DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mamo and BtbVII

DIOPT Version :9

Sequence 1:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster
Sequence 2:	NP_647774.2	Gene:	BtbVII / 38376	FlyBaseID:	FBgn0263108	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	1500	Identity:	310/1500 - (20%)
Similarity:	463/1500 - (30%)	Gaps:	688/1500 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGSEHYCLRWNNYQSNLLGVFSQLLQDGSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHP 65
            |..:.:||||||:|.|.:.|.|.||.:|:|||||| .:||..::|||:||||||||||:||..:|
  Fly     1 MSVQQFCLRWNNHQPNFISVCSSLLHNGTLVDVTL-AAEGRQLQAHKIVLSACSSYFQALFTTNP 64

  Fly    66 EGHLIVILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGLAEMTNQ--NTTLREP 128
            ..|.|||||||::.:|:|:|:|||.|||||...||..:|||||.||:||||||...  |.|..:.
  Fly    65 CQHPIVILKDVQYDDLKTMVDFMYYGEVNVSQEQLPHILKTAEMLKIKGLAEMPTDPANLTKSDS 129

  Fly   129 EREPDRLRPQGGGGSGGSAHKAADSPAAALDATAATQAATATATATAAAATSTSTSATSAAATAA 193
            :...|.....||.|.|
  Fly   130 KSSTDGTEMVGGAGVG------------------------------------------------- 145

  Fly   194 ATAATSASTTATAAAGSSNTTTTTAATTTATCATAATSTAATSSSSSVTSAAAAAAAAASASGVA 258
                                                            |.|..:|.:..:.||.:
  Fly   146 ------------------------------------------------TGAGNSAGSLGAGSGSS 162

  Fly   259 HSEEATSSSSSTGGQKREASDRSSPTPAKRSSRMHPADKVDVAEDREQEQNQADELLSEELLGRN 323
            ..:...|||                               :..:.::|:|.||.:
  Fly   163 VGDSLWSSS-------------------------------EAQQFQQQQQQQAQQ---------- 186

  Fly   324 LKDEEDDDVDELDENEETKLRGRDEDDDDEDEEEDTPMPLDLYQRPNVEPKSAAAATAAQQGGSN 388
                                                                    .|.||
  Fly   187 --------------------------------------------------------QAQQQ---- 191

  Fly   389 SLSGSSNACHTNSSSNSNNNNNNNNNSSSNNNNNTSSGKTSASSNGGTASSGGTADSVVAVDDDD 453
                     |
  Fly   192 ---------H------------------------------------------------------- 192

  Fly   454 DDDDGGHHHQRQVMDDRLEQDVDEEDLDDDVVVVGPATAMARGIAQRLAHQNLQRLHHTHHHAQH 518
                  ||||:|   .:|:|.                       .|:...|..|:.||.|||.|.
  Fly   193 ------HHHQQQ---QQLQQQ-----------------------QQQAQQQQQQQQHHHHHHQQQ 225

  Fly   519 QHSQHHHPHSQHHHTPHHQQHHTHSD-DEDAMPVIAKSEILDDDYDDEMDLEDDDEADNSSNDLG 582
            |..|     :|...|.|||...|.|. .....|...:..:.....:...|..:.:|..|||.|.|
  Fly   226 QSGQ-----AQAAQTHHHQMRRTPSPLSAGTSPATRRKRLRKSSNNGSGDRNNAEEQHNSSLDAG 285

  Fly   583 LNMKMGSGGA------------GGGGGVDLSTGSTLIPSPLITLPSSSAAAAAAAAAAMESQRST 635
                .|:|.|            |.|||:   .|.:|..:.|:         ..:|:|.:|.|...
  Fly   286 ----SGAGNAGLSLAQMNQMTFGAGGGL---AGHSLHAAKLL---------KESASAELEQQPQD 334

  Fly   636 PAMSAAQAAGAGASDLSIGGCGGRPASRSSRDGGGN-------DGGRGGASSSSLLSPGTVANLL 693
                         |||.              ||.|:       :...||.:
  Fly   335 -------------SDLD--------------DGHGHLHMQIKPEVDIGGVN-------------- 358

  Fly   694 PVQSVPLSLKKEIDCSEDD----NSSHSR----------HMQQRSASAGGGLGGDLDYRASHESL 744
              |::||.:......||.|    .||||.          |....:||:..|..|..:
  Fly   359 --QTMPLDISGGTTPSEHDAPNSQSSHSEPSPAHAPHPPHPPLGAASSSSGGSGSFE-------- 413

  Fly   745 LRNFSSPMSAMAASRCPTPFAFPFSPLGLSLFDIDPSRILSLLHHQTWLAEEALRTRGLLTAPKD 809
             |:||  :..:.:..| .|...|.||..:.
  Fly   414 -RSFS--IGGVGSVEC-DPDGTPSSPAVMG----------------------------------- 439

  Fly   810 FPHRFTTLSDLLTKDYQPGAGQPMVTATATATTASSTSQVSASRSGDTQYNKHAQQPQQPQTGGA 874
                 |..:.:||:       ||.|  ...:.:.|||:|:|                  |.|...
  Fly   440 -----TKRNRVLTR-------QPRV--KRDSDSISSTNQIS------------------PDTAAT 472

  Fly   875 TGSGVGGLGGSP--TAGA-SFNLRYPTPTAFYQQQQQQG--------------KGAKSSPSPQQM 922
            |      |...|  .||| |...|..:.|..:....|..              :...|.|:| .:
  Fly   473 T------LDFDPFNAAGATSATARDYSTTGSHHLHHQSAVHHHHHLLTVPPRIERHASEPAP-SL 530

  Fly   923 ATSSTTVMSNDSGEDSCKRSSADSDEVTIMELPSERSAQLYKESLEQLLQRQRRTPILAGSGSGS 987
            |.|:..::|                      :||. :..|.|:..:.||.||.... :|||||||
  Fly   531 APSTPHLLS----------------------VPSS-TPYLIKQHSDPLLPRQSALH-MAGSGSGS 571

  Fly   988 GSGTGSGSVIVDAAGL-RQYTQLLLAGAGSGGA----------SDLKEKSSSSSTSSTPPLLTQQ 1041
            .|...:||  ...|.| |||:..|   :||..:          ..:....|..::.|.||..:.|
  Fly   572 SSAMATGS--NPFAPLHRQYSHPL---SGSNASYVTPAPLHHPHHISLPESIYASGSPPPAGSSQ 631

  Fly  1042 L---SQMLKSP---SDTCSSLFSSSGGGTGSTGPGITGETIEEETRCVVCNAHFPNVWLLEQHAA 1100
            .   ::::..|   |:|.::..::|.|.:.:....::          ||.:   ||..|  |::|
  Fly   632 YLVPTRVVACPVVSSETAATPTNASPGSSSTVSAAVS----------VVTS---PNAGL--QNSA 681

  Fly  1101 LQHPHVGPGEEKPFICEQCGQSYRYRSAYAKHKEQNHRARLPADKLFTCDVCGMQFRYLKSFKKH 1165
            .:|| :.|             ::...|..|..:...|...:...::
  Fly   682 SRHP-LSP-------------TFSIGSDVAHERRSPHSPSISRSQV------------------- 713

  Fly  1166 RLNHALERLHGKKSVGVIGRLGGSGSGPSSSAISVSVAAPTSVSASGSVTSV----DQDVVTSSQ 1226
                 :||               :|..|:.:|........||.|||||:|..    .|..::||.
  Fly   714 -----VER---------------AGKNPAEAANGGGSRLRTSKSASGSITGTHLHPGQATMSSSF 758

  Fly  1227 E--PMLADEGEDLRVNVKREGTADEQSAESRANDLEEHEQDNTVDSAGITMLYQDNNSSASASTS 1289
            |  |.|..:.|:|:.:|....|..|                         ::..:|..|:.....
  Fly   759 EHLPTLRVKNEELQRSVSSPQTQRE-------------------------IITLENPRSSHCPVI 798

  Fly  1290 ATEPNISSSDGIHSTNKRSRLHHLETDPSYPHHHHHHHHHHHQQQHHQAQHQHHNPQSQLPTHL- 1353
            ...|.:..:...::.:...|:...:|                         ::|.|:.|  |:|
  Fly   799 RPGPALGCNFCWNTIDGHGRILRRKT-------------------------KYHCPECQ--TNLC 836

  Fly  1354 -------GHVSLPLVATSAAGSSSSAAAAAVVAAAQAQVSSGATGSGATGSGAPGSGNVGSAGSS 1411
                   .|..|         ::.:|||::..||...|:||..||||::.|| ..|..|.|||||
  Fly   837 IVPCFQEYHERL---------NNEAAAASSGAAAGDNQLSSSTTGSGSSSSG-KASPYVSSAGSS 891

  Fly  1412 GAGGG 1416
            .:|.|
  Fly   892 SSGAG 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB	21..118	CDD:279045	60/96 (63%)
		BTB	32..118	CDD:197585	54/85 (64%)
		C2H2 Zn finger	1082..1105	CDD:275368	8/22 (36%)
		C2H2 Zn finger	1116..1137	CDD:275368	2/20 (10%)
		C2H2 Zn finger	1149..1169	CDD:275368	0/19 (0%)
		zf-C2H2	1469..1491	CDD:278523
		C2H2 Zn finger	1471..1491	CDD:275368
		zf-H2C2_2	1483..1506	CDD:290200
		C2H2 Zn finger	1499..1519	CDD:275368
		zf-H2C2_2	1511..1536	CDD:290200
		C2H2 Zn finger	1527..1547	CDD:275368
BtbVII	NP_647774.2	BTB	24..117	CDD:279045	59/93 (63%)
BtbVII	NP_647774.2	BTB	32..117	CDD:197585	54/85 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.100