DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jub and SCEL

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_659001.2	Gene:	SCEL / 8796	HGNCID:	10573	Length:	688	Species:	Homo sapiens

Alignment Length:	734	Identity:	132/734 - (17%)
Similarity:	232/734 - (31%)	Gaps:	235/734 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RSYQRSPGAIENYLQESQQQQQQHQMQQMQQLHHNQDYKLYERGNIIAA-SKYATPRPVEQIQHT 117
            |::.:....|:...:|.:.:.....:......|...|.|:.||....|. |:|::...:::|. .
Human    37 RTFLQDNSWIKKRPEEEKDENYGRVVLNRHNSHDALDRKVNERDVPKATISRYSSDDTLDRIS-D 100

  Fly   118 HNGSAQIYAPTAQILGQRIAPQKHSPVYENLEFYGQFDSNHKRAQP-QSPGSRQSAILNGYLLMQ 181
            .|.:|:.|  .|..|..::..:..| ::.:||.        .:.|| .|..:..|..:.......
Human   101 RNDAAKTY--KANTLDNQLTNRSMS-MFRSLEV--------TKLQPGGSLNANTSNTIASTSATT 154

  Fly   182 PIRAGR--FAHTPVPENQGSASLGTTRAAGG-----PPPPSGRSAALGPTGDLEEHAAPIYENII 239
            |::..|  :...|.|....|:|.||.|...|     ||.||                :|:..
Human   155 PVKKKRQSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPS----------------SPVSS--- 200

  Fly   240 PHSGQRAQPQASPATATMYQEMQPTSNSSGSSSTAGLDL-NALLASPMHQRS---------ISSN 294
            |:..::...|..|....:|.|    :|.|...:....|| |.:..:...|||         |..|
Human   201 PNQLRQDNRQIHPPKPGVYTE----TNRSAERNIRSQDLDNIVKVATSLQRSDKGEELDNLIKMN 261

  Fly   295 TASSSSLGSPT------------QRYRNLSLPSHLSP--------VPTAQSVAKLQQHTPVKSPG 339
            .:.:.:.|..:            :|.::|....::|.        :.:..|..|:.|.|.....|
Human   262 KSLNRNQGLDSLFRANPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQRTDKNEKG 326

  Fly   340 -------GAINVSVN--PNYIEDINSSDYVCMTANLHRNTAAGLATGRAAATGAPAQRTVQEPPI 395
                   ..:|..:|  ....||::::..|  ....|.||     ||:....
Human   327 RQNLESVAKVNARMNKTSRRSEDLDNATEV--NPKGHENT-----TGKKDLD------------- 371

  Fly   396 ITSSLAMGMATAAPPTTSNAPTSAAAAPAAPTSTASL----RATPIAMTAPLAVATSPTPSQGST 456
                   |:....|.|..|.           |...||    :.||....:          :|||.
Human   372 -------GLIKVDPETNKNI-----------TRGQSLDNLIKVTPEVKRS----------NQGSK 408

  Fly   457 AVNAALKPRRGLTK---------NLLPYSVTPPRPAGPTEAQRKIEELTRQLEEEIEQSEEH-GE 511
            .:|..:|...|..|         :|:  .|||.|.. ..:..:.:|.|.:.:....:.||:. .|
Human   409 DLNNFIKVYPGTEKSTEGGQSLDSLI--KVTPERNR-TNQGNQDLENLIKVIPSANKSSEQGLDE 470

  Fly   512 YFGIC-----HTCGE----------------------------------------------KVKG 525
            :..:.     :|.|:                                              |||.
Human   471 HINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDLANLIKVNPAVIRNNQSQDLDNLIKVKP 535

  Fly   526 AG----QACQAMGNLYHTNCFI------CCSCGRALRGKAFYNVHGRVYCEEDYM-YSGFQQ--- 576
            :.    ...|.:.||...|..:      ..:.|....|.....|:.|.|.|.... ..|:|:
Human   536 SALRNTNRDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENIS 600

  Fly   577 ---------TAEK-------CAICGHLI---MEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVD 622
                     |:::       |..|...:   .:|||..:....|..||:|.:|.:.|:.:.....
Human   601 GKYIQTVYSTSDRSVIERDMCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDS 665

  Fly   623 V---DHKIYCVNDYHRMFA 638
            :   ...|:|...|.::.|
Human   666 IWIYRQTIHCEPCYSKIMA 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	15/113 (13%)
		LIM2_Ajuba_like	581..633	CDD:188741	13/57 (23%)
		LIM3_Ajuba_like	641..702	CDD:188822
SCEL	NP_659001.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..231		26/119 (22%)
		16 X approximate tandem repeats	251..563		56/362 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..373		9/59 (15%)
		LIM	620..678	CDD:214528	13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900