DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and Ampd3

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_113732.2	Gene:	Ampd3 / 25095	RGDID:	2111	Length:	801	Species:	Rattus norvegicus

Alignment Length:	783	Identity:	379/783 - (48%)
Similarity:	524/783 - (66%)	Gaps:	56/783 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TSMSMPQKPSSLRATCDLADSP--VDEKAEADV---EVTNEISAPYEVPQ-FPIEQIE-KKLQIQ 111
            |...||::...|..: ||.:..  :.||..|.|   |.:.::.:.:.||: .||.|.| |:.::|
  Rat    33 TKTEMPRQFPKLNMS-DLDEHVRLLAEKVFAKVLREEDSKDVMSLFTVPEDCPIGQKEAKERELQ 96

  Fly   112 RHLNEKQAT---------------------------GPRPVATAAVLATNRESSSSTEGRESAVT 149
            :.|.|:::.                           ||..|:.|....|.....::::...:...
  Rat    97 KELAEQKSVETAKRKKSFKMIRSQSMSLQMPTQDWKGPPSVSPAMSPTTPLVLGAASKPGLAPYD 161

  Fly   150 MERNDADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMAMSDQSFPSTTARFLKTVK 214
            |.      .:|||:|||:..:|:.:||.|:|:..|.:||.:|..|..::...||.|||::
  Rat   162 MP------EYQRVTISGDYCAGITVEDYEQAAKSLAKALMIREKYARLAYHRFPRTTAQY----- 215

  Fly   215 LKDRINNLPVKE-VSDVHLRHSPMKITNPWNVE-FPNDEDFKIKPLNGVFHIYEND---DESSEI 274
            |..:..::|::| :.|.|  ..|:...:|:.:: .|.:..:.::...||..:|:|.   :.....
  Rat   216 LAHQGESVPLEEGLPDFH--PPPLPQEDPYCLDNAPPNLGYLVRMQGGVLFVYDNQTMLERQEPH 278

  Fly   275 KYEYPDMSQFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHVLLNELRELAAQKAVPHRDFY 339
            ...|||:..::.||..:..:|.|||.|::|:|||.:|.||:.:|.:|||:.|....|:.||||||
  Rat   279 SLPYPDLETYIVDMSHILALITDGPTKTYCHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFY 343

  Fly   340 NTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQMTLAQVFQSMNLTTYDLTVDML 404
            |.||||||||||:||||||||||||.|.:...:..|....|:::||.|||.|:::..||||||.|
  Rat   344 NVRKVDTHIHAAACMNQKHLLRFIKYTYQTEPDRTVAEKLGRKITLRQVFDSLHMDPYDLTVDSL 408

  Fly   405 DVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFAQIIKEVAFDLEESKYQNAELR 469
            ||||.|.||||||||||||||:|.|.||:::|||:|||.|:|||:::||||.:||:||||.:|.|
  Rat   409 DVHAGRQTFHRFDKFNSKYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEDSKYQYSEPR 473

  Fly   470 LSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNKMMKSFQEILNNIFLPLFEAT 534
            |||||:||.||..||:|.|.:.|||.|:||:||:||::|||:|.|::.||.::|.|||||||:||
  Rat   474 LSIYGRSPKEWSSLARWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPSFGKMLENIFLPLFQAT 538

  Fly   535 ARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWTYEENPPYAYYIYYMYANMTVL 599
            ..|..|.|||.||:||.||||||||||..:.:|.:..|.|:.||.|:||||:||:||||||:.||
  Rat   539 INPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPSPDLWTSEQNPPYSYYLYYMYANIMVL 603

  Fly   600 NKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRKVPVLQYLYYLTQIGIAMSPL 664
            |..|:.|.::||:.||||||||.:.|||..||.|:||||||||:|.|||||||||.||.||||||
  Rat   604 NNLRRERGLSTFLFRPHCGEAGSITHLVSAFLTADNISHGLLLKKSPVLQYLYYLAQIPIAMSPL 668

  Fly   665 SNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSSCDMCELARN 729
            |||||||.|.:|||.|:|.:||.:|||||||:|||:|||.|||||:|||||||||:||:||:|||
  Rat   669 SNNSLFLEYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALMEEYAIAAQVWKLSTCDLCEIARN 733

  Fly   730 SVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYETLLDE---LSNIFKVNQTCS 791
            ||:.||..|..||::||..||::|..||||.:|||.:||:|:|||||.:|   ||:..|..:..:
  Rat   734 SVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFRYETLCNELSFLSDAMKSEEITA 798

  Fly   792 IAD 794
            :||
  Rat   799 LAD 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	321/541 (59%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	311/498 (62%)
Ampd3	NP_113732.2	AMP_deaminase	181..787	CDD:273618	340/612 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11272
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54904
OrthoDB	1	1.010	-	-		D115023at33208
OrthoFinder	1	1.000	-	-		FOG0001065
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100681
Panther	1	1.100	-	-	O	PTHR11359
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X640
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.790