DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and AMPD2

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001355738.1	Gene:	AMPD2 / 271	HGNCID:	469	Length:	825	Species:	Homo sapiens

Alignment Length:	795	Identity:	455/795 - (57%)
Similarity:	567/795 - (71%)	Gaps:	50/795 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHAATNAAGPLGSKASGKSLNACTSMSMPQKPSSLRATCDLADSPVDEKAEAD---VEVTNEI-- 90
            |.||..|.|.||:    ..|.:..|:..|       |.| |...|:|.:...|   .|:..|:
Human    26 STAAPEARGGLGA----PPLQSARSLPGP-------APC-LKHFPLDLRTSMDGKCKEIAEELFT 78

  Fly    91 ---------SAPYEVP-QFPIEQIEKKLQ-IQRHLNEKQATGPRPVATAA--VLATNRES----- 137
                     |||||.| :.||||:|::.| ::|.:::.....|..:..|.  .|.|:.:|
Human    79 RSLAESELRSAPYEFPEESPIEQLEERRQRLERQISQDVKLEPDILLRAKQDFLKTDSDSDLQLY 143

  Fly   138 SSSTEGRESAVTMERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMAMSDQSF 202
            ....||:......||:..:..||||:||||:..|||..||..|:..::.||.:|..|||:|.|||
Human   144 KEQGEGQGDRSLRERDVLEREFQRVTISGEEKCGVPFTDLLDAAKSVVRALFIREKYMALSLQSF 208

  Fly   203 PSTTARFLKTVKLK-------DRINNLPVKEVSDVH---LRHSPMKITNPWNVEFPNDEDFKIKP 257
            ..||.|:|:.:..|       ::..:.||...:.||   |...|.:...|..:  |.|....::.
Human   209 CPTTRRYLQQLAEKPLETRTYEQGPDTPVSADAPVHPPALEQHPYEHCEPSTM--PGDLGLGLRM 271

  Fly   258 LNGVFHIY---ENDDESSEIKYEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHV 319
            :.||.|:|   |.|:..||::..|||:.:||.|:.|:..:|.:||:||||||||.|||||:||||
Human   272 VRGVVHVYTRREPDEHCSEVELPYPDLQEFVADVNVLMALIINGPIKSFCYRRLQYLSSKFQMHV 336

  Fly   320 LLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQMT 384
            ||||::||||||.||||||||.|||||||||:|||||||||||||:.:|.:..|:|.|..|::.|
Human   337 LLNEMKELAAQKKVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEIVHVEQGREQT 401

  Fly   385 LAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFAQ 449
            |.:||:|||||.|||:||.|||||||||||||||||:||||||||.|||:|:||||.::|||||.
Human   402 LREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNAKYNPIGESVLREIFIKTDNRVSGKYFAH 466

  Fly   450 IIKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNK 514
            |||||..||||||||||||||||||:|.|||.|||:||:.:.|:|.|:|||:|:|||||::::..
Human   467 IIKEVMSDLEESKYQNAELRLSIYGRSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKG 531

  Fly   515 MMKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWTY 579
            .:.:|||:|.||||||||||..|:.|||||.||::|.|||||||||||||.:|:.:.|.||.|..
Human   532 QLANFQEMLENIFLPLFEATVHPASHPELHLFLEHVDGFDSVDDESKPENHVFNLESPLPEAWVE 596

  Fly   580 EENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRK 644
            |:|||||||:||.:|||.:||..|:.|..:|||||||||||||:.|||..|::||||||||||||
Human   597 EDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFVLRPHCGEAGPIHHLVSAFMLAENISHGLLLRK 661

  Fly   645 VPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEEY 709
            .|||||||||.||||||||||||||||:||||||||||:|||::|||||||||||||||||||||
Human   662 APVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEY 726

  Fly   710 SIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYE 774
            |||.||||||||||||||||||:||||.|.:|..||||.|.::|..||||.|||||:|||.||||
Human   727 SIATQVWKLSSCDMCELARNSVLMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYE 791

  Fly   775 TLLDELSNIFKVNQT 789
            ||..||:.|.:..|:
Human   792 TLCQELALITQAVQS 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	377/538 (70%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	362/495 (73%)
AMPD2	NP_001355738.1	AMPD	301..797	CDD:238644	362/495 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141436
Domainoid	1	1.000	647	1.000	Domainoid score	I159
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2979
Inparanoid	1	1.050	870	1.000	Inparanoid score	I423
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115023at33208
OrthoFinder	1	1.000	-	-		FOG0001065
OrthoInspector	1	1.000	-	-		oto91081
orthoMCL	1	0.900	-	-		OOG6_100681
Panther	1	1.100	-	-	LDO	PTHR11359
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R55
SonicParanoid	1	1.000	-	-		X640
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790