DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and ada1

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_595153.2	Gene:	ada1 / 2540105	PomBaseID:	SPBC106.04	Length:	831	Species:	Schizosaccharomyces pombe

Alignment Length:	792	Identity:	354/792 - (44%)
Similarity:	475/792 - (59%)	Gaps:	105/792 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 MSMPQK----PSSLRATCDLADSPVDEKAEADVEVTNEISAP--YEVPQFPIEQIEKKLQIQRHL 114
            |:|.|:    |:....|..|.....:..|..|.||.   :||  .:.|.|.. ..|:.|   ||.
pombe     1 MNMEQEDDQVPAVAAETVPLKRYVTNPGANRDEEVA---AAPSSQDTPYFDY-AYERSL---RHQ 58

  Fly   115 NEKQATGPRPVATAAVLATN-----RESSSSTEGRESAVTME--RNDADINFQRVSISGEDTSGV 172
            :.|            .||.|     |:...|...|..:|:..  ||..|:|..:..    ..||.
pombe    59 DAK------------FLAMNGTQNGRDGLPSKSPRRPSVSASTVRNSDDVNHSKAG----PGSGK 107

  Fly   173 PLEDLERASTLLIEALRLRSHYMAMSDQSF------PSTTARFLKTVKLKDRINNLPVKEVSDVH 231
            .|.|     ||..:...:...::...|.:.      |.|....::|.      :.|...|:::::
pombe   108 LLND-----TLQSKISSIHMPHVQQGDNAVVSSVGGPETDPGNMETT------DPLFSDELAEIY 161

  Fly   232 L--------RHSPMKIT------NP-----WNVEFP------------NDEDFKIKPL------- 258
            |        ||..::::      ||     | :.:|            |..|.||..:
pombe   162 LSIHKCMDMRHKYIRVSLQGELDNPIDDDSW-IIYPDCKEGEDDTGLFNFADCKIPGIENEMEYH 225

  Fly   259 ---NGVFHIYENDDE--SSEIKYEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMH 318
               .|:|.:||||..  :....:..|.:..:..|::.:.:..:|||.|||.:|||.||..::.|:
pombe   226 MDHQGIFQVYENDSAYIAGTPSFHIPTIRDYYIDLEFLLSASSDGPSKSFSFRRLQYLEGRWNMY 290

  Fly   319 VLLNELRELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQM 383
            :||||.:|||..|.||||||||.||||||:|.::..||||||||||..|:...||.|...:|:.:
pombe   291 MLLNEYQELADTKKVPHRDFYNVRKVDTHVHHSALANQKHLLRFIKAKLRKCPNEKVIWRDGKFL 355

  Fly   384 TLAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFA 448
            ||.:||.|:.||:|||::|.||:||..:|||||||||.|||||||||||.:||||||.:||:|.|
pombe   356 TLQEVFDSLKLTSYDLSIDTLDMHAHTDTFHRFDKFNLKYNPIGESRLRTIFLKTDNDINGRYLA 420

  Fly   449 QIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSN 513
            ::.|||..||...|||.||.|:||||::.:||.|||.|.|||:::|.|:|||||:|||:|::|.:
pombe   421 ELTKEVFTDLRTQKYQMAEYRISIYGRNREEWDKLAAWIIDNELFSPNVRWLIQVPRLYDVYKKS 485

  Fly   514 KMMKSFQEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWT 578
            .::::|:|::.|:|.||||.|..|..||:||.|||.||||||||||||||...| ...|.|:.|.
pombe   486 GIVETFEEVVRNVFEPLFEVTKDPRTHPKLHVFLQRVIGFDSVDDESKPERRTF-RKFPYPKHWD 549

  Fly   579 YEENPPYAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLR 643
            ...||||:|::||||||||.||.:|:.|..|||||||||||||...||...||::..|:||:|||
pombe   550 INLNPPYSYWLYYMYANMTSLNSWRKIRGFNTFVLRPHCGEAGDTDHLASAFLLSHGINHGILLR 614

  Fly   644 KVPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEE 708
            |||.||||:||.||.|||||||||:|||.|.:||...|..|||.:||||||||||.||:|||:||
pombe   615 KVPFLQYLWYLDQIPIAMSPLSNNALFLAYDKNPFLTYFKRGLNVSLSTDDPLQFAFTREPLIEE 679

  Fly   709 YSIAAQVWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRY 773
            |::|||::|||:.||||||||||:.|||...:|::|||..:       .||.|||||.||:|||.
pombe   680 YAVAAQIYKLSAVDMCELARNSVLQSGFERQLKERWLGVDF-------QDIDRTNVPIIRLAYRA 737

  Fly   774 ETLLDELSNIFK 785
            .||..|::.:.|
pombe   738 LTLTQEIALVNK 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	305/559 (55%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	292/495 (59%)
ada1	NP_595153.2	PLN03055	154..747	CDD:178613	312/601 (52%)
ada1	NP_595153.2	AMP_deaminase	155..747	CDD:273618	312/600 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	531	1.000	Domainoid score	I43
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2979
Inparanoid	1	1.050	624	1.000	Inparanoid score	I148
OMA	1	1.010	-	-		QHG54904
OrthoFinder	1	1.000	-	-		FOG0001065
OrthoInspector	1	1.000	-	-		oto101821
orthoMCL	1	0.900	-	-		OOG6_100681
Panther	1	1.100	-	-	LDO	PTHR11359
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R55
SonicParanoid	1	1.000	-	-		X640
TreeFam	1	0.960	-	-
	14	13.860