DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment yl and sorl1

DIOPT Version :9

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_031762503.1 Gene:sorl1 / 100490681 XenbaseID:XB-GENE-995776 Length:2199 Species:Xenopus tropicalis


Alignment Length:1754 Identity:397/1754 - (22%)
Similarity:593/1754 - (33%) Gaps:688/1754 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 PHWFPCAQPHGACLAAELMCNGIDNCPGGEDELNCPVRPGFRFGDTAHRMRSCSKYEFMCQQDRT 196
            ||::.... ||..|.|  :..|:|.                            ::.::...:..|
 Frog   528 PHYYTWGD-HGGILVA--IAQGVDT----------------------------NQLKYSTNEGET 561

  Fly   197 CIPIDFMCDGRPDCTDKSDEVAGCKQAEITCPGE--------GHLCANGRCLRRKQWVCDGVD-- 251
            ....:|        :||:..|.|.    :|.|||        |.....|.     .|:...::  
 Frog   562 WKTFNF--------SDKAMIVYGL----LTEPGEKSTVFTIFGSYTERGH-----SWIILQINAS 609

  Fly   252 -----DCGDG-------SDERG--CLNLCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSD-ET 301
                 .|.|.       |||||  ||      .|:.....|.|         .|:.|.:|.| :.
 Frog   610 DVLGVPCTDSDYKLWSPSDERGNECL------LGRKTVFKRRT---------AHATCFNGEDFDR 659

  Fly   302 DLCHSKPDCDAK--KCALGAK---------CHMMPASGAECF-----CP--------KGFRLAKF 342
            .:..|...|..:  :|..|.|         |...|....:.:     ||        ||:|    
 Frog   660 PITVSNCSCTREDFECDFGFKLSKDLSSELCVPDPEFAGKLYPIPIPCPVGTTYTRTKGYR---- 720

  Fly   343 EDKCEDVDECKEQDDLCSQG-CENTSGGYRCVCDAGYLLDKDNRTCRAVVYGSKEQQPLLLYTTQ 406
                      |...|.||.| .||...|....|..|                  |:...:||.  
 Frog   721 ----------KVSGDTCSGGDVENRLQGEEVPCPVG------------------EENEFILYA-- 755

  Fly   407 MTIMGMHLREDNVRNHVYQVAGNLSKVI-----------GVA----YDGSHIYWTNIQNEAESIV 456
                        :||.:|:.  :||..|           .||    |..:.:||.::..|....:
 Frog   756 ------------MRNSIYRY--DLSSGINEELPLKGLHDAVALDFDYQSNCLYWADVTLETIQRL 806

  Fly   457 KANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDG-LNCAVLVTQDVHQPR 520
            ..|| .|:.|:::.:||:..|.||.|.|:|.:|:.|..|:.|.|.|.|| |...:|.:..:.:||
 Frog   807 CLNG-SSSQEVIVRNGLETIESLAFDPLSQLLYWVDAGMKKIEVASADGDLRLTILNSTVLERPR 870

  Fly   521 SLAVWPQKGLMFWTDWG-EKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRIYWVDAKLGS 584
            :||:.|::||||||||| |:..|.|:.||||..:.::.:.|:|||||.:|  :|.|||.:|.:..
 Frog   871 ALALVPKEGLMFWTDWGDERHGIYRSEMDGSSVKHLIFEGIKWPNGICVD--EQWIYWTEAYMDR 933

  Fly   585 VQTVRPDGTGRRTVLDGMLKHPYGLAIFEDQLYWSDWATKSVHACHKFSG-KDHRILAKDRTIYA 648
            ::.:..:|..|..:||. |.|||.:|:|::::||.||:..|:....|::| :...|:.:...:..
 Frog   934 IERIDFNGQQRMIILDN-LPHPYAIAVFKNEIYWDDWSQLSIFRASKYNGARMEGIIGRLTGVMD 997

  Fly   649 VHIYHPAKQPNSPHGCENATCSHLCLLAEPEIGGHS-CACPDGMRLAPDHRRCMLMEKRQRLFIG 712
            :.|::..| ....:.|....||.|||   |:..... |.|.:|::..|               :.
 Frog   998 MKIFYKDK-ATGHNACVLKPCSLLCL---PKANNSKICRCSEGVKGTP---------------LS 1043

  Fly   713 LGQVLLEIEHTAFGRHQVSKSYTLPCLINEMVYNRINGSLIIA------DNDQRLILEFQPESHE 771
            .|.:..:.......:::........||.::  |...||:.|.:      |||             
 Frog  1044 SGDIQCDCPQGYLLKNKTCVKQENTCLPSQ--YRCSNGNCINSIWQCDTDND------------- 1093

  Fly   772 SNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTRHRALIRFFPGQEVPIGLTVMPAE 836
                    .|::|    |..:......|.|              ||.|             ....
 Frog  1094 --------CGDMS----DEKNCPTTTCDPE--------------ALFR-------------CQGS 1119

  Fly   837 GYLYVVLKAKRHSHIDKIPLSGKGEQVHVFEDDLGDDDIKLVTDYETQTIFWSDSDLGRISYSNY 901
            |..              ||||.|.:    .|||.||:               ||..         
 Frog  1120 GAC--------------IPLSYKCD----LEDDCGDN---------------SDES--------- 1142

  Fly   902 RVPHSQIFRGKLRRPYSLAMVHHDLFWNELGTPRIYWTHKSNMGPRKVIDIMEKDDPAAIMPYVP 966
               |.                                                            
 Frog  1143 ---HC------------------------------------------------------------ 1144

  Fly   967 VATPNGIPLAASSPVGQESHPCQQQNGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVEALDC 1031
                             |:|.|::.                                        
 Frog  1145 -----------------EAHQCKED---------------------------------------- 1152

  Fly  1032 EFRCHSGECLTMNHRCNGRRDCVDNSDEMNCDE-EHRRKPKVLCSPNQFACHSGEQCVDKERRCD 1095
            ||.|.||.|:.::..|:|..||.|.|||.||.. .|      .|....|.||. ..|:.::..||
 Frog  1153 EFNCSSGMCIRLSWVCDGDNDCRDWSDEANCTAISH------TCEATSFQCHD-SHCIPQKWVCD 1210

  Fly  1096 NRKDCHDHSDEQH--CEKFDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEA---- 1154
            ...||.|.|||.|  ||     |||:..|  |.||.|:.|...|||.|||.|.:||..||.    
 Frog  1211 GDTDCQDGSDEDHSICE-----KKCNGFQ--CQNGSCIPSVKHCDGVNDCPDGADEQQCEPLCTR 1268

  Fly  1155 --------------------------------------------TSRCEPGMFQCGSGSCIAGSW 1175
                                                        ...|:|..|.|.:|.||:..|
 Frog  1269 YMDFVCRNRQQCLFHSMVCDGVKQCRDGSDEDPQYAGCSQGPEFQRTCDPHSFLCQNGVCISLVW 1333

  Fly  1176 ECDGRIDCSDGSDEHDKCVHRSCPPDMQR-----CLLGQCLDRSLVCDGHNDCGDKSDELNCG-- 1233
            :|||..||.|.|||.: |.:.:..|...|     |..|.|:.....||..|||||.|||.:||  
 Frog  1334 KCDGMDDCGDYSDEAN-CENPTDIPTCSRYYQFPCQNGHCIPTRWKCDHENDCGDWSDEKDCGET 1397

  Fly  1234 -TDSSTMNISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADC---------------GDV 1282
             ..:::...:|..:.::|.:.  :|:.:|..|:|..:|..|.||..|               |. 
 Frog  1398 IPQTTSRPATCPSNHFRCDNG--VCILNTWVCDGYKDCIHGSDEEGCPASANKTVVPTILPHGQ- 1459

  Fly  1283 CSIYEFKCRSGRECIRREFRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFD- 1346
            ||.:||:|:..::||.....|||.:||.||:|||:|...|                   |.|.. 
 Frog  1460 CSQFEFECKKWKDCIPSWRHCDGNRDCRDGTDELNCPTHK-------------------PSLCVN 1505

  Fly  1347 ---CQDGE-CVDLSRVCNNFPDCTNGHDEGPKCATACRSASGRQVCQH-KCRATPAGAV------ 1400
               |:||| |:.|...|:.|.||::|.||     ..|...:..|..|: :..|...|.:      
 Frog  1506 GSLCEDGEACIALLDFCDGFLDCSDGSDE-----NNCTDDTIVQKVQNLQWTADFTGNITLMWTR 1565

  Fly  1401 ------CSCFDG--YRLDAD------------------------------QKSCL-------DI- 1419
                  .||...  ||:..:                              |..||       || 
 Frog  1566 PKKMPQSSCVYNIYYRIVGESTWKSLETHSNKTVYVLKILKPDTTYQAKVQVQCLRKAYNTNDII 1630

  Fly  1420 ---------DECQEQQPCAQLCE--NTLGGYQCQCHADFMLRQDRV--SCKSLQSGATLLFSSFN 1471
                     |..|..|......|  |..|.:....:|..::|:..|  |...::...:|..:|.|
 Frog  1631 TLRTPEGVPDPPQHLQLSIMKDEFGNIFGSWTAPANAHGLIREYIVEYSMSGVKEWTSLSVTSNN 1695

  Fly  1472 E-VRNLSEQPVMLNVAWSANDSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQTKVIVRALG--LP 1533
            . ::||..     |..::...:.:|.      |.:|.:|            :||.|....|  :|
 Frog  1696 VLIKNLPR-----NTMYAVRVAAVTS------RGVGDWS------------ETKSITTVQGKDIP 1737

  Fly  1534 APT----KLSVDWVTGNVYVLSGAQEIQA----CSFVGRMCGRIVHVKSPRHVKHLAVDGYHARI 1590
            .||    ..:.|.:|.|:.|.|   ||..    .|||...   ..||:..|.:|   .||     
 Frog  1738 VPTIKILSFNEDSITFNLKVDS---EISVNYYFVSFVWEF---DTHVQERRTLK---FDG----- 1788

  Fly  1591 FYIVIRTEGY------GQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMR 1648
                 :|:.:      .|||.||                 .:::|.:..|......:||.|.::
 Frog  1789 -----KTKDFKVGNLTAQTSYEI-----------------SAWITTIIGDSSVSFEHFVTQGLK 1830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060
LDLa 131..166 CDD:238060 8/33 (24%)
LDLa 184..216 CDD:238060 4/31 (13%)
LDLa 227..262 CDD:238060 13/58 (22%)
LDLa 271..302 CDD:238060 7/31 (23%)
FXa_inhibition 352..387 CDD:291342 10/35 (29%)
Ldl_recept_b 442..482 CDD:278487 12/39 (31%)
LY 466..508 CDD:214531 18/42 (43%)
Ldl_recept_b 529..569 CDD:278487 22/40 (55%)
LY 553..595 CDD:214531 13/41 (32%)
LY 596..637 CDD:214531 15/41 (37%)
FXa_inhibition 669..700 CDD:291342 10/31 (32%)
LY 774..815 CDD:214531 5/40 (13%)
LDLa 1032..1062 CDD:238060 14/29 (48%)
LDLa 1074..1109 CDD:238060 14/36 (39%)
LDLa 1118..1152 CDD:238060 16/33 (48%)
LDLa 1157..1189 CDD:197566 15/31 (48%)
LDLa 1198..1232 CDD:238060 15/38 (39%)
LDLa 1243..1279 CDD:238060 10/35 (29%)
LDLa 1283..1318 CDD:238060 17/34 (50%)
LDLa 1340..1371 CDD:197566 13/35 (37%)
FXa_inhibition 1388..1416 CDD:291342 8/72 (11%)
EGF_CA 1418..1452 CDD:214542 10/45 (22%)
sorl1XP_031762503.1 VPS10 115..744 CDD:214740 57/292 (20%)
LY 777..812 CDD:214531 8/35 (23%)
LY 815..854 CDD:214531 15/38 (39%)
Ldl_recept_b 879..920 CDD:395012 22/40 (55%)
LY 904..944 CDD:214531 13/41 (32%)
LY 944..982 CDD:214531 15/38 (39%)
LDLa 1069..1103 CDD:238060 12/60 (20%)
LDLa 1114..1144 CDD:238060 14/87 (16%)
Ldl_recept_a 1148..1183 CDD:395011 15/74 (20%)
LDLa 1189..1221 CDD:197566 11/32 (34%)
LDLa 1231..1262 CDD:238060 15/32 (47%)
LDLa 1272..1299 CDD:197566 0/26 (0%)
LDLa 1316..1350 CDD:238060 17/34 (50%)
LDLa 1363..1394 CDD:238060 13/30 (43%)
LDLa 1408..1442 CDD:238060 10/35 (29%)
LDLa 1460..1495 CDD:238060 17/34 (50%)
LDLa 1509..1537 CDD:238060 13/32 (41%)
FN3 1546..1617 CDD:214495 7/70 (10%)
FN3 1639..1730 CDD:238020 23/113 (20%)
FN3 1922..2003 CDD:214495
FN3 2013..2100 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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