DRSC/TRiP Functional Genomics Resources

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Protein Alignment mamo and SP1

DIOPT Version :9

Sequence 1:NP_572932.2 Gene:mamo / 32353 FlyBaseID:FBgn0267033 Length:1553 Species:Drosophila melanogaster
Sequence 2:NP_612482.2 Gene:SP1 / 6667 HGNCID:11205 Length:785 Species:Homo sapiens


Alignment Length:802 Identity:167/802 - (20%)
Similarity:268/802 - (33%) Gaps:245/802 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   878 GVGG-LGGSPTAGASFNLRYPTPTAFYQQQQQQGKGAKSSPSPQQMATSSTTVMSNDSGEDSCKR 941
            |||| .||:...|.:|:....:.|.  ......|.|.:|.|||..:..:            :|.|
Human    20 GVGGNNGGNGNGGGAFSQARSSSTG--SSSSTGGGGQESQPSPLALLAA------------TCSR 70

  Fly   942 SSADSDEVTIMELPSERSAQLYKESLEQLLQRQRRTPILAGSGSGSGSGTGSGSVIVDAAGLRQY 1006
                      :|.|:|.|                      .:..|.....|:|.:.:.|..|.|.
Human    71 ----------IESPNENS----------------------NNSQGPSQSGGTGELDLTATQLSQG 103

  Fly  1007 TQLLLAGAGSGGASDLKEKSSSSSTSSTPPLLTQQLSQMLKSPSDTCSSLFSSSGGGTGSTGPGI 1071
            .......:.|.||:...::.|.|||:.:             :.|::..:...|.|....:..|.:
Human   104 ANGWQIISSSSGATPTSKEQSGSSTNGS-------------NGSESSKNRTVSGGQYVVAAAPNL 155

  Fly  1072 TGETIEEETRCVVCNAHF---PNVWLLE----QHAA----LQHPHVG-----PGEEKPFICEQCG 1120
            ..:.:......|:.|..:   |....::    |.||    :|....|     ||..:..|..: |
Human   156 QNQQVLTGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNR-G 219

  Fly  1121 QSYRYRSAYAKHKEQNHRARLPADKLFTCDVCGMQFRYLKSFKKHRLNHALERLHGKKSVGVIGR 1185
            ......:|.....:|    .:|...|.. :|...|.:|        :.:....|:|..::..:..
Human   220 SGGNIIAAMPNLLQQ----AVPLQGLAN-NVLSGQTQY--------VTNVPVALNGNITLLPVNS 271

  Fly  1186 LGGSGSGPSSSAISVSVAAPTSVSASGSVTSVDQDV---VTSSQEPMLADEGEDLRVNVKREGTA 1247
            :..:...|||.|:        ::|:|||..|..|.|   .|.|...:::.:             |
Human   272 VSAATLTPSSQAV--------TISSSGSQESGSQPVTSGTTISSASLVSSQ-------------A 315

  Fly  1248 DEQSAESRANDLEEHEQDNTVDSAGITMLYQDNNSSASASTSATEPNISSSDGIHSTNKRSRLHH 1312
            ...|..:.||   .:....|..:.|| |.:..:.||.:.|...|...:|...|..:.|    :..
Human   316 SSSSFFTNAN---SYSTTTTTSNMGI-MNFTTSGSSGTNSQGQTPQRVSGLQGSDALN----IQQ 372

  Fly  1313 LETDPSYPHHHHHHHHHHHQQ-------------------------------------------- 1333
            .:|...............:||                                            
Human   373 NQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQN 437

  Fly  1334 ---------------------------QHHQAQH-QHHNPQSQLPTHLGHVSLPLVATSAAGSSS 1370
                                       |..|.|: |..|||:|..|     ..|:...|...:||
Human   438 LQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQNPQAQTIT-----LAPMQGVSLGQTSS 497

  Fly  1371 SAAAAAVVAAAQAQVSSGATGSGATGSGAPG--SGNVGSAGSSGAGGGISSLSSL-TSLINAERI 1432
            |......:|:|.:..:...|.:.|..|..||  :.|:.:.|:||.  .:..:..| .::.||...
Human   498 SNTTLTPIASAASIPAGTVTVNAAQLSSMPGLQTINLSALGTSGI--QVHPIQGLPLAIANAPGD 560

  Fly  1433 PNEQFLGLNPQEASILNFLRVDAA-----ERQRDKRPATSR------FACPF------------- 1473
            ...| |||:....   :.:..|.|     |...|.:|...|      ..||:             
Human   561 HGAQ-LGLHGAGG---DGIHDDTAGGEEGENSPDAQPQAGRRTRREACTCPYCKDSEGRGSGDPG 621

  Fly  1474 -----------CGKCVRSKENLKLHVRKHTGERPFVCL--FCGRAFGGKSDLTRHLRIHTGERPY 1525
                       |||......:|:.|:|.|||||||:|.  :||:.|....:|.||.|.||||:.:
Human   622 KKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPFMCTWSYCGKRFTRSDELQRHKRTHTGEKKF 686

  Fly  1526 HCESCGKCFARADYLSKHLTTH 1547
            .|..|.|.|.|:|:||||:.||
Human   687 ACPECPKRFMRSDHLSKHIKTH 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mamoNP_572932.2 BTB 21..118 CDD:279045
BTB 32..118 CDD:197585
C2H2 Zn finger 1082..1105 CDD:275368 7/33 (21%)
C2H2 Zn finger 1116..1137 CDD:275368 3/20 (15%)
C2H2 Zn finger 1149..1169 CDD:275368 3/19 (16%)
zf-C2H2 1469..1491 CDD:278523 8/45 (18%)
C2H2 Zn finger 1471..1491 CDD:275368 8/43 (19%)
zf-H2C2_2 1483..1506 CDD:290200 13/24 (54%)
C2H2 Zn finger 1499..1519 CDD:275368 8/21 (38%)
zf-H2C2_2 1511..1536 CDD:290200 12/24 (50%)
C2H2 Zn finger 1527..1547 CDD:275368 10/19 (53%)
SP1NP_612482.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..93 24/118 (20%)
Repressor domain 2..82 21/107 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..141 8/44 (18%)
Transactivation domain A (Gln-rich) 146..251 19/110 (17%)
Transactivation domain B (Gln-rich) 261..495 43/267 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 329..395 14/70 (20%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 462..470 2/7 (29%)
Transactivation domain C (highly charged) 496..610 29/119 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 567..598 6/33 (18%)
VZV IE62-binding 619..785 37/90 (41%)
C2H2 Zn finger 628..650 CDD:275368 6/21 (29%)
zf-H2C2_2 642..669 CDD:290200 14/26 (54%)
C2H2 Zn finger 658..680 CDD:275368 8/21 (38%)
zf-H2C2_2 672..695 CDD:290200 11/22 (50%)
zf-C2H2 686..708 CDD:278523 10/21 (48%)
C2H2 Zn finger 688..708 CDD:275368 10/19 (53%)
Domain D 708..785 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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