DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mamo and br

DIOPT Version :9

Sequence 1:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster
Sequence 2:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	1294	Identity:	292/1294 - (22%)
Similarity:	430/1294 - (33%)	Gaps:	501/1294 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SEHYCLRWNNYQSNLLGVFSQLLQDGSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHPEG 67
            ::|:|||||||||::...|..|..|.:.|||||.| ||.||:||:|||||||.||:.|....|..
  Fly     4 TQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLAC-EGRSIKAHRVVLSACSPYFRELLKSTPCK 67

  Fly    68 HLIVILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGL----AEMTNQ------- 121
            |.:::|:||.|.:|..||||:|.|||||....|.:.|||||.|:|.||    ||.|:.
  Fly    68 HPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQIQN 132

  Fly   122 --NTTLREPEREPDRLRPQGGGGS----GGS----AHKAADSPAAALDATAATQAATATATATAA 176
              |:..|.|.....:..|....||    |||    :.:.|.||               ..||..:
  Fly   133 LANSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSP---------------PPTAVPS 182

  Fly   177 AATSTSTSATSAAA----TAAATAATSASTTATAAAGSSNTTTTTAATTTATCATAATSTAATSS 237
            ..:..:.......|    ::||.||...|.......||.|:..          .:.|..:.:.::
  Fly   183 LPSHINNQLLKRMAMMHRSSAAAAAEETSHAFKRLRGSDNSLP----------LSGAVGSGSNNN 237

  Fly   238 SSSVTSAAAAAAA----AASASGVAHSEEATSSSSSTGGQKREASDRSSPT-------------P 285
            |..:....|.:|:    .|..|.:.|     .::::|...|.|  .|:.||             .
  Fly   238 SPDLPPLHARSASPQQTPADFSTIKH-----HNNNNTPPLKEE--KRNGPTGNGNSGNGNGNGNG 295

  Fly   286 AKRSSRMHPADKVDVAEDREQEQNQADELLSEEL------LGRNLKDE-EDDDVDELDENEETK- 342
            |...:.:..:||:.........:..||::.||.:      ...|..|| .:|...|.|.|..:.
  Fly   296 ASNGNGISISDKLGSLTPSPLARAGADDVKSEPMDMVCSNNNANANDEHSNDSTGEHDANRSSSG 360

  Fly   343 -------LRGRDEDDDD------------EDEEEDTPMPLDLYQRPNVEP-----------KSAA 377
                   ..|.||:..|            ....|:.......:..||::|           :|..
  Fly   361 DGGKGSLSSGNDEEIGDGLASHHAAPQFIMSPAENKMFHAAAFNFPNIDPSALLGLNTQLQQSGD 425

  Fly   378 AATAAQQGGSNSL------SGSSNACHTNSSSNSNNNNNNN-----------------NNSSSNN 419
            .|.:.|.|.:.||      .|.|....:|||||:||||:||                 .:.|:.:
  Fly   426 LAVSPQGGSTGSLLSGVIVPGGSGGTPSNSSSNNNNNNSNNQQQKVEQQSSPHQLLQQQHHSTPH 490

  Fly   420 NNNTSSGKTSASSNGGTASSGGTADSVVAVDDDDD--------DDDGGH---------HHQRQVM 467
            .|:....:....|.||:..|   :|..:|...:..        .|.|||         :|:|:..
  Fly   491 TNSPQLKQEQPKSGGGSCKS---SDLHIAAGSERSLSRSSQGMPDAGGHSATPSPTAAYHKRERE 552

  Fly   468 DDRLEQDVDEEDLDDDVVVVGPATAMARGIAQRLAHQ-NLQR------------LHHTHHHAQHQ 519
            .:| |::.:.|                |...:.|.|: :|:|            .||: |..||.
  Fly   553 RER-ERERERE----------------RERERSLDHERDLERPGGTGSPPPPPPSHHS-HFGQHP 599

  Fly   520 HS---QHHHPHSQHHH----TPHHQQHHTHSDDEDAMPVIAKSEILDDDYDDEMDLEDDDEADNS 577
            .|   .||..|:.||.    ..||...|.|
  Fly   600 LSLLPSHHQLHATHHELSAAAAHHAHAHAH----------------------------------- 629

  Fly   578 SNDLGLNMKMGSGGAGGGGGVDLSTGSTLIPSPLITLPSSSAAAAAAAAAAME------SQRSTP 636
                                                  ::.|.|.|.|.:.||      .:|::.
  Fly   630 --------------------------------------AAHAHALARAGSPMEHHHLLHHRRASL 656

  Fly   637 AMSAAQAAGAGASDLSIGGCGGRPASRSSRDGGGNDGGRGGASSSSLLSPGTV-AN--LLPVQSV 698
            :.|.|.::.:||     ||.||         |.|..||.||:..||:.:.... ||  |||   :
  Fly   657 SPSGAVSSASGA-----GGRGG---------GAGGPGGPGGSLLSSVRAQDVAQANRLLLP---L 704

  Fly   699 PLSLKKEID-CSE--DDNSSHSRHMQQRSASAGGGLGGDLDYRASHESLLRNFSSPMSAMAASRC 760
            ||:.....| |.:  ....:..||.:|:                 |...|.|
  Fly   705 PLNACHRCDVCGKLLSTKLTLKRHKEQQ-----------------HLQPLNN------------- 739

  Fly   761 PTPFAFPFSPLGLSLFDIDPSRILSLLHHQTWLAEEALRTRGLLTAPKDFPHRFTTLSDLLTKD- 824
                                 .:.:|.|       :..||...|...|...||       ..|:
  Fly   740 ---------------------AVCNLCH-------KVFRTLNSLNNHKSIYHR-------RQKNH 769

  Fly   825 ---YQPGAGQPMVTATATATTASSTSQVSASRSGDTQYNKHAQQPQQPQTGGATGSGVGG----- 881
               :..|||.....:..:....|.:|..:|:.:.:...|          .||.:..|.||
  Fly   770 HSYFHHGAGVSQAGSPGSRLHQSLSSLSAAAAAANNSVN----------VGGGSVGGAGGNAVAA 824

  Fly   882 ----------------LGGSPTAG--ASFNLRYPTPTAFYQQQQQQGKGAKSSP----------- 917
                            :|.:..||  ||..|:.   .|.:||||||     |||
  Fly   825 AAAAAAAAAELLLSPIVGAAAVAGGTASSTLQL---AAAHQQQQQQ-----SSPGIVKPCMDFLX 881

  Fly   918 SPQQMATSSTTVMSNDSGEDSCKRSSADSDEVTIMELPSERSAQLYKESLEQLLQRQRRTPILAG 982
            ..||:......|..|:|...:...::|.:                                 ..|
  Fly   882 DQQQLLQQLFHVALNNSAAAAAAAAAAAA---------------------------------AGG 913

  Fly   983 SGSGSGSGTGSGSVIVDAAGLRQYTQLLLAGAGSGGASDLKEKSSSSSTSSTPPLLTQQLSQMLK 1047
            ||.|.| |.|:|...::..| ::|          ||.         ...|.||   |..|:|
  Fly   914 SGGGPG-GVGAGPESINGGG-QEY----------GGV---------QGPSGTP---TVDLTQ--- 951

  Fly  1048 SPSDTCSSLFSSSGGGTGSTGPGITGETIEEETRCVVCNAHFPNVWLLEQH-AALQHPH 1105
                    |..::|||..|....:              ..|.|: .|..|| .:.||||
  Fly   952 --------LEHAAGGGGFSAAAAL--------------QHHLPH-HLAHQHPMSHQHPH 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB	21..118	CDD:279045	53/100 (53%)
		BTB	32..118	CDD:197585	49/89 (55%)
		C2H2 Zn finger	1082..1105	CDD:275368	7/23 (30%)
		C2H2 Zn finger	1116..1137	CDD:275368
		C2H2 Zn finger	1149..1169	CDD:275368
		zf-C2H2	1469..1491	CDD:278523
		C2H2 Zn finger	1471..1491	CDD:275368
		zf-H2C2_2	1483..1506	CDD:290200
		C2H2 Zn finger	1499..1519	CDD:275368
		zf-H2C2_2	1511..1536	CDD:290200
		C2H2 Zn finger	1527..1547	CDD:275368
br	NP_001162638.2	BTB	22..118	CDD:279045	52/96 (54%)
		BTB	33..118	CDD:197585	48/85 (56%)
		C2H2 Zn finger	712..729	CDD:275368	3/16 (19%)
		C2H2 Zn finger	742..763	CDD:275368	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010