DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mamo and SP3

DIOPT Version :9

Sequence 1:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster
Sequence 2:	NP_003102.1	Gene:	SP3 / 6670	HGNCID:	11208	Length:	781	Species:	Homo sapiens

Alignment Length:	860	Identity:	177/860 - (20%)
Similarity:	284/860 - (33%)	Gaps:	314/860 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   857 TQYNKHAQQPQQPQTGGATGSGVGGLGGSPTAGASFNLRYPTPTAFYQQQQQQGKGA-------- 913
            |...|..:|.:.......:|.|.||.||.              ..:.|||||.|.||
Human     2 TAPEKPVKQEEMAALDVDSGGGGGGGGGH--------------GEYLQQQQQHGNGAVAAAAAAQ 52

  Fly   914 KSSPSPQQMATSSTTVMSNDS-GEDSCKRSSADSDEVTIMELPSERSAQLYKESLEQLLQRQRRT 977
            .:.|||..:..::.:.:...| |:|..:.::|
Human    53 DTQPSPLALLAATCSKIGPPSPGDDEEEAAAA--------------------------------- 84

  Fly   978 PILAGSGSGSGSGTGSGSVIVDAAGLRQYTQLLLAGAGSGGASDLKEKSSSSSTSSTPPLLTQQL 1042
               ||:.:.:|: ||.                 ||.|..|||.:..|     ..|:||..:..:.
Human    85 ---AGAPAAAGA-TGD-----------------LASAQLGGAPNRWE-----VLSATPTTIKDEA 123

  Fly  1043 SQMLKSPSDTCSS--------------LFSSSGGGTGSTGPGITGETIEEETRCVVCNAHFPNVW 1093
            ..:::.||...||              :||.:.|...|.|   |..:::.:.        .|.:
Human   124 GNLVQIPSAATSSGQYVLPLQNLQNQQIFSVAPGSDSSNG---TVSSVQYQV--------IPQI- 176

  Fly  1094 LLEQHAALQHPHVGPGEEKPFICEQCGQSYRYRSAYAKHKEQNHRARLPADKLFTCDVCGMQFRY 1158
               |.|..|...:|               :...|......:::.:.::         :.|.....
Human   177 ---QSADGQQVQIG---------------FTGSSDNGGINQESSQIQI---------IPGSNQTL 214

  Fly  1159 LKSFKKHRLNHALERLHGKKSVGV---IGRLG-----GSGSGPSSSAISVSVAAPTSVSASGSVT 1215
            |.|              |..|..:   |.:.|     |...|.||......|.|...:...|::|
Human   215 LAS--------------GTPSANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNIT 265

  Fly  1216 -----SVDQDVVTSSQEPMLADEGEDLRVNVKREGTA------DEQSAESRANDLEEHEQDN--- 1266
                 |||.|.:..|........|.:...::...|.|      .|::.|..:.|:.|...|.
Human   266 FVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDINETNTDTDLF 330

  Fly  1267 -----------TVDSAGITMLYQDNNSSASASTSATEPNISSSDG--IHS-TNKRSRLHHLETDP 1317
                       |:||.||  |.|:.|   |.:||:.:.:.|...|  |.| .::.::..:::...
Human   331 VPTSSSSQLPVTIDSTGI--LQQNTN---SLTTSSGQVHSSDLQGNYIQSPVSEETQAQNIQVST 390

  Fly  1318 SYPHHHHHHHHHHHQQQHHQAQHQHHNPQSQLPTHLGHVSLPLVATSAAGSSSSAAAAAVVAAAQ 1382
            :.|           ..||.|.| :...|.||.....|.....:....|:|.:.|..|   :...|
Human   391 AQP-----------VVQHLQLQ-ESQQPTSQAQIVQGITPQTIHGVQASGQNISQQA---LQNLQ 440

  Fly  1383 AQVSSG--------ATGSGATG------SGAPGSGNVG-----------------SAGSSGAGGG 1416
            .|::.|        .|.||...      .|.....|:.                 :.|...|||
Human   441 LQLNPGTFLIQAQTVTPSGQVTWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGG- 504

  Fly  1417 ISSLSSLTSLINAERIPNEQFLGLN-----------------------------PQEASI----- 1447
              :.:|....::..::||.|.:.:|                             |:|..:
Human   505 --AFTSTPVSLSTGQLPNLQTVTVNSIDSAGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDST 567

  Fly  1448 -----LNFLRVDAAERQRDKR----PATSRFAC-------------------------PFCGKCV 1478
                 |..|||...:.:.|::    ....|.||                         |.|||..
Human   568 LNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVY 632

  Fly  1479 RSKENLKLHVRKHTGERPFVC--LFCGRAFGGKSDLTRHLRIHTGERPYHCESCGKCFARADYLS 1541
            ....:|:.|:|.|:|||||||  ::||:.|....:|.||.|.||||:.:.|..|.|.|.|:|:|:
Human   633 GKTSHLRAHLRWHSGERPFVCNWMYCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLA 697

  Fly  1542 KHLTTH-----IHNA 1551
            ||:.||     ||::
Human   698 KHIKTHQNKKGIHSS 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB	21..118	CDD:279045
		BTB	32..118	CDD:197585
		C2H2 Zn finger	1082..1105	CDD:275368	4/22 (18%)
		C2H2 Zn finger	1116..1137	CDD:275368	1/20 (5%)
		C2H2 Zn finger	1149..1169	CDD:275368	3/19 (16%)
		zf-C2H2	1469..1491	CDD:278523	9/46 (20%)
		C2H2 Zn finger	1471..1491	CDD:275368	8/44 (18%)
		zf-H2C2_2	1483..1506	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1499..1519	CDD:275368	8/21 (38%)
		zf-H2C2_2	1511..1536	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1527..1547	CDD:275368	9/19 (47%)
SP3	NP_003102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		17/64 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..88		6/58 (10%)
		Transactivation domain (Gln-rich)	138..237		19/151 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338		6/36 (17%)
		Transactivation domain (Gln-rich)	350..499		30/166 (18%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	461..469		0/7 (0%)
		Repressor domain	534..620		10/85 (12%)
		C2H2 Zn finger	623..645	CDD:275368	7/21 (33%)
		COG5048	<636..718	CDD:227381	35/77 (45%)
		zf-H2C2_2	637..664	CDD:290200	14/26 (54%)
		C2H2 Zn finger	653..675	CDD:275368	8/21 (38%)
		zf-H2C2_2	667..690	CDD:290200	11/22 (50%)
		zf-C2H2	681..703	CDD:278523	9/21 (43%)
		C2H2 Zn finger	683..703	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910