DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mamo and bab1

DIOPT Version :9

Sequence 1:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster
Sequence 2:	NP_728565.1	Gene:	bab1 / 38116	FlyBaseID:	FBgn0004870	Length:	977	Species:	Drosophila melanogaster

Alignment Length:	1528	Identity:	286/1528 - (18%)
Similarity:	416/1528 - (27%)	Gaps:	772/1528 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SEHYCLRWNNYQSNLLGVFSQLLQDGSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHPEG 67
            |:.:||||||||:||..:|.||||:...|||||.| :|.|::|||:||||||.|||:|..|.|..
  Fly    99 SQQFCLRWNNYQTNLTTIFDQLLQNECFVDVTLAC-DGRSMKAHKMVLSACSPYFQTLLAETPCQ 162

  Fly    68 HLIVILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGLAEMTNQNTTLREPEREP 132
            |.|||::||.:::|:.:|||||:||:||...|:..||:.||.|||:|||::|:.
  Fly   163 HPIVIMRDVNWSDLKAIVEFMYRGEINVSQDQIGPLLRIAEMLKVRGLADVTHM----------- 216

  Fly   133 DRLRPQGGGGSGGSAHKAADSPAAALDATAATQAATATATATAAAATSTSTSATSAAATAAATAA 197

  Fly   217 ----------------------------------------------------------------- 216

  Fly   198 TSASTTATAAAGSSNTTTTTAATTTATCATAATSTAATSSSSSVTSAAAAAAAAASASGVAHS-E 261
                                                         .||.|||||||:..:..| :
  Fly   217 ---------------------------------------------EAATAAAAAASSERMPSSPK 236

  Fly   262 EATSSSSSTGGQKREASDR---SSPTPAKRSSRMHPADKVDVAEDREQEQNQADELLSEELLGRN 323
            |:||:|.:...::|||.:.   ..|....|:|...||:......:|:|              |||
  Fly   237 ESTSTSRTEHDREREAEELLAFMQPEKKLRTSDWDPAELRLSPLERQQ--------------GRN 287

  Fly   324 LKDEEDDDVD---------------------ELDENEETKLRGRDEDDDDEDEEEDTPMPLDLYQ 367
            ::.......|                     ||::.|..:.|         |....||.|
  Fly   288 VRKRRWPSADTIFNPPAPPSPLSSLIAAERMELEQKERERQR---------DCSLMTPPP----- 338

  Fly   368 RPNVEPKSAAAATAAQQGGSNSLSGSSNACHTNSSSNSNNNNNNNNNSSSNNNNNTSSGKTSASS 432
            :|.:                                                    |||.|..::
  Fly   339 KPPM----------------------------------------------------SSGSTVGAT 351

  Fly   433 NGGTASSGGTADSVVAVDDDDDDDDGGHHHQRQVMDDRLEQDVDEEDLDDDVVVVGPATAMARGI 497
            .                                    |||..:...|:.......||.:..:|..
  Fly   352 R------------------------------------RLETAIHALDMPSPAATPGPLSRSSRPH 380

  Fly   498 AQRLAHQNLQRLH--------HTHHHAQHQHSQHHHPHSQHHHTPHHQQHHTHSDDEDAMPVIAK 554
            :|....|..|:..        |.||||    |...|| ||...:.||          .|.|
  Fly   381 SQSPQQQQAQQQGQLPLPLPLHPHHHA----SPAPHP-SQTAGSAHH----------PASP---- 426

  Fly   555 SEILDDDYDDEMDLEDDDEADNSSNDLGLNMKMGSGGAGGGGGVDLSTGSTLIPSPLITLPSSSA 619
                               |.:|...||
  Fly   427 -------------------AGDSRFPLG------------------------------------- 435

  Fly   620 AAAAAAAAAMESQRSTPAMSAAQAA--------GAGASDLSIGGCGGRPASRSSRDGGGNDGGRG 676
             .|||.|||.|.....|..||....        |.|    .:||.|         .|||..||.|
  Fly   436 -PAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGG----GVGGGG---------VGGGGAGGVG 486

  Fly   677 GASSSSL-----LSPGTVANLLPVQSVPLSLKKEIDCSEDDNSSHSRHMQQRSASAGGGLGGDLD 736
            ....|||     :.|| :|.::               .|::.:
  Fly   487 SGGGSSLADDLEIKPG-IAEMI---------------REEERA---------------------- 513

  Fly   737 YRASHESLLRNFSSPMSAMAASRCPTPFAFPFSPLGLSLFDIDPSRILSLLHHQTWLAEEALRTR 801
                  .::.|..:.|.|..::.....:.:....:....::.:.    :|:||..:      |.|
  Fly   514 ------KMMENSHAWMGATGSTLAADSYQYQLQSMWQKCWNTNQ----NLMHHMRF------RER 562

  Fly   802 GLLTAPKDFPHRFTTLSDLLTKDYQPGAGQPMVTATATATTASSTSQVSASRSGDTQYNKHAQQP 866
            |.|                  |.::|            .|.|.:...|...
  Fly   563 GPL------------------KSWRP------------ETMAEAIFSVLKE-------------- 583

  Fly   867 QQPQTGGATGSGVGGLGGSPTAGASFNLRYPTPTAFYQQQQQQGKGAKSSPSPQQMATSSTTVMS 931
                          ||..| .|...:::.||| ...|..:.....|.                 |
  Fly   584 --------------GLSLS-QAARKYDIPYPT-FVLYANRVHNMLGP-----------------S 615

  Fly   932 NDSGEDSCKRSSADSDEVTIMELPSERSAQLYKESLEQLLQRQRRTPILAGSGSGSGSGTGSGSV 996
            .|.|.|...:.......:.:...|.|.    .|..::.::.|..:
  Fly   616 IDGGPDLRPKGRGRPQRILLGIWPDEH----IKGVIKTVVFRDTK-------------------- 656

  Fly   997 IVDAAGLRQYTQLLLAGAGSGGASDLKEKSSSSST----SSTPPLLTQQLSQMLKSPSDTCSSLF 1057
                                    |:|::|.::..    ..:|....|.|.......|...:...
  Fly   657 ------------------------DIKDESLAAHMPPYGRHSPAFPLQDLPLSYPGASGALAGAP 697

  Fly  1058 SSSGGGTGS---TGPGITGET-IEEETRCVVCNAHFPNVWLLEQHAALQHPHVGPGEEKPFICEQ 1118
            ||.....||   ||.|:.||. :.:||...|              ||:.|
  Fly   698 SSMACPNGSGPQTGVGVAGEQHMSQETAAAV--------------AAVAH--------------- 733

  Fly  1119 CGQSYRYRSAYAKHKEQNHRARLPADKLFTCDVCGMQFRYLKSFKKHRLNHALERLHGKKSVGVI 1183
                        ..::|...|.:|.                          .|..|.....||
  Fly   734 ------------NIRQQMQMAAVPP--------------------------GLFNLPPHPGVG-- 758

  Fly  1184 GRLGGSGSGPSSSAISVSVAAPTSVSASGSVTSVDQDVVTSSQEPMLADEGEDLRVNVKREGTAD 1248
               ||.|:.|.::....|: :|...|.||
  Fly   759 ---GGVGNVPGAAGGRASI-SPALSSGSG------------------------------------ 783

  Fly  1249 EQSAESRANDLEEHEQDNTVDSAGITMLYQDNNSSASASTSATEPNI--SSSDGIHSTNKRSRLH 1311
                                          ..::.:....:...||:  |.:..:|...::...|
  Fly   784 ------------------------------PRHAPSPCGPAGLLPNLPPSMAVALHHQQQQQAAH 818

  Fly  1312 H----LETDPSYPH-HHHHHHHHHHQQQHHQAQH----------------------QHHNPQS-- 1347
            |    |.......| |||.......||||||..|                      |||.|::
  Fly   819 HHMQQLHLQQQQAHLHHHQQQQQQQQQQHHQGGHQVAHKSGFGASSSSSASSSSMGQHHAPKAKS 883

  Fly  1348 --------QLPTHLGHVSL--------------------PLVATSAAGSSSSAAAAAVVAAAQAQ 1384
                    :|.:.||.:.|                    .||..|.:.|||||||    |.|..:
  Fly   884 SPLRSETPRLHSPLGDLGLDMASYKREFSPSRLFAEDLAELVGASVSSSSSSAAA----ATAPPE 944

  Fly  1385 VSSGATGSGATGSGAPGSGNVGSAGSSGAGGGI 1417
            .|:|| .|.|||:.||         ||.:.|||
  Fly   945 RSAGA-ASAATGADAP---------SSSSSGGI 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB	21..118	CDD:279045	55/96 (57%)
		BTB	32..118	CDD:197585	49/85 (58%)
		C2H2 Zn finger	1082..1105	CDD:275368	4/22 (18%)
		C2H2 Zn finger	1116..1137	CDD:275368	1/20 (5%)
		C2H2 Zn finger	1149..1169	CDD:275368	0/19 (0%)
		zf-C2H2	1469..1491	CDD:278523
		C2H2 Zn finger	1471..1491	CDD:275368
		zf-H2C2_2	1483..1506	CDD:290200
		C2H2 Zn finger	1499..1519	CDD:275368
		zf-H2C2_2	1511..1536	CDD:290200
		C2H2 Zn finger	1527..1547	CDD:275368
bab1	NP_728565.1	BTB	117..216	CDD:279045	56/99 (57%)
		BTB	128..213	CDD:197585	49/85 (58%)
		HTH_psq	569..614	CDD:283007	12/86 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447068
Domainoid	1	1.000	59	1.000	Domainoid score	I10615
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.030