DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and Ampd2

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	XP_006233230.3	Gene:	Ampd2 / 362015	RGDID:	2110	Length:	900	Species:	Rattus norvegicus

Alignment Length:	808	Identity:	460/808 - (56%)
Similarity:	575/808 - (71%)	Gaps:	53/808 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LRVQDVDSFDGSMMSHAATN-AAGPLGSKASGKSLNACTSMSMPQKPSSLRATCDLADSPVDEK- 79
            ||....||  |||.|.|.:. .|.||   .|.:||.. |:..:...|..||.:.|.....:.|:
  Rat    93 LRGAPRDS--GSMASEARSGLGASPL---QSARSLPG-TAPCLKHFPLDLRTSMDGKCKEIAEEL 151

  Fly    80 -----AEADVEVTNEISAPYEVP-QFPIEQIEKKLQ-IQRHLNEKQATGPRPVATAA--VLATNR 135
                 ||:::.     |||||.| :.||||:|::.| ::|.:::.....|..:..|.  .|.|:.
  Rat   152 FSRSLAESELR-----SAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLRAKQDFLKTDS 211

  Fly   136 ES-----SSSTEGR------ESAVTMERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALR 189
            :|     ....||:      |..|.:||     .||||.||||:..|||..||..|:..::.||.
  Rat   212 DSDLQLYKEQGEGQGDRGLWERDVVLER-----EFQRVIISGEEKCGVPFTDLLDAAKSVVRALF 271

  Fly   190 LRSHYMAMSDQSFPSTTARFLKTVKLK-------DRINNLPVKEVSDVH---LRHSPMKITNPWN 244
            :|..|||:|.|||..||.|:|:.:..|       ::..:.||...:.||   |...|.:...|..
  Rat   272 IREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQSPDTPVSADAPVHPPALEQHPYEHCEPST 336

  Fly   245 VEFPNDEDFKIKPLNGVFHIY---ENDDESSEIKYEYPDMSQFVNDMQVMCNMIADGPLKSFCYR 306
            :  |.|....::.:.||.|:|   :.|:...|::..|||:.:||.|:.|:..:|.:||:||||||
  Rat   337 M--PGDLGLGLRMVRGVVHVYTRRDPDEHCPEVELPYPDLQEFVADVNVLMALIINGPIKSFCYR 399

  Fly   307 RLCYLSSKYQMHVLLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNA 371
            ||.|||||:||||||||::||||||.||||||||.|||||||||:|||||||||||||:.:|.:.
  Rat   400 RLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHL 464

  Fly   372 NEVVTVTNGQQMTLAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFL 436
            .|:|.|..|::.||.:||:|||||.|||:||.|||||||||||||||||:||||||||.|||:|:
  Rat   465 EEIVHVEQGREQTLREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGESVLREIFI 529

  Fly   437 KTDNYLNGKYFAQIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLI 501
            ||||.::|||||.|||||..||||||||||||||||||:|.|||.|||:||:::.|:|.|:|||:
  Rat   530 KTDNKISGKYFAHIIKEVMSDLEESKYQNAELRLSIYGRSRDEWDKLARWAVNHRVHSPNVRWLV 594

  Fly   502 QIPRLFDIFKSNKMMKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPL 566
            |:|||||::::...:.:|||:|.||||||||||..|:.|||||.||::|.|||||||||||||.:
  Rat   595 QVPRLFDVYRTKGQLANFQEMLENIFLPLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHV 659

  Fly   567 FDNDVPRPEEWTYEENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFL 631
            |:.:.|.||.|..|:|||||||:||.:|||.:||..|:.|..:|||||||||||||:.|||..|:
  Rat   660 FNLESPLPEAWVEEDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFM 724

  Fly   632 MAENISHGLLLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPL 696
            :||||||||||||.|||||||||.||||||||||||||||:||||||||||:|||::||||||||
  Rat   725 LAENISHGLLLRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPL 789

  Fly   697 QFHFTKEPLMEEYSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITR 761
            ||||||||||||||||.||||||||||||||||||:||||.|.:|..||||.|.::|..||||.|
  Rat   790 QFHFTKEPLMEEYSIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRR 854

  Fly   762 TNVPEIRVAYRYETLLDELSNIFKVNQT 789
            ||||:|||.||||||..||:.|.:..|:
  Rat   855 TNVPDIRVGYRYETLCQELALITQAVQS 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	375/538 (70%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	362/495 (73%)
Ampd2	XP_006233230.3	AMPD	377..873	CDD:238644	362/495 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335116
Domainoid	1	1.000	648	1.000	Domainoid score	I153
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2979
Inparanoid	1	1.050	866	1.000	Inparanoid score	I399
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115023at33208
OrthoFinder	1	1.000	-	-		FOG0001065
OrthoInspector	1	1.000	-	-		oto98173
orthoMCL	1	0.900	-	-		OOG6_100681
Panther	1	1.100	-	-	LDO	PTHR11359
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X640
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760