DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11584 and SNAP91

DIOPT Version :9

Sequence 1:	NP_572941.1	Gene:	CG11584 / 32363	FlyBaseID:	FBgn0030541	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001229721.1	Gene:	SNAP91 / 9892	HGNCID:	14986	Length:	907	Species:	Homo sapiens

Alignment Length:	725	Identity:	167/725 - (23%)
Similarity:	251/725 - (34%)	Gaps:	204/725 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QSFQQLVQTQLQQHIQSQIHPQVESIQASVPLASFTIQSSGQQQYQSAPAPAPAPVSIPA----- 97
            |:...|::| |:||:.                   |::.......:.:.||:|...|.||
Human   269 QAPSSLMET-LEQHLN-------------------TLEGKKPGNNEGSGAPSPLSKSSPATTVTS 313

  Fly    98 ----PAPVVNSAP-------APAPAPVEVQQPAPQVIYEAPKPVIATQTAAKNAYLPPAP----- 146
                ||..::::|       |.|..||...:|:..::...| ...:...||..|..||.|
Human   314 PNSTPAKTIDTSPPVDLFATASAAVPVSTSKPSSDLLDLQP-DFSSGGAAAAAAPAPPPPAGGAT 377

  Fly   147 ------------VQQFVPAPEPVVANIAPQQETITTTYNAPAAAPVPAPAPIAIPVPAVQEQHQV 199
                        ....||:...:....||:....|||.....|:   |.|.....|.||..:..:
Human   378 AWGDLLGEDSLAALSSVPSEAQISDPFAPEPTPPTTTAEIATAS---ASASTTTTVTAVTAEVDL 439

  Fly   200 IQQTYSV-PAPAPAVQQSYSAPA-PAPVVQ--QTYSAPAPVVQEQTYTAAAPVQAVQQLTYSAPA 260
            ....::. |..|||..:..:||| |.||..  ...|...|....:....|||     :|...|..
Human   440 FGDAFAASPGEAPAASEGAAAPATPTPVAAALDACSGNDPFAPSEGSAEAAP-----ELDLFAMK 499

  Fly   261 PVTQEQYYSAPASVVQQTSSAPAPAPAPVQEQFYSAPAPAIQQTYSAPAPAPVVQQTYSAPAPAP 325
            |...    |.|......:::.|.||.||       :||||:....:|...|.....|.:..:.|.
Human   500 PPET----SVPVVTPTASTAPPVPATAP-------SPAPAVAAAAAATTAATAAATTTTTTSAAT 553

  Fly   326 QQTYSAPAPAVQ------EQTQVVQSYSAPAPAPVAQ--QTYSYPAPVVQQAPVVQAVAQQAPVV 382
            ..|  || ||:.      |.|..|.:...|..||...  .|.::.:|....:||.::......:.
Human   554 ATT--AP-PALDIFGDLFESTPEVAAAPKPDAAPSIDLFSTDAFSSPPQGASPVPESSLTADLLS 615

  Fly   383 QQSYSAPAPAPVVQQTYSAPAPVVQETIQQAPVIQQ-APVVQQSYSAPAPAPVVQQSYSAPAPVV 446
            ..:::||:||     |.::||.|     ..:.||.. ......|.|.|.||.....|.||.|.::
Human   616 VDAFAAPSPA-----TTASPAKV-----DSSGVIDLFGDAFGSSASEPQPASQAASSSSASADLL 670

  Fly   447 QETIQQAPVIQQAPVVQQSYSAPAPVVQETIQQAPVI-QQAPVVQQSYSA---PAPAPVVQQSYS 507
            ..             ...|:.||:|        :||. .|..::|.::.|   ..|:.....|:.
Human   671 AG-------------FGGSFMAPSP--------SPVTPAQNNLLQPNFEAAFGTTPSTSSSSSFD 714

  Fly   508 -----------APAPAPVVQESIQQAPVIQQSYTAPAPVSI--PEP------------------- 540
                       .|..||..|               |||||:  |.|
Human   715 PSVFDGLGDLLMPTMAPAGQ---------------PAPVSMVPPSPAMAASKALGSDLDSSLASL 764

  Fly   541 ---------------VQQIVQQPQYSGYSYQTPQQAPAPIQQSLPAPAPV------VISAPAPAP 584
                           :|....:.:.:|.:...|:.|||.....:|..||:      ..|.|..|.
Human   765 VGNLGISGTTTKKGDLQWNAGEKKLTGGANWQPKVAPATWSAGVPPSAPLQGAVPPTSSVPPVAG 829

  Fly   585 APAPVQLQQSFVPAPPA----PIQIQQP---AQPIVQYSPPVVQQQVTYTQ--PAPAPIQVAAAA 640
            ||:..|....| ..|||    |:..|||   |||:::  ||.....|..||  |:|.|...:...
Human   830 APSVGQPGAGF-GMPPAGTGMPMMPQQPVMFAQPMMR--PPFGAAAVPGTQLSPSPTPASQSPKK 891

  Fly   641 PVAVSAPAEI 650
            |.|....|::
Human   892 PPAKDPLADL 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11584	NP_572941.1	rne	<209..408	CDD:236766	55/209 (26%)
		rne	<329..539	CDD:236766	53/235 (23%)
		TFIIA	475..>635	CDD:281188	52/225 (23%)
SNAP91	NP_001229721.1	ANTH	21..284	CDD:311541	6/34 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..326		8/40 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	342..380		8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..414		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..525		6/26 (23%)
		Atrophin-1	<595..897	CDD:331285	80/350 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	867..907		10/35 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000