Protein Alignment mamo and Sp1

DIOPT Version :10

• Sequence 1: NP_572932.2
• Gene: mamo / 32353
• FlyBaseID: FBgn0267033
• Length: 1553
• Species: Drosophila melanogaster
• Sequence 2: NP_036787.2
• Gene: Sp1 / 24790
• RGDID: 3738
• Length: 786
• Species: Rattus norvegicus
• Alignment Length: 839
• Identity: 168/839 - (20%)
• Similarity: 257/839 - (30%)
• Gaps: 314/839 - (37%)

  Fly   872 GGATGSGVGGLGGSPTAGASFNLRYPTPTAFYQQQQQQGKGAKSSPSPQQMATSSTTVMSNDSGE 936
            |...|||.||       ||:|:....:.|. .......|.|.:|.|||..:..:
  Rat    22 GNNGGSGNGG-------GAAFSQTRSSSTG-SSSSSGGGGGQESQPSPLALLAA----------- 67

  Fly   937 DSCKRSSADSDEVTIMELPSERSAQLYKESLEQLLQRQRRTPILAGSGSGSGSGTGSGSVIVDAA 1001
             :|.|          :|.|:|.|                      .:..|.....|:|.:.:.|.
  Rat    68 -TCSR----------IESPNENS----------------------NNSQGPSQSGGTGELDLTAT 99

  Fly  1002 GLRQYT---QLLLAGAGSGGASDLKEKSSSSSTSS--------------------TPPLLTQQLS 1043
            .|.|..   |::  .:.||.....||:|.:|:..|                    ||.|..||:.
  Rat   100 QLSQGANGWQII--SSSSGATPTSKEQSGNSTNGSNGSESSKNRTVSGGQYVVAATPNLQNQQVL 162

  Fly  1044 QMLKS--PS------------DTCSSLFSSSGGGTGSTGPGITGETIEEETRCVVCN-------- 1086
            ..|..  |:            |.....|:::|......|.|.. :.|....:.::.|
  Rat   163 TGLPGVMPNIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQI-QIIPGANQQIITNRGSGGNII 226

  Fly  1087 AHFPNVWLLEQHAALQHPHVGPGEEKPFICEQCGQSYRYRSAYAKHKEQNHRARLPADKLFTCDV 1151
            |..||  ||:|...||
  Rat   227 AAMPN--LLQQAVPLQ------------------------------------------------- 240

  Fly  1152 CGMQFRYLKSFKKHRLNHALERLHGKKSVGVIGRLGGSGSGPSSSAISVSVAAPTSVSASGSVTS 1216
             |:....|....::..|..: .|:|..::..:..:..:...|||.|        .::|:|||..|
  Rat   241 -GLANNVLSGQTQYVTNVPV-ALNGNITLLPVNSVSAATLTPSSQA--------GTISSSGSQES 295

  Fly  1217 VDQDVVTSSQEPMLADEGEDLRVNVKREGTA--------DEQSAESRANDLEEHEQDNTVDSAGI 1273
            ..|.|.:                     |||        .:.|:.|...:...:....|..:.||
  Rat   296 GSQPVTS---------------------GTAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGI 339

  Fly  1274 TMLYQDNNSSASASTSATEPNISSSDGIHSTNKRSRLHHLETDPSYPHHHHHHHHHHHQQQHHQ- 1337
             |.:..:.||.::|...|...:....|..|.|    :...:|................||...|
  Rat   340 -MNFTSSGSSGTSSQGQTSQRVGGLQGSDSLN----IQQNQTSGGSLQGSQQKEGEQSQQTQQQQ 399

  Fly  1338 --------------------------------AQHQHHNPQSQLPTHLGHVSLPLVATSAAGSSS 1370
                                            :|....|.|.|...:.|.:   ::.|...|.:.
  Rat   400 ILIQPQLVQGGQALQALQAAPLSGQTFTTQAISQETLQNLQLQAVQNSGPI---IIRTPTVGPNG 461

  Fly  1371 SAA---------------AAAVVAAAQAQVSSGATGSG-------ATGSGAP-GSGNVGSAG-SS 1411
            ..:               |..:..|....||.|.|.|.       |:.:..| |:..|.:|. ||
  Rat   462 QVSWQTLQLQNLQVQNPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSS 526

  Fly  1412 GAGGGISSLSSL-TSLINAERIPNEQFL--------------------GLNPQEASILNFLRVDA 1455
            ..|....:||:| ||.|...::|.....                    |::.:.|.      .:.
  Rat   527 MPGLQTINLSALGTSGIQVHQLPGLPLAIANTPGDHGAQLGLHGPGGDGIHDETAG------GEE 585

  Fly  1456 AERQRDKRPATSR------FACPF------------------------CGKCVRSKENLKLHVRK 1490
            .|...|.:|...|      ..||:                        |||......:|:.|:|.
  Rat   586 GENSPDPQPQAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRW 650

  Fly  1491 HTGERPFVC--LFCGRAFGGKSDLTRHLRIHTGERPYHCESCGKCFARADYLSKHLTTH 1547
            |||||||:|  .:||:.|....:|.||.|.||||:.:.|..|.|.|.|:|:||||:.||
  Rat   651 HTGERPFMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTH 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB_POZ_BAB-like	30..114	CDD:349624
		C2H2 Zn finger	1082..1105	CDD:275368	9/30 (30%)
		C2H2 Zn finger	1116..1137	CDD:275368	0/20 (0%)
		C2H2 Zn finger	1149..1169	CDD:275368	2/19 (11%)
		zf-C2H2	1469..1491	CDD:395048	8/45 (18%)
		C2H2 Zn finger	1471..1491	CDD:275368	8/43 (19%)
		zf-H2C2_2	1483..1506	CDD:463886	13/24 (54%)
		C2H2 Zn finger	1499..1519	CDD:275368	8/21 (38%)
		zf-H2C2_2	1511..1536	CDD:463886	12/24 (50%)
		C2H2 Zn finger	1527..1547	CDD:275368	10/19 (53%)
Sp1	NP_036787.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..94		25/123 (20%)
		Repressor domain. /evidence=ECO:0000250	2..83		22/112 (20%)
		SP1_N	55..628	CDD:411775	119/715 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	110..143		7/34 (21%)
		Transactivation domain A (Gln-rich). /evidence=ECO:0000250	147..252		24/157 (15%)
		Transactivation domain B (Gln-rich). /evidence=ECO:0000250	262..496		44/270 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..303		10/50 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	332..397		14/69 (20%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P08047	463..471		0/7 (0%)
		Transactivation domain C (highly charged). /evidence=ECO:0000250	497..611		24/119 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..600		6/43 (14%)
		VZV IE62-binding. /evidence=ECO:0000250	620..786		37/90 (41%)
		zf-C2H2	627..651	CDD:395048	6/23 (26%)
		C2H2 Zn finger	629..651	CDD:275368	6/21 (29%)
		zf-H2C2_2	643..670	CDD:463886	14/26 (54%)
		C2H2 Zn finger	659..681	CDD:275368	8/21 (38%)
		zf-H2C2_2	673..696	CDD:463886	11/22 (50%)
		zf-C2H2	687..709	CDD:395048	10/21 (48%)
		C2H2 Zn finger	689..709	CDD:275368	10/19 (53%)
		Domain D. /evidence=ECO:0000250	709..786		1/1 (100%)