DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jub and ZNF185

DIOPT Version :9

Sequence 1:	NP_572930.3	Gene:	jub / 32351	FlyBaseID:	FBgn0030530	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_016885310.1	Gene:	ZNF185 / 7739	HGNCID:	12976	Length:	766	Species:	Homo sapiens

Alignment Length:	576	Identity:	118/576 - (20%)
Similarity:	180/576 - (31%)	Gaps:	175/576 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 KLYERGNIIAASKYATPRPVEQIQHTHNGSAQIYAPTAQILGQRIAP---QKHSPVYENLEFYGQ 153
            :|..||..|...:..|||          ...::.||..:  |.|.:|   .|.:|....|    |
Human   275 ELSSRGEEIVRLQILTPR----------AGLRLVAPDVE--GMRSSPGNKDKEAPCSREL----Q 323

  Fly   154 FDSNHKRA--QPQSPGSRQSAILNGYLLMQPIRAGRFAHTPVPENQGSASLGTTRAAGGPPPPSG 216
            .|...:.|  .|.:..:|.||.|:..      ..|..|....||...:..:|:.|         |
Human   324 RDLAGEEAFRAPNTDAARSSAQLSDG------NVGSGATGSRPEGLAAVDIGSER---------G 373

  Fly   217 RSAALGPTG----DLEEHAAPIYENIIPHSGQRAQPQ----ASPATATMYQEMQPTSNSSGSSST 273
            |..|.....    |.:.|:|         :.|..:|:    :|.||:.........|||:.:...
Human   374 RLCAAASFASFLEDQDGHSA---------NSQSCKPRPAAISSSATSVSAVPADRKSNSTAAQED 429

  Fly   274 AGLDLNALLAS------------------------------PMHQRSISSNTASSSSLGSPTQRY 308
            |..|....||.                              |..|.:..|.....||.....|..
Human   430 AKADPKGALADYEGKDVATRVGEAWQERPGAPRGGQGDPAVPAQQPADPSTPERQSSPSGSEQLV 494

  Fly   309 RNLSLPSHLSPVPTAQSVAKLQQHTPVKSPG-GAINVSVNPNYIEDINSSDYVCMTANLHRNTAA 372
            |..|..|...|.|  .|..|.....|...|| |:|.......:|.|       |:.     ...|
Human   495 RRESCGSRRVPQP--DSSPKKIPPLPCGGPGQGSIRRDKAGGHIGD-------CLL-----TPGA 545

  Fly   373 GLAT---GRAAAT----------GAPAQRTVQEPPIITSSLAMGMATAAPPTTSNAP-------- 416
            .:.|   |:..||          |||  |..|..|.:.:...   |..:.|...|:|
Human   546 SVLTDFEGKDVATKVGEAWQDRPGAP--RGGQGDPAVPTQQP---ADPSTPEQQNSPSGSEQFVR 605

  Fly   417 ----TSAAAAPAAPTSTASLRATP----IAMTAPLAVATSPTPSQG----STAVNAAL----KPR 465
                ||...:|::...|.::.||.    |.:.||.:...|.:.::|    ...|||:.    ||.
Human   606 RESCTSRVRSPSSCMVTVTVTATSEQPHIYIPAPASELDSSSTTKGILFVKEYVNASEVSSGKPV 670

  Fly   466 RGLTKNLL----PYSVTPPRPAGPTEAQRKIEELTRQLEEEIEQSEEHGEYFGICHTCGEKVKGA 526
            .....|:.    .:::....|.|.|....:...                   |||..|..:::..
Human   671 SARYSNVSSIEDSFAMEKKPPCGSTPYSERTTG-------------------GICTYCNREIRDC 716

  Fly   527 GQ-ACQAMGNLYHTNCFICCSCGRALRGKAFYNVHGRVYCEEDYMYSGFQQTAEKC 581
            .: ..:.:|...|..||.|..|     .|...::..:::...|.::.|      ||
Human   717 PKITLEHLGICCHEYCFKCGIC-----SKPMGDLLDQIFIHRDTIHCG------KC 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jub	NP_572930.3	LIM1_Ajuba_like	516..569	CDD:188738	9/53 (17%)
		LIM2_Ajuba_like	581..633	CDD:188741	1/1 (100%)
		LIM3_Ajuba_like	641..702	CDD:188822
ZNF185	XP_016885310.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900