DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and AJUBA

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_116265.1	Gene:	AJUBA / 84962	HGNCID:	20250	Length:	538	Species:	Homo sapiens

Alignment Length:	567	Identity:	213/567 - (37%)
Similarity:	273/567 - (48%)	Gaps:	109/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 NQGSASLGTTRAAG-GPPPPSGRSAALGPTGD--LE----------------EHAAPIYENIIPH 241
            :.|:...|..|.:| |.|..||...|.|..||  ||                ...||.||...|.
Human    27 SDGTPGPGKGRLSGLGGPRKSGPRGATGGPGDEPLEPAREQGSLDAERNQRGSFEAPRYEGSFPA 91

  Fly   242 SGQRAQPQASPATATMYQEMQPTS-----NSSGSSSTA-----------GLDLNALLASPMHQRS 290
            .....:....|.:......::||:     .||.:||:|           .|.|:...|.......
Human    92 GPPPTRALPLPQSLPPDFRLEPTAPALSPRSSFASSSASDASKPSSPRGSLLLDGAGAGGAGGSR 156

  Fly   291 ISSNTASSSSLGSPTQRYRNLSLPSHLSPVPTAQSV--AKLQQHTPVKSPGGAINVSVNPNYIED 353
            ..||..|..|:|. .||        |.||:|....:  ..|.......||||.
Human   157 PCSNRTSGISMGY-DQR--------HGSPLPAGPCLFGPPLAGAPAGYSPGGV------------ 200

  Fly   354 INSSDYVCMTANLHRNTAAGLATGRAAATGAPAQRTVQEPPIITSSLAM---GMATAAPPTTSNA 415
              .|.|..:.|.|.|     |...|.|..|....|. ..||.:.|..|:   |:..|.|.....|
Human   201 --PSAYPELHAALDR-----LYAQRPAGFGCQESRH-SYPPALGSPGALAGAGVGAAGPLERRGA 257

  Fly   416 PTS----------AAAAPAAPTSTASLRATPIAMTAPLAVATSPTPSQGSTAVNAALKPRRGLTK 470
            ...          |..|......||.||         |.|.|....: |:....:.::| .||.:
Human   258 QPGRHSVTGYGDCAVGARYQDELTALLR---------LTVGTGGREA-GARGEPSGIEP-SGLEE 311

  Fly   471 NLLPYSVTPPRPAGPTEAQRKIEELTRQLEEEIEQSEEHGEYFGICHTCGEKVKGAGQACQAMGN 535
                    ||.|..|..|:.::.|           .|...:|||.|..|.:.:.|...||||:.:
Human   312 --------PPGPFVPEAARARMRE-----------PEAREDYFGTCIKCNKGIYGQSNACQALDS 357

  Fly   536 LYHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYMYSGFQQTAEKCAICGHLIMEMILQAMGKSY 600
            ||||.||:||||||.||.||||:|:|.|||||||::||||:.||||.:|||||:|.|||||||||
Human   358 LYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSY 422

  Fly   601 HPGCFRCCVCNECLDGVPFTVDVDHKIYCVNDYHRMFAPKCASCGKGITPVEGTDETVRVVSMDK 665
            |||||||.|||:||||:|||||..:::|||.|||:.:|||||:||:.|.|.||.::.|||:|||:
Human   423 HPGCFRCIVCNKCLDGIPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDR 487

  Fly   666 DFHVDCYICEECGMQLTDEPDKRCYPLDGRLLCRGCHLQRLALQSSP 712
            |:|.:||.||:|.|||:||....|:||||.|||.|||:|||..:..|
Human   488 DYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLNARQPP 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	32/52 (62%)
		LIM2_Ajuba_like	581..633	CDD:188741	38/51 (75%)
		LIM3_Ajuba_like	641..702	CDD:188822	35/60 (58%)
AJUBA	NP_116265.1	PreLIM	1..335		84/366 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..172		35/145 (24%)
		PHA03418	<18..>103	CDD:177646	19/75 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	280..288		5/16 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..315		6/33 (18%)
		LIM1_Ajuba_like	338..391	CDD:188738	32/52 (62%)
		LIM2_Ajuba_like	403..455	CDD:188741	38/51 (75%)
		LIM3_Ajuba_like	463..524	CDD:188822	35/60 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I7012
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24219
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.870