DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mamo and Hic2

DIOPT Version :9

Sequence 1:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster
Sequence 2:	NP_849253.2	Gene:	Hic2 / 58180	MGIID:	1929869	Length:	619	Species:	Mus musculus

Alignment Length:	868	Identity:	184/868 - (21%)
Similarity:	266/868 - (30%)	Gaps:	306/868 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   715 SHSRHM-----QQRSASAGGGLGGDLDYRASHESLLRNFSSPMSAMAASRCPTPFAFPFSPLGL- 773
            |||:.:     |||   |.|.|   .|.....|:.:  |.:..:.:|||      :..|..|.|
Mouse    27 SHSKQLLLQLNQQR---AKGFL---CDVIIMVENSI--FRAHKNVLAAS------SIYFKSLVLH 77

  Fly   774 -SLFDIDPSRILSLLHHQTWLAEEALRTRGLLTAPKDFPHRFTTLSDLLTKDYQPGAGQPMVTAT 837
             :|.::|...:.|.:..|            :|.        |.....||..|      ||.....
Mouse    78 DNLINLDTDMVSSTVFQQ------------ILD--------FIYTGKLLPSD------QPSEPNF 116

  Fly   838 ATATTASSTSQVSASRSGDTQYNKHAQQPQQPQTGGATGSGVGGLGGSPTAGASFNLRYPTPTAF 902
            :|..||:|..|:....:...:..|.|.:|..|...|..|.      |.||.....:      ||.
Mouse   117 STLLTAASYLQLPELAALCRRKLKRAGKPFGPGRVGTAGI------GRPTRSQRLS------TAS 169

  Fly   903 YQQQQQQG--KGAKSSPSPQQMATSSTTVMSNDSGEDSCKRSSADSDEVTIMELPSERSAQLYKE 965
            ..|.:..|  ...|..|:||::..:        .|.|         ||:.:.....|.:..|
Mouse   170 VIQARFPGLVDVRKGHPAPQELPQA--------KGSD---------DELFLGTSTQESTHGL--- 214

  Fly   966 SLEQLLQRQRRTPILAGSGSGSGSGTGSGSVIVDAAGLRQYTQLLLAGAGSGGAS-----DLKEK 1025
                            |.|..:|...|.|.......|            .|||..     ||.:|
Mouse   215 ----------------GLGGPAGGEMGLGGCSTSTNG------------SSGGCEQELGLDLSKK 251

  Fly  1026 SSSSSTSSTPPLLT----QQLS-QMLKSPSDTCSSLFSSSGGGTGSTGPGITGETIEEETRCVVC 1085
            |.....::..|.||    .||| ...:||:.|          .|.:...|.:...:|
Mouse   252 SPPLPPTTPGPHLTPEDPAQLSDSQRESPAPT----------STSALPVGNSASFVE-------- 298

  Fly  1086 NAHFPNVWLLEQHAALQHPHVGPGEEKPFICEQCGQSYRYRSAYAKHKEQNHRARLPADKLFTCD 1150
                                :|...|:|...|..              |:||.:.|...
Mouse   299 --------------------LGATPEEPMDVEGA--------------EENHLSLLEGQ------ 323

  Fly  1151 VCGMQFRYLKSFKKHRLNHALERLHGKKSVGVIG------RLGGSGSGPSSSAISVSVAAPTSV- 1208
              |.|.|  ||     |.|:..:....|...|.|      ..|..||.|...........|..|
Mouse   324 --GGQPR--KS-----LRHSARKKDWNKKEPVAGSPFDRRETGSKGSCPGEEGEGTGDRVPNGVL 379

  Fly  1209 --SASGSVTSVDQDVVTSSQEPMLADEGEDLRVNVKREGTADEQSAESRANDLEEHEQDNTVDSA 1271
              ||.|...|              |..|              |||...:  :.||:.:|.:.||.
Mouse   380 ASSAGGGGPS--------------ASYG--------------EQSFPCK--EEEENGKDGSEDSG 414

  Fly  1272 GITMLYQDNNSSASASTSATEPNISSSDGIHSTNKRSRLHHLETDPSYPHHHHHHHHHHHQQQHH 1336
                  |..:...|..|.|                                     |:.::|:.:
Mouse   415 ------QSGSEGGSGHTGA-------------------------------------HYVYRQEGY 436

  Fly  1337 QAQHQHHNPQSQLPTHLGHVSLPLVATSAAGSSSSAAAAAVVAAAQAQVSSGATGSGATGSGAPG 1401
            :......|....:|...|.            .||....|.|....:.::.....|:..||||
Mouse   437 ETVSYGDNVYVCIPCAKGF------------PSSEQLNAHVETHTEEELFIKEEGAYETGSG--- 486

  Fly  1402 SGNVGSAGSSGAGGGISSLSSLTSLINAERIPNEQFLGLNPQEASILNFLRVDAAE-RQRDKRPA 1465
                      ||......||:.::...|:.         .|.:.|:......|.|. ||.:|...
Mouse   487 ----------GAEEEAEDLSTPSAAYTADS---------RPFKCSVCEKTYKDPATLRQHEKTHW 532

  Fly  1466 TSR-FACPFCGKCVRSKENLKLHVRKHTGERPFVCLFCGRAFGGKSDLTRHLRIHTGERPYHCES 1529
            .:| |.|..|||....:..:..|:|.|.|.:||.|..||..|..:..||.|:|:|:||:||.|:.
Mouse   533 LTRPFPCNICGKMFTQRGTMTRHMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQL 597

  Fly  1530 CGKCFARADYLSKHLTTHIHNAP 1552
            ||..|.:...|..||  .:|.:|
Mouse   598 CGGKFTQQRNLISHL--RMHTSP 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB	21..118	CDD:279045
		BTB	32..118	CDD:197585
		C2H2 Zn finger	1082..1105	CDD:275368	0/22 (0%)
		C2H2 Zn finger	1116..1137	CDD:275368	2/20 (10%)
		C2H2 Zn finger	1149..1169	CDD:275368	6/19 (32%)
		zf-C2H2	1469..1491	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1471..1491	CDD:275368	6/19 (32%)
		zf-H2C2_2	1483..1506	CDD:290200	9/22 (41%)
		C2H2 Zn finger	1499..1519	CDD:275368	8/19 (42%)
		zf-H2C2_2	1511..1536	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1527..1547	CDD:275368	7/19 (37%)
Hic2	NP_849253.2	BTB	40..140	CDD:279045	29/139 (21%)
		BTB	47..141	CDD:197585	25/127 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..293		34/170 (20%)
		Binding to CtBP. /evidence=ECO:0000250	247..249		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..426		37/183 (20%)
		C2H2 Zn finger	448..468	CDD:275368	6/31 (19%)
		zf-C2H2	509..531	CDD:278523	6/21 (29%)
		C2H2 Zn finger	511..531	CDD:275368	6/19 (32%)
		zf-C2H2	537..559	CDD:278523	7/21 (33%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		zf-H2C2_2	552..576	CDD:290200	10/23 (43%)
		COG5048	563..>617	CDD:227381	23/55 (42%)
		C2H2 Zn finger	567..587	CDD:275368	8/19 (42%)
		zf-H2C2_2	580..604	CDD:290200	13/23 (57%)
		C2H2 Zn finger	595..615	CDD:275368	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000