DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mamo and sp3b

DIOPT Version :9

Sequence 1:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster
Sequence 2:	XP_005165855.1	Gene:	sp3b / 322961	ZFINID:	ZDB-GENE-110815-3	Length:	783	Species:	Danio rerio

Alignment Length:	890	Identity:	181/890 - (20%)
Similarity:	276/890 - (31%)	Gaps:	325/890 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   775 LFDIDPSRIL-SL----LHHQTWLAEEALRTRGLLTAPKDFPHRFTTLSDLLTKDYQPGAGQPMV 834
            :|:..|.||: ||    ||..|    ::...:....|  .|..|.....|.:.....|...||..
Zfish    37 IFNEVPDRIIKSLFVCSLHFTT----DSFTNKTQFDA--GFSERLKVKDDAVPTILDPKVMQPQR 95

  Fly   835 TATATATTASSTSQVSASRSGDTQ-----------YNKHAQQPQQPQTGGATGSGVGGLGGSPTA 888
            ::..|:......::...::.|..|           ....::.|:||.
Zfish    96 SSHKTSREMGCQTEELNTQDGQCQTFPDLKPHTLKLEPRSETPEQPA------------------ 142

  Fly   889 GASFNLRYPTPTAFYQQQQQQGKGAKSSPS---------PQQMATSSTTVM---SNDSGEDSCKR 941
                           :||:.......||.|         ..|..|..|.:.   |:|..|.....
Zfish   143 ---------------KQQEMAALDVDSSQSDFLQPASGAQDQQTTDLTAIQMTGSSDRWEVLTPV 192

  Fly   942 SSADSDEVTIMELPSE---RSAQLYKESLEQLLQRQRRTPILAGSGSGSGSGTGSGSVIVDAAGL 1003
            ||. ..|..::.:||.   .|...|...|:.:..:.:...:.||.     .|||:..|
Zfish   193 SSV-KGEPAVVHVPSGGLLGSNGQYVVPLQTMAGQTQPVFVTAGV-----DGTGANGV------- 244

  Fly  1004 RQYTQLLLAGAGSGGAS-DLKEKSSSSSTSSTP----PLLTQQLS--------QMLKSPSDTCSS 1055
             || |::....|:.||| .....::..||..|.    |..||.::        |.|.|.|.....
Zfish   245 -QY-QVIPQLQGADGASLSYTASAADGSTLGTDIAILPDGTQGIATATNANDLQGLLSQSGHVQQ 307

  Fly  1056 L--FSSSGGGTGSTGPGITGETIEEETRCVVCNAHFP-NVWLLEQHAALQHPHVGPGEEKPFICE 1117
            :  .|.:|.|.|:.|.             ||.|...| |:.|
Zfish   308 IPTVSLAGSGFGTQGQ-------------VVANMGLPGNITL----------------------- 336

  Fly  1118 QCGQSYRYRSAYAKHKEQNHRARLPADKLFTCDVCGMQFRYLKSFKKHRLNHALERLHGKKSVGV 1182
                                   :|.:.|...|:                          :|:|:
Zfish   337 -----------------------VPINSLSNVDL--------------------------ESLGL 352

  Fly  1183 IGRLGGSGSGPSSSAISVSVAAPTSVSASGSVTSVDQDVVTSSQEPMLADEGEDLRVNVKREGTA 1247
            .|              :.::|  |||:|.|.:........||..:.......|.|..|.......
Zfish   353 AG--------------AQTIA--TSVTADGQLIMTGPTTTTSDNQGESGKCTESLNANDANANAF 401

  Fly  1248 DEQSAESRANDLEEHEQDNTVDSAGI------------TMLY-QDNNSSASASTSATEPNISSSD 1299
            ...:..|.:..|.|     |:|..|:            .:.| |.|:::.........| ..::|
Zfish   402 VPTTTSSTSTSLPE-----TIDGTGVLTQATAVSAGHQDLSYIQQNHTTGGEQVVQLLP-AQTAD 460

  Fly  1300 GIHSTNKRSRLHHLET--------DPSYPHHHHHHHHHHHQQQHHQAQHQHHNPQSQLPTHLGHV 1356
            |...|.:..:|.:..|        .|:                   .|.|....|.|...:|.::
Zfish   461 GAAQTLQSVQLLNAGTFLIQAQTVSPT-------------------GQIQWQTFQVQGVQNLQNL 506

  Fly  1357 SLPLVATSAAGSSSSAAAAAVVAAAQAQVSSGATGSGATGSGAPGSGNVGSAGSSGAGGGISSLS 1421
            .||     |||..||..    :..|..|..|                 :|.:|::||.|.|.:|.
Zfish   507 QLP-----AAGGVSSPQ----ITLAPVQTLS-----------------LGQSGTTGALGQIPNLQ 545

  Fly  1422 SLT----------------SLINAERIPNEQFLGLNPQEASILNFLRVDAAER------QRDKRP 1464
            ::|                :.|..:..|.......:....|.|..|||...|.      |..||
Zfish   546 TVTVNSVGQYQQDENTESHTDIQIKEEPESDDWPNSTLSTSDLAHLRVRLVEEDMEGTGQEGKR- 609

  Fly  1465 ATSRFAC-------------------------PFCGKCVRSKENLKLHVRKHTGERPFVC--LFC 1502
             ..|.||                         |.|||......:|:.|:|.|:|||||:|  .:|
Zfish   610 -LRRVACTCPNCKEAGGRGSSMGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICSWSYC 673

  Fly  1503 GRAFGGKSDLTRHLRIHTGERPYHCESCGKCFARADYLSKHLTTH 1547
            |:.|....:|.||.|.||||:.:.|..|.|.|.|:|:|:||:.||
Zfish   674 GKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTH 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB	21..118	CDD:279045
		BTB	32..118	CDD:197585
		C2H2 Zn finger	1082..1105	CDD:275368	6/23 (26%)
		C2H2 Zn finger	1116..1137	CDD:275368	0/20 (0%)
		C2H2 Zn finger	1149..1169	CDD:275368	1/19 (5%)
		zf-C2H2	1469..1491	CDD:278523	9/46 (20%)
		C2H2 Zn finger	1471..1491	CDD:275368	8/44 (18%)
		zf-H2C2_2	1483..1506	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1499..1519	CDD:275368	8/21 (38%)
		zf-H2C2_2	1511..1536	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1527..1547	CDD:275368	9/19 (47%)
sp3b	XP_005165855.1	THAP	8..85	CDD:283206	13/53 (25%)
		C2H2 Zn finger	638..660	CDD:275368	7/21 (33%)
		COG5048	<651..728	CDD:227381	32/68 (47%)
		zf-C2H2	666..690	CDD:278523	9/23 (39%)
		C2H2 Zn finger	668..690	CDD:275368	8/21 (38%)
		zf-H2C2_2	682..705	CDD:290200	11/22 (50%)
		zf-C2H2	696..718	CDD:278523	9/21 (43%)
		C2H2 Zn finger	698..718	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910