Protein Alignment AMPdeam and AMPD2

DIOPT Version :10

• Sequence 1: NP_001285233.1
• Gene: AMPdeam / 32352
• FlyBaseID: FBgn0052626
• Length: 798
• Species: Drosophila melanogaster
• Sequence 2: NP_004028.4
• Gene: AMPD2 / 271
• HGNCID: 469
• Length: 825
• Species: Homo sapiens
• Alignment Length: 795
• Identity: 455/795 - (57%)
• Similarity: 567/795 - (71%)
• Gaps: 50/795 - (6%)

  Fly    31 SHAATNAAGPLGSKASGKSLNACTSMSMPQKPSSLRATCDLADSPVDEKAEAD---VEVTNEI-- 90
            |.||..|.|.||:    ..|.:..|:..|       |.| |...|:|.:...|   .|:..|:
Human    26 STAAPEARGGLGA----PPLQSARSLPGP-------APC-LKHFPLDLRTSMDGKCKEIAEELFT 78

  Fly    91 ---------SAPYEVP-QFPIEQIEKKLQ-IQRHLNEKQATGPRPVATAA--VLATNRES----- 137
                     |||||.| :.||||:|::.| ::|.:::.....|..:..|.  .|.|:.:|
Human    79 RSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLRAKQDFLKTDSDSDLQLY 143

  Fly   138 SSSTEGRESAVTMERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMAMSDQSF 202
            ....||:......||:..:..||||:||||:..|||..||..|:..::.||.:|..|||:|.|||
Human   144 KEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDAAKSVVRALFIREKYMALSLQSF 208

  Fly   203 PSTTARFLKTVKLK-------DRINNLPVKEVSDVH---LRHSPMKITNPWNVEFPNDEDFKIKP 257
            ..||.|:|:.:..|       ::..:.||...:.||   |...|.:...|..:  |.|....::.
Human   209 CPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPPALEQHPYEHCEPSTM--PGDLGLGLRM 271

  Fly   258 LNGVFHIY---ENDDESSEIKYEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHV 319
            :.||.|:|   |.|:..||::..|||:.:||.|:.|:..:|.:||:||||||||.|||||:||||
Human   272 VRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVNVLMALIINGPIKSFCYRRLQYLSSKFQMHV 336

  Fly   320 LLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQMT 384
            ||||::||||||.||||||||.|||||||||:|||||||||||||:.:|.:..|:|.|..|::.|
Human   337 LLNEMKELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQT 401

  Fly   385 LAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFAQ 449
            |.:||:|||||.|||:||.|||||||||||||||||:||||||||.|||:|:||||.::|||||.
Human   402 LREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAH 466

  Fly   450 IIKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNK 514
            |||||..||||||||||||||||||:|.|||.|||:||:.:.|:|.|:|||:|:|||||::::..
Human   467 IIKEVMSDLEESKYQNAELRLSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKG 531

  Fly   515 MMKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWTY 579
            .:.:|||:|.||||||||||..|:.|||||.||::|.|||||||||||||.:|:.:.|.||.|..
Human   532 QLANFQEMLENIFLPLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVE 596

  Fly   580 EENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRK 644
            |:|||||||:||.:|||.:||..|:.|..:|||||||||||||:.|||..|::||||||||||||
Human   597 EDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRK 661

  Fly   645 VPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEEY 709
            .|||||||||.||||||||||||||||:||||||||||:|||::|||||||||||||||||||||
Human   662 APVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEY 726

  Fly   710 SIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYE 774
            |||.||||||||||||||||||:||||.|.:|..||||.|.::|..||||.|||||:|||.||||
Human   727 SIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYE 791

  Fly   775 TLLDELSNIFKVNQT 789
            ||..||:.|.:..|:
Human   792 TLCQELALITQAVQS 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	362/495 (73%)
AMPD2	NP_004028.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		9/26 (35%)
		AMP_deaminase	163..806	CDD:437158	414/644 (64%)