DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AMPdeam and Ampd2

DIOPT Version :9

Sequence 1:	NP_001285233.1	Gene:	AMPdeam / 32352	FlyBaseID:	FBgn0052626	Length:	798	Species:	Drosophila melanogaster
Sequence 2:	NP_001276649.1	Gene:	Ampd2 / 109674	MGIID:	88016	Length:	835	Species:	Mus musculus

Alignment Length:	838	Identity:	462/838 - (55%)
Similarity:	577/838 - (68%)	Gaps:	73/838 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SYRGMLSTSDGSPVELRVQDVDSFDGSMMSHAATNAAGPLGSK--ASGKSL--NA-CTSMSMPQK 61
            ||.|...:....|.:.|.       |...|.||..|...||:.  .|.:||  || |    :...
Mouse     3 SYPGPGKSKAKYPFKKRA-------GLQASAAAPEARSGLGASPLQSARSLPGNAPC----LKHF 56

  Fly    62 PSSLRATCDLADSPVDEK------AEADVEVTNEISAPYEVP-QFPIEQIEKKLQ-IQRHLNEKQ 118
            |..||.:.|.....:.|:      ||:::.     |||||.| :.||||:|::.| ::|.:::..
Mouse    57 PLDLRTSMDGKCKEIAEELFSRSLAESELR-----SAPYEFPEESPIEQLEERRQRLERQISQDV 116

  Fly   119 ATGPRPVATAA--VLATNRES-----SSSTEGR------ESAVTMERNDADINFQRVSISGEDTS 170
            ...|..:..|.  .|.|:.:|     ....||:      |..|.:||     .||||.||||:..
Mouse   117 KLEPDILLRAKQDFLKTDSDSDLQLYKEQGEGQGDRGLWERDVVLER-----EFQRVIISGEEKC 176

  Fly   171 GVPLEDLERASTLLIEALRLRSHYMAMSDQSFPSTTARFLKTVKLK-------DRINNLPVKEVS 228
            |||..||..|:..::.||.:|..|||:|.|||..||.|:|:.:..|       ::..:.||...:
Mouse   177 GVPFTDLLDAAKSVVRALFIREKYMALSLQSFCPTTRRYLQQLAEKPLETRTYEQSPDTPVSADA 241

  Fly   229 DVH---LRHSPMKITNPWNVEFPNDEDFKIKPLNGVFHIY---ENDDESSEIKYEYPDMSQFVND 287
            .||   |...|.:...|  ...|.|....::.:.||.|:|   :.|:...|::..|||:.:||.|
Mouse   242 PVHPPALEQHPYEHCEP--SAMPGDLGLGLRMVRGVVHVYTRRDPDEHCPEVELPYPDLQEFVAD 304

  Fly   288 MQVMCNMIADGPLKSFCYRRLCYLSSKYQMHVLLNELRELAAQKAVPHRDFYNTRKVDTHIHAAS 352
            :.|:..:|.:||:||||||||.|||||:||||||||::||||||.||||||||.|||||||||:|
Mouse   305 VNVLMALIINGPIKSFCYRRLQYLSSKFQMHVLLNEMKELAAQKKVPHRDFYNIRKVDTHIHASS 369

  Fly   353 CMNQKHLLRFIKKTLKNNANEVVTVTNGQQMTLAQVFQSMNLTTYDLTVDMLDVHADRNTFHRFD 417
            ||||||||||||:.:|.:..|:|.|..|::.||.:||:|||||.|||:||.||||||||||||||
Mouse   370 CMNQKHLLRFIKRAMKRHLEEIVHVEQGREQTLREVFESMNLTAYDLSVDTLDVHADRNTFHRFD 434

  Fly   418 KFNSKYNPIGESRLREVFLKTDNYLNGKYFAQIIKEVAFDLEESKYQNAELRLSIYGKSPDEWYK 482
            |||:||||||||.|||:|:||||.::|||||.|||||..||||||||||||||||||:|.|||.|
Mouse   435 KFNAKYNPIGESVLREIFIKTDNKISGKYFAHIIKEVMADLEESKYQNAELRLSIYGRSRDEWDK 499

  Fly   483 LAKWAIDNDVYSSNIRWLIQIPRLFDIFKSNKMMKSFQEILNNIFLPLFEATARPSKHPELHRFL 547
            ||:||:::.|:|.|:|||:|:|||||::::...:.:|||:|.||||||||||..|:.|||||.||
Mouse   500 LARWAVNHKVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLPLFEATVHPASHPELHLFL 564

  Fly   548 QYVIGFDSVDDESKPENPLFDNDVPRPEEWTYEENPPYAYYIYYMYANMTVLNKFRQSRNMNTFV 612
            ::|.|||||||||||||.:|:.:.|.||.|..|:|||||||:||.:|||.:||..|:.|..:|||
Mouse   565 EHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYLYYTFANMAMLNHLRRQRGFHTFV 629

  Fly   613 LRPHCGEAGPVQHLVCGFLMAENISHGLLLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLNYHRNP 677
            ||||||||||:.|||..|::||||||||||||.|||||||||.||||||||||||||||:|||||
Mouse   630 LRPHCGEAGPIHHLVSAFMLAENISHGLLLRKAPVLQYLYYLAQIGIAMSPLSNNSLFLSYHRNP 694

  Fly   678 LPEYLARGLIISLSTDDPLQFHFTK-----------EPLMEEYSIAAQVWKLSSCDMCELARNSV 731
            |||||:|||::||||||||||||||           ||||||||||.||||||||||||||||||
Mouse   695 LPEYLSRGLMVSLSTDDPLQFHFTKVRPRPAGSQGQEPLMEEYSIATQVWKLSSCDMCELARNSV 759

  Fly   732 MMSGFPHAIKQQWLGPIYYEDGIMGNDITRTNVPEIRVAYRYETLLDELSNIFKVNQT 789
            :||||.|.:|..||||.|.::|..||||.|||||:|||.||||||..||:.|.:..|:
Mouse   760 LMSGFSHKVKSHWLGPNYTKEGPEGNDIRRTNVPDIRVGYRYETLCQELALITQAVQS 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AMPdeam	NP_001285233.1	PLN03055	248..784	CDD:178613	375/549 (68%)
AMPdeam	NP_001285233.1	AMPD	284..780	CDD:238644	362/506 (72%)
Ampd2	NP_001276649.1	PLN03055	198..811	CDD:178613	394/614 (64%)
Ampd2	NP_001276649.1	AMPD	301..808	CDD:238644	362/506 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831381
Domainoid	1	1.000	649	1.000	Domainoid score	I161
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2979
Inparanoid	1	1.050	861	1.000	Inparanoid score	I423
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115023at33208
OrthoFinder	1	1.000	-	-		FOG0001065
OrthoInspector	1	1.000	-	-		oto94666
orthoMCL	1	0.900	-	-		OOG6_100681
Panther	1	1.100	-	-	LDO	PTHR11359
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R55
SonicParanoid	1	1.000	-	-		X640
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790