DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12480 and prc

DIOPT Version :9

Sequence 1:	NP_572937.1	Gene:	CG12480 / 32359	FlyBaseID:	FBgn0030537	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_524658.2	Gene:	prc / 43930	FlyBaseID:	FBgn0028573	Length:	1713	Species:	Drosophila melanogaster

Alignment Length:	605	Identity:	124/605 - (20%)
Similarity:	180/605 - (29%)	Gaps:	178/605 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GLAADGGYGLTALSSAP--SSSSSSSSEVVQGGDSSSYQYSKSAEVVPGGDASSYQPAEYTPAHL 120
            |:....|.|.....:.|  .......::...||.:.:.|....::...||...:.||
  Fly  1002 GIGGQTGAGQPGYGAQPGFGGQLGYGNQPGVGGQTGAGQPGYGSQPGVGGQTGAGQP-------- 1058

  Fly   121 KSADVVP--------GGDSSSYQPAEYTPEHLRTVDVAPGVDSSSYQPAEYTPEHLKAAEVVPGG 177
             ...|:|        ||.:::.:|. |..:        ||:..|   |...|.:.......:.||
  Fly  1059 -GYGVIPGFGGQPGIGGQTAAGKPG-YGGQ--------PGIGGS---PVYGTQQGTGGQSGISGG 1110

  Fly   178 DSSSYQPAEYT-PEHLKAAE----VVP--GGDSSSYQPAEYTPAHLKAAVPAAIGADT------Y 229
                 ||...| |....|.:    .:|  ||.:::.||. |.|..     ...||..|      |
  Fly  1111 -----QPGYGTQPGQTGAGQPGYGSLPGTGGQATAGQPG-YGPGS-----QPGIGGQTVGGHGGY 1164

  Fly   230 APVPAAIGADTYTPEKFIPQDVQEAHYKYNQEQEQGAAVPGGDSSS----YQPAEY-----TPAY 285
            ...|...||..|..:                        |||...:    .||.:.     .|.|
  Fly  1165 GSQPGIGGAPVYGTQ------------------------PGGGGQTGVIGGQPGQIGDRVGQPGY 1205

  Fly   286 LKQTSSATVDAKVVPGGDSSSYQPAEYTPAHLKAAVPAAIGA------------DTYAPVPAAIG 338
            ..||.....              |..||..  ...||.|:|.            |.::...::||
  Fly  1206 GTQTGQIGA--------------PGRYTDG--SQTVPGAVGTGGVVAAGTSGADDAFSQAESSIG 1254

  Fly   339 ADTYTPEKFIPQDVQEAHYKYN----QEQEQGAAVPGGD-SSSYQPAEYTPEHLKAAEVVPGGDS 398
            ..         |....|..|.|    :.|..|....||. |:|...::  .:...:|:|....|.
  Fly  1255 DG---------QASASAQGKKNGGTAKTQVSGTYSSGGTFSASAMTSD--ADRAASAQVTGNADG 1308

  Fly   399 S-SYQPAEYTPAHLKASVPAAIGADTYAPVPAAIGADTYTPEKFIPQDVQEAHYKYIQEQEQEQG 462
            : |.......||..:|.|..|....|.|...:.         ..|.|...|.|       ..::|
  Fly  1309 AVSQSQGSGGPAQSQAQVQVAKDGGTKASSQSG---------GIIQQSQSEVH-------ANDKG 1357

  Fly   463 AAVPG-----GDSSSYQPAEYTPAQLKKSVVASTA--ASAISGADSSSYQSAVSQTSYVNSQAKT 520
            .....     |.:||.....:.|.|....:.|:..  ||:.||..||...|.:..||
  Fly  1358 GLADAQSSGPGQTSSQAQIGFRPGQEANPIAANGGGQASSSSGTHSSQSSSQIHGTS-------- 1414

  Fly   521 IVAGSSSSSYQSAQPIAAYVQGQTPVVIGANTITPAHLYEEPTSNGIEEFNPDTHVPVAIGADTI 585
                |...||..|...|:..:.|......||    ..|:     |.|.:|..:.:. |...||.:
  Fly  1415 ----SFGVSYHGAAQSASGTKEQVATYREAN----RELF-----NTISQFGNNANA-VTDRADAV 1465

  Fly   586 TPAHLQASYSKSVQETQYAS 605
            .........|..|.|.|..|
  Fly  1466 YSGPALTDESDRVPEAQLKS 1485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12480	NP_572937.1	PHA03247	<112..395	CDD:223021	65/329 (20%)
prc	NP_524658.2	Pericardin_rpt	159..191	CDD:284468
		Pericardin_rpt	176..208	CDD:284468
		Loricrin	216..534	CDD:292475
		Pericardin_rpt	227..259	CDD:284468
		Pericardin_rpt	244..276	CDD:284468
		Pericardin_rpt	295..326	CDD:284468
		Pericardin_rpt	312..344	CDD:284468
		Pericardin_rpt	346..378	CDD:284468
		Pericardin_rpt	363..395	CDD:284468
		Pericardin_rpt	397..429	CDD:284468
		Pericardin_rpt	431..463	CDD:284468
		Pericardin_rpt	465..497	CDD:284468
		Pericardin_rpt	482..514	CDD:284468
		Pericardin_rpt	516..547	CDD:284468
		Pericardin_rpt	533..565	CDD:284468
		Pericardin_rpt	567..598	CDD:284468
		Pericardin_rpt	584..616	CDD:284468
		Pericardin_rpt	624..656	CDD:284468
		Pericardin_rpt	641..673	CDD:284468
		Pericardin_rpt	841..873	CDD:284468
		Pericardin_rpt	893..929	CDD:284468
		Glutenin_hmw	925..>1382	CDD:281191	93/478 (19%)
		Pericardin_rpt	948..992	CDD:284468
		Pericardin_rpt	977..1009	CDD:284468	1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BNT3
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900