DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and YBR284W

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_009843.3	Gene:	YBR284W / 852587	SGDID:	S000000488	Length:	797	Species:	Saccharomyces cerevisiae

Alignment Length:	881	Identity:	240/881 - (27%)
Similarity:	374/881 - (42%)	Gaps:	207/881 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SYRGMLSTSDGSPVELRVQDVDSFDGSMMSHAATNAAGPLGSKASGKSLNACTSMSMPQKPSSLR 66
            ||:...|||     .:|:.|:|..|.  :|.......|.:|..:..:..|....:........:.
Yeast    15 SYKESPSTS-----PIRLDDLDGNDA--VSDQGLAFDGDVGITSQARVRNPRAQIFEDSNTDVVL 72

  Fly    67 ATCDLADSPVDEKAEADVEVTNEISAPYEVPQFPIEQIEKKLQIQRHLNEKQATGPRPVATAAVL 131
            ...||...|::.|.:..:|:.:.::.|.|.|. |:|.::.|
Yeast    73 HLDDLDMVPLNTKFDMQMEMGSPMAMPAETPP-PVEPLKTK------------------------ 112

  Fly   132 ATNRESSSSTEGRESAVTMERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMA 196
                :.:.|:.....:...|:....|:                      ...|:|..:||.:|:.
Yeast   113 ----DLAYSSLAHLPSYFFEQTHFRID----------------------RKCLLEMSKLRRNYLT 151

  Fly   197 MSDQ---SFPSTTAR----FLKTVKLKDRINNLPVKEVSDVHLRHSPMKITNPWNVEFPNDEDFK 254
            :|.|   |.|...:|    :||           |||| ....:||. :.:.....|....|.::.
Yeast   152 ISKQDALSCPQLHSRVAGGYLK-----------PVKE-KLFGIRHF-LDLEESNTVNLLQDGNYM 203

  Fly   255 IKPLNGVFHIYENDDESSEIKYEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHV 319
            .:..|...:|              |...:|..|.:....:|.|..|..|..:||.||.:|:.:..
Yeast   204 TELFNSQINI--------------PTFKEFREDFEWCLKIIRDRSLSRFSEKRLQYLVNKFPVFQ 254

  Fly   320 LLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVV-TVTNGQQM 383
            .|:...|:...|.|||:||||.||:|.::..:.|.:|..|..||...|:...:.|: ...||..:
Yeast   255 HLHSKEEMRQSKKVPHKDFYNCRKIDLNLLLSGCFSQWQLTEFIWTKLRKEPDRVIHQAFNGSHI 319

  Fly   384 TLAQVF--------QSMN-----------------LTTYDLTVDMLDVHADRNTFHRFDKFNSKY 423
            ||:|:|        |..|                 |..|.|..|.:::|.           .|..
Yeast   320 TLSQLFKVNFEETGQFFNGLKIIDDSFLEWYKVIYLAKYHLVNDEMEIHT-----------GSHG 373

  Fly   424 NPIGESRLREVFLKTDNYLNGKYFAQIIKEVAF-DLEESKYQNAELRLSI-----YGKSP-DEWY 481
            ..:....:.:.||:.|||:||:|.|:::|.... ..||||||..:|.:..     |..|. |.|:
Yeast   374 KQLRYYLIAKTFLEFDNYINGEYLAELLKTFLIKPQEESKYQLCQLSVDFQFYLHYDNSDVDNWW 438

  Fly   482 KL-AKWAIDNDVYSSNIRWLIQIPRLF-DIFKSNKMMKSFQEILNNIFLPLFEAT--ARPSKHPE 542
            .: |.|....:::|:||||.|:|.|:: :::.:.| :|:|||.||.||.|||.|.  ...|..|.
Yeast   439 MVFANWLNHYNIFSNNIRWNIRISRIYPELYHTGK-VKNFQEYLNLIFKPLFNAENYLHKSLGPI 502

  Fly   543 LHRFLQYVIGFDSVDDESKPENPLFDNDVP---RPEEWTY-EENPPYAYYIYYMYANMTVLNKFR 603
            |.:||..|...|....::  :|.::.|...   .|::||. .:||..:.|:||:|.|:|.||..|
Yeast   503 LLKFLSQVSSIDLCIQDT--DNYIWKNFTAVSCLPKDWTSGGDNPTISQYMYYVYVNLTKLNHIR 565

  Fly   604 QSRNMNTFVLRPHCGEAGP------------VQH---------LVC-GFLMAENISHGLLLRKVP 646
            |:.:.|||.||..|.....            .:|         |.| |||.|||     |....|
Yeast   566 QALHQNTFTLRSSCSPTSMNRTSQFSNTLNFTEHTEAILNNFLLACGGFLNAEN-----LWNAPP 625

  Fly   647 VLQYLYYLTQIGIAMSPLSN--------------NSLFLN----YHRNPLPEYLARGLIISLSTD 693
            .|.||:||:||.:.::||::              ..|.|.    |.:||..::...|..||||::
Yeast   626 SLVYLFYLSQIPMVVAPLNSIVDSKPTMLQEQAPTGLVLEPSKPYKKNPFMKFFEMGFKISLSSE 690

  Fly   694 DPLQFH-FTKEPLMEEYSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLG------PIYYE 751
            ..|..: :||||::||||:||.:::|.|.|:|||.||||:.|||...:|.:|||      ..:.|
Yeast   691 SILYNNSYTKEPIIEEYSVAASIYRLHSADLCELLRNSVITSGFSSTLKNKWLGVSLASHDYFVE 755

  Fly   752 D-GIMG-------NDITRTNVPEIRVAYRYETLLDE 779
            : |.:.       |.....|||.||..||..||..|
Yeast   756 NTGFVDKWYDCKPNTSLEHNVPIIRRQYRSSTLAGE 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	194/628 (31%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	190/592 (32%)
YBR284W	NP_009843.3	Add	341..748	CDD:224729	138/425 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11359
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.800