  2437 CI------NNIGSYRCFCNPGYTTDIGGTACVDLDECSQSPKPCNFICKNTEGSYQCSCPRGYIL 2495

  Fly  1410 DADQKSCLDIDECQ-EQQPCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEV 1473
            ..|.|||.|:|||| :|..|..||.||:||:.|:|...|  .|...:|.......|         
 Frog  2496 QEDGKSCKDLDECQTKQHNCQFLCVNTIGGFTCKCPPGF--TQHHTACIDNNECGT--------- 2549

  Fly  1474 RNLSEQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAE-DEGIVYQIDLQTKVIVRALGLPAPTK 1537
                             .|.:.|.........|.|:.| ..|  |.:|        :.|:...  
 Frog  2550 -----------------QSNVCGLKGVCQNSPGSFTCECQRG--YSLD--------STGMNCE-- 2585

  Fly  1538 LSVDWVTGNVYVLSGAQEIQACSFVGRMCGRIVHVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQ 1602
             .||...||.....|.|.|                          |.||....      .:||.|
 Frog  2586 -DVDECGGNHRCQHGCQNI--------------------------VGGYRCSC------PQGYIQ 2617

  Fly  1603 TSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQH-------------MRTLERIS 1654
                                             |.|....||::             ..||.  |
 Frog  2618 ---------------------------------HYQWNQCVDENECASQNTCGSASCFNTLG--S 2647

  Fly  1655 YRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHKISINVLNA 1719
            |:...                  |:|.:.   |.|                |..||.:.      
 Frog  2648 YKCAC------------------PTGFTF---NQF----------------SSACHDVD------ 2669

  Fly  1720 QDIVVAGRSRQPQKASHPCAHAHCHGLCLQADYGYECMCGNRLVAEGERCPHGSGNEVAVLGAVN 1784
                      :...:.:||.:.     |...:.||  :||         ||.|            
 Frog  2670 ----------ECTSSKNPCNYG-----CSNTEGGY--LCG---------CPPG------------ 2696

  Fly  1785 SLELEHEHEQNGHFHWLMALFVLAAGSLIAGLGYMYYQYRQRGHTDLNINMHFQNPLATLGGTKA 1849
                               .:.:..|..::|:|:...||...|..:..     .|.|:..|..:.
 Frog  2697 -------------------YYRVGQGHCVSGIGFNRGQYLPVGKENSE-----DNALSPEGCYEC 2737

  Fly  1850 FLEHERAEAGVGFTTETGTVS--------SRGSNDTFTTTSATSSFAAQQFSVPNALQRLLRPRQ 1906
            .|.        |:|.:||.:.        .||:|:|....:...|..:....:|           
 Frog  2738 QLN--------GYTKKTGRMRRNAKNPELERGANNTEQAMNGQISLKSLDMDLP----------- 2783

  Fly  1907 SASGDPMAQELLLESPSRESKLHALD 1932
                    .:::|......||.|.|:
 Frog  2784 --------LKMVLNISHLNSKKHILE 2801

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 7/33 (21%)
LDLa 131..166 CDD:238060 9/67 (13%)
LDLa 184..216 CDD:238060 12/38 (32%)
LDLa 227..262 CDD:238060 10/35 (29%)
LDLa 271..302 CDD:238060 8/33 (24%)
FXa_inhibition 352..387 CDD:464251 16/35 (46%)
Ldl_recept_b 442..483 CDD:459654 11/51 (22%)
LY 466..508 CDD:214531 12/53 (23%)
Ldl_recept_b 529..569 CDD:459654 6/39 (15%)
LY 553..595 CDD:214531 6/41 (15%)
LY 596..637 CDD:214531 7/40 (18%)
FXa_inhibition 669..700 CDD:464251 8/30 (27%)
LY 774..815 CDD:214531 6/56 (11%)
LDLa 1032..1062 CDD:238060 11/38 (29%)
LDLa 1074..1109 CDD:238060 10/55 (18%)
LDLa 1118..1152 CDD:238060 13/71 (18%)
LDLa 1157..1189 CDD:197566 11/33 (33%)
LDLa 1198..1232 CDD:238060 9/41 (22%)
LDLa 1243..1279 CDD:238060 14/43 (33%)
LDLa 1283..1318 CDD:238060 11/74 (15%)
LDLa 1340..1371 CDD:197566 10/36 (28%)
FXa_inhibition 1388..1416 CDD:464251 11/27 (41%)
EGF_CA 1418..1452 CDD:214542 16/34 (47%)
fbn2XP_002931771.2 Fibrillin_U_N 66..102 CDD:436338
EGF_CA 308..349 CDD:214542
TB 363..407 CDD:459903
EGF_CA 507..537 CDD:214542
EGF_CA 547..587 CDD:214542
EGF_CA 589..629 CDD:214542
EGF_CA 630..670 CDD:214542
TB 685..728 CDD:459903
EGF_CA 782..817 CDD:238011
TB 877..>909 CDD:459903
EGF_CA 927..957 CDD:429571
TB 982..1024 CDD:459903
EGF_CA 1087..1121 CDD:214542 11/27 (41%)
EGF_CA 1130..1162 CDD:214542 14/46 (30%)
EGF_CA 1172..1204 CDD:214542 4/31 (13%)
FXa_inhibition 1218..1253 CDD:464251 6/34 (18%)
EGF_3 1343..1378 CDD:463759 4/34 (12%)
EGF_3 1384..1419 CDD:463759 9/37 (24%)
EGF_CA 1421..1453 CDD:214542 18/31 (58%)
EGF_CA 1463..1497 CDD:238011 5/35 (14%)
EGF_CA 1504..1535 CDD:214542 9/35 (26%)
TB 1565..1605 CDD:459903 9/80 (11%)
EGF_CA 1622..1654 CDD:214542 10/77 (13%)
TB 1720..1763 CDD:459903 10/53 (19%)
EGF_CA 1780..1812 CDD:214542 6/35 (17%)
vWFA <1819..1860 CDD:469594 9/58 (16%)
vWFA <1855..1901 CDD:469594 9/45 (20%)
EGF_CA 1906..1940 CDD:214542 8/36 (22%)
EGF_CA 1945..1987 CDD:214542 3/41 (7%)
EGF_CA 1988..2020 CDD:214542 7/31 (23%)
EGF_CA 2028..2068 CDD:214542 13/46 (28%)
TB 2083..2127 CDD:459903 6/43 (14%)
EGF_CA 2143..2173 CDD:429571 7/33 (21%)
EGF_CA 2185..2219 CDD:214542 12/38 (32%)
EGF_CA 2266..2298 CDD:429571 9/35 (26%)
EGF_CA 2310..2343 CDD:214542 13/41 (32%)
TB <2376..2409 CDD:459903 7/32 (22%)
EGF_CA 2421..2454 CDD:214542 10/40 (25%)
FXa_inhibition 2467..2502 CDD:464251 11/34 (32%)
EGF_CA 2504..2533 CDD:429571 15/28 (54%)
EGF_CA 2586..>2615 CDD:214542 10/60 (17%)
EGF_CA 2626..2657 CDD:214542 7/50 (14%)
Blue background indicates that the domain is not in the aligned region.

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