DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mamo and Sp3

DIOPT Version :9

Sequence 1:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster
Sequence 2:	NP_001018052.1	Gene:	Sp3 / 20687	MGIID:	1277166	Length:	783	Species:	Mus musculus

Alignment Length:	844	Identity:	172/844 - (20%)
Similarity:	273/844 - (32%)	Gaps:	291/844 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   866 PQQP----QTGGATGSGVGGLGGSPTAGASFNLRYPTPTAFYQQQQQQGKGAKSS------PSPQ 920
            |::|    :.......|.||.||.   |.....:       .|||||.|.||.::      |||.
Mouse     4 PEKPVKQEEMAALDVDGGGGGGGH---GEYLQQQ-------QQQQQQHGNGAAAAAAQDTQPSPL 58

  Fly   921 QMATSSTTVMSNDSGEDSCKRSSADSDEVTIMELPSERSAQLYKESLEQLLQRQRRTPILAGSGS 985
            .:..::.:.:...|..|       |.:|..:                          ...||..:
Mouse    59 ALLAATCSKIGPPSPGD-------DDEEAAV--------------------------AAAAGVPA 90

  Fly   986 GSGSGTGSGSVIVDAAGLRQYTQLLLAGAGSGGASDLKEKSSSSSTSSTPPLLTQQLSQMLKSPS 1050
            .:...||.                 ||.|..|||.:..|     ..|:||..:..:...:::.|.
Mouse    91 AAAGATGD-----------------LASAQLGGAPNRWE-----VLSATPTTIKDEAGNLVQIPG 133

  Fly  1051 DTCSS--------------LFSSSGGGTGSTGPGITGETIEEETRCVVCNAHF---PNVWLLEQH 1098
            ...||              :||.:.|...|.|              .|.|..:   |.:    |.
Mouse   134 AATSSGQYVLPLQNLQNQQIFSVAPGSDSSNG--------------TVSNVQYQVIPQI----QS 180

  Fly  1099 AALQHPHVGPGEEKPFICEQCGQSYRYRSAYAKHKEQNHRARLPADKLFTCDVCGMQFRYLKSFK 1163
            ...|...:|               :...|......::|.:.::         :.|.....|.|..
Mouse   181 TDAQQVQIG---------------FTGSSDNGGINQENSQIQI---------IPGSNQTLLASGT 221

  Fly  1164 KHRLNHALERLHGKKSVGVIGRLGGSGSGPSSSAISVSVAAPTSVSASGSVTSVDQDVVTSSQEP 1228
            .......|....|:..|..:...|.|..|.:....:|.:..|.:::.. .:.|||.|.:..|...
Mouse   222 PPANIQNLIPQTGQVQVQGVAIGGSSFPGQTQVVANVPLGLPGNITFV-PINSVDLDSLGLSGSS 285

  Fly  1229 MLADEGEDLRVNVKREGTA------DEQSAESRANDLEEHEQDN--------------TVDSAGI 1273
            .....|.:...::...|.|      .|::.|..:.|:.|...|.              |:||.||
Mouse   286 QTMTAGINADGHLINTGQAMDSSDNSERTGERVSPDVNETNADTDLFVPTSSSSQLPVTIDSTGI 350

  Fly  1274 TMLYQDNNSSASASTSATEPNISSSD----GIHS-TNKRSRLHHLETDPSYPHHHHHHHHHHHQQ 1333
              |.|:.|     |.:.|...:.|||    .|.| .::.::..:::...:.|           ..
Mouse   351 --LQQNTN-----SLTTTSGQVHSSDLQGNYIQSPVSEETQAQNIQVSTAQP-----------VV 397

  Fly  1334 QHHQAQHQHHNPQSQLPTHLGHVSLPLVATSAAGSSSSAAAAAVVAAAQAQVSSGA---TGSGAT 1395
            ||.|.| ....|.||.....|.....:....|:|.:.|..|   :...|.|::.|.   .....|
Mouse   398 QHLQLQ-DSQQPTSQAQIVQGITPQTIHGVQASGQNISQQA---LQNLQLQLNPGTFLIQAQTVT 458

  Fly  1396 GSG--------APGSGNVG--------------------SAGSSGAGGGISSLSSLTSLINAERI 1432
            .||        ..|..|:.                    :.|...|||   :|:|....::..::
Mouse   459 PSGQITWQTFQVQGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGG---ALTSTPVSLSTGQL 520

  Fly  1433 PNEQFLGLN-----------------------------PQEASI----------LNFLRVDAAER 1458
            ||.|.:.:|                             |:|..:          |..|||...:.
Mouse   521 PNLQTVTVNSIDSTGIQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDE 585

  Fly  1459 QRDKR----PATSRFAC-------------------------PFCGKCVRSKENLKLHVRKHTGE 1494
            :.|::    ....|.||                         |.|||......:|:.|:|.|:||
Mouse   586 EGDQQHQEGKRLRRVACTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGE 650

  Fly  1495 RPFVC--LFCGRAFGGKSDLTRHLRIHTGERPYHCESCGKCFARADYLSKHLTTH-----IHNA 1551
            |||:|  :|||:.|....:|.||.|.||||:.:.|..|.|.|.|:|:|:||:.||     ||::
Mouse   651 RPFICNWMFCGKRFTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTHQNKKVIHSS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB	21..118	CDD:279045
		BTB	32..118	CDD:197585
		C2H2 Zn finger	1082..1105	CDD:275368	5/25 (20%)
		C2H2 Zn finger	1116..1137	CDD:275368	1/20 (5%)
		C2H2 Zn finger	1149..1169	CDD:275368	3/19 (16%)
		zf-C2H2	1469..1491	CDD:278523	9/46 (20%)
		C2H2 Zn finger	1471..1491	CDD:275368	8/44 (18%)
		zf-H2C2_2	1483..1506	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1499..1519	CDD:275368	9/21 (43%)
		zf-H2C2_2	1511..1536	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1527..1547	CDD:275368	9/19 (47%)
Sp3	NP_001018052.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		16/60 (27%)
		Transactivation domain (Gln-rich). /evidence=ECO:0000250	140..239		18/140 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..340		7/37 (19%)
		Transactivation domain (Gln-rich). /evidence=ECO:0000250	352..501		30/168 (18%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:Q02447	463..471		0/7 (0%)
		Repressor domain. /evidence=ECO:0000250	536..622		10/85 (12%)
		C2H2 Zn finger	625..647	CDD:275368	7/21 (33%)
		COG5048	<638..720	CDD:227381	35/77 (45%)
		zf-H2C2_2	639..666	CDD:290200	14/26 (54%)
		C2H2 Zn finger	655..677	CDD:275368	9/21 (43%)
		zf-H2C2_2	669..692	CDD:290200	11/22 (50%)
		zf-C2H2	683..705	CDD:278523	9/21 (43%)
		C2H2 Zn finger	685..705	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910