DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mamo and btbd18

DIOPT Version :9

Sequence 1:	NP_572932.2	Gene:	mamo / 32353	FlyBaseID:	FBgn0267033	Length:	1553	Species:	Drosophila melanogaster
Sequence 2:	XP_017951392.1	Gene:	btbd18 / 100498010	-ID:	-	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	574	Identity:	105/574 - (18%)
Similarity:	179/574 - (31%)	Gaps:	182/574 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WNNYQSNLLGVFSQLLQD---GSLVDVTLVCSEGTSIRAHKVVLSACSSYFQSLFLEHPE----- 66
            ||  ...|..:|.||.:.   |...||||...||..:..|..:|:|||.|...|.....|
Frog    10 WN--PRLLRTMFLQLQRQQNTGFFCDVTLQGGEGEGVSVHACLLAACSPYLAKLLASVTEVSQLD 72

  Fly    67 ----------GHLIVILKDVRFAELQTLVEFMYKGEVNVQYCQLSALLKTAESLKVKGLAEMTNQ 121
                      ||::.: ..:....|..||.:||..|:.|....:..:|:.|..|::..|..:..:
Frog    73 TDSAIQTDCTGHILTV-PGIPSCYLLPLVHYMYTSELEVTPENVHGVLEAARRLQIPELEGLRLE 136

  Fly   122 NTTLREPEREPDRLRPQGGGGSGGSAHKAADSPAAALDATAATQAATATATATAAAATS------ 180
            ...|..||                .|.|.......::.:..||::.......|....||
Frog   137 GGRLVRPE----------------LARKLNRDCFGSVISQYATESGNGKQIFTKEEITSGRNVPV 185

  Fly   181 -------------TSTSATSAAATAA-------ATAATSASTTATAAAGSSNTTTTTAATTTATC 225
                         |:...|..|.|.:       |:::...:........:.|.|..:..:|..||
Frog   186 RMHEQGPCILEKRTNKEHTFPADTGSLLRGKMEASSSLQGNIENPLLEITKNPTEKSGPSTVQTC 250

  Fly   226 ATAATSTAATSSSSSVTSAAAAAAAAASASGVAHSEEATSSSSS------TGGQKRE--ASDRSS 282
            ..:..:.......|..|.         :.|.:....|.|..||.      ...|||.  .|:..:
Frog   251 FQSRENYECAFQDSGTTQ---------NVSAINQDIEMTKLSSEIPLIVLNPDQKRHILVSEHGA 306

  Fly   283 PT-PAKRSS-------RMHPADKVDVAEDREQEQNQADELLSEEL-LGRNLKDE--EDDDVDELD 336
            .| |::::.       ::..|.||     |::...||.:..:..: |.|.:|.:  |..|:.::|
Frog   307 DTVPSRKTDMQDKKLFKLQRAYKV-----RKETGEQATKGKTNIIPLSRIIKLDRGEKQDMPQMD 366

  Fly   337 ENEETKLRGRDEDDDDEDEEEDTPMPLDLYQRPNVEPKSAAAATAAQQGGSNSLSGSSNACHTNS 401
            ||                                                          ...|.
Frog   367 EN----------------------------------------------------------IKNNF 373

  Fly   402 SSNSNNNNNNNNNSSSNNNNNTSSGKTSASSNGGTASSGGTADSVVAVDDDDDDDDGGHH----- 461
            ....|:|.|:|.|...:........|.|              ...:.::.:|.......|
Frog   374 KHKQNHNMNSNLNPQDSVLKQVCRNKNS--------------QCTIKLELNDPSIQTQSHIQVCP 424

  Fly   462 HQRQVMDDRLEQDVDEEDLDDDVVVVGPATAMARGIAQR-LAHQNLQ--RLHHT 512
            .|::::...||::.   .|..||.|   ...:|:.:|.. |.|:.::  :|.||
Frog   425 EQQRIVQSHLEENA---ALQKDVCV---TCVIAKPMANTLLQHKTVKVVKLQHT 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mamo	NP_572932.2	BTB	21..118	CDD:279045	31/114 (27%)
		BTB	32..118	CDD:197585	27/100 (27%)
		C2H2 Zn finger	1082..1105	CDD:275368
		C2H2 Zn finger	1116..1137	CDD:275368
		C2H2 Zn finger	1149..1169	CDD:275368
		zf-C2H2	1469..1491	CDD:278523
		C2H2 Zn finger	1471..1491	CDD:275368
		zf-H2C2_2	1483..1506	CDD:290200
		C2H2 Zn finger	1499..1519	CDD:275368
		zf-H2C2_2	1511..1536	CDD:290200
		C2H2 Zn finger	1527..1547	CDD:275368
btbd18	XP_017951392.1	BTB_POZ_BTBD18	17..148	CDD:349602	35/147 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910