DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and Ajuba

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_445955.1	Gene:	Ajuba / 85265	RGDID:	620407	Length:	548	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	201/528 - (38%)
Similarity:	264/528 - (50%)	Gaps:	108/528 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 GGPPPPSGRSAALGPTGDLE-EHAAPIYENIIPHSGQRAQPQASPATATMYQEMQPTS------- 265
            |||||.......|....|.. |..||           ...|::|.|:::.....:|:|
  Rat   101 GGPPPTRALPLPLSSPPDFRLETTAP-----------ALSPRSSFASSSASDASKPSSPRGSLLL 154

  Fly   266 NSSGSSSTAGLDLNALLASPMHQRSISSNTASSSSLGSPTQRYRNLSLPSHLSPVPTAQSVAKLQ 330
            :.:|:|...|       :.|      .||..|..|:|. .||        |.||:|....:..|.
  Rat   155 DGAGASGAGG-------SRP------CSNRTSGISMGY-DQR--------HGSPLPAGPCLFGLP 197

  Fly   331 QHTPVKSPGGAINVSVNPNYIEDINSSDYVCMTANLHRNT----------------AAGLATGRA 379
            ..|   :|.|..:..|...|.|...:.|.:|    .||..                :.|..||..
  Rat   198 LTT---APSGYSSGGVPSAYPELHAALDRLC----AHRPVGFGCQESRHSYPPALGSPGALTGAV 255

  Fly   380 AATGAPAQRTVQEPPIITSSLAMGMATAAPPTTSNAPTSAAAAPAAPTSTASLRATPIAMTAPLA 444
            ..|..|.:|...:|              ...:.:.....||.|......||.||         |.
  Rat   256 VGTAGPLERRGTQP--------------GRHSVTGYGDCAAGARYQDELTALLR---------LT 297

  Fly   445 VATSPTPSQGSTAVNAALKPRRGLTKNLLPYSVTPPRPAGPTEAQRKIEELTRQLEEEIEQSEEH 509
            |||....: |:......::| .||.::  |.|..|       ||.|          ..|.:.|..
  Rat   298 VATGGREA-GARGEPLGIEP-SGLEES--PGSFVP-------EASR----------SRIREPEAR 341

  Fly   510 GEYFGICHTCGEKVKGAGQACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYMYSGF 574
            .:|||.|..|.:.:.|...||||:.:||||.||:||||||.||.||||:|:|.|||||||::|||
  Rat   342 EDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGF 406

  Fly   575 QQTAEKCAICGHLIMEMILQAMGKSYHPGCFRCCVCNECLDGVPFTVDVDHKIYCVNDYHRMFAP 639
            |:.||||.:|||||:|.||||||||||||||||.|||:||||||||||..:::|||.|||:.:||
  Rat   407 QEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGVPFTVDFSNQVYCVTDYHKNYAP 471

  Fly   640 KCASCGKGITPVEGTDETVRVVSMDKDFHVDCYICEECGMQLTDEPDKRCYPLDGRLLCRGCHLQ 704
            |||:||:.|.|.||.::.|||:|||:|:|.:||.||:|.|||:||....|:||||.|||.|||:|
  Rat   472 KCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQ 536

  Fly   705 RLALQSSP 712
            ||:.:..|
  Rat   537 RLSARQPP 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	32/52 (62%)
		LIM2_Ajuba_like	581..633	CDD:188741	39/51 (76%)
		LIM3_Ajuba_like	641..702	CDD:188822	35/60 (58%)
Ajuba	NP_445955.1	PreLIM	1..345		71/327 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..182		24/105 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	290..298		5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..333		9/45 (20%)
		LIM1_Ajuba_like	348..401	CDD:188738	32/52 (62%)
		LIM2_Ajuba_like	413..465	CDD:188741	39/51 (76%)
		LIM3_Ajuba_like	473..534	CDD:188822	35/60 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6613
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24219
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.870