DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and AMPD1

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_000027.3	Gene:	AMPD1 / 270	HGNCID:	468	Length:	747	Species:	Homo sapiens

Alignment Length:	756	Identity:	366/756 - (48%)
Similarity:	490/756 - (64%)	Gaps:	70/756 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PVDEKAEADV-----------EVTNEISAPYEVPQFPIEQIEKKLQIQRHLNEKQATGPRPVATA 128
            |.:||...|.           ||.:| ....|:..|.:::|   ..|..|  |.||    .:...
Human     7 PAEEKQIDDAMRNFAEKVFASEVKDE-GGRQEISPFDVDEI---CPISHH--EMQA----HIFHL 61

  Fly   129 AVLATNRES--SSSTEGRE-----------SAVTMERNDADI----------NFQRVSISGEDTS 170
            ..|:|:.|:  ....:||:           |:..:...|..|          :||||.|:|:..|
Human    62 ETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYAS 126

  Fly   171 GVPLEDLERASTLLIEALRLRSHYMAMSDQSFPSTTARFLKTVKLKDRINN--------LPVKEV 227
            ||.:||.|.....|..||.:|..||..|.|.||.|.:::|:.:..:..:.|        .|||:.
Human   127 GVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKG 191

  Fly   228 SDVHLRHSPMKITNPWNVEFPNDEDFKIKPLNGVFHIYEND-----DESSEIKYEYPDMSQFVND 287
            .|      |.:..|     .|.:..:.:|..:||.::|.|:     ||...:  .||::..|::|
Human   192 ED------PFRTDN-----LPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPL--PYPNLDTFLDD 243

  Fly   288 MQVMCNMIADGPLKSFCYRRLCYLSSKYQMHVLLNELRELAAQKAVPHRDFYNTRKVDTHIHAAS 352
            |..:..:||.||:|::.:|||.:||||:|:|.:|||:.||...|..|||||||.||||||||||:
Human   244 MNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAA 308

  Fly   353 CMNQKHLLRFIKKTLKNNANEVVTVTNGQQMTLAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFD 417
            |||||||||||||:.:.:|:.||..|..:.:||.::|..:.:..||||||.|||||.|.||.|||
Human   309 CMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFD 373

  Fly   418 KFNSKYNPIGESRLREVFLKTDNYLNGKYFAQIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYK 482
            |||.||||:|.|.||:::||||||:||:|||.|||||..||.|:|||:||.||||||:|||||.|
Human   374 KFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSK 438

  Fly   483 LAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNKMMKSFQEILNNIFLPLFEATARPSKHPELHRFL 547
            |:.|.:.|.::..|:.|:||:||::|:|:|...:..|.::|.|||:|:||||..|...|||..||
Human   439 LSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFL 503

  Fly   548 QYVIGFDSVDDESKPENPLFDNDVPRPEEWTYEENPPYAYYIYYMYANMTVLNKFRQSRNMNTFV 612
            :::.||||||||||....:|.:..|:|:|||.|:||.|.||.||||||:.|||..|:.|.||||:
Human   504 KHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTFL 568

  Fly   613 LRPHCGEAGPVQHLVCGFLMAENISHGLLLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNP 677
            .||||||||.:.||:..|::|::|||||.|:|.||||||::|.||.|||||||||||||.|.:||
Human   569 FRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNP 633

  Fly   678 LPEYLARGLIISLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQ 742
            ..::|.:||:||||||||:|||||||||||||:|||||:|||:|||||:|||||:..|..|..|.
Human   634 FLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKV 698

  Fly   743 QWLGPIYYEDGIMGNDITRTNVPEIRVAYRYETLLDELSNI 783
            ::||..|.|:|..||||.||||.:||:||||||...||:.|
Human   699 KFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLI 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	312/541 (58%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	299/495 (60%)
AMPD1	NP_000027.3	AMPD	240..736	CDD:238644	299/495 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11588
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115023at33208
OrthoFinder	1	1.000	-	-		FOG0001065
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100681
Panther	1	1.100	-	-	O	PTHR11359
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X640
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.780