DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mamo and rib

DIOPT Version :9

Sequence 1:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster
Sequence 2:	NP_001261085.1	Gene:	rib / 44855	FlyBaseID:	FBgn0003254	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	162/727 - (22%)
Similarity:	264/727 - (36%)	Gaps:	154/727 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YCLRWNNYQSNLLGVFSQLLQDGSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHPEGHLI 70
            |||||||:|:||:.:...|.:.||.||.:||..: ...:||:|||:|.|.|||.:..:.|:.|..
  Fly    18 YCLRWNNHQTNLVQILHALHEVGSYVDCSLVVDD-EQFQAHRVVLAANSPYFQHILKDVPQDHCS 81

  Fly    71 VILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGLAE---MTNQNTTLREPEREP 132
            :||..|:..|:..|:::||.||..|...|...:|:||:.|:||||.:   ..|..:.........
  Fly    82 IILPGVKGFEIAALLQYMYTGETTVTKSQEPEILRTAKELQVKGLYDNLMKFNHASVTPTSSSGA 146

  Fly   133 DRLRPQGGGGSGGSAHKAAD----SPAAALDATAA-----------------TQAATATATATAA 176
            ...:||.|..|..|:...:.    ||:||:.::.:                 .|...:.:...|.
  Fly   147 GGAKPQNGSASNHSSSVISTSTHISPSAAISSSCSPPPPPQFGYQPGYSHYPQQQPMSASQIPAG 211

  Fly   177 AATSTSTSAT-SAAATAAATAATSASTTATAAAGSSNTTTTTAATTT-----ATCATAATSTAAT 235
            .|..|.|.|| .:||:.|..|......|.:|||...|:...:||...     ...|.::...:..
  Fly   212 EAPLTPTQATPHSAASGAGEAGGQWPLTPSAAAAMLNSVYESAADMNPLKRKKLSAISSMLLSGN 276

  Fly   236 SSSSSVTSAAAAAAAAASAS-------------------------GVAHSEEATS-SSSSTGGQK 274
            ..:..:.:..|.|..|.|:.                         ||:..|...| :.|..||.|
  Fly   277 RDTPILRNVLAQANPADSSQPGPMNANGEKTPTHPHQNTQLPAGLGVSGGERNHSFNGSDYGGDK 341

  Fly   275 REAS---DRSSPTPAKRSSRMHPADKVDVAEDREQEQNQADELLSEELLGRNLKDEEDDDVDELD 336
            ...|   |||......:|....|..|      |.::..:||.:.:.:.:        .:.:..|.
  Fly   342 EPLSPYTDRSFEEETGQSGGKKPEWK------RYKQYTRADMMCAIQAV--------REGMSALQ 392

  Fly   337 ENEETKLRGRDEDDDDEDEEEDTPMPLDLYQRPNV--------EPKSAAAATAAQQGGSNSLSGS 393
            .:.:..|..|              ...|..::.|:        .||.:.....:.||.|.|.:.:
  Fly   393 ASRKYGLPSR--------------TLYDKVRKLNITTGRGTHRTPKRSPPGAESSQGFSYSAAAA 443

  Fly   394 SNACHTNSSSNSNNNNNNNNNSSSNNNNNTSSGKTSASSNGGTASSGGTADSVVAVDDDDDDDDG 458
            : |.|       |..:.:.::|....:....    ...::.|...:  ...|..|:.|
  Fly   444 A-AAH-------NYGHGHGHHSEVKRDQKVD----HVPAHHGMPPT--IPPSAAALLD------- 487

  Fly   459 GHHHQRQVMDDRLEQDVDEEDLDDDVVVVGPATAMARGIAQRLAHQNLQRLHHTHHHAQHQHSQH 523
             |...:|.:::|.......|.|.          |||...|   ||....||..:......:.:.|
  Fly   488 -HAFLQQALENRGGDMAGREALH----------AMALAAA---AHAAANRLSSSPAEMDQRSNGH 538

  Fly   524 --HHPHSQHHHTPHHQQHHTHSDDEDAMPVIAKSEILD--DDYDDEMDLEDDDEADNS------- 577
              ..|..|..|.||.|:......::....:|.:....|  :|.|||.|.|.:...|.|
  Fly   539 GMRSPSPQGRHYPHEQEAMDLEMEKHEQNIIKRERDQDEREDADDEEDHEQEHVEDLSLARKERP 603

  Fly   578 ---------SNDLGLNMKMGSGGAGGGGGVDLSTGSTLIPSPL---ITLPSSSAAAAAAAAAAME 630
                     ....|:.|...|..|.|...||..:....:|..|   :.....:.|.|......|.
  Fly   604 PSPYSPQPTEAGAGVIMHASSASANGKDHVDYPSSPQFVPIGLKRELMEGEDAQARADXLTLTMA 668

  Fly   631 SQRSTPAMSAAQ 642
            .|.:|.::.:.:
  Fly   669 WQYATDSLDSLE 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB	21..118	CDD:279045	38/99 (38%)
		BTB	32..118	CDD:197585	34/88 (39%)
		C2H2 Zn finger	1082..1105	CDD:275368
		C2H2 Zn finger	1116..1137	CDD:275368
		C2H2 Zn finger	1149..1169	CDD:275368
		zf-C2H2	1469..1491	CDD:278523
		C2H2 Zn finger	1471..1491	CDD:275368
		zf-H2C2_2	1483..1506	CDD:290200
		C2H2 Zn finger	1499..1519	CDD:275368
		zf-H2C2_2	1511..1536	CDD:290200
		C2H2 Zn finger	1527..1547	CDD:275368
rib	NP_001261085.1	BTB	33..133	CDD:279045	38/100 (38%)
		BTB	44..133	CDD:197585	34/89 (38%)
		HTH_psq	373..417	CDD:283007	7/65 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010