DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and ampd3b

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_956142.1	Gene:	ampd3b / 333997	ZFINID:	ZDB-GENE-030131-5929	Length:	779	Species:	Danio rerio

Alignment Length:	815	Identity:	385/815 - (47%)
Similarity:	539/815 - (66%)	Gaps:	62/815 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSYRGM-LSTSDGSP----------VELRVQDVDSFDGSMMSHAATNAAGPLGSKASGKSLNACT 54
            ||.:|. ||....:|          .::.:.|||.....|......:|.....:|      |..:
Zfish     1 MSKKGTPLSKQQSTPNFGREMPRQFTKISLHDVDENIRLMAEKVYASALKEEDTK------NTFS 59

  Fly    55 SMSMPQKPSSLRATCDLADSPVDEKAEADVEVTNEISAPYEVPQFPIEQIEKKLQIQRHLNEKQA 119
            ..::|:            |.|:..:...:.|:..|:.....      |:..|:.|..:.:..:..
Zfish    60 MFTVPE------------DCPIGLQQAKEWELRKELDEQRS------EESVKRKQSFKLMRSQSM 106

  Fly   120 TGPRPVAT--AAVLATNRESSSSTEGRESAVTMERNDADINFQRVSISGEDTSGVPLEDLERAST 182
            :...|||.  |..:.:...:.|:.||:......|       ||||:|||:..:|:.:||.|:|:.
Zfish   107 SLQIPVAPDWAMSVVSTLLTPSAPEGQMPVNIPE-------FQRVTISGDYCAGITVEDYEQAAK 164

  Fly   183 LLIEALRLRSHYMAMSDQSFPSTTARFLKTVKLKDRINNLPVKEVSDV--HLRHSPMKITNPWNV 245
            .|:.||.:|..|..::...||.|.|:||::.      ||....|..:|  .:..||.:..:|:::
Zfish   165 SLLTALFIREKYSRLAYHRFPRTAAKFLRSA------NNEKWSEDEEVLPDICPSPSEGEDPYSM 223

  Fly   246 E-FPNDEDFKIKPLNGVFHIYENDDESSEIKYE------YPDMSQFVNDMQVMCNMIADGPLKSF 303
            | .|.:.::.:|..:|:.::|:|:|   .:|.:      |||:..|..|:..:..||||||.|::
Zfish   224 EDLPQNLNYSLKMKDGIIYVYDNED---ALKQDLPRSLPYPDLETFAIDLSHVLAMIADGPTKTY 285

  Fly   304 CYRRLCYLSSKYQMHVLLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLK 368
            |:|||.:|:||:|:|.:|||:.||...|.||||||||.||||||||||:||||||||:||:.:.:
Zfish   286 CHRRLNFLTSKFQLHEMLNEMAELKELKCVPHRDFYNVRKVDTHIHAAACMNQKHLLKFIQDSYQ 350

  Fly   369 NNANEVVTVTNGQQMTLAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLRE 433
            ..|:.||....|::.||.|||:::.:..||||||.|||||.|.||||||||||||||:|.:.|||
Zfish   351 TEADRVVLEKGGKKFTLKQVFENLKMDPYDLTVDSLDVHAGRQTFHRFDKFNSKYNPVGANELRE 415

  Fly   434 VFLKTDNYLNGKYFAQIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIR 498
            ::||||||:||:|||::|||||.||||||||:||.||||||::|:||..|:||.|...::|.|:|
Zfish   416 IYLKTDNYINGEYFARLIKEVAHDLEESKYQHAEPRLSIYGRAPEEWESLSKWFIMQKLHSPNMR 480

  Fly   499 WLIQIPRLFDIFKSNKMMKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPE 563
            |:||:||::|||:|.|::.:|.::|.|||||||:||..|.||.|:|.||::|.||:|||||||..
Zfish   481 WMIQVPRIYDIFRSKKIIANFAKMLENIFLPLFQATVNPQKHKEMHVFLKHVTGFNSVDDESKHS 545

  Fly   564 NPLFDNDVPRPEEWTYEENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVC 628
            :.:|:...|:|||||.||||||.||:::||||:.|||..|:.|.:|||:.||||||||.:.|||.
Zfish   546 DHIFNYKSPKPEEWTSEENPPYTYYLFHMYANIMVLNNLRKERGLNTFLFRPHCGEAGSITHLVS 610

  Fly   629 GFLMAENISHGLLLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTD 693
            .||.|:||||||.|:|.|||||||||.|:.|||||||||||||.|.:|||.|:|.:||.:|||||
Zfish   611 AFLTADNISHGLNLKKSPVLQYLYYLAQVPIAMSPLSNNSLFLEYSKNPLREFLQKGLCVSLSTD 675

  Fly   694 DPLQFHFTKEPLMEEYSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGND 758
            ||||||:|||.|||||:||||:||||:||.||:|||||:.||..|..|:.:||..|.:||..|||
Zfish   676 DPLQFHYTKEALMEEYAIAAQLWKLSTCDTCEIARNSVLQSGLSHQEKKYFLGEKYLDDGPEGND 740

  Fly   759 ITRTNVPEIRVAYRYETLLDELSNIFKVNQTCSIA 793
            |.:|||.:||:|||:|||.:|||.:.:..::.::|
Zfish   741 IRKTNVAQIRMAYRHETLCNELSFLVEAVKSEALA 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	324/541 (60%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	311/495 (63%)
ampd3b	NP_956142.1	PLN03055	157..765	CDD:178613	347/616 (56%)
ampd3b	NP_956142.1	metallo-dependent_hydrolases	157..765	CDD:294200	347/616 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11432
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54904
OrthoDB	1	1.010	-	-		D115023at33208
OrthoFinder	1	1.000	-	-		FOG0001065
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100681
Panther	1	1.100	-	-	O	PTHR11359
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X640
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.790