DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and ampd-1

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001343751.1	Gene:	ampd-1 / 173891	WormBaseID:	WBGene00016415	Length:	948	Species:	Caenorhabditis elegans

Alignment Length:	790	Identity:	426/790 - (53%)
Similarity:	537/790 - (67%)	Gaps:	64/790 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KASGKSLNACTSMSMPQKPSSLRATCD--LADSPVDEKAEADVEVTNEISAPYEVPQFPIEQIEK 106
            |.|..|.|..|.   ..|.:..:.|.|  |.||...:|..|.....:..::|:|:...|||
Worm   176 KRSRISANISTK---EDKSNGSKKTVDSELFDSGPFKKNFAFGNADHSTASPFEISTTPIE---- 233

  Fly   107 KLQIQRHLNEKQATGPRPVATAAVLATNRE---SSSSTEGRESAVTME--------------RND 154
                   :||.:|.....::..|.|.:..:   |.||.:.....:..|              |:.
Worm   234 -------VNESRAHKTIEISNRARLESQNDGCLSPSSLKSVLDEIQTEPRCKSPQHIDLHTFRDA 291

  Fly   155 ADINFQRVSISGEDTSGVPLEDLERASTLLIEALRLRSHYMAMSDQSFPSTTARFLK---TVKL- 215
            .|:|:||::|:||:.||||||||:.||..|||||.|||.||......|||||..||.   ...|
Worm   292 VDVNYQRMAITGEELSGVPLEDLKTASGHLIEALHLRSKYMERIGNQFPSTTRNFLSGHYPANLP 356

  Fly   216 KDRINNLPVKEVSDVHLRHSP--------MKITNPWNVEFPNDEDFKIKPL---NGVFHIYE--- 266
            |.|:.|....:|    |.|.|        ....||  .:.|.|...|..||   ..::|:..
Worm   357 KHRVKNTETTQV----LFHPPSVPDLEAVQTSFNP--PDPPKDHWGKNDPLPKYEKIYHLRRNRG 415

  Fly   267 -----NDDESSEIKYEYPDMS--QFVNDMQVMCNMIADGPLKSFCYRRLCYLSSKYQMHVLLNEL 324
                 |||.|.:.:::..:::  :|:||.:.:..||.||||||||:|||.||.:|:|:|||||||
Worm   416 VTEICNDDGSIDQQFKNVNVTKEEFLNDTEKLTAMIVDGPLKSFCFRRLSYLENKFQLHVLLNEL 480

  Fly   325 RELAAQKAVPHRDFYNTRKVDTHIHAASCMNQKHLLRFIKKTLKNNANEVVTVTNGQQMTLAQVF 389
            |||..||.|.||||||.|||||||||||.||||||||||||.:|..|:.||...||.::|:.:||
Worm   481 RELHEQKGVSHRDFYNIRKVDTHIHAASSMNQKHLLRFIKKKIKTEADTVVLNNNGTKVTMKEVF 545

  Fly   390 QSMNLTTYDLTVDMLDVHADRNTFHRFDKFNSKYNPIGESRLREVFLKTDNYLNGKYFAQIIKEV 454
            :.|.:..|||:||||||||||||||||||||:||||:|||.|||:|:|||||:.|||||.::|||
Worm   546 KKMGIDAYDLSVDMLDVHADRNTFHRFDKFNTKYNPVGESTLREIFIKTDNYVGGKYFADLLKEV 610

  Fly   455 AFDLEESKYQNAELRLSIYGKSPDEWYKLAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNKMMKSF 519
            ..|||:||||:||.||||||:|.:||..|||||:.:||:|.|.|||:|||||:|::::..|:|:|
Worm   611 LSDLEDSKYQHAEPRLSIYGRSKNEWDNLAKWALTHDVWSPNARWLVQIPRLYDVYRAKNMVKNF 675

  Fly   520 QEILNNIFLPLFEATARPSKHPELHRFLQYVIGFDSVDDESKPENPLFDNDVPRPEEWTYEENPP 584
            .::|:|:|.||||.|..||.|||||.|||.:.|.||||||||.|...||...|.|.|:|..||||
Worm   676 DDMLDNLFTPLFEVTNDPSSHPELHLFLQQISGIDSVDDESKHEFVNFDRSTPCPPEYTDLENPP 740

  Fly   585 YAYYIYYMYANMTVLNKFRQSRNMNTFVLRPHCGEAGPVQHLVCGFLMAENISHGLLLRKVPVLQ 649
            |.||::|||.|:..||.||::|.:|||.|||||||||.|.||:.|:|.:|:|:||:|||||||||
Worm   741 YNYYLFYMYRNICALNAFRRARGLNTFALRPHCGEAGHVSHLLTGYLTSESIAHGILLRKVPVLQ 805

  Fly   650 YLYYLTQIGIAMSPLSNNSLFLNYHRNPLPEYLARGLIISLSTDDPLQFHFTKEPLMEEYSIAAQ 714
            |||||||||||||||||||||::|.||||||||.:||.:|||||||||||:|||.||||:|||||
Worm   806 YLYYLTQIGIAMSPLSNNSLFISYQRNPLPEYLQKGLNVSLSTDDPLQFHYTKEALMEEFSIAAQ 870

  Fly   715 VWKLSSCDMCELARNSVMMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYETLLDE 779
            ||||||||||||||||||.|||...:|..||||.|.|:|::||||.|||||:|||::|:|.|:||
Worm   871 VWKLSSCDMCELARNSVMQSGFEDKVKIHWLGPNYKEEGVLGNDIHRTNVPDIRVSFRHEALVDE 935

  Fly   780 LSNIFKVNQT 789
            |.|:|:|..|
Worm   936 LYNLFRVQNT 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	351/548 (64%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	338/495 (68%)
ampd-1	NP_001343751.1	AMP_deaminase	312..939	CDD:273618	382/632 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156471
Domainoid	1	1.000	597	1.000	Domainoid score	I97
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2979
Inparanoid	1	1.050	793	1.000	Inparanoid score	I255
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54904
OrthoDB	1	1.010	-	-		D115023at33208
OrthoFinder	1	1.000	-	-		FOG0001065
OrthoInspector	1	1.000	-	-		oto20357
orthoMCL	1	0.900	-	-		OOG6_100681
Panther	1	1.100	-	-	LDO	PTHR11359
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R55
SonicParanoid	1	1.000	-	-		X640
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940