DRSC/TRiP Functional Genomics Resources

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Protein Alignment yl and lrp2

DIOPT Version :10

Sequence 1:NP_996433.1 Gene:yl / 32367 FlyBaseID:FBgn0004649 Length:1984 Species:Drosophila melanogaster
Sequence 2:XP_012826499.2 Gene:lrp2 / 100489914 XenbaseID:XB-GENE-486052 Length:4662 Species:Xenopus tropicalis


Alignment Length:2120 Identity:602/2120 - (28%)
Similarity:907/2120 - (42%) Gaps:429/2120 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 RAHPSSGGSTSSRYGNCQRTHLIINGRHVAISLLLLVGLCGGTAAGTPGSADT-----RCDAGQF 95
            :||..:..|.|.|   |.      |||.:.:|     ..|.|||..|..|.:.     .|...||
 Frog    27 KAHSQTCSSGSFR---CS------NGRCIPLS-----WRCDGTADCTDNSDEAGCPPRTCSTSQF 77

  Fly    96 QCRDGGCILQAKMCDGRGDCKDSSDELDCDYRLCRPPHWFPCAQPHGACLAAELMCNGIDNCPGG 160
            :|.||.||..:.:||...||.|.|||..|..|.|.... |.|:.  |.|:.....|:.:.:|..|
 Frog    78 RCGDGDCITSSWVCDDEEDCDDGSDEQHCPGRTCSAQQ-FTCSS--GQCIPRAYRCDRMKDCTDG 139

  Fly   161 EDELNC--PVRPGFRFGDTAHRMRS---------------------CSKYEFMCQQDRTCIPIDF 202
            .||.||  ||......|..|...||                     |...:|.|.... |||.||
 Frog   140 ADERNCLYPVCTELSCGSGACYNRSQRCDGIVDCRDSSDESNCTQRCLSSQFQCPSGE-CIPRDF 203

  Fly   203 MCDGRPDCTDKSDEVAGCKQAEITCPGEGHLCANGRCLRRKQWVCDGVDDCGDGSDERGC---LN 264
            :||...||.|:||| ..|...  ||.|:...|:||||: .:.|:|||.|||.|..||.||   ..
 Frog   204 LCDHDDDCGDESDE-KNCTYP--TCRGDYFTCSNGRCI-HQTWLCDGDDDCDDNGDEWGCEGGHR 264

  Fly   265 LCEPQKGKFLCRNRETCLTLSEVCDGHSDCSDGSDETDLCHSKPDCDAKKCA---LGAKCHMMPA 326
            .|.|  |::.|.:...|:.:.:||||...|..|.||:::...: :|....||   ...:||..||
 Frog   265 ECGP--GEWACPSSGQCIPVDKVCDGIVHCRFGEDESNITAGR-NCSTNNCASLSCQHRCHSSPA 326

  Fly   327 SGAECFCPKGFRLAKFEDK-CEDVDECKEQDDLCSQGCENTSGGYRCVCDAGYLLDKDNRTCRAV 390
            .|. |:||.|:.::..:.: |.|.|:|| ...:|.|.||:..|.|||.|..||:|: .::.||| 
 Frog   327 GGL-CYCPAGYVISSNDSRTCIDFDDCK-MWGICDQFCEDRIGSYRCSCAEGYILE-HHKHCRA- 387

  Fly   391 VYGSKEQQPLLLYTTQMTIMGMHLREDN----VRNHVYQVAGNLSKVIGVAYDGS--HIYWTN-I 448
              .|....|.::::....::...:...|    |::|      |....:||.:...  .::||: :
 Frog   388 --NSTRGPPSIIFSNGRDLLIGDIHGGNSRILVQSH------NRGVAVGVDFHFQLRRVFWTDTV 444

  Fly   449 QNEAESIVKANGDGSNAEILLTSGLDAPEDLAVDWLTQNIYFSDNIMRHIAVCSNDGLNCAVLVT 513
            ||:..|:   :.||||...:|...::.||:|||||::..||..:..::.|.:...||.|...|:.
 Frog   445 QNKVFSV---DIDGSNVREVLNISIETPENLAVDWVSNKIYVVETSIKRIDMVDLDGQNRITLIA 506

  Fly   514 QDVHQPRSLAVWPQKGLMFWTDWG---EKPMIGRASMDGSRSRPIVSDNIEWPNGIALDMHQQRI 575
            :|:..||.:|:.|..|.:|::|||   |:..:.||.|||:....|:...:.||.|:.||:..:|:
 Frog   507 EDLGNPRGIALDPSVGYLFFSDWGSNSEESKLERAFMDGTNRHDIIKTKLGWPAGMTLDIITKRL 571

  Fly   576 YWVDAKLGSVQTVRPDGTGRRTVLDG--MLKHPYGLAIFEDQLYWSDWATKSVHACHKFSGKDHR 638
            ||||::...::|...||..||||:.|  ::.|||||:|||..||::||...||...:||:....:
 Frog   572 YWVDSRYDYIETTTYDGLDRRTVVHGGNVIPHPYGLSIFEHYLYFTDWTKVSVMKANKFTDNSTQ 636

  Fly   639 ILAKDRT-IYAVHIYHPAKQP--NSPHGCENATCSHLCLLA-EPEIG--GHSCACPDGMRLAPDH 697
            ::.:..: .|.|.:||.|:||  .:|.|..|..|..:|:|: ..:.|  |:.|.|..|..|..|.
 Frog   637 VVYRSSSRPYGVTVYHSARQPYVRNPCGTNNGGCEQICVLSHRTDNGGLGYRCRCKLGFDLHEDG 701

  Fly   698 RRCMLMEKRQRLFIGLGQVLLEIEHTAFG---RHQVSKSYT-LPCLINEMVYNRINGSLIIADND 758
            |||:::.|    |: |....|.:....|.   :..|....| :|.....:.::..:.::..:|..
 Frog   702 RRCVVVRK----FL-LFSSQLAVRGIPFNLSTQEDVIIPITGVPSYFVGIDFDAQDNAIFYSDTV 761

  Fly   759 QRLILEFQPESHESNVLVRSNLGNVSALAFDHLSRNLYWADTERAVIEVLSLQTR-HRALIRFFP 822
            :.:|.:.:.:.....:|..:.:..|..||:|.:|:||||.|.....|.|:.|..: .||:|:   
 Frog   762 KDMIYKQKTDGTGKEILTANRVEGVEDLAYDWISKNLYWTDPRYRSISVMKLADKSRRAIIQ--- 823

  Fly   823 GQEVPIGLTVMPAEGYL-----YVVLKAKR----HSHIDKIPLSGKGEQVHVFEDDLGDDDIKLV 878
            ....|..:.|.|..||:     |...|..|    .||:..|..|..|.            ...|.
 Frog   824 NLNNPRSIVVHPVIGYIFWTDWYRPAKIMRAWCDGSHLQPIVNSSLGW------------PNGLA 876

  Fly   879 TDYETQTIFWSDSDLGRISYSNYRVPHSQIFRGKLRR------PYSLAMVHHDLF---WNELGTP 934
            .|:.:..::|.|:...::.:|.:    ..:.|..|.|      |:.|.:.....:   |...|..
 Frog   877 MDWSSLRLYWVDAFFDKVEHSTF----DGLDRQTLNRITQMTHPFGLTIYGGYAYITDWRLGGIV 937

  Fly   935 RIYWTHKSNMGPRKVI-----DIMEKDDPAAIMPYVPVATPNGIPLAASSPVGQESHPCQQ---Q 991
            |:   .|.:.|...:|     :||....                 ..||:.:|  |:.|.:   .
 Frog   938 RV---RKYDGGEMTIIRRGINNIMHVKS-----------------FDASTQIG--SNYCNRPTNP 980

  Fly   992 NGGCSHICVGEGPYHSICLCPAGFVYRDAGNRTCVE-------ALDC---EFRCHSGECLTMNHR 1046
            ||.|||.|........:|.||.|...| ...:||.:       .:.|   .|.|.:|:|:.:..|
 Frog   981 NGDCSHFCYPVPNLQRVCGCPYGMRLR-PDQQTCFDDPASEPPTMQCGSYSFPCANGKCVPVYDR 1044

  Fly  1047 CNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVDKERRCDNRKDCHDHSDEQHCEK 1111
            |:|..||.|||||.||...:.     .||...|.|.:| ||:....|||...||.|.||||:|..
 Frog  1045 CDGVDDCHDNSDEANCGTRNN-----TCSSRAFTCGNG-QCIPLNWRCDGHNDCVDRSDEQNCPT 1103

  Fly  1112 FDKSKKCHVHQHGCDNGKCVDSSLVCDGTNDCGDNSDELLCEATSRCEPGMFQCGSGSCIAGSWE 1176
             ...:.|......|.|.:|:....:||..|||||.||||.|..||.||||.|||....||..|:.
 Frog  1104 -QGPRSCSSTSFTCQNNRCIPRIWLCDTDNDCGDGSDELNCNFTSTCEPGQFQCPDHRCIDPSYV 1167

  Fly  1177 CDGRIDCSDGSDEHDKCVHRSCPPDMQRCLLG-QCLDRSLVCDGHNDCGDKSDELNCGTDSSTMN 1240
            |||..||.|||||.. |.: :|.....:|..| ||:.....|||..||.|.||||||.|..:.| 
 Frog  1168 CDGDKDCVDGSDEMG-CTY-NCSYSEFKCASGDQCISTGYQCDGVFDCNDHSDELNCPTRPAGM- 1229

  Fly  1241 ISCAEDQYQCTSNLKICLPSTVRCNGTTECPRGEDEADCGDV--CSIYEFKCRSGRECIRREFRC 1303
              |.::::||.|: ..|:||...|:|..:|..|.||.:...|  |....|:|.:| .||.|.:.|
 Frog  1230 --CHQNEFQCQSD-GACIPSNWECDGHPDCIDGSDEHNTCPVRSCPPSMFRCDNG-NCIYRSWIC 1290

  Fly  1304 DGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGE-CVDLSRVCNNFPDCTN 1367
            ||..||.|.|||..|               .|....|....:.|.... |:::|:||:|.|||.|
 Frog  1291 DGDNDCRDMSDEKDC---------------PTPPFRCPSWQWQCPGNTICINVSKVCDNTPDCPN 1340

  Fly  1368 GHDEGPKC------ATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQEQQ 1426
            |.||.|.|      ..:|  ......|.|:|...|.||.|:|.:||.|..|.|:|.||:||....
 Frog  1341 GADESPLCNEYQPDQESC--TDNNAGCTHQCIQGPFGAQCTCPEGYSLSNDSKTCEDINECLTPG 1403

  Fly  1427 PCAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQS-GATLLFSSFNEV--RNLSEQ-----PV-- 1481
            .|:|.|.|..|.|:|.|...::|..:..:||:..| ...||.:|.|::  .|::.|     ||  
 Frog  1404 FCSQTCYNERGSYRCYCEDGYILEPNGRTCKAAGSANLLLLVASRNQIIADNITTQAHNIYPVIR 1468

  Fly  1482 ----MLNVAWSANDSRITGFDLAMHRQMGYF-SAEDEGIVYQIDLQTKVIVRALGLPAPTKLSVD 1541
                ::.:.:.:..:||...|:|..:....| :..|..:::.           .|:.....::||
 Frog  1469 DGRTIVAIDFDSVTNRIFWSDIAQDKIWSAFVNGTDRKVIFD-----------SGVTVTESIAVD 1522

  Fly  1542 WVTGNV----YVLSGAQEIQACSFVGRMCG--RIV----HVKSPRHVKHLAVDGYHARIFYIVIR 1596
            ||..|:    |||...:       |.::.|  |.|    :|.:||   .|.:|.          |
 Frog  1523 WVGRNLYWTDYVLETIE-------VSQLDGTHRTVLISENVTNPR---GLVLDP----------R 1567

  Fly  1597 TEG-------YGQTSSEIHMARLDGSRRDMLLQRSESFMTALTTDPHQQLLYFVDQHMRTLERIS 1654
            |:.       :|: :..|..|.:||..|.:::.....:...|..|...:.|||.|.:   |:.|.
 Frog  1568 TDAHVMFWTDWGR-NPRIERASMDGKMRTVIVSNKIYWPNGLAIDYPNKRLYFADAY---LDYID 1628

  Fly  1655 YRLKTGPMRRPEIMLQKSNALMHPSGLSVYENNAFIVNLGSVEAVQCALYGSRICHK-------- 1711
            |....|..|:.  .:.....|.||..::::|:..:..:          .|.||:...        
 Frog  1629 YCDYDGNNRKQ--AMASDLVLQHPHAITIFEDYVYWTD----------RYTSRVIRANKFHGGNQ 1681

  Fly  1712 --ISINVLNAQDIVVAGRSRQPQKASHPCAHAHCHGLCLQADYG---YECMC--GNRLVAEGERC 1769
              :..|:.....|......:|| ...:|||...|..:||.:..|   |.|.|  |..||::...|
 Frog  1682 TVMIYNIHQPLGISAVHSVKQP-GGVNPCAFNPCSHICLLSSIGPKFYSCACPSGWTLVSDSVNC 1745

  Fly  1770 ----------------------PHGSGNE--VAVLGAVNSLELEHEH--------EQNGHFHWLM 1802
                                  |....|:  |.|.|..|..:::.:.        |..|..|.:.
 Frog  1746 QRDEKPFLVVVRDSIIFGMSLNPDDKTNDAMVPVAGIRNGYDVDFDDSEQMIYWIENPGEIHRVK 1810

  Fly  1803 A----LFVLAAGSLI---AGLGYMYYQYRQRGHTDLNINMHFQNPLATLGGTKAFLEHERAEAGV 1860
            :    ..|.|..::|   .||...:          ::.|:::.||.                   
 Frog  1811 SDGTNRTVFAPAAIIGAPVGLALDW----------ISGNLYYTNPR------------------- 1846

  Fly  1861 GFTTETGTVSSRGS---NDTFTTTSATSSFAAQQFSVPNALQRLLRPRQSASGDPMAQELLLESP 1922
              |.....:..||.   ..|..|...|                     |:.:|.|:.   :...|
 Frog  1847 --TQSIEVIKLRGEVKHRKTLITNDGT---------------------QTGAGAPIG---IAVDP 1885

  Fly  1923 SRESKLH----ALDGGG----AGGDGDGGRGVGRQVPDIL 1954
            :| .|::    .:|||.    |..|.||..      |.:|
 Frog  1886 AR-GKMYWTDQGIDGGTPAKVASADMDGSN------PSVL 1918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ylNP_996433.1 LDLa 90..124 CDD:238060 16/33 (48%)
LDLa 131..166 CDD:238060 9/34 (26%)
LDLa 184..216 CDD:238060 14/31 (45%)
LDLa 227..262 CDD:238060 17/34 (50%)
LDLa 271..302 CDD:238060 11/30 (37%)
FXa_inhibition 352..387 CDD:464251 14/34 (41%)
Ldl_recept_b 442..483 CDD:459654 15/41 (37%)
LY 466..508 CDD:214531 13/41 (32%)
Ldl_recept_b 529..569 CDD:459654 15/42 (36%)
LY 553..595 CDD:214531 14/41 (34%)
LY 596..637 CDD:214531 20/42 (48%)
FXa_inhibition 669..700 CDD:464251 11/33 (33%)
LY 774..815 CDD:214531 14/41 (34%)
LDLa 1032..1062 CDD:238060 14/29 (48%)
LDLa 1074..1109 CDD:238060 17/34 (50%)
LDLa 1118..1152 CDD:238060 15/33 (45%)
LDLa 1157..1189 CDD:197566 18/31 (58%)
LDLa 1198..1232 CDD:238060 15/34 (44%)
LDLa 1243..1279 CDD:238060 13/35 (37%)
LDLa 1283..1318 CDD:238060 16/34 (47%)
LDLa 1340..1371 CDD:197566 12/31 (39%)
FXa_inhibition 1388..1416 CDD:464251 13/27 (48%)
EGF_CA 1418..1452 CDD:214542 13/33 (39%)
lrp2XP_012826499.2 LDLa 33..67 CDD:238060 14/47 (30%)
LDLa 111..145 CDD:238060 10/36 (28%)
LDLa 151..182 CDD:238060 4/30 (13%)
LDLa 186..220 CDD:238060 16/35 (46%)
LDLa 266..300 CDD:238060 13/35 (37%)
EGF_CA 348..385 CDD:214542 16/38 (42%)
YncE 389..577 CDD:442618 59/196 (30%)
LY 503..548 CDD:214531 17/44 (39%)
LY 551..591 CDD:214531 14/39 (36%)
FXa_inhibition 663..704 CDD:464251 13/40 (33%)
LY 776..818 CDD:214531 14/41 (34%)
Ldl_recept_b 838..879 CDD:459654 11/52 (21%)
LY 864..904 CDD:214531 8/55 (15%)
FXa_inhibition 981..1013 CDD:464251 11/32 (34%)
LDLa 1026..1060 CDD:238060 15/33 (45%)
LDLa 1067..1101 CDD:238060 17/34 (50%)
LDLa 1109..1143 CDD:238060 15/33 (45%)
LDLa 1149..1183 CDD:238060 20/34 (59%)
LDLa 1187..1222 CDD:238060 15/34 (44%)
LDLa 1230..1264 CDD:238060 13/34 (38%)
LDLa 1271..1305 CDD:238060 16/34 (47%)
LDLa 1311..1344 CDD:197566 12/32 (38%)
FXa_inhibition 1358..1393 CDD:464251 14/36 (39%)
EGF_CA 1395..1434 CDD:214542 13/38 (34%)
Ldl_recept_b 1483..1523 CDD:459654 8/50 (16%)
LY 1506..1548 CDD:214531 11/59 (19%)
LY 1550..1594 CDD:214531 13/57 (23%)
LY 1596..1637 CDD:214531 10/43 (23%)
FXa_inhibition 1714..1745 CDD:464251 10/30 (33%)
YncE 1754..1984 CDD:442618 38/227 (17%)
LY 1825..1857 CDD:214531 7/62 (11%)
Ldl_recept_b 1888..1932 CDD:459654 10/37 (27%)
LY 1917..1958 CDD:214531 1/2 (50%)
FXa_inhibition 2027..2063 CDD:464251
Vgb 2090..>2298 CDD:443399
LY 2187..2230 CDD:214531
LY 2232..2272 CDD:214531
FXa_inhibition 2351..2387 CDD:464251
Vgb 2416..2647 CDD:443399
LY 2463..2505 CDD:214531
Ldl_recept_b 2524..2565 CDD:459654
LY 2550..2590 CDD:214531
FXa_inhibition 2660..2697 CDD:464251
LDLa 2705..2737 CDD:238060
LDLa 2746..2780 CDD:238060
LDLa 2785..2822 CDD:238060
LDLa 2826..2859 CDD:197566
LDLa 2868..2900 CDD:197566
LDLa 2910..2942 CDD:197566
LDLa 2953..2993 CDD:238060
LDLa 2998..3032 CDD:238060
LDLa <3046..3068 CDD:197566
LDLa 3080..3114 CDD:238060
FXa_inhibition 3126..3155 CDD:464251
vWFA <3152..3195 CDD:469594
LY 3224..3265 CDD:214531
LY 3267..3309 CDD:214531
Ldl_recept_b 3338..3379 CDD:459654
LY 3363..3404 CDD:214531
LY 3405..3446 CDD:214531
LDLa 3517..3549 CDD:238060
LDLa 3558..3589 CDD:197566
LDLa 3598..3630 CDD:197566
LDLa 3639..3671 CDD:197566
LDLa 3724..3759 CDD:238060
LDLa 3764..3798 CDD:238060
LDLa 3802..3834 CDD:197566
LDLa 3847..3879 CDD:238060
LDLa 3890..3920 CDD:197566
LDLa 3933..3967 CDD:238060
LY 4146..4181 CDD:214531
Ldl_recept_b 4202..4243 CDD:459654
LY 4226..4269 CDD:214531
FXa_inhibition 4344..4371 CDD:464251
Blue background indicates that the domain is not in the aligned region.

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