DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and ampd3a

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	XP_009301872.1	Gene:	ampd3a / 556578	ZFINID:	ZDB-GENE-110407-2	Length:	778	Species:	Danio rerio

Alignment Length:	786	Identity:	397/786 - (50%)
Similarity:	524/786 - (66%)	Gaps:	55/786 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 MMSHAATNAAGPLGSKASGKSLNACTSMSMP-QKPSSLRATCDLADSPVDEKAEADV---EVTNE 89
            ||....|..|..|.|...||        .|| |.|.......|.....:.||..|..   |.|.:
Zfish     1 MMRRLQTPIAKQLSSPCLGK--------DMPRQFPKIALTDVDEEVRLLAEKVYASALKEEDTKD 57

  Fly    90 ISAPYEVPQ-FPIE-QIEKKLQIQRHLNEKQA--TGPR----------------PVATAAV--LA 132
            ..:.|.||: .||. |..|:.::.|.|.|:|:  :..|                |::|.:|  :.
Zfish    58 ALSMYTVPEDCPIGLQEAKQRELLRELAEQQSEESAKRKKSFKMIRSQSMSLQIPLSTESVRGVV 122

  Fly   133 TNRESSSSTEGRESAVTMERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMAM 197
            |...:.|||....|....|       :|||:|||:..:|:.:||.|:|:..|::||.:|..|..:
Zfish   123 TPLITPSSTCSSISPNFPE-------YQRVTISGDYCAGITVEDYEQAAKSLLKALFIREKYSKL 180

  Fly   198 SDQSFPSTTARFLKTV---KLKDRINNLPVKEVSDVHLRHSPMKITNPWNVE-FPNDEDFKIKPL 258
            :...||.|||:||:..   |..:....||       .:...|.:..:|:::| .|.:.::::|..
Zfish   181 AYHRFPRTTAQFLRNAANEKWTEEDEILP-------DICPCPGEGEDPYSMENVPENLNYQMKMK 238

  Fly   259 NGVFHIYENDDESSEIK---YEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHVL 320
            :|:.::|||.:..|..|   ..|||:..|..||..:..||||||.|::|:|||.:|.||:.:|.:
Zfish   239 DGIIYVYENAEALSMNKPRCLPYPDLETFAIDMSHVLAMIADGPTKTYCHRRLNFLGSKFYLHEM 303

  Fly   321 LNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQMTL 385
            |||:.||...|.||||||||.||||||||||:||||||||.||:.|.|.:|..||....|.::||
Zfish   304 LNEMAELKELKGVPHRDFYNVRKVDTHIHAAACMNQKHLLDFIQTTYKTDAERVVLEKAGLKLTL 368

  Fly   386 AQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFAQI 450
            .|||.::|:..||||||.|||||.|.||||||||||||||:|.|.|||::||.|||:||:|||::
Zfish   369 KQVFNNLNMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGASELREIYLKADNYINGEYFARL 433

  Fly   451 IKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNKM 515
            |||||.:|||||||:||.||||||:||:||..|:.|.|.|.|||.|:||:||:||::|||:|.|:
Zfish   434 IKEVAHNLEESKYQHAEPRLSIYGRSPEEWESLSHWFIQNKVYSPNMRWIIQVPRIYDIFRSRKL 498

  Fly   516 MKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWTYE 580
            :.:|.::|.|:||||||||..|.||.|||.||:||.||||||||||..:.:|....|:||:||.:
Zfish   499 VPNFAKMLENVFLPLFEATVNPQKHKELHVFLKYVTGFDSVDDESKHSDHMFSYKSPKPEQWTTD 563

  Fly   581 ENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRKV 645
            :||||:||:::||||:.|||..|:.|.::||..||||||||.:.|||..||.|:||||||.|:|.
Zfish   564 DNPPYSYYLFHMYANIMVLNNLRKERGLSTFQFRPHCGEAGSITHLVSAFLTADNISHGLNLKKS 628

  Fly   646 PVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEEYS 710
            |||||||||.|:.|||||||||||||.|.:|||.|:|.:||.:|||||||:|||:|||.|||||:
Zfish   629 PVLQYLYYLAQVPIAMSPLSNNSLFLEYSKNPLREFLHKGLCVSLSTDDPMQFHYTKEALMEEYA 693

  Fly   711 IAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYET 775
            ||||:||||:||:||:|||||:.||..|..|:.:||..|.:||..||||.||||.:||:|||:||
Zfish   694 IAAQLWKLSTCDVCEIARNSVLQSGLSHEEKKHFLGVSYLKDGPEGNDIRRTNVAQIRMAYRHET 758

  Fly   776 LLDELS 781
            |.:|||
Zfish   759 LCNELS 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	329/537 (61%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	315/495 (64%)
ampd3a	XP_009301872.1	metallo-dependent_hydrolases	158..766	CDD:294200	351/614 (57%)
ampd3a	XP_009301872.1	PLN03055	199..766	CDD:178613	335/573 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11432
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54904
OrthoDB	1	1.010	-	-		D115023at33208
OrthoFinder	1	1.000	-	-		FOG0001065
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100681
Panther	1	1.100	-	-	O	PTHR11359
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X640
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.790